Agentes da theileriose e da anaplasmose granulocítica em equídeos de microrregiões do estado do Rio de Janeiro

Detalhes bibliográficos
Autor(a) principal: Santos, Tiago Marques dos
Data de Publicação: 2011
Tipo de documento: Tese
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRRJ
Texto Completo: https://rima.ufrrj.br/jspui/handle/20.500.14407/9707
Resumo: Este trabalho foi realizado nas microrregiões de Itaguaí e Serrana no estado do Rio de Janeiro para estudar os agentes da theileriose e da anaplasmose granulocítica equina. Amostras de soro e sangue foram submetidas à reação de imunofluorescência indireta (RIFI), reação em cadeia da polimerase em tempo real (RT-PCR) e a análise hematológica. A prevalência geral para T. equi foi de 81,09% (n=579), com maior prevalência (p<0,05) para microrregião de Itaguaí (85,43%), quando comparado a Serrana (76,92%). A região, altitude, nível da propriedade e origem dos equinos foram associados (p<0,05) com a soropositividade para T. equi. Equinos criados na microrregião de Itaguaí apresentaram 11% mais chance (RP=1,11; p=0,003) de terem contato com T. equi comparado aqueles criados na microrregião Serrana. Além disso, quando são criados a altitudes abaixo de 500m apresentaram 10% de chance a mais abaixo de 500m (RP=1.10; p=0,014) de se tornarem soropositivos. Equinos criados em propriedades de nível ruim (RP=1,13; p=0,018) e nascidos na propriedade (RP=1,10; p=0,008) apresentaram mais chance de terem contato com T. equi. A frequência de equinos soropositivos para A. phagocytophilum foi de 17% (n=17) das amostras examinadas no município de Seropédica. Apenas a idade apresentou associação (p=0,044) com a soropositividade dos equinos para A. phagocytophilum. Das 350 amostras avaliadas pela RT-PCR, 0,86% (n=3) apresentaram amplificação específica para o gene msp2. As amostras positivas apresentaram valores médios do CT de 35,09±1,48 ciclos e de Tm de 78,56±0,53ºC, semelhante a do controle positivo, de 78,45±0,32ºC. As microrregiões de Itaguaí e Serrana são endêmicas para theileriose equina e de estabilidade enzoótica para T. equi. Apenas os fatores relacionados à área de coleta influenciam a soropositividade dos equinos para T. equi nas microrregiões estudadas. A presença de anticorpos anti-A. phagocytophilum e a evidência molecular da infecção por esse agente em equinos do município de Seropédica, no estado do Rio de Janeiro, sugere a circulação de A. phagocytophilum nessa região.
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spelling Santos, Tiago Marques dosMassard, Carlos Luiz257781297-34http://lattes.cnpq.br/7743112049924654Almeida, Fernando Queiroz deLinhares, Guido Fontgalland CoelhoLeite, Romário CerqueiraFaccini, João Luiz HorácioBaldani, Cristiane Divan830436081-00http://lattes.cnpq.br/33487057410126782023-12-21T18:42:55Z2023-12-21T18:42:55Z2011-03-01Santos, Tiago Marques dos. Agentes da theileriose e da anaplasmose granulocítica em equídeos de microrregiões do estado do Rio de Janeiro. 2011. 103 f. Tese (Doutorado em Ciências Veterinárias) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica - RJ, 2011.https://rima.ufrrj.br/jspui/handle/20.500.14407/9707Este trabalho foi realizado nas microrregiões de Itaguaí e Serrana no estado do Rio de Janeiro para estudar os agentes da theileriose e da anaplasmose granulocítica equina. Amostras de soro e sangue foram submetidas à reação de imunofluorescência indireta (RIFI), reação em cadeia da polimerase em tempo real (RT-PCR) e a análise hematológica. A prevalência geral para T. equi foi de 81,09% (n=579), com maior prevalência (p<0,05) para microrregião de Itaguaí (85,43%), quando comparado a Serrana (76,92%). A região, altitude, nível da propriedade e origem dos equinos foram associados (p<0,05) com a soropositividade para T. equi. Equinos criados na microrregião de Itaguaí apresentaram 11% mais chance (RP=1,11; p=0,003) de terem contato com T. equi comparado aqueles criados na microrregião Serrana. Além disso, quando são criados a altitudes abaixo de 500m apresentaram 10% de chance a mais abaixo de 500m (RP=1.10; p=0,014) de se tornarem soropositivos. Equinos criados em propriedades de nível ruim (RP=1,13; p=0,018) e nascidos na propriedade (RP=1,10; p=0,008) apresentaram mais chance de terem contato com T. equi. A frequência de equinos soropositivos para A. phagocytophilum foi de 17% (n=17) das amostras examinadas no município de Seropédica. Apenas a idade apresentou associação (p=0,044) com a soropositividade dos equinos para A. phagocytophilum. Das 350 amostras avaliadas pela RT-PCR, 0,86% (n=3) apresentaram amplificação específica para o gene msp2. As amostras positivas apresentaram valores médios do CT de 35,09±1,48 ciclos e de Tm de 78,56±0,53ºC, semelhante a do controle positivo, de 78,45±0,32ºC. As microrregiões de Itaguaí e Serrana são endêmicas para theileriose equina e de estabilidade enzoótica para T. equi. Apenas os fatores relacionados à área de coleta influenciam a soropositividade dos equinos para T. equi nas microrregiões estudadas. A presença de anticorpos anti-A. phagocytophilum e a evidência molecular da infecção por esse agente em equinos do município de Seropédica, no estado do Rio de Janeiro, sugere a circulação de A. phagocytophilum nessa região.Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do RJ - FAPERJThis study was carried out in the microregions of Itaguaí and Serrana, State of Rio de Janeiro in order to study of granulocytic anaplasmosis and theileriosis equine agents. Blood and serum samples were subjected to indirect fluorescent antibody test (IFAT), real time polymerase chain reaction (RT-PCR) and hematological analysis. The overall prevalence for T. equi was 81.09% (n=579), with higher prevalence (p<0.05) for Itaguaí microregion (85.43%), when compared to Serrana (76.92%). The region, altitude, level of farm and origin of horses were associated (p<0.05) with seropositivity for T. equi. Horses reared in the Itaguaí microregion had 11% more likely (PR=1.11, p=0.003) of having contact with T. equi compared to those reared in the Serrana microregion. Moreover, when are raired at altitudes below 500m showed 10% chance less (PR=1.10; p=0,014) of becoming seropositive. Horses reared in poor level farms (PR=1.13, p=0.018) and born on the farm (PR=1.10, p=0.008) showed more chance of having contact with T. equi. The main ticks found attached in horses were Amblyomma cajennense and Dermacentor (Anocentor) nitens. The frequency of seropositive horses for A. phagocytophilum was 17% (n=17) of the samples tested in the Seropédica county. No association (p>0.05) was observed among the studied factors and seropositivity of horses to A. phagocytophilum. Of 350 samples tested by RT-PCR, 0.86% (n=3) showed specific amplification for msp2 gene. The positive samples showed average CT value of 35.09±1.48 cycles and Tm of 78.56±0.53°C, similar to the positive control, 78.45±0.32°C. The Itaguaí and Serrana microregions are endemic for equine theileriosis and of enzootic stability for T. equi. Only factors related to collection area influenced the seropositivity of horses for T. equi in the microregions studied. The presence of anti-A. phagocytophilum antibodies and molecular evidence of infection by this pathogen in horses of Seropédica municipality in the Rio de Janeiro state, suggests the circulation of A. phagocytophilum in this region.application/pdfporUniversidade Federal Rural do Rio de JaneiroPrograma de Pós-Graduação em Ciências VeterináriasUFRRJBrasilInstituto de VeterináriaEquídeosTheileria equiAnaplasma phagocytophilumEpidemiologiaDiagnóstico sorológico e molecularEquidsTheileria equiAnaplasma phagocytophilumEpidemiologySorological and molecular diagnosis.Medicina VeterináriaAgentes da theileriose e da anaplasmose granulocítica em equídeos de microrregiões do estado do Rio de JaneiroAgents of theileriosis and granulocytic anaplasmosis in equids of microregions in the State of Rio de Janeiroinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisAGUERO-ROSENFELD, M. E.; KALANTARPOUR, F.; BALUCH, M.; HOROWITZ, H. W.; MCKENNA, D. F.; RAFFALLI, J. 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Comparison of major antigenic proteins of six strains of the human granulocytic ehrlichiosis agent by Western immunoblot analysis. Journal of Clinical Microbiology, v.35, n.10, p.2606–2611, 1997.https://tede.ufrrj.br/retrieve/54202/2011%20-%20Tiago%20Marques%20dos%20Santos.pdf.jpghttps://tede.ufrrj.br/jspui/handle/jspui/2739Submitted by Sandra Pereira (srpereira@ufrrj.br) on 2019-06-11T16:47:44Z No. of bitstreams: 1 2011 - Tiago Marques dos Santos.pdf: 3461896 bytes, checksum: ec8177b9ae48982ca835665110176395 (MD5)Made available in DSpace on 2019-06-11T16:47:44Z (GMT). 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dc.title.por.fl_str_mv Agentes da theileriose e da anaplasmose granulocítica em equídeos de microrregiões do estado do Rio de Janeiro
dc.title.alternative.eng.fl_str_mv Agents of theileriosis and granulocytic anaplasmosis in equids of microregions in the State of Rio de Janeiro
title Agentes da theileriose e da anaplasmose granulocítica em equídeos de microrregiões do estado do Rio de Janeiro
spellingShingle Agentes da theileriose e da anaplasmose granulocítica em equídeos de microrregiões do estado do Rio de Janeiro
Santos, Tiago Marques dos
Equídeos
Theileria equi
Anaplasma phagocytophilum
Epidemiologia
Diagnóstico sorológico e molecular
Equids
Theileria equi
Anaplasma phagocytophilum
Epidemiology
Sorological and molecular diagnosis.
Medicina Veterinária
title_short Agentes da theileriose e da anaplasmose granulocítica em equídeos de microrregiões do estado do Rio de Janeiro
title_full Agentes da theileriose e da anaplasmose granulocítica em equídeos de microrregiões do estado do Rio de Janeiro
title_fullStr Agentes da theileriose e da anaplasmose granulocítica em equídeos de microrregiões do estado do Rio de Janeiro
title_full_unstemmed Agentes da theileriose e da anaplasmose granulocítica em equídeos de microrregiões do estado do Rio de Janeiro
title_sort Agentes da theileriose e da anaplasmose granulocítica em equídeos de microrregiões do estado do Rio de Janeiro
author Santos, Tiago Marques dos
author_facet Santos, Tiago Marques dos
author_role author
dc.contributor.author.fl_str_mv Santos, Tiago Marques dos
dc.contributor.advisor1.fl_str_mv Massard, Carlos Luiz
dc.contributor.advisor1ID.fl_str_mv 257781297-34
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/7743112049924654
dc.contributor.advisor-co1.fl_str_mv Almeida, Fernando Queiroz de
dc.contributor.referee1.fl_str_mv Linhares, Guido Fontgalland Coelho
dc.contributor.referee2.fl_str_mv Leite, Romário Cerqueira
dc.contributor.referee3.fl_str_mv Faccini, João Luiz Horácio
dc.contributor.referee4.fl_str_mv Baldani, Cristiane Divan
dc.contributor.authorID.fl_str_mv 830436081-00
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/3348705741012678
contributor_str_mv Massard, Carlos Luiz
Almeida, Fernando Queiroz de
Linhares, Guido Fontgalland Coelho
Leite, Romário Cerqueira
Faccini, João Luiz Horácio
Baldani, Cristiane Divan
dc.subject.por.fl_str_mv Equídeos
Theileria equi
Anaplasma phagocytophilum
Epidemiologia
Diagnóstico sorológico e molecular
topic Equídeos
Theileria equi
Anaplasma phagocytophilum
Epidemiologia
Diagnóstico sorológico e molecular
Equids
Theileria equi
Anaplasma phagocytophilum
Epidemiology
Sorological and molecular diagnosis.
Medicina Veterinária
dc.subject.eng.fl_str_mv Equids
Theileria equi
Anaplasma phagocytophilum
Epidemiology
Sorological and molecular diagnosis.
dc.subject.cnpq.fl_str_mv Medicina Veterinária
description Este trabalho foi realizado nas microrregiões de Itaguaí e Serrana no estado do Rio de Janeiro para estudar os agentes da theileriose e da anaplasmose granulocítica equina. Amostras de soro e sangue foram submetidas à reação de imunofluorescência indireta (RIFI), reação em cadeia da polimerase em tempo real (RT-PCR) e a análise hematológica. A prevalência geral para T. equi foi de 81,09% (n=579), com maior prevalência (p<0,05) para microrregião de Itaguaí (85,43%), quando comparado a Serrana (76,92%). A região, altitude, nível da propriedade e origem dos equinos foram associados (p<0,05) com a soropositividade para T. equi. Equinos criados na microrregião de Itaguaí apresentaram 11% mais chance (RP=1,11; p=0,003) de terem contato com T. equi comparado aqueles criados na microrregião Serrana. Além disso, quando são criados a altitudes abaixo de 500m apresentaram 10% de chance a mais abaixo de 500m (RP=1.10; p=0,014) de se tornarem soropositivos. Equinos criados em propriedades de nível ruim (RP=1,13; p=0,018) e nascidos na propriedade (RP=1,10; p=0,008) apresentaram mais chance de terem contato com T. equi. A frequência de equinos soropositivos para A. phagocytophilum foi de 17% (n=17) das amostras examinadas no município de Seropédica. Apenas a idade apresentou associação (p=0,044) com a soropositividade dos equinos para A. phagocytophilum. Das 350 amostras avaliadas pela RT-PCR, 0,86% (n=3) apresentaram amplificação específica para o gene msp2. As amostras positivas apresentaram valores médios do CT de 35,09±1,48 ciclos e de Tm de 78,56±0,53ºC, semelhante a do controle positivo, de 78,45±0,32ºC. As microrregiões de Itaguaí e Serrana são endêmicas para theileriose equina e de estabilidade enzoótica para T. equi. Apenas os fatores relacionados à área de coleta influenciam a soropositividade dos equinos para T. equi nas microrregiões estudadas. A presença de anticorpos anti-A. phagocytophilum e a evidência molecular da infecção por esse agente em equinos do município de Seropédica, no estado do Rio de Janeiro, sugere a circulação de A. phagocytophilum nessa região.
publishDate 2011
dc.date.issued.fl_str_mv 2011-03-01
dc.date.accessioned.fl_str_mv 2023-12-21T18:42:55Z
dc.date.available.fl_str_mv 2023-12-21T18:42:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv Santos, Tiago Marques dos. Agentes da theileriose e da anaplasmose granulocítica em equídeos de microrregiões do estado do Rio de Janeiro. 2011. 103 f. Tese (Doutorado em Ciências Veterinárias) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica - RJ, 2011.
dc.identifier.uri.fl_str_mv https://rima.ufrrj.br/jspui/handle/20.500.14407/9707
identifier_str_mv Santos, Tiago Marques dos. Agentes da theileriose e da anaplasmose granulocítica em equídeos de microrregiões do estado do Rio de Janeiro. 2011. 103 f. Tese (Doutorado em Ciências Veterinárias) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica - RJ, 2011.
url https://rima.ufrrj.br/jspui/handle/20.500.14407/9707
dc.language.iso.fl_str_mv por
language por
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