Imunofenotipagem comparada dos plasmocitomas extramedulares, histiocitomas e linfomas cutâneos em cães

Detalhes bibliográficos
Autor(a) principal: Santos, Bartolomeu Benedito Neves dos
Data de Publicação: 2020
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRRJ
Texto Completo: https://rima.ufrrj.br/jspui/handle/20.500.14407/14169
Resumo: A literatura sobre plasmocitomas extramedulares caninos (PEMCs) é ampla e com informações divergentes. Devido sua grande variação morfológica, essa neoplasia é comumente confundida com outros tumores benignos e malignos na rotina de diagnóstico histopatológico; principalmente com o histiocitoma cutâneo canino (HCC), o sarcoma histiocítico canino (SHC) e o linfoma canino (LC). Com o objetivo de fornecer informações adicionais sobre a imunofenotipagem dos PEMCs, testes de imuno-histoquímica foram realizados em microarranjo de tecidos (TMA) com cores de 2mm, usando os marcadores convencionais CD79a (em duplicata), CD3 (em duplicata), MUM1 (em duplicata), Iba1 e cadeias leves λ e κ de imunoglobulina em amostras de 39 PEMCs, 27 HCCs e 8 LCs. Para fins de comparação e controle, o estudo também incluiu amostras de 2 SHCs, 2 mastocitomas cutâneos (MCC), 2 melanomas orais, 1 mieloma múltiplo e espécimes de linfonodo, baço, medula óssea e pele caninos. Além disso, foi feita uma investigação inédita com o anticorpo monoclonal antireceptor α da interleucina 3 (CD123) aplicado a cães. O CD123 tem sido amplamente estudado na medicina humana como eficiente marcador de algumas neoplasias linfoides, de mastócitos e de células dendríticas plasmocitoides blásticas, mas é praticamente inexplorado na medicina veterinária. Com o objetivo de avaliar a eficiência do microarranjo de tecidos (TMA) para alguns dos marcadores, realizou-se um estudo imuno-histoquímico piloto nas seções histológicas convencionais com MUM1 e CD79a em 27 amostras de PEMCs e 10 de HCCs, com os anticorpos anti-CD3 e CD79a em 8 amostras de LCs (5 cutâneos e 3 nodais) e com o anti-CD123 em amostras de 7 PEMCs e 2 HCCs. As conclusões mais importantes foram: 1) MUM1 é muito sensível (89,7%) para detectar PEMCs e eficiente para diferenciar os PEMCs de neoplasias histiocíticas. 2) Linfomas de células T podem expressar MUM1. 3) O CD123 é expresso por PEMCs, MCCs e SHCs, além de plasmócitos normais, endotélio e possivelmente por células dendríticas plasmocitoides caninas. 4) A expressão do antígeno CD123 em neoplasias malignas como MCC e SHC deve ser melhor investigada. 5) O anticorpo Iba1 teve 100% de sensibilidade para detectar HCCs e SHCs e, é muito específico para essas neoplasias.
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spelling Santos, Bartolomeu Benedito Neves dosFrança, Ticiana do Nascimento027.897.197-05http://lattes.cnpq.br/3545873525091315Hassan, Claudia Esther Alicia Rocio053.521.647-56França, Ticiana do NascimentoNascimento, Aparecida Alves doNogueira, Vivian de AssunçãoDriemeier, David037.024.961-57https://orcid.org/0000-0002-6147-319Xhttp://lattes.cnpq.br/05962682956402392023-12-22T02:57:02Z2023-12-22T02:57:02Z2020-02-19SANTOS, Bartolomeu Benedito Neves. Imunofenotipagem comparada dos plasmocitomas extramedulares, histiocitomas e linfomas cutâneos em cães. 2020. 56 f. Dissertação (Mestrado em Medicina Veterinária, Patologia e Ciências Clínicas) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, 2020.https://rima.ufrrj.br/jspui/handle/20.500.14407/14169A literatura sobre plasmocitomas extramedulares caninos (PEMCs) é ampla e com informações divergentes. Devido sua grande variação morfológica, essa neoplasia é comumente confundida com outros tumores benignos e malignos na rotina de diagnóstico histopatológico; principalmente com o histiocitoma cutâneo canino (HCC), o sarcoma histiocítico canino (SHC) e o linfoma canino (LC). Com o objetivo de fornecer informações adicionais sobre a imunofenotipagem dos PEMCs, testes de imuno-histoquímica foram realizados em microarranjo de tecidos (TMA) com cores de 2mm, usando os marcadores convencionais CD79a (em duplicata), CD3 (em duplicata), MUM1 (em duplicata), Iba1 e cadeias leves λ e κ de imunoglobulina em amostras de 39 PEMCs, 27 HCCs e 8 LCs. Para fins de comparação e controle, o estudo também incluiu amostras de 2 SHCs, 2 mastocitomas cutâneos (MCC), 2 melanomas orais, 1 mieloma múltiplo e espécimes de linfonodo, baço, medula óssea e pele caninos. Além disso, foi feita uma investigação inédita com o anticorpo monoclonal antireceptor α da interleucina 3 (CD123) aplicado a cães. O CD123 tem sido amplamente estudado na medicina humana como eficiente marcador de algumas neoplasias linfoides, de mastócitos e de células dendríticas plasmocitoides blásticas, mas é praticamente inexplorado na medicina veterinária. Com o objetivo de avaliar a eficiência do microarranjo de tecidos (TMA) para alguns dos marcadores, realizou-se um estudo imuno-histoquímico piloto nas seções histológicas convencionais com MUM1 e CD79a em 27 amostras de PEMCs e 10 de HCCs, com os anticorpos anti-CD3 e CD79a em 8 amostras de LCs (5 cutâneos e 3 nodais) e com o anti-CD123 em amostras de 7 PEMCs e 2 HCCs. As conclusões mais importantes foram: 1) MUM1 é muito sensível (89,7%) para detectar PEMCs e eficiente para diferenciar os PEMCs de neoplasias histiocíticas. 2) Linfomas de células T podem expressar MUM1. 3) O CD123 é expresso por PEMCs, MCCs e SHCs, além de plasmócitos normais, endotélio e possivelmente por células dendríticas plasmocitoides caninas. 4) A expressão do antígeno CD123 em neoplasias malignas como MCC e SHC deve ser melhor investigada. 5) O anticorpo Iba1 teve 100% de sensibilidade para detectar HCCs e SHCs e, é muito específico para essas neoplasias.CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorThe literature about canine extramedullary plasmacytoma (CEP) is wide and contradictory. Due its great morphological variety, this neoplasm is commonly confused with others benign and malignant tumors in histopathologic diagnostic routine; mainly with Canine Cutaneous Histiocytoma (CCH), Canine Histiocytic Sarcoma (CHS) and Canine Lymphoma (CL). Aiming to compile information to investigate and clarify aspects regarding the immunophenotyping of CEPs, immunohistochemistry tests were performed in tissue microarray (TMA) with 2mm colors, using the conventional markers CD79a (in duplicate), CD3 (in duplicate), MUM1 (in duplicate), Iba1 and immunoglobulin λ and κ light chains in 39 CEPs, 27 CCHs and 8 CLs. For comparison and control purposes, the study also included samples from 2 CHSs, 2 cutaneous mast cell tumors (MCT), 2 oral melanomas and 1 multiple myeloma; in addition to normal and reactive tissues from canine lymph nodes, spleen, bone marrow and skin. Furthermore, an analysis unprecedented was carried out with the antibody anti- Interleukin 3 alpha receptor (CD123) applied in dogs. The CD123 has been widely studied in human medicine as an efficient marker of some lymphoid neoplasms, mast cells and blastic plasmacytoid dendritic cells, but it is practically unexplored in medicine veterinary. To evaluate the efficiency of the tissue microarray (TMA) for some markers used, a pilot immunohistochemical study was carried out in the conventional histological sections with MUM1 and CD79a in 27 samples of CEPs and 10 of CCHs, with antibodies anti-CD3 and CD79a in 8 samples of CLs (5 cutaneous and 3 nodal) and with anti-CD123 in samples of 7 CEPs and 2 CCHs. The mainly conclusions found out were: 1) MUM1 is very sensitive (89.7%) to detect CEPs and efficient to differentiate CEPs from histiocytic neoplasms; 2) T-cell lymphomas can to express MUM1; 3) CD123 is expressed in CEPs, MCCs and CHSs, in addition to normal plasmocytes, endothelium and possibly by canine plasmacytoid dendritic cells; 4) CD123 antigen expressions in malignant neoplasms such as MCC and CHS must be further investigated; 5) The Iba1 antibody had 100% sensitivity to detect CCHs and CHSs, being very specific for these neoplasms.application/pdfporUniversidade Federal Rural do Rio de JaneiroPrograma de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas)UFRRJBrasilInstituto de VeterináriaPlasmocitoma caninoCélula dendrítica plasmocitoideCD123Canine plasmacytomaPlasmacytoid dendritic cellMedicina VeterináriaImunofenotipagem comparada dos plasmocitomas extramedulares, histiocitomas e linfomas cutâneos em cãesCompared immunophenotyping of extramedullary plasmacytomas, histiocytomas and cutaneous lymphomas in dogsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisALCULUMBRE, S.; RAIELI, S.; HOFFMANN, C.; CHELBI, R.; DANLOS, F. 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dc.title.por.fl_str_mv Imunofenotipagem comparada dos plasmocitomas extramedulares, histiocitomas e linfomas cutâneos em cães
dc.title.alternative.eng.fl_str_mv Compared immunophenotyping of extramedullary plasmacytomas, histiocytomas and cutaneous lymphomas in dogs
title Imunofenotipagem comparada dos plasmocitomas extramedulares, histiocitomas e linfomas cutâneos em cães
spellingShingle Imunofenotipagem comparada dos plasmocitomas extramedulares, histiocitomas e linfomas cutâneos em cães
Santos, Bartolomeu Benedito Neves dos
Plasmocitoma canino
Célula dendrítica plasmocitoide
CD123
Canine plasmacytoma
Plasmacytoid dendritic cell
Medicina Veterinária
title_short Imunofenotipagem comparada dos plasmocitomas extramedulares, histiocitomas e linfomas cutâneos em cães
title_full Imunofenotipagem comparada dos plasmocitomas extramedulares, histiocitomas e linfomas cutâneos em cães
title_fullStr Imunofenotipagem comparada dos plasmocitomas extramedulares, histiocitomas e linfomas cutâneos em cães
title_full_unstemmed Imunofenotipagem comparada dos plasmocitomas extramedulares, histiocitomas e linfomas cutâneos em cães
title_sort Imunofenotipagem comparada dos plasmocitomas extramedulares, histiocitomas e linfomas cutâneos em cães
author Santos, Bartolomeu Benedito Neves dos
author_facet Santos, Bartolomeu Benedito Neves dos
author_role author
dc.contributor.author.fl_str_mv Santos, Bartolomeu Benedito Neves dos
dc.contributor.advisor1.fl_str_mv França, Ticiana do Nascimento
dc.contributor.advisor1ID.fl_str_mv 027.897.197-05
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3545873525091315
dc.contributor.advisor-co1.fl_str_mv Hassan, Claudia Esther Alicia Rocio
dc.contributor.advisor-co1ID.fl_str_mv 053.521.647-56
dc.contributor.referee1.fl_str_mv França, Ticiana do Nascimento
dc.contributor.referee2.fl_str_mv Nascimento, Aparecida Alves do
dc.contributor.referee3.fl_str_mv Nogueira, Vivian de Assunção
dc.contributor.referee4.fl_str_mv Driemeier, David
dc.contributor.authorID.fl_str_mv 037.024.961-57
https://orcid.org/0000-0002-6147-319X
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/0596268295640239
contributor_str_mv França, Ticiana do Nascimento
Hassan, Claudia Esther Alicia Rocio
França, Ticiana do Nascimento
Nascimento, Aparecida Alves do
Nogueira, Vivian de Assunção
Driemeier, David
dc.subject.por.fl_str_mv Plasmocitoma canino
Célula dendrítica plasmocitoide
CD123
topic Plasmocitoma canino
Célula dendrítica plasmocitoide
CD123
Canine plasmacytoma
Plasmacytoid dendritic cell
Medicina Veterinária
dc.subject.eng.fl_str_mv Canine plasmacytoma
Plasmacytoid dendritic cell
dc.subject.cnpq.fl_str_mv Medicina Veterinária
description A literatura sobre plasmocitomas extramedulares caninos (PEMCs) é ampla e com informações divergentes. Devido sua grande variação morfológica, essa neoplasia é comumente confundida com outros tumores benignos e malignos na rotina de diagnóstico histopatológico; principalmente com o histiocitoma cutâneo canino (HCC), o sarcoma histiocítico canino (SHC) e o linfoma canino (LC). Com o objetivo de fornecer informações adicionais sobre a imunofenotipagem dos PEMCs, testes de imuno-histoquímica foram realizados em microarranjo de tecidos (TMA) com cores de 2mm, usando os marcadores convencionais CD79a (em duplicata), CD3 (em duplicata), MUM1 (em duplicata), Iba1 e cadeias leves λ e κ de imunoglobulina em amostras de 39 PEMCs, 27 HCCs e 8 LCs. Para fins de comparação e controle, o estudo também incluiu amostras de 2 SHCs, 2 mastocitomas cutâneos (MCC), 2 melanomas orais, 1 mieloma múltiplo e espécimes de linfonodo, baço, medula óssea e pele caninos. Além disso, foi feita uma investigação inédita com o anticorpo monoclonal antireceptor α da interleucina 3 (CD123) aplicado a cães. O CD123 tem sido amplamente estudado na medicina humana como eficiente marcador de algumas neoplasias linfoides, de mastócitos e de células dendríticas plasmocitoides blásticas, mas é praticamente inexplorado na medicina veterinária. Com o objetivo de avaliar a eficiência do microarranjo de tecidos (TMA) para alguns dos marcadores, realizou-se um estudo imuno-histoquímico piloto nas seções histológicas convencionais com MUM1 e CD79a em 27 amostras de PEMCs e 10 de HCCs, com os anticorpos anti-CD3 e CD79a em 8 amostras de LCs (5 cutâneos e 3 nodais) e com o anti-CD123 em amostras de 7 PEMCs e 2 HCCs. As conclusões mais importantes foram: 1) MUM1 é muito sensível (89,7%) para detectar PEMCs e eficiente para diferenciar os PEMCs de neoplasias histiocíticas. 2) Linfomas de células T podem expressar MUM1. 3) O CD123 é expresso por PEMCs, MCCs e SHCs, além de plasmócitos normais, endotélio e possivelmente por células dendríticas plasmocitoides caninas. 4) A expressão do antígeno CD123 em neoplasias malignas como MCC e SHC deve ser melhor investigada. 5) O anticorpo Iba1 teve 100% de sensibilidade para detectar HCCs e SHCs e, é muito específico para essas neoplasias.
publishDate 2020
dc.date.issued.fl_str_mv 2020-02-19
dc.date.accessioned.fl_str_mv 2023-12-22T02:57:02Z
dc.date.available.fl_str_mv 2023-12-22T02:57:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, Bartolomeu Benedito Neves. Imunofenotipagem comparada dos plasmocitomas extramedulares, histiocitomas e linfomas cutâneos em cães. 2020. 56 f. Dissertação (Mestrado em Medicina Veterinária, Patologia e Ciências Clínicas) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, 2020.
dc.identifier.uri.fl_str_mv https://rima.ufrrj.br/jspui/handle/20.500.14407/14169
identifier_str_mv SANTOS, Bartolomeu Benedito Neves. Imunofenotipagem comparada dos plasmocitomas extramedulares, histiocitomas e linfomas cutâneos em cães. 2020. 56 f. Dissertação (Mestrado em Medicina Veterinária, Patologia e Ciências Clínicas) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, 2020.
url https://rima.ufrrj.br/jspui/handle/20.500.14407/14169
dc.language.iso.fl_str_mv por
language por
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dc.publisher.none.fl_str_mv Universidade Federal Rural do Rio de Janeiro
dc.publisher.program.fl_str_mv Programa de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas)
dc.publisher.initials.fl_str_mv UFRRJ
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Instituto de Veterinária
publisher.none.fl_str_mv Universidade Federal Rural do Rio de Janeiro
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ
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