Estudos imuno-histoqu?mico complementar e lectino-histoqu?mico do tumor ven?reo transmiss?vel canino no Brasil

Detalhes bibliográficos
Autor(a) principal: Mascarenhas, Mariana Bezerra
Data de Publicação: 2014
Tipo de documento: Tese
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRRJ
Texto Completo: https://tede.ufrrj.br/jspui/handle/jspui/3332
Resumo: To further investigate the nature (origin) of the canine transmissible venereal tumor (CTVT), as well as provide support for establishing the diagnosis and differential diagnosis of this neoplasm, this complementary study was performed by means of immunohistochemistry and lectin histochemistry analysis. The immunohistochemical was performed on 10 genital TVTCs and on 6 exclusively extragenital TVTCs previously diagnosed by cytology and histopathology. CTVT samples were incubated with biotinylated antibodies raised against specific membrane and cytoplasmic antigens (anti-lysozyme, anti-macrophage, anti-vimentin, anti-CD18, anti-CD3, anti-CD79, anti-CD117) and subsequently developed using the avidin-biotin-peroxidase complex technique. Lectins Con A, DBA, SBA, PNA, UEA-1, WGA, sWGA, GSL, JSA, PSA, PHA-L, PHA-E and RCA were additionally tested in four genital TVTCs. A strong reactivity with the anti-vimentin antibody was found in 100% of the tumors tested (16/16). The CTVTs also showed strong staining with anti-CD117 and anti-CD3 antibody. There was no reactivity to anti-lysozyme, anti-macrophage, anti-CD18 and anti-CD79a antibodies. In lectin histochemical was observed strong staining of tumors to Con-A, PHA-L and RCA. There was no histopathological and immuno-reactivity difference among genital and extragenital CTVTs. These findings do not corroborate the hypothesis of histiocytic origin of CTVT (no reactivity to anti-lysozyme antibody, anti-macrophage and anti-CD18), however, they do indicate a probable lymphoid/myeloid origin of this tumor (reactivity for CD3, ConA, PHA -L and RCA).
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spelling Fran?a, Ticiana do Nascimento027.897.197-05http://lattes.cnpq.br/3545873525091315Peixoto, Paulo de Vargas270.761.210-34http://lattes.cnpq.br/3002512195318611Bezerra Junior, Pedro SoaresCerqueira, Val?ria DuartePeixoto, Tiago da CunhaRamadinha, Regina Helena Ruckert055.187.017-64http://lattes.cnpq.br/5125135856204760Mascarenhas, Mariana Bezerra2020-02-19T12:27:28Z2014-02-14MASCARENHAS, Mariana Bezerra. Estudos imuno-histoqu?mico complementar e lectino-histoqu?mico do tumor ven?reo transmiss?vel canino no Brasil. 2014. 68 f. Disserta??o (Mestrado em Medicina Veterin?ria, Patologia e Ci?ncias Cl?nicas) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2014.https://tede.ufrrj.br/jspui/handle/jspui/3332To further investigate the nature (origin) of the canine transmissible venereal tumor (CTVT), as well as provide support for establishing the diagnosis and differential diagnosis of this neoplasm, this complementary study was performed by means of immunohistochemistry and lectin histochemistry analysis. The immunohistochemical was performed on 10 genital TVTCs and on 6 exclusively extragenital TVTCs previously diagnosed by cytology and histopathology. CTVT samples were incubated with biotinylated antibodies raised against specific membrane and cytoplasmic antigens (anti-lysozyme, anti-macrophage, anti-vimentin, anti-CD18, anti-CD3, anti-CD79, anti-CD117) and subsequently developed using the avidin-biotin-peroxidase complex technique. Lectins Con A, DBA, SBA, PNA, UEA-1, WGA, sWGA, GSL, JSA, PSA, PHA-L, PHA-E and RCA were additionally tested in four genital TVTCs. A strong reactivity with the anti-vimentin antibody was found in 100% of the tumors tested (16/16). The CTVTs also showed strong staining with anti-CD117 and anti-CD3 antibody. There was no reactivity to anti-lysozyme, anti-macrophage, anti-CD18 and anti-CD79a antibodies. In lectin histochemical was observed strong staining of tumors to Con-A, PHA-L and RCA. There was no histopathological and immuno-reactivity difference among genital and extragenital CTVTs. These findings do not corroborate the hypothesis of histiocytic origin of CTVT (no reactivity to anti-lysozyme antibody, anti-macrophage and anti-CD18), however, they do indicate a probable lymphoid/myeloid origin of this tumor (reactivity for CD3, ConA, PHA -L and RCA).Com a finalidade de aprofundar a investiga??o sobre a natureza (origem) do tumor ven?reo transmiss?vel canino (TVTC), bem como, fornecer subs?dios para o estabelecimento do diagn?stico e diagn?stico diferencial, esse estudo complementar foi realizado por meio de avalia??o imuno-histoqu?mica e lectino-histoqu?mica. A avalia??o imuno-histoqu?mica foi feita em 10 TVTCs genitais e em 6 exclusivamente extragenitais previamente diagnosticados atrav?s da citologia e da histopatologia. Os TVTCs foram testados para reagentes espec?ficos de ant?genos de membrana e citoplasm?ticos (anti-lisozima, anti-macr?fago, anti-vimentina, anti-CD18, anti-CD3, anti-CD79, anti-CD117) com utiliza??o da t?cnica complexo avidina-biotina-peroxidase. Adicionalmente, foram testadas as lectinas Con A, DBA, SBA, PNA, UEA-1, WGA, sWGA, GSL, SJA, PSA, PHA-L, PHA-E e RCA em quatro TVTCs genitais. Em 100% dos tumores testados (16/16) com anticorpo anti-vimentina houve forte imuno-reatividade. Os TVTCs tamb?m apresentaram forte marca??o com o anticorpo anti-CD117 e anti-CD3. N?o houve reatividade para os anticorpos anti-lisozima, anti-macr?fago, anti-CD18 e anti-CD79a. Na avalia??o lectino-histoqu?mica foi verificada forte marca??o das c?lulas tumorais com Con-A, PHA-L e RCA. N?o houve diferen?a histopatol?gica e de imuno-reatividade entre os TVTCs genitais e extragenitais. Estes achados n?o corroboram com a hip?tese da origem histioc?tica do TVTC (aus?ncia de reatividade dos anticorpos anti-lisozima, anti-macr?fago e anti-CD18), entretanto, indicam uma prov?vel origem linf?ide/miel?ide deste tumor (reatividade para CD3, ConA, PHA-L e RCA).Submitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2020-02-19T12:27:27Z No. of bitstreams: 1 2014 - Mariana Bezerra Mascarenhas.pdf: 9183051 bytes, checksum: ed6cf8cae14230a1d260ffa07e0028d9 (MD5)Made available in DSpace on 2020-02-19T12:27:28Z (GMT). No. of bitstreams: 1 2014 - Mariana Bezerra Mascarenhas.pdf: 9183051 bytes, checksum: ed6cf8cae14230a1d260ffa07e0028d9 (MD5) Previous issue date: 2014-02-14Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPESapplication/pdfhttps://tede.ufrrj.br/retrieve/12909/2014%20-%20Mariana%20Bezerra%20Mascarenhas.pdf.jpghttps://tede.ufrrj.br/retrieve/17314/2014%20-%20Mariana%20Bezerra%20Mascarenhas.pdf.jpghttps://tede.ufrrj.br/retrieve/23632/2014%20-%20Mariana%20Bezerra%20Mascarenhas.pdf.jpghttps://tede.ufrrj.br/retrieve/30010/2014%20-%20Mariana%20Bezerra%20Mascarenhas.pdf.jpghttps://tede.ufrrj.br/retrieve/36384/2014%20-%20Mariana%20Bezerra%20Mascarenhas.pdf.jpghttps://tede.ufrrj.br/retrieve/42762/2014%20-%20Mariana%20Bezerra%20Mascarenhas.pdf.jpghttps://tede.ufrrj.br/retrieve/49142/2014%20-%20Mariana%20Bezerra%20Mascarenhas.pdf.jpghttps://tede.ufrrj.br/retrieve/55588/2014%20-%20Mariana%20Bezerra%20Mascarenhas.pdf.jpgporUniversidade Federal Rural do Rio de JaneiroPrograma de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas)UFRRJBrasilInstituto de Veterin?riaADAMS, E.W., SLAUGHTER, L.J. 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Immunother., vol. 33, p. 255-262, 1991.TVTCimuno-histoqu?micalectino-histoqu?micac?opatologiaimmunohistochemistrylectin histochemistrydogpathologyMedicina Veterin?riaEstudos imuno-histoqu?mico complementar e lectino-histoqu?mico do tumor ven?reo transmiss?vel canino no BrasilComplementary immunohistochemical studies and lectin histochemical of canine transmissible venereal tumor in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFRRJinstname:Universidade Federal Rural do Rio de Janeiro (UFRRJ)instacron:UFRRJTHUMBNAIL2014 - Mariana Bezerra Mascarenhas.pdf.jpg2014 - Mariana Bezerra Mascarenhas.pdf.jpgimage/jpeg1943http://localhost:8080/tede/bitstream/jspui/3332/18/2014+-+Mariana+Bezerra+Mascarenhas.pdf.jpgcc73c4c239a4c332d642ba1e7c7a9fb2MD518TEXT2014 - Mariana Bezerra Mascarenhas.pdf.txt2014 - Mariana Bezerra Mascarenhas.pdf.txttext/plain163849http://localhost:8080/tede/bitstream/jspui/3332/17/2014+-+Mariana+Bezerra+Mascarenhas.pdf.txt4c769e615590a83e0335b9000fc0908bMD517ORIGINAL2014 - Mariana Bezerra Mascarenhas.pdf2014 - Mariana Bezerra Mascarenhas.pdfapplication/pdf4164043http://localhost:8080/tede/bitstream/jspui/3332/19/2014+-+Mariana+Bezerra+Mascarenhas.pdfaca050ef06bb6a6ffa88c7d1c0a0b16bMD519LICENSElicense.txtlicense.txttext/plain; charset=utf-82089http://localhost:8080/tede/bitstream/jspui/3332/1/license.txt7b5ba3d2445355f386edab96125d42b7MD51jspui/33322022-10-06 15:11:06.931oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttps://tede.ufrrj.br/PUBhttps://tede.ufrrj.br/oai/requestbibliot@ufrrj.br||bibliot@ufrrj.bropendoar:2022-10-06T18:11:06Biblioteca Digital de Teses e Dissertações da UFRRJ - Universidade Federal Rural do Rio de Janeiro (UFRRJ)false
dc.title.por.fl_str_mv Estudos imuno-histoqu?mico complementar e lectino-histoqu?mico do tumor ven?reo transmiss?vel canino no Brasil
dc.title.alternative.eng.fl_str_mv Complementary immunohistochemical studies and lectin histochemical of canine transmissible venereal tumor in Brazil
title Estudos imuno-histoqu?mico complementar e lectino-histoqu?mico do tumor ven?reo transmiss?vel canino no Brasil
spellingShingle Estudos imuno-histoqu?mico complementar e lectino-histoqu?mico do tumor ven?reo transmiss?vel canino no Brasil
Mascarenhas, Mariana Bezerra
TVTC
imuno-histoqu?mica
lectino-histoqu?mica
c?o
patologia
immunohistochemistry
lectin histochemistry
dog
pathology
Medicina Veterin?ria
title_short Estudos imuno-histoqu?mico complementar e lectino-histoqu?mico do tumor ven?reo transmiss?vel canino no Brasil
title_full Estudos imuno-histoqu?mico complementar e lectino-histoqu?mico do tumor ven?reo transmiss?vel canino no Brasil
title_fullStr Estudos imuno-histoqu?mico complementar e lectino-histoqu?mico do tumor ven?reo transmiss?vel canino no Brasil
title_full_unstemmed Estudos imuno-histoqu?mico complementar e lectino-histoqu?mico do tumor ven?reo transmiss?vel canino no Brasil
title_sort Estudos imuno-histoqu?mico complementar e lectino-histoqu?mico do tumor ven?reo transmiss?vel canino no Brasil
author Mascarenhas, Mariana Bezerra
author_facet Mascarenhas, Mariana Bezerra
author_role author
dc.contributor.advisor1.fl_str_mv Fran?a, Ticiana do Nascimento
dc.contributor.advisor1ID.fl_str_mv 027.897.197-05
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3545873525091315
dc.contributor.advisor-co1.fl_str_mv Peixoto, Paulo de Vargas
dc.contributor.advisor-co1ID.fl_str_mv 270.761.210-34
dc.contributor.advisor-co1Lattes.fl_str_mv http://lattes.cnpq.br/3002512195318611
dc.contributor.referee1.fl_str_mv Bezerra Junior, Pedro Soares
dc.contributor.referee2.fl_str_mv Cerqueira, Val?ria Duarte
dc.contributor.referee3.fl_str_mv Peixoto, Tiago da Cunha
dc.contributor.referee4.fl_str_mv Ramadinha, Regina Helena Ruckert
dc.contributor.authorID.fl_str_mv 055.187.017-64
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/5125135856204760
dc.contributor.author.fl_str_mv Mascarenhas, Mariana Bezerra
contributor_str_mv Fran?a, Ticiana do Nascimento
Peixoto, Paulo de Vargas
Bezerra Junior, Pedro Soares
Cerqueira, Val?ria Duarte
Peixoto, Tiago da Cunha
Ramadinha, Regina Helena Ruckert
dc.subject.por.fl_str_mv TVTC
imuno-histoqu?mica
lectino-histoqu?mica
c?o
patologia
topic TVTC
imuno-histoqu?mica
lectino-histoqu?mica
c?o
patologia
immunohistochemistry
lectin histochemistry
dog
pathology
Medicina Veterin?ria
dc.subject.eng.fl_str_mv immunohistochemistry
lectin histochemistry
dog
pathology
dc.subject.cnpq.fl_str_mv Medicina Veterin?ria
description To further investigate the nature (origin) of the canine transmissible venereal tumor (CTVT), as well as provide support for establishing the diagnosis and differential diagnosis of this neoplasm, this complementary study was performed by means of immunohistochemistry and lectin histochemistry analysis. The immunohistochemical was performed on 10 genital TVTCs and on 6 exclusively extragenital TVTCs previously diagnosed by cytology and histopathology. CTVT samples were incubated with biotinylated antibodies raised against specific membrane and cytoplasmic antigens (anti-lysozyme, anti-macrophage, anti-vimentin, anti-CD18, anti-CD3, anti-CD79, anti-CD117) and subsequently developed using the avidin-biotin-peroxidase complex technique. Lectins Con A, DBA, SBA, PNA, UEA-1, WGA, sWGA, GSL, JSA, PSA, PHA-L, PHA-E and RCA were additionally tested in four genital TVTCs. A strong reactivity with the anti-vimentin antibody was found in 100% of the tumors tested (16/16). The CTVTs also showed strong staining with anti-CD117 and anti-CD3 antibody. There was no reactivity to anti-lysozyme, anti-macrophage, anti-CD18 and anti-CD79a antibodies. In lectin histochemical was observed strong staining of tumors to Con-A, PHA-L and RCA. There was no histopathological and immuno-reactivity difference among genital and extragenital CTVTs. These findings do not corroborate the hypothesis of histiocytic origin of CTVT (no reactivity to anti-lysozyme antibody, anti-macrophage and anti-CD18), however, they do indicate a probable lymphoid/myeloid origin of this tumor (reactivity for CD3, ConA, PHA -L and RCA).
publishDate 2014
dc.date.issued.fl_str_mv 2014-02-14
dc.date.accessioned.fl_str_mv 2020-02-19T12:27:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv MASCARENHAS, Mariana Bezerra. Estudos imuno-histoqu?mico complementar e lectino-histoqu?mico do tumor ven?reo transmiss?vel canino no Brasil. 2014. 68 f. Disserta??o (Mestrado em Medicina Veterin?ria, Patologia e Ci?ncias Cl?nicas) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2014.
dc.identifier.uri.fl_str_mv https://tede.ufrrj.br/jspui/handle/jspui/3332
identifier_str_mv MASCARENHAS, Mariana Bezerra. Estudos imuno-histoqu?mico complementar e lectino-histoqu?mico do tumor ven?reo transmiss?vel canino no Brasil. 2014. 68 f. Disserta??o (Mestrado em Medicina Veterin?ria, Patologia e Ci?ncias Cl?nicas) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2014.
url https://tede.ufrrj.br/jspui/handle/jspui/3332
dc.language.iso.fl_str_mv por
language por
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