Avalia??o lectino-histoqu?mica de f?gado e rim de ovinos e equinos com fotossensibiliza??o causada, respectivamente, por Brachiaria decumbens e B. humidicola

Detalhes bibliográficos
Autor(a) principal: Costa, Samay Zillmann Rocha
Data de Publicação: 2012
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRRJ
Texto Completo: https://tede.ufrrj.br/jspui/handle/jspui/3661
Resumo: Brachiaria spp. are important pasture grasses in Brazil, but they can be poisonous. Outbreaks of hepatogenous photosensitization in several herbivorous livestock cause significant economic losses. Animals grazing toxic Brachiaria spp. commonly show in their liver foamy macrophages, isolated or grouped together, and crystals inside the biliary ducts. Steroidal saponins have been identified in these crystals and are liable for damage to the bilary system leading to accumulation of phylloerytrin. Occasionally negative images of the crystals may be seen in the cytoplasm of foamy macrophages. The pathogenesis of formation and the type of material stored in the foamy cells is still unknown. The lectin histochemistry aims to assist in the detection of foamy macrophages and consequently in the diagnosis of the poisoning. Lectin histochemistry detects what kind of specific sugar residues exists in the cytoplasm of the foamy cells. The purpose of the present study was to identify the most suitable lectins in the detection of steroidal saponins in the liver and kidney of sheep and horses with photosensitization caused respectively by Brachiara decumbens and B. humiducola. Fragments of liver and kidney of fifteen sheep of both sexes and variable age, from Concei??o do Mato Dentro, Minas Gerais, and seven horse (five females and two males), were evaluated by lectin histochemistry. Fourteen lectins were used (Con-A, DBA, SBA, PNA, RCA-I, UEA-I, WGA, SWGA, GSL, PSA, PHA-L, PHA-E and LCA). It was found that the PNA lectin detected in the liver of sheep with photosensitization, caused by ingestion of Brachiaria decumbens, showed specificity and great binding reactivity for foamy macrophages, and also specificity and slight binding reactivity for hepatocytes. The WGA lectin showed specificity and moderate binding reactivity for foamy macrophages of the liver, and also specificity and slight binding reactivity for hepatocytes. The SBA, GSL and LCA lectins showed specificity and moderate binding reactivity for foamy macrophages, but were not specific for hepatocytes. The PNA lectin showed greater binding reactivity in the kidney of the sheep. In the horses with photosensitization, caused by Brachiaria humidicola, non of the lectins showed specificity for the identification of saponins or their subproducts in liver and kidney.
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spelling Fran?a, Ticiana do Nascimento027.897.197-05http://lattes.cnpq.br/3545873525091315Nogueira, Vivian de Assun??oCerqueira, Val?ria DuarteD?bereiner, J?rgen117.209.617-48http://lattes.cnpq.br/7071350800206490Costa, Samay Zillmann Rocha2020-06-23T22:30:46Z2012-07-19COSTA, Samay Zillmann Rocha. Avalia??o lectino-histoqu?mica de f?gado e rim de ovinos e equinos com fotossensibiliza??o causada, respectivamente, por Brachiaria decumbens e B. humidicola. 2012. 87 f. Disserta??o (Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas)) - Universidade Federal Rural do Rio de Janeiro, Serop?dica.https://tede.ufrrj.br/jspui/handle/jspui/3661Brachiaria spp. are important pasture grasses in Brazil, but they can be poisonous. Outbreaks of hepatogenous photosensitization in several herbivorous livestock cause significant economic losses. Animals grazing toxic Brachiaria spp. commonly show in their liver foamy macrophages, isolated or grouped together, and crystals inside the biliary ducts. Steroidal saponins have been identified in these crystals and are liable for damage to the bilary system leading to accumulation of phylloerytrin. Occasionally negative images of the crystals may be seen in the cytoplasm of foamy macrophages. The pathogenesis of formation and the type of material stored in the foamy cells is still unknown. The lectin histochemistry aims to assist in the detection of foamy macrophages and consequently in the diagnosis of the poisoning. Lectin histochemistry detects what kind of specific sugar residues exists in the cytoplasm of the foamy cells. The purpose of the present study was to identify the most suitable lectins in the detection of steroidal saponins in the liver and kidney of sheep and horses with photosensitization caused respectively by Brachiara decumbens and B. humiducola. Fragments of liver and kidney of fifteen sheep of both sexes and variable age, from Concei??o do Mato Dentro, Minas Gerais, and seven horse (five females and two males), were evaluated by lectin histochemistry. Fourteen lectins were used (Con-A, DBA, SBA, PNA, RCA-I, UEA-I, WGA, SWGA, GSL, PSA, PHA-L, PHA-E and LCA). It was found that the PNA lectin detected in the liver of sheep with photosensitization, caused by ingestion of Brachiaria decumbens, showed specificity and great binding reactivity for foamy macrophages, and also specificity and slight binding reactivity for hepatocytes. The WGA lectin showed specificity and moderate binding reactivity for foamy macrophages of the liver, and also specificity and slight binding reactivity for hepatocytes. The SBA, GSL and LCA lectins showed specificity and moderate binding reactivity for foamy macrophages, but were not specific for hepatocytes. The PNA lectin showed greater binding reactivity in the kidney of the sheep. In the horses with photosensitization, caused by Brachiaria humidicola, non of the lectins showed specificity for the identification of saponins or their subproducts in liver and kidney.Brachiaria spp. s?o importantes plantas t?xicas no Brasil. Surtos de fotossensibiliza??o hepat?gena em diversas esp?cies determinam perdas econ?micas significativas. Animais que se alimentam em pastos de Brachiaria spp. comumente apresentam macr?fagos espumosos isolados ou agrupados formando ilhas no f?gado, al?m de cristais no interior de ductos biliares. Saponinas esteroidais tem sido identificadas nestes cristais e s?o responsabilizadas por lesionar o sistema biliar levando ao ac?mulo de filoeritrina. Por vezes imagens negativas desses cristais podem estar presentes no citoplasma de macr?fagos espumosos. A patog?nese de forma??o e o tipo de material armazenado nas c?lulas espumosas ainda s?o desconhecidos. A lectino-histoqu?mica visa auxiliar na detec??o desses macr?fagos e consequentemente no diagn?stico. Al?m de tentar detectar quais os res?duos de a??cares espec?ficos est?o presentes no citoplasma das c?lulas espumosas. Assim, este trabalho teve por objetivo identificar quais as lectinas mais indicadas na detec??o de saponinas esteroidais no f?gado e rim de ovinos e equinos com fotossensibiliza??o, respectivamente, por Brachiaria decumbens e B. humidicola. Fragmentos de f?gado e rim de quinze ovinos, de ambos os sexos de idade vari?vel, oriundos de Concei??o do Mato Dentro, Minas Gerais e de sete equinos, (cinco f?meas e dois machos), foram avaliados pela t?cnica de lectino-histoqu?mica. Quatorze lectinas foram utilizadas (Con-A, DBA, SBA, PNA, RCA-I, UEA-I, WGA, SWGA, GSL, PSA, PHA-L, PHA-E e LCA). Verificou-se que, no f?gado de ovinos com fotossensibiliza??o provocada pela ingest?o de Brachiaria decumbens, a lectina PNA apresentou especificidade e acentuada reatividade aos macr?fagos espumosos, bem como especificidade e leve reatividade aos hepat?citos. A lectina WGA teve especificidade e moderada reatividade aos macr?fagos espumosos do f?gado e especificidade e leve reatividade aos hepat?citos. As lectinas SBA, GSL e LCA apresentaram especificidade e moderada reatividade aos macr?fagos espumosos, entretanto, n?o foram espec?ficas para hepat?citos. No rim dos ovinos, a lectina PNA foi a que apresentou maior reatividade. Nos cavalos com fotossensibiliza??o, causada por Brachiaria humidicola, nenhuma lectina se mostrou espec?fica na identifica??o de saponinas ou seus subprodutos no f?gado e no rim.Submitted by Sandra Pereira (srpereira@ufrrj.br) on 2020-06-23T22:30:46Z No. of bitstreams: 1 2012 - Samay Zillmann Rocha Costa.pdf: 4814858 bytes, checksum: 6c2f12ca990574a602c9293431c35029 (MD5)Made available in DSpace on 2020-06-23T22:30:46Z (GMT). No. of bitstreams: 1 2012 - Samay Zillmann Rocha Costa.pdf: 4814858 bytes, checksum: 6c2f12ca990574a602c9293431c35029 (MD5) Previous issue date: 2012-07-19Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior, CAPES, Brasil.application/pdfhttps://tede.ufrrj.br/retrieve/60834/2012%20-%20Samay%20Zillmann%20Rocha%20Costa.pdf.jpgporUniversidade Federal Rural do Rio de JaneiroPrograma de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas)UFRRJBrasilInstituto de Veterin?riaALBERNAZ, T.T., SILVEIRA, J.A.S., SILVA, N.S., OLIVEIRA, C.H.S., REIS, A.S.B., OLIVEIRA, C.M.C., DUARTE, M.D., BARBOSA, J.D. Fotossensibiliza??o em ovinos associada ? ingest?o de Brachiaria brizantha no estado do Par?. Pesq. Vet. Bras., v. 30, n. 9, p. 741-748, 2010. ALROY, J., GOYAL, V., SKUTELSKY, E. Lectin histochemistry of mammalian endothelium. Histochemistry, v.86, p.603-607, 1987. ALROY, J., UCCI, A.A., GOYAL, V., WOODS, W. Lectin Histochemistry of Glycolipid Storage Diseases on Frozen and Paraffin-Embedded Tissue Sections. Journal of Histochemistry and Cytochemistry, v.34, n.4, p.501-505, 1986. ALUJA, A.S. Further investigation regarding the toxicity of members of the genus Lantana in Mexico. Anais XIX Congr. Mundial Veterinaria, Mexico, v.1, p.327-331, 1971. ANDRADE, R.P., BOAS, H.D.V., SILVEIRA, G.C., PAIVA, L. Parceria Embrapa- Unipastos e seu impacto na pesquisa e desenvolvimento de pastagens tropicais do Brasil. Mat?ria t?cnica. Associa??o Brasileira de sementes e mudas, 2004. ARMI?N, A.G., TOKARNIA, C.H., PEIXOTO, P.V., FRESE, K. Spontaneous and experimental glycoprotein storage disease of goats induced by Ipomoea carnea subsp fistulosa (Convolvulaceae). Vet Pathology, v.44, p.170-184, 2007. BARBEITO, C., MASSONE, A.R., QUIROGA, M.A. Introduction a las t?cnicas de lectinhistoqu?mica. Aplicaciones em Patologia Veterin?ria. Decimoseptimo curso internacional de posgrado em t?cnicas de inmunohistoquimica, lectinhistoquimica y microscopia electronica, 117p., 2005. BARBOSA, J.D., OLIVEIRA, C.M.C., TOKARNIA, C.H., PEIXOTO P.V. Fotossensibiliza??o hepat?gena em eq?inos pela ingest?o de Brachiaria humidicola (Gramineae) no Estado do Par?. Pesq. Vet. Bras., v. 26, n. 3, p. 147-153, 2006. BARONDES, S. H. Soluble lectins: a new class of extracellular proteins. Science, v. 223, p. 1259-1264, 1984. BLAKEMORE, W. G. GM1 gangliosidosis in a cat. J. Comp. Pathol., v. 82, p. 179-185, 1972. BOABAID, F.M., ANTONIASSI, N.A.B., PESCADOR, C.A., SOUZA, M.A., GASPARETTO, N.D., CRUZ, C.E.F., BEZERRA J?NIOR, P.S., DRIEMEIER, D., COLODEL, E.M. Lectin Histochemistry on Sections of Liver and Hepatic Lymph Nodes from Sheep Grazing on Brachiaria spp. In: RIET-CORREA F., PFISTER J., SCHILD A. L., WIERENGA T. (Eds), Poisoning by Plants, Mycotoxins and related Toxins. CAB International, London,2011. 82 BRITO, M.F, TOKARNIA, C.H., D?BEREINER, J. A toxidez de diversas lantanas para bovinos e ovinos no Brasil. Pesq. Vet. Bras., v.24, n.3, p.153-159, 2004. BRITO, M.F, TOKARNIA, C.H. Estudo comparativo da toxidez de Lantana camara var. aculeata em bovinos e ovinos. Pesq. Vet. Bras., v.15, n.2/3, p.79-84, 1995. BRITO, M.F. Sensibilidade do coelho a Lantana camara var. aculeata (Verbenaceae) em estado fresco e dessecado. Pesq. Vet. Bras., v.15, n.4, p.107-110, 1995. BROOKS, S.A., LEATHEM, A.J.C., SCHUMACHER, U. Lectin Histochemistry ? a concise practical handbook. Microscopy Handbooks 36. Bios Scientific Publishers in association with the Royal Microscopical Society, Oxford, 177p, 1997. BRUM, K.B., HARAGUCHI, M., LEMOS, R.A.A. Crystal-associated cholangiopathy in sheep grazing Brachiaria decumbens containing the saponin protodioscin. Pesq. Vet. Bras., v. 27, n. 1, p.39-42, 2007. BURAKOVAS, R.G., YOKOSUKA, A., MIMAKI, Y., RIET-CORREA, F., MEDEIROS, R.M.T., DANTAS, A.F.M., MATOS, P.F., KATIKI, L.M., VER?SSIMO, C.J., BUENO, M.S., BRUM, K.B., FIORAVANTI, M.C.S., BARBOSA, NETO J.D., HARAGUCHI, M. Investiga??o das saponinas furost?nicas nas gram?neas de Panicum. 30a Reuni?o Anual da Sociedade Brasileira de Qu?mica (SBQ), 2007. BUTTON, C., PAYNTER, D.I., SHIEL, M.J., COLSON, A.R., PATERSON, P.J., LYFORD, R.L. Crystal-associeted colangiohepatopathy and photosensitization in lambs. Aust. Vet. J., v.64, n.6, p.176-180, 1987. CASTAGNARO, M., CANESE, M.G. Lectin histochemistry on squamous metaplasia in different epithelial tumors of dogs. Vet. Pathol., v.28, p.8-15, 1991. CHEEKE, P.R. Nutritional and physiological implications of saponins. A review Canadian J. Anim. Sci., v.51, p.621-632, 1971. CHICK, H., ELLINGER, P. The photo-sensitizing action of buckwheat (Fagopyrum esculentum). J. Physiol., v.100, p.212-230, 1941. CINTRA, A.F., ALENCAR, R.A., MELLO, R.E.A., ANDRADE, S.O., NOBRE, D., CAMARGO, W.V., NAZ?RIO, W., AMANTE, E. Informa??es do instituto biol?gico relativas ? fotossensibiliza??o em equinos e bovinos. O Biol?gico, v.43, n.5/6, p.141-144, 1977. DOLLAHITE, J.W., YOUNGER, R.L., HOFFMAN, G.O. Photosensitization in cattle and sheep caused by feeding Ammi majus (greater Ammi; Bishop's-Weed). Am. J. Vet. Res., v.39, n.1, p. 193-197, 1978. DAMJANOV, I. Lectin cytochemistry and histochemistry. Lab. Inv., v.57, p.5-20,1987. DELVES, P.J. The role of glycosylation in autoimmune disease. Autoimmunity, v.27, p.239-253, 1997. 83 DENNIS, L.W., GRANOVSKY, M., WARREN, C.E. Glycoprotein glycosylation and cancer progression. Biochimica et Biophysica Acta, v.1473, p.21-34, 1999. DRICKAMER, K., WEIS, W. I., TAYLOR, M.E. The C-type lectin superfamily in the immune system. Immunol. Rev., v.163, n.1, p.19?34, 1998. DRIEMEIER, D., COLODEL, E.M., GIMENO, E.J., BARROS, S.S. Lysosomal storage disease caused by Sida carpinifolia poisoning in goats. Veterinary Pathology, v.37, p.153- 159, 2000. DRIEMEIER, D., D?BEREINER, J., PEIXOTO, P.V., BRITO, M.F. Rela??o entre macr?fagos espumosos (?foam cells?) no f?gado de bovinos e ingest?o de Brachiaria spp no Brasil. Pesq. Vet. Bras., v.19, n.2, p.79-83, 1999. ELLIS, M.B. Dematiaceous hyphomycetes. Kew: Commonw Mycol. Inst., 608p., 1971. FURLAN, A.C., SANTOLON, M.R., SCAPINELLO, C., MOREIRA, I., FARIA, H.G. Avalia??o nutricional do trigo mourisco (Fagopyrum esculentum, Moench) para coelhos em crescimento. Acta Sci. Anim. Sci. Maring?, v.28, n.1, p.21-26, 2006. FL??YEN, A., WILKINS, A.L. Metabolism of Saponins From Narthecium Ossifragum - a Plant Implicated in the Aetiology of Alveld, a Hepatogenous Photosensitization of Sheep. Vet. Res. Com., v.21, n.5, p.335-345, 1997. FL??YEN, A., WILKINS, A.L., DENG, D., BREKKE, T. Ovine Metabolism of Saponins: Evaluation of a Method for Estimating the Ovine Uptake of Steroidal Saponins from Narthecium ossifragum. Vet. Res. Com., v.25, n.3, p.225-238, 2001. GIDDENS, E.W, Jr., D.V.M., LABBE, R.F., SWANGO, D.V.M., PADGETT, G.A. Feline congenital erythropoietic porphyria associated with severe anemia and renal disease. Am. J. Pathol., v.80, p.367-386, 1975. GOLDSTEIN, I.J., HUGHES, R.C., MONSIGNY, M., OSAWA, T., SHARON, N. What should be called a lectin?. Nature, v.285, p.66, 1980. GOMAR, M.S., DRIEMEIER, D., COLODEL, E. M., GIMENO E. J. Lectin Histochemistry of foam cells in tissues of cattle grazing Brachiaria spp. J. Vet. Med. A., v.52, p.18-21, 2005. HARLEY, K.L.S. Biological control of Lantana in Australia. Proc. 3rd Int. Symp. Biol. Control Weeds, Montpellier, France, p.23-29, 1973. HSU, S.M., REE, H.J. Histochemical studies on lectin binding in reactive lymphoid tissues. J. Histochem. Cytochem., v.31, p.538-546, 1983. JONES, T.C., HUNT, R.D., KING, N.W. Patologia Veterin?ria. 6a. ed. Editora Manole: Barueri, 1415p., 2000. JUNQUEIRA, L.C., CARNEIRO, J. Histologia b?sica. 10a ed. 448p., 2004. 84 KAMIYA, S., YAMAGAMI, T., UMEDA, M., SUGIYAMA, M., DAIGO, M. Lectin histochemistry of foamy cells in non-nervous tissues of feline sphingomyelinosis. J. Comp. Path., v.105, p.241-245, 1991. KARAYANNOPOULOU, G., WEISS, J., DAMJANOV, I. Detection of fungi in tissue sections by lectin histochemistry. Arch. Pathol. Lab. Med., v.112, n.7, p.746-8, 1988. KELLERMAN, T.S., COETZER, J.A.W., NAUD?, T.W., BOTHA C.J. Plant Poisonings and Mycotoxicoses. Oxford University Press, Cape Town, RSA., 310p., 2005. KURIWAKI, K., YOSHIDA, H. Morphological characteristics of lipid accumulation in liver-constituting cells of acid lipase deficiency rats (Wolman?s disease model rats). Pathol. Int., v.49, p.291-297, 1999. LAGERON, A. Characterization by lectin binding of the sugar moiety of glycocompounds stored in inherited diseases. Histochemical journal, v.19, p.419-425, 1987. LAJIS, N.H., SALAM ABDULLAH, H., SALIM, S.J., BREMNER, J.B., KHAN, M.N. Episarsasapogenin and epi-smilagenin: two sapogenins isoleted from the rumen content of sheep intoxicated by Brachiaria decumbens. Steroids, v.58, p.387-389, 1991. L?U, H.D. Efeitos t?xicos de Lantana camara e de Pithomyces chartarum em b?falos. Doc. 54, Embrapa-CPATU, Bel?m, Par?. 18p. 1990. LEMOS, R.A.A., FERREIRA, L.C.L., SILVA, S.M., NAKAZATO, L., SALVADOR, S.C. Fotossensibiliza??o e colangiopatia associada a cristais em ovinos em pastagens com Brachiaria decumbens. Ci?ncia Rural, Santa Maria, v.26, n.1, p.109-113, 1996. LIS, H., SHARON, N. Lectins: carbohydrate-specific proteins that mediate cellular recognition. Chem. Rev., v.98, p.637-674, 1998. MASSONE, A.R., ITAGAKI, S., DOI, K., GIMENO, E.J. Lectinhistochemical study on normal and paratuberculosis-affected bovine ileum. J. Vet. Med. Sci., v.53, n.4, p.761-763, 1991. MATSUMOTO, H., MURAMATSU, H., MURAMATSU, T., SHIMAZU, H. Carbohydrate profiles shown by a lectin and a monoclonal antibody correlate with metastatic potential and prognosis of human lung carcinomas. Cancer, v.69, p.2084-2090, 1992. MCGAVIN, M.D., ZACHARY, J.F. Bases da patologia em veterin?ria. Tradu??o da 4? edi??o. Elsevier, 1476p, 2007. MEAGHER, L.P., SMITH, B.L., WILKINS, A.L. Metabolism of diosgenin-derived saponinas: implicationsfor hepatogenous photosensitization diseases in ruminant. Animal Feed Sci. Techn., v.91, p.157-170, 2001. MEAGHER, L.P., WILKINS, A.L., MILES, C.O., COLLING, R.G., FAGLIARI, J.J. Hepatogenous photosensitization of ruminants by Brachiaria decumbens and Panicum dichotomiflorum in the absence of sporodesmin: lithogenic saponinas may be responsible. Vet. Human Toxicol, v.38, n.4, p.271-4, 1996. 85 MELLO, A.M., ELLINGUER, F., LOUREN?O, L.A.P., CASTRO, L.M.S., ZIMMERMAN, M.A.T. Doen?a de Wolman (xantomatose familiar), relato de caso. Pediat. (S. Paulo), v.4, p.159-162, 1982. MELO-JUNIOR, M.R., TELLES, M.S., ALBURQUERQUE, F.E.B., PONTES-FILHO, N.T., CARVALHO Jr, L.B., BELTR?O, E.I. Altered lectin-binding sites in normal colon and ulcerative colitis. J. Bras. Patol. Med. Lab., v.40, n.2, p.123-5, 2004. M?NDEZ, M.C., RIET-CORREA, F., SCHILD, A.L., FERREIRA, J.L., PIMENTEL, M.A. Fotossensibiliza??o em bovinos causada por Ammi majus (Umbelliferac) no Rio Grande do Sul. Pesq. Vet. Bras., v.11, n.1/2, p.17-19, 1991. MILES, C.O., WILKINS, A.L., ERASMUS, G.L., KELLERMAN, T.S., COETZER, J.A.W. Photosensitivity in South-Africa. VII. Chemical-composition of biliary crystals from a sheep with experimentally-induced geeldikkop. Ond. J. Vet. Res., v.61, n.3, p.215-222, 1994. MILES, C.O. A role for steroidal saponins in hepatogenous photosensitization. N. Z. Vet.J., v.41, n.221, 1993. MORTIMER, P.H., MENNA, M.E., WHITE, E.P. Pithomycotoxicosis. ?Facial eczema? in cattle. In: WYLLIE, T.D., MOREHOUSSE, L.G. (ed). Mycotixic fungi, mycotoxins, mycotoxicosis. An encyclopedic handbook. Vol.II. Marcel Dekker, New York, p.63-72, 1978. MORTIMER, P.H. The experimental intoxication of sheep with sporidesmin, a metabolic product of Pithomyces chartarum. IV. Histological and histochemical examinations of orally-dosed sheep. Res. Vet. Sci., v.4, p.166-185, 1963. MOTTA, A.C, RIVERO, G.R., SCHILD, A.L., RIET-CORREA, F., M?NDEZ, M.C., FERREIRA, J.L. Fotossensibiliza??o em bovinos no sul do Rio Grande do Sul. Ci?ncia Rural, v.30, n.1, p.143-149, 2000. MURNAME, R. D., AHERN-RINDELL, A. J., PRIEUER, D. J. Lectin histochemistry of an ovine lysosomal storage disease with deficiencies of beta-galactosidase and alfaneuraminidase. American Journal of Pathology, v.135, n.4, p.623-630, 1989. ODRIOZOLA, E. fotosensibilizacion y queratoconjuntivitis en ruminantes por consume de semillas de falsa visnaga (Ammi majus). Vet. Arg., v.1, n.7, 1984. PAPADOPOULOU, K., MELTON, R.E., LEGGETT, M., DANIELS, M. J., OSBOURN, A.E. Compromised disease resistance in saponin-deficient plants. PNAS, v.26, n.96, p.12923-12928, 1999. PATALAMAI, B., HEJTMANCIK, E., BRIDGES, C. H. et al. The isolation and identification of steroidal sapogenins in kleingrass. Vet. Hum. Toxicol., v.32, p. 314-318, 1990. PIMENTEL, L.A., RIET-CORREA, F., GUEDES, K.M.R., MAC?DO, J.T.S.A., MEDEIROS, R.M.T., DANTAS, A.F.M. Fotossensibiliza??o prim?ria em equ?deos e 86 ruminantes no semi-?rido causada por Froelichia humboldtiana (Amaranthaceae). Pesq. Vet. Bras., v.27, n.1, 2007. REE, H.J., KADIN, M.E. Macrophages-histiocytes in Hodgkin?s disease: the relation of Peanut-Agglutinin-Binding macrophages-histiocytes to clinicalpathologic presentation and course of disease. Cancer, v.56, p.333-338, 1985. RIET-ALVARIZA, F., CORBO, M., MENY, H., DEL PUERTO, O., COSCKER, P. Fotosensibilizacion primaria en ganado lechero associada con Ammi majus (n.v. cicuta negra). III Jornadas Uruguayas de Buiatria, Paysand?, 1975. RIET-CORREA, F., M?NDEZ, M.C., SCHILD, A.L., RIET-CORREA, I., SILVA NETO, S.R. Intoxica??o por Lantana glutinosa em bovinos no estado de Santa Catarina. Pesq. Vet. Bras., v.4, p.147-153, 1984. RIET-CORREA, B., CASTRO, M. B., LEMOS, R.A.A., RIET-CORREA, G., MUSTAFA, V., RIET-CORREA, F. Brachiaria spp. poisoning of ruminants in Brazil. Pesq. Vet. Bras., v.31, n.3, p.183-192, 2011. RIET-CORREA, F., MEDEIROS, R.M.T. Intoxica??es por plantas em ruminantes no Brasil e no Uruguai: import?ncia econ?mica, controle e riscos para a sa?de p?blica. Pesq. Vet. Bras., v.21, n.1, p.38-42, 2001. ROE, D.A., KROOK, L., WILKIE, B.N. Hepatic protoporphyria in weanling pigs. Journal of Investigative dermatology, v.54, n.1, p.53-64, 1970. RUSSOMANNO, O.M.R., PORTUGAL, M.A.S.C., COUTINHO, L.N., CALIL, E.M.B., FIGUEIREDO, M.B. Leptosphaerulina chartarum (=Pithomyces chartarum) e seu envolvimento no eczema facial. Arq. Inst. Biol., v.70, n.3, p.385-390, 2003. SALAM ABDULLAH, A., LAJIS, N.H., BREMNER, J.B. et al. Hepatotoxic constituents in the rumen of Brachiaria decumbens intoxicated sheep. Vet. Hum. Toxicol, v.35, p.154-155, 1992. SATURNINO, K.C., MARIANI, T.M., BARBOSA-FERREIRA, M., BRUM, K.B., FERNANDES, C.E.S., LEMOS, R.A.A. Intoxica??o experimental por Brachiaria decumbens em ovinos confinados. Pesq. Vet. Bras., v.30, n.3, p.195-202, 2010. SCHENKEL, E.P., GOSMANN, G., ATHAYDE, M.L. Farmacognosia. Capt.27 ? Saponinas, p.711-740, 2004. SEAWRIGHT, A.A. Studies on experimental intoxication of sheep with Lantana camara. Aust. Vet. J., v.39, p.340.344, 1963. SEIXAS, J.N. Diferencia??o das intoxica??es por Brachiaria spp. e Pithomyces chartarum atrav?s dos aspectos epidemiol?gicos, cl?nico-patol?gicos e toxicol?gicos. Tese (Doutorado em Ci?ncias) ? Curso de P?s-Gradua??o em Ci?ncias veterin?rias, UFRRJ, 2009. SHARON, N., Lis, H. Lectins. 454p., 2007. 87 SLIFKIN, M., DOYLE, R.J. Lectins and their application to clinical microbiology. Clinical Microbiology Reviews, p.197-218, 1990. SMITH, B.L., MILES, C.O. A role for Brachiaria decumbens in hepatogenous photosensitization of ruminants. A letter to the editor. Vet. Hum. Toxicol., v.35, p.256-257, 1993. SOUZA, R.I.C., RIET-CORREA, F., BRUM, K.B., FERNANDES, C.E., BARBOSAFERREIRA, M., LEMOS, R.A.A. Intoxica??o por Brachiaria spp. em bovinos no Mato Grosso do Sul. Pesq. Vet. Bras., v.30, n.12, p.1036-1042, 2010. STEGELMEIER, B.A., MOLYNEUX, R.J., ELBEIN, A.D., JAMES, L.F. The lesions of locoweed (Astragalus mollissimus), swainsonine, and castanospermine in rats. Veterinary Pathology, v.32, p.289-198, 1995. SVENSSON, C.K., COWEN, E.W., GASPARI, A.A. Cutaneous drug reactions. Pharmacological Reviews, v.53, n.3, 2000. TOKARNIA, C.H., BRITO, M.F., BARBOSA, J.D., PEIXOTO, P.V., D?BEREINER, J. Plantas t?xicas do Brasil para animais de produ??o. 2a Ed. 566p., 2012. TOKARNIA, C.H., ARMI?N, A.G., BARROS, S.S., PEIXOTO, P.V., D?BEREINER, J. Estudos complementares sobre a toxidez de Lantana camara (Verbenaceae) em bovinos. Pesq. Vet. Bras., v.19, n.3/4, p.128-132, 1999. TOKARNIA, C.H., D?BEREINER, J. Intoxica??o experimental por Senecio brasiliensis (Compositae) em bovinos. Pesq. vet. Bras., v.4, n.1, p.39-65, 1984. TULSIANI, D.R.P., TOUSTER, O. Swainsonine causes the production of hybrid glycoproteins by human skin fibroblasts and rat liver Golgi preparations. J. Biol. Chem., v.258, p.7578-7585, 1983. USHIYAMA, M., IKEDA, S., NAKAYAMA, J., YANAGISAWA N., HANYU N, KATSUYAMA, T. Type III GM1-gangliosidosis histochemical and ultrastructural studies of rectal biopsy. J. Neurol. Sci., v.71, p.209-223, 1985. VARASCHIN, M.S., WOUTERS, F., PRADO, E.S. Porfiria eritropo?tica cong?nita em bovino no estado de Minas Gerais. Ci?ncia Rural, v.8, n.4, p.695-698, 1998. WITZEL, D.A., DOLLAHITE, J.W., JONES, L.P. Photosensitization in sheep fed Ammi majus (Bishop?s weed) seed. Am. J. Vet. 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dc.title.por.fl_str_mv Avalia??o lectino-histoqu?mica de f?gado e rim de ovinos e equinos com fotossensibiliza??o causada, respectivamente, por Brachiaria decumbens e B. humidicola
dc.title.alternative.eng.fl_str_mv Lectin histochemistry evaluation of liver and kidney of sheep and horses with photosensitization caused respectively by Brachiaria decumbens and B. humidicola.
title Avalia??o lectino-histoqu?mica de f?gado e rim de ovinos e equinos com fotossensibiliza??o causada, respectivamente, por Brachiaria decumbens e B. humidicola
spellingShingle Avalia??o lectino-histoqu?mica de f?gado e rim de ovinos e equinos com fotossensibiliza??o causada, respectivamente, por Brachiaria decumbens e B. humidicola
Costa, Samay Zillmann Rocha
Brachiaria
fotossensibiliza??o
lectino-histoqu?mica
Brachiaria
photosensitization
lectin histochemistry
Medicina Veterin?ria
title_short Avalia??o lectino-histoqu?mica de f?gado e rim de ovinos e equinos com fotossensibiliza??o causada, respectivamente, por Brachiaria decumbens e B. humidicola
title_full Avalia??o lectino-histoqu?mica de f?gado e rim de ovinos e equinos com fotossensibiliza??o causada, respectivamente, por Brachiaria decumbens e B. humidicola
title_fullStr Avalia??o lectino-histoqu?mica de f?gado e rim de ovinos e equinos com fotossensibiliza??o causada, respectivamente, por Brachiaria decumbens e B. humidicola
title_full_unstemmed Avalia??o lectino-histoqu?mica de f?gado e rim de ovinos e equinos com fotossensibiliza??o causada, respectivamente, por Brachiaria decumbens e B. humidicola
title_sort Avalia??o lectino-histoqu?mica de f?gado e rim de ovinos e equinos com fotossensibiliza??o causada, respectivamente, por Brachiaria decumbens e B. humidicola
author Costa, Samay Zillmann Rocha
author_facet Costa, Samay Zillmann Rocha
author_role author
dc.contributor.advisor1.fl_str_mv Fran?a, Ticiana do Nascimento
dc.contributor.advisor1ID.fl_str_mv 027.897.197-05
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3545873525091315
dc.contributor.advisor-co1.fl_str_mv Nogueira, Vivian de Assun??o
dc.contributor.referee1.fl_str_mv Cerqueira, Val?ria Duarte
dc.contributor.referee2.fl_str_mv D?bereiner, J?rgen
dc.contributor.authorID.fl_str_mv 117.209.617-48
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/7071350800206490
dc.contributor.author.fl_str_mv Costa, Samay Zillmann Rocha
contributor_str_mv Fran?a, Ticiana do Nascimento
Nogueira, Vivian de Assun??o
Cerqueira, Val?ria Duarte
D?bereiner, J?rgen
dc.subject.por.fl_str_mv Brachiaria
fotossensibiliza??o
lectino-histoqu?mica
topic Brachiaria
fotossensibiliza??o
lectino-histoqu?mica
Brachiaria
photosensitization
lectin histochemistry
Medicina Veterin?ria
dc.subject.eng.fl_str_mv Brachiaria
photosensitization
lectin histochemistry
dc.subject.cnpq.fl_str_mv Medicina Veterin?ria
description Brachiaria spp. are important pasture grasses in Brazil, but they can be poisonous. Outbreaks of hepatogenous photosensitization in several herbivorous livestock cause significant economic losses. Animals grazing toxic Brachiaria spp. commonly show in their liver foamy macrophages, isolated or grouped together, and crystals inside the biliary ducts. Steroidal saponins have been identified in these crystals and are liable for damage to the bilary system leading to accumulation of phylloerytrin. Occasionally negative images of the crystals may be seen in the cytoplasm of foamy macrophages. The pathogenesis of formation and the type of material stored in the foamy cells is still unknown. The lectin histochemistry aims to assist in the detection of foamy macrophages and consequently in the diagnosis of the poisoning. Lectin histochemistry detects what kind of specific sugar residues exists in the cytoplasm of the foamy cells. The purpose of the present study was to identify the most suitable lectins in the detection of steroidal saponins in the liver and kidney of sheep and horses with photosensitization caused respectively by Brachiara decumbens and B. humiducola. Fragments of liver and kidney of fifteen sheep of both sexes and variable age, from Concei??o do Mato Dentro, Minas Gerais, and seven horse (five females and two males), were evaluated by lectin histochemistry. Fourteen lectins were used (Con-A, DBA, SBA, PNA, RCA-I, UEA-I, WGA, SWGA, GSL, PSA, PHA-L, PHA-E and LCA). It was found that the PNA lectin detected in the liver of sheep with photosensitization, caused by ingestion of Brachiaria decumbens, showed specificity and great binding reactivity for foamy macrophages, and also specificity and slight binding reactivity for hepatocytes. The WGA lectin showed specificity and moderate binding reactivity for foamy macrophages of the liver, and also specificity and slight binding reactivity for hepatocytes. The SBA, GSL and LCA lectins showed specificity and moderate binding reactivity for foamy macrophages, but were not specific for hepatocytes. The PNA lectin showed greater binding reactivity in the kidney of the sheep. In the horses with photosensitization, caused by Brachiaria humidicola, non of the lectins showed specificity for the identification of saponins or their subproducts in liver and kidney.
publishDate 2012
dc.date.issued.fl_str_mv 2012-07-19
dc.date.accessioned.fl_str_mv 2020-06-23T22:30:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv COSTA, Samay Zillmann Rocha. Avalia??o lectino-histoqu?mica de f?gado e rim de ovinos e equinos com fotossensibiliza??o causada, respectivamente, por Brachiaria decumbens e B. humidicola. 2012. 87 f. Disserta??o (Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas)) - Universidade Federal Rural do Rio de Janeiro, Serop?dica.
dc.identifier.uri.fl_str_mv https://tede.ufrrj.br/jspui/handle/jspui/3661
identifier_str_mv COSTA, Samay Zillmann Rocha. Avalia??o lectino-histoqu?mica de f?gado e rim de ovinos e equinos com fotossensibiliza??o causada, respectivamente, por Brachiaria decumbens e B. humidicola. 2012. 87 f. Disserta??o (Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas)) - Universidade Federal Rural do Rio de Janeiro, Serop?dica.
url https://tede.ufrrj.br/jspui/handle/jspui/3661
dc.language.iso.fl_str_mv por
language por
dc.relation.references.por.fl_str_mv ALBERNAZ, T.T., SILVEIRA, J.A.S., SILVA, N.S., OLIVEIRA, C.H.S., REIS, A.S.B., OLIVEIRA, C.M.C., DUARTE, M.D., BARBOSA, J.D. Fotossensibiliza??o em ovinos associada ? ingest?o de Brachiaria brizantha no estado do Par?. Pesq. Vet. Bras., v. 30, n. 9, p. 741-748, 2010. ALROY, J., GOYAL, V., SKUTELSKY, E. Lectin histochemistry of mammalian endothelium. Histochemistry, v.86, p.603-607, 1987. ALROY, J., UCCI, A.A., GOYAL, V., WOODS, W. Lectin Histochemistry of Glycolipid Storage Diseases on Frozen and Paraffin-Embedded Tissue Sections. Journal of Histochemistry and Cytochemistry, v.34, n.4, p.501-505, 1986. ALUJA, A.S. Further investigation regarding the toxicity of members of the genus Lantana in Mexico. Anais XIX Congr. Mundial Veterinaria, Mexico, v.1, p.327-331, 1971. ANDRADE, R.P., BOAS, H.D.V., SILVEIRA, G.C., PAIVA, L. Parceria Embrapa- Unipastos e seu impacto na pesquisa e desenvolvimento de pastagens tropicais do Brasil. Mat?ria t?cnica. Associa??o Brasileira de sementes e mudas, 2004. ARMI?N, A.G., TOKARNIA, C.H., PEIXOTO, P.V., FRESE, K. Spontaneous and experimental glycoprotein storage disease of goats induced by Ipomoea carnea subsp fistulosa (Convolvulaceae). Vet Pathology, v.44, p.170-184, 2007. BARBEITO, C., MASSONE, A.R., QUIROGA, M.A. Introduction a las t?cnicas de lectinhistoqu?mica. Aplicaciones em Patologia Veterin?ria. Decimoseptimo curso internacional de posgrado em t?cnicas de inmunohistoquimica, lectinhistoquimica y microscopia electronica, 117p., 2005. BARBOSA, J.D., OLIVEIRA, C.M.C., TOKARNIA, C.H., PEIXOTO P.V. Fotossensibiliza??o hepat?gena em eq?inos pela ingest?o de Brachiaria humidicola (Gramineae) no Estado do Par?. Pesq. Vet. Bras., v. 26, n. 3, p. 147-153, 2006. BARONDES, S. H. Soluble lectins: a new class of extracellular proteins. Science, v. 223, p. 1259-1264, 1984. BLAKEMORE, W. G. GM1 gangliosidosis in a cat. J. Comp. Pathol., v. 82, p. 179-185, 1972. BOABAID, F.M., ANTONIASSI, N.A.B., PESCADOR, C.A., SOUZA, M.A., GASPARETTO, N.D., CRUZ, C.E.F., BEZERRA J?NIOR, P.S., DRIEMEIER, D., COLODEL, E.M. Lectin Histochemistry on Sections of Liver and Hepatic Lymph Nodes from Sheep Grazing on Brachiaria spp. In: RIET-CORREA F., PFISTER J., SCHILD A. L., WIERENGA T. (Eds), Poisoning by Plants, Mycotoxins and related Toxins. CAB International, London,2011. 82 BRITO, M.F, TOKARNIA, C.H., D?BEREINER, J. A toxidez de diversas lantanas para bovinos e ovinos no Brasil. Pesq. Vet. Bras., v.24, n.3, p.153-159, 2004. BRITO, M.F, TOKARNIA, C.H. Estudo comparativo da toxidez de Lantana camara var. aculeata em bovinos e ovinos. Pesq. Vet. Bras., v.15, n.2/3, p.79-84, 1995. BRITO, M.F. Sensibilidade do coelho a Lantana camara var. aculeata (Verbenaceae) em estado fresco e dessecado. Pesq. Vet. Bras., v.15, n.4, p.107-110, 1995. BROOKS, S.A., LEATHEM, A.J.C., SCHUMACHER, U. Lectin Histochemistry ? a concise practical handbook. Microscopy Handbooks 36. Bios Scientific Publishers in association with the Royal Microscopical Society, Oxford, 177p, 1997. BRUM, K.B., HARAGUCHI, M., LEMOS, R.A.A. Crystal-associated cholangiopathy in sheep grazing Brachiaria decumbens containing the saponin protodioscin. Pesq. Vet. Bras., v. 27, n. 1, p.39-42, 2007. BURAKOVAS, R.G., YOKOSUKA, A., MIMAKI, Y., RIET-CORREA, F., MEDEIROS, R.M.T., DANTAS, A.F.M., MATOS, P.F., KATIKI, L.M., VER?SSIMO, C.J., BUENO, M.S., BRUM, K.B., FIORAVANTI, M.C.S., BARBOSA, NETO J.D., HARAGUCHI, M. Investiga??o das saponinas furost?nicas nas gram?neas de Panicum. 30a Reuni?o Anual da Sociedade Brasileira de Qu?mica (SBQ), 2007. BUTTON, C., PAYNTER, D.I., SHIEL, M.J., COLSON, A.R., PATERSON, P.J., LYFORD, R.L. Crystal-associeted colangiohepatopathy and photosensitization in lambs. Aust. Vet. J., v.64, n.6, p.176-180, 1987. CASTAGNARO, M., CANESE, M.G. Lectin histochemistry on squamous metaplasia in different epithelial tumors of dogs. Vet. Pathol., v.28, p.8-15, 1991. CHEEKE, P.R. Nutritional and physiological implications of saponins. A review Canadian J. Anim. Sci., v.51, p.621-632, 1971. CHICK, H., ELLINGER, P. The photo-sensitizing action of buckwheat (Fagopyrum esculentum). J. Physiol., v.100, p.212-230, 1941. CINTRA, A.F., ALENCAR, R.A., MELLO, R.E.A., ANDRADE, S.O., NOBRE, D., CAMARGO, W.V., NAZ?RIO, W., AMANTE, E. Informa??es do instituto biol?gico relativas ? fotossensibiliza??o em equinos e bovinos. O Biol?gico, v.43, n.5/6, p.141-144, 1977. DOLLAHITE, J.W., YOUNGER, R.L., HOFFMAN, G.O. Photosensitization in cattle and sheep caused by feeding Ammi majus (greater Ammi; Bishop's-Weed). Am. J. Vet. Res., v.39, n.1, p. 193-197, 1978. DAMJANOV, I. Lectin cytochemistry and histochemistry. Lab. Inv., v.57, p.5-20,1987. DELVES, P.J. The role of glycosylation in autoimmune disease. Autoimmunity, v.27, p.239-253, 1997. 83 DENNIS, L.W., GRANOVSKY, M., WARREN, C.E. Glycoprotein glycosylation and cancer progression. Biochimica et Biophysica Acta, v.1473, p.21-34, 1999. DRICKAMER, K., WEIS, W. I., TAYLOR, M.E. The C-type lectin superfamily in the immune system. Immunol. Rev., v.163, n.1, p.19?34, 1998. DRIEMEIER, D., COLODEL, E.M., GIMENO, E.J., BARROS, S.S. Lysosomal storage disease caused by Sida carpinifolia poisoning in goats. Veterinary Pathology, v.37, p.153- 159, 2000. DRIEMEIER, D., D?BEREINER, J., PEIXOTO, P.V., BRITO, M.F. Rela??o entre macr?fagos espumosos (?foam cells?) no f?gado de bovinos e ingest?o de Brachiaria spp no Brasil. Pesq. Vet. Bras., v.19, n.2, p.79-83, 1999. ELLIS, M.B. Dematiaceous hyphomycetes. Kew: Commonw Mycol. Inst., 608p., 1971. FURLAN, A.C., SANTOLON, M.R., SCAPINELLO, C., MOREIRA, I., FARIA, H.G. Avalia??o nutricional do trigo mourisco (Fagopyrum esculentum, Moench) para coelhos em crescimento. Acta Sci. Anim. Sci. Maring?, v.28, n.1, p.21-26, 2006. FL??YEN, A., WILKINS, A.L. Metabolism of Saponins From Narthecium Ossifragum - a Plant Implicated in the Aetiology of Alveld, a Hepatogenous Photosensitization of Sheep. Vet. Res. Com., v.21, n.5, p.335-345, 1997. FL??YEN, A., WILKINS, A.L., DENG, D., BREKKE, T. Ovine Metabolism of Saponins: Evaluation of a Method for Estimating the Ovine Uptake of Steroidal Saponins from Narthecium ossifragum. Vet. Res. Com., v.25, n.3, p.225-238, 2001. GIDDENS, E.W, Jr., D.V.M., LABBE, R.F., SWANGO, D.V.M., PADGETT, G.A. Feline congenital erythropoietic porphyria associated with severe anemia and renal disease. Am. J. Pathol., v.80, p.367-386, 1975. GOLDSTEIN, I.J., HUGHES, R.C., MONSIGNY, M., OSAWA, T., SHARON, N. What should be called a lectin?. Nature, v.285, p.66, 1980. GOMAR, M.S., DRIEMEIER, D., COLODEL, E. M., GIMENO E. J. Lectin Histochemistry of foam cells in tissues of cattle grazing Brachiaria spp. J. Vet. Med. A., v.52, p.18-21, 2005. HARLEY, K.L.S. Biological control of Lantana in Australia. Proc. 3rd Int. Symp. Biol. Control Weeds, Montpellier, France, p.23-29, 1973. HSU, S.M., REE, H.J. Histochemical studies on lectin binding in reactive lymphoid tissues. J. Histochem. Cytochem., v.31, p.538-546, 1983. JONES, T.C., HUNT, R.D., KING, N.W. Patologia Veterin?ria. 6a. ed. Editora Manole: Barueri, 1415p., 2000. JUNQUEIRA, L.C., CARNEIRO, J. Histologia b?sica. 10a ed. 448p., 2004. 84 KAMIYA, S., YAMAGAMI, T., UMEDA, M., SUGIYAMA, M., DAIGO, M. Lectin histochemistry of foamy cells in non-nervous tissues of feline sphingomyelinosis. J. Comp. Path., v.105, p.241-245, 1991. KARAYANNOPOULOU, G., WEISS, J., DAMJANOV, I. Detection of fungi in tissue sections by lectin histochemistry. Arch. Pathol. Lab. Med., v.112, n.7, p.746-8, 1988. KELLERMAN, T.S., COETZER, J.A.W., NAUD?, T.W., BOTHA C.J. Plant Poisonings and Mycotoxicoses. Oxford University Press, Cape Town, RSA., 310p., 2005. KURIWAKI, K., YOSHIDA, H. Morphological characteristics of lipid accumulation in liver-constituting cells of acid lipase deficiency rats (Wolman?s disease model rats). Pathol. Int., v.49, p.291-297, 1999. LAGERON, A. Characterization by lectin binding of the sugar moiety of glycocompounds stored in inherited diseases. Histochemical journal, v.19, p.419-425, 1987. LAJIS, N.H., SALAM ABDULLAH, H., SALIM, S.J., BREMNER, J.B., KHAN, M.N. Episarsasapogenin and epi-smilagenin: two sapogenins isoleted from the rumen content of sheep intoxicated by Brachiaria decumbens. Steroids, v.58, p.387-389, 1991. L?U, H.D. Efeitos t?xicos de Lantana camara e de Pithomyces chartarum em b?falos. Doc. 54, Embrapa-CPATU, Bel?m, Par?. 18p. 1990. LEMOS, R.A.A., FERREIRA, L.C.L., SILVA, S.M., NAKAZATO, L., SALVADOR, S.C. Fotossensibiliza??o e colangiopatia associada a cristais em ovinos em pastagens com Brachiaria decumbens. Ci?ncia Rural, Santa Maria, v.26, n.1, p.109-113, 1996. LIS, H., SHARON, N. Lectins: carbohydrate-specific proteins that mediate cellular recognition. Chem. Rev., v.98, p.637-674, 1998. MASSONE, A.R., ITAGAKI, S., DOI, K., GIMENO, E.J. Lectinhistochemical study on normal and paratuberculosis-affected bovine ileum. J. Vet. Med. Sci., v.53, n.4, p.761-763, 1991. MATSUMOTO, H., MURAMATSU, H., MURAMATSU, T., SHIMAZU, H. Carbohydrate profiles shown by a lectin and a monoclonal antibody correlate with metastatic potential and prognosis of human lung carcinomas. Cancer, v.69, p.2084-2090, 1992. MCGAVIN, M.D., ZACHARY, J.F. Bases da patologia em veterin?ria. Tradu??o da 4? edi??o. Elsevier, 1476p, 2007. MEAGHER, L.P., SMITH, B.L., WILKINS, A.L. Metabolism of diosgenin-derived saponinas: implicationsfor hepatogenous photosensitization diseases in ruminant. Animal Feed Sci. Techn., v.91, p.157-170, 2001. MEAGHER, L.P., WILKINS, A.L., MILES, C.O., COLLING, R.G., FAGLIARI, J.J. Hepatogenous photosensitization of ruminants by Brachiaria decumbens and Panicum dichotomiflorum in the absence of sporodesmin: lithogenic saponinas may be responsible. Vet. Human Toxicol, v.38, n.4, p.271-4, 1996. 85 MELLO, A.M., ELLINGUER, F., LOUREN?O, L.A.P., CASTRO, L.M.S., ZIMMERMAN, M.A.T. Doen?a de Wolman (xantomatose familiar), relato de caso. Pediat. (S. Paulo), v.4, p.159-162, 1982. MELO-JUNIOR, M.R., TELLES, M.S., ALBURQUERQUE, F.E.B., PONTES-FILHO, N.T., CARVALHO Jr, L.B., BELTR?O, E.I. Altered lectin-binding sites in normal colon and ulcerative colitis. J. Bras. Patol. Med. Lab., v.40, n.2, p.123-5, 2004. M?NDEZ, M.C., RIET-CORREA, F., SCHILD, A.L., FERREIRA, J.L., PIMENTEL, M.A. Fotossensibiliza??o em bovinos causada por Ammi majus (Umbelliferac) no Rio Grande do Sul. Pesq. Vet. Bras., v.11, n.1/2, p.17-19, 1991. MILES, C.O., WILKINS, A.L., ERASMUS, G.L., KELLERMAN, T.S., COETZER, J.A.W. Photosensitivity in South-Africa. VII. Chemical-composition of biliary crystals from a sheep with experimentally-induced geeldikkop. Ond. J. Vet. Res., v.61, n.3, p.215-222, 1994. MILES, C.O. A role for steroidal saponins in hepatogenous photosensitization. N. Z. Vet.J., v.41, n.221, 1993. MORTIMER, P.H., MENNA, M.E., WHITE, E.P. Pithomycotoxicosis. ?Facial eczema? in cattle. In: WYLLIE, T.D., MOREHOUSSE, L.G. (ed). Mycotixic fungi, mycotoxins, mycotoxicosis. An encyclopedic handbook. Vol.II. Marcel Dekker, New York, p.63-72, 1978. MORTIMER, P.H. The experimental intoxication of sheep with sporidesmin, a metabolic product of Pithomyces chartarum. IV. Histological and histochemical examinations of orally-dosed sheep. Res. Vet. Sci., v.4, p.166-185, 1963. MOTTA, A.C, RIVERO, G.R., SCHILD, A.L., RIET-CORREA, F., M?NDEZ, M.C., FERREIRA, J.L. Fotossensibiliza??o em bovinos no sul do Rio Grande do Sul. Ci?ncia Rural, v.30, n.1, p.143-149, 2000. MURNAME, R. D., AHERN-RINDELL, A. J., PRIEUER, D. J. Lectin histochemistry of an ovine lysosomal storage disease with deficiencies of beta-galactosidase and alfaneuraminidase. American Journal of Pathology, v.135, n.4, p.623-630, 1989. ODRIOZOLA, E. fotosensibilizacion y queratoconjuntivitis en ruminantes por consume de semillas de falsa visnaga (Ammi majus). Vet. Arg., v.1, n.7, 1984. PAPADOPOULOU, K., MELTON, R.E., LEGGETT, M., DANIELS, M. J., OSBOURN, A.E. Compromised disease resistance in saponin-deficient plants. PNAS, v.26, n.96, p.12923-12928, 1999. PATALAMAI, B., HEJTMANCIK, E., BRIDGES, C. H. et al. The isolation and identification of steroidal sapogenins in kleingrass. Vet. Hum. Toxicol., v.32, p. 314-318, 1990. PIMENTEL, L.A., RIET-CORREA, F., GUEDES, K.M.R., MAC?DO, J.T.S.A., MEDEIROS, R.M.T., DANTAS, A.F.M. Fotossensibiliza??o prim?ria em equ?deos e 86 ruminantes no semi-?rido causada por Froelichia humboldtiana (Amaranthaceae). Pesq. Vet. Bras., v.27, n.1, 2007. REE, H.J., KADIN, M.E. Macrophages-histiocytes in Hodgkin?s disease: the relation of Peanut-Agglutinin-Binding macrophages-histiocytes to clinicalpathologic presentation and course of disease. Cancer, v.56, p.333-338, 1985. RIET-ALVARIZA, F., CORBO, M., MENY, H., DEL PUERTO, O., COSCKER, P. Fotosensibilizacion primaria en ganado lechero associada con Ammi majus (n.v. cicuta negra). III Jornadas Uruguayas de Buiatria, Paysand?, 1975. RIET-CORREA, F., M?NDEZ, M.C., SCHILD, A.L., RIET-CORREA, I., SILVA NETO, S.R. Intoxica??o por Lantana glutinosa em bovinos no estado de Santa Catarina. Pesq. Vet. Bras., v.4, p.147-153, 1984. RIET-CORREA, B., CASTRO, M. B., LEMOS, R.A.A., RIET-CORREA, G., MUSTAFA, V., RIET-CORREA, F. Brachiaria spp. poisoning of ruminants in Brazil. Pesq. Vet. Bras., v.31, n.3, p.183-192, 2011. RIET-CORREA, F., MEDEIROS, R.M.T. Intoxica??es por plantas em ruminantes no Brasil e no Uruguai: import?ncia econ?mica, controle e riscos para a sa?de p?blica. Pesq. Vet. Bras., v.21, n.1, p.38-42, 2001. ROE, D.A., KROOK, L., WILKIE, B.N. Hepatic protoporphyria in weanling pigs. Journal of Investigative dermatology, v.54, n.1, p.53-64, 1970. RUSSOMANNO, O.M.R., PORTUGAL, M.A.S.C., COUTINHO, L.N., CALIL, E.M.B., FIGUEIREDO, M.B. Leptosphaerulina chartarum (=Pithomyces chartarum) e seu envolvimento no eczema facial. Arq. Inst. Biol., v.70, n.3, p.385-390, 2003. SALAM ABDULLAH, A., LAJIS, N.H., BREMNER, J.B. et al. Hepatotoxic constituents in the rumen of Brachiaria decumbens intoxicated sheep. Vet. Hum. Toxicol, v.35, p.154-155, 1992. SATURNINO, K.C., MARIANI, T.M., BARBOSA-FERREIRA, M., BRUM, K.B., FERNANDES, C.E.S., LEMOS, R.A.A. Intoxica??o experimental por Brachiaria decumbens em ovinos confinados. Pesq. Vet. Bras., v.30, n.3, p.195-202, 2010. SCHENKEL, E.P., GOSMANN, G., ATHAYDE, M.L. Farmacognosia. Capt.27 ? Saponinas, p.711-740, 2004. SEAWRIGHT, A.A. Studies on experimental intoxication of sheep with Lantana camara. Aust. Vet. J., v.39, p.340.344, 1963. SEIXAS, J.N. Diferencia??o das intoxica??es por Brachiaria spp. e Pithomyces chartarum atrav?s dos aspectos epidemiol?gicos, cl?nico-patol?gicos e toxicol?gicos. Tese (Doutorado em Ci?ncias) ? Curso de P?s-Gradua??o em Ci?ncias veterin?rias, UFRRJ, 2009. SHARON, N., Lis, H. Lectins. 454p., 2007. 87 SLIFKIN, M., DOYLE, R.J. Lectins and their application to clinical microbiology. Clinical Microbiology Reviews, p.197-218, 1990. SMITH, B.L., MILES, C.O. A role for Brachiaria decumbens in hepatogenous photosensitization of ruminants. A letter to the editor. Vet. Hum. Toxicol., v.35, p.256-257, 1993. SOUZA, R.I.C., RIET-CORREA, F., BRUM, K.B., FERNANDES, C.E., BARBOSAFERREIRA, M., LEMOS, R.A.A. Intoxica??o por Brachiaria spp. em bovinos no Mato Grosso do Sul. Pesq. Vet. Bras., v.30, n.12, p.1036-1042, 2010. STEGELMEIER, B.A., MOLYNEUX, R.J., ELBEIN, A.D., JAMES, L.F. The lesions of locoweed (Astragalus mollissimus), swainsonine, and castanospermine in rats. Veterinary Pathology, v.32, p.289-198, 1995. SVENSSON, C.K., COWEN, E.W., GASPARI, A.A. Cutaneous drug reactions. Pharmacological Reviews, v.53, n.3, 2000. TOKARNIA, C.H., BRITO, M.F., BARBOSA, J.D., PEIXOTO, P.V., D?BEREINER, J. Plantas t?xicas do Brasil para animais de produ??o. 2a Ed. 566p., 2012. TOKARNIA, C.H., ARMI?N, A.G., BARROS, S.S., PEIXOTO, P.V., D?BEREINER, J. Estudos complementares sobre a toxidez de Lantana camara (Verbenaceae) em bovinos. Pesq. Vet. Bras., v.19, n.3/4, p.128-132, 1999. TOKARNIA, C.H., D?BEREINER, J. Intoxica??o experimental por Senecio brasiliensis (Compositae) em bovinos. Pesq. vet. Bras., v.4, n.1, p.39-65, 1984. TULSIANI, D.R.P., TOUSTER, O. Swainsonine causes the production of hybrid glycoproteins by human skin fibroblasts and rat liver Golgi preparations. J. Biol. Chem., v.258, p.7578-7585, 1983. USHIYAMA, M., IKEDA, S., NAKAYAMA, J., YANAGISAWA N., HANYU N, KATSUYAMA, T. Type III GM1-gangliosidosis histochemical and ultrastructural studies of rectal biopsy. J. Neurol. Sci., v.71, p.209-223, 1985. VARASCHIN, M.S., WOUTERS, F., PRADO, E.S. Porfiria eritropo?tica cong?nita em bovino no estado de Minas Gerais. Ci?ncia Rural, v.8, n.4, p.695-698, 1998. WITZEL, D.A., DOLLAHITE, J.W., JONES, L.P. Photosensitization in sheep fed Ammi majus (Bishop?s weed) seed. Am. J. Vet. Res., v.39, n.2, 1978.
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