Nalbufina, butorfanol e morfina no controle da dor pós-operatória imediata em cadelas submetidas a ovariohisterectomia eletiva

Detalhes bibliográficos
Autor(a) principal: Gomes, Viviane Horta
Data de Publicação: 2018
Tipo de documento: Tese
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRRJ
Texto Completo: https://rima.ufrrj.br/jspui/handle/20.500.14407/10137
Resumo: Os opioides são utilizados no manejo da dor perioperatória, formando a base do plano analgésico balanceado. O objetivo deste estudo foi comparar a eficácia analgésica da nalbufina, butorfanol e morfina no pós-operatório imediato, em cadelas submetidas a ovariohisterectomia eletiva. Quarenta e oito cadelas hígidas de diferentes raças foram distribuídas de forma aleatória em quatro tratamentos: nalbufina 0,5 mg kg-1(N0.5) e 1,0 mg kg-1 (N1.0), butorfanol 0,4 mg kg-1(B0.4) ou morfina 0,2 mg kg-1(M0.2) associados à acepromazina 0,02 mg kg-1 , por via intravenosa (IV). A anestesia foi induzida com propofol e mantida com isofluorano. A Escala Analógica Visual Dinâmica e Interativa (DIVAS, 0–100 mm), fases I (DIVAS I), II (DIVAS II) e III (DIVAS III), e a Escala de Dor Composta de Glasgow Modificada (GCMPS, 0–10) foram utilizadas para avaliar a dor antes da administração dos fármacos (BL), 1, 2, 3, 4, 5 e 6 horas após a extubação. O resgateanalgésico (0,2 mg kg-1 IV de morfina combinada a 0,2 mg kg-1 IV de meloxicam) foi administrado se o cão apresentasse DIVAS > 70 mm ou GCMPS > 3,5. B0.4 apresentou maior escore em DIVAS II comparado ao N1.0, nas horas 2 (p = 0,038) e 3 (p = 0,002), e ao N0.5, na hora 3 (p = 0,003). Não houve diferença em DIVAS I, III e GCMPS entre os tratamentos. Trinta e quatro cadelas necessitaram de resgate analgésico. Não houve diferença entre os grupos em relação a número de resgates analgésicos (p = 0,813) e a dose total de morfina administrada como resgate (p = 0,763). A administração preemptiva de nalbufina, butorfanol e morfina promove similar analgesia pós-operatória com grande possibilidade de resgate analgésico nas 6 primeiras horas, dessa forma, nesse período devem ser realizadas avaliações regulares e interativas para garantir analgesia adequada às cadelas submetidas a ovariohisterectomia.
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spelling Gomes, Viviane HortaSilva, Marta Fernanda Albuquerque da0544591266946007http://lattes.cnpq.br/0544591266946007Paiva, Jonimar Pereira0555358847663175http://lattes.cnpq.br/0555358847663175Abreu, Mariana Boechat de0171700191037164http://lattes.cnpq.br/0171700191037164Moreno, Juan Carlos Duque8509640024284103http://lattes.cnpq.br/8509640024284103Santos, Paulo Sergio Patto dos5331938962896664http://lattes.cnpq.br/53319389628966648842502819385308http://lattes.cnpq.br/88425028193853082023-12-21T18:57:54Z2023-12-21T18:57:54Z2018-08-21GOMES, Viviane Horta. Nalbufina, butorfanol e morfina no controle da dor pós-operatória imediata em cadelas submetidas a ovariohisterectomia eletiva. 2018. 51 f. Tese (Mestrado em Medicina Veterinária) - Instituto de Veterinária, Departamento de Medicina e Cirurgia Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2018.https://rima.ufrrj.br/jspui/handle/20.500.14407/10137Os opioides são utilizados no manejo da dor perioperatória, formando a base do plano analgésico balanceado. O objetivo deste estudo foi comparar a eficácia analgésica da nalbufina, butorfanol e morfina no pós-operatório imediato, em cadelas submetidas a ovariohisterectomia eletiva. Quarenta e oito cadelas hígidas de diferentes raças foram distribuídas de forma aleatória em quatro tratamentos: nalbufina 0,5 mg kg-1(N0.5) e 1,0 mg kg-1 (N1.0), butorfanol 0,4 mg kg-1(B0.4) ou morfina 0,2 mg kg-1(M0.2) associados à acepromazina 0,02 mg kg-1 , por via intravenosa (IV). A anestesia foi induzida com propofol e mantida com isofluorano. A Escala Analógica Visual Dinâmica e Interativa (DIVAS, 0–100 mm), fases I (DIVAS I), II (DIVAS II) e III (DIVAS III), e a Escala de Dor Composta de Glasgow Modificada (GCMPS, 0–10) foram utilizadas para avaliar a dor antes da administração dos fármacos (BL), 1, 2, 3, 4, 5 e 6 horas após a extubação. O resgateanalgésico (0,2 mg kg-1 IV de morfina combinada a 0,2 mg kg-1 IV de meloxicam) foi administrado se o cão apresentasse DIVAS > 70 mm ou GCMPS > 3,5. B0.4 apresentou maior escore em DIVAS II comparado ao N1.0, nas horas 2 (p = 0,038) e 3 (p = 0,002), e ao N0.5, na hora 3 (p = 0,003). Não houve diferença em DIVAS I, III e GCMPS entre os tratamentos. Trinta e quatro cadelas necessitaram de resgate analgésico. Não houve diferença entre os grupos em relação a número de resgates analgésicos (p = 0,813) e a dose total de morfina administrada como resgate (p = 0,763). A administração preemptiva de nalbufina, butorfanol e morfina promove similar analgesia pós-operatória com grande possibilidade de resgate analgésico nas 6 primeiras horas, dessa forma, nesse período devem ser realizadas avaliações regulares e interativas para garantir analgesia adequada às cadelas submetidas a ovariohisterectomia.The management of perioperative pain can be performed by opioids, drugs that form the base of a balanced analgesic plane. The aim of this study was to compare the analgesic efficacy of nalbuphine, butorphanol and morphine in the early postoperative analgesia, in bitches submitted to ovariohysterectomy. Forty-eight healthy bitches of different breeds were randomly assigned to four treatments: nalbuphine 0,5 mg kg-1 (N0.5) and 1,0 mg kg-1(N1.0), butorphanol 0,4 mg kg-1(B0.4) or morphine 0,2 mg kg-1 (M0.2), combined with acepromazine 0,02 mg kg-1intravenously. Anesthesia was induced with propofol and maintained with isoflurane. Dynamic Interactive Visual Analog Scale (DIVAS, 0–100 mm), phases I (DIVAS I), II (DIVAS II) and III (DIVAS III), and the Modified Glasgow Composite Measure Pain Scale (GCMPS, 0–10) were used to used to assess pain prior administration of the drugs (BL), 1, 2, 3, 4, 5 and 6 hours after extubation. The analgesic rescue (0,2 mg kg1IV of morphine combined with 0,2 mg kg-1IV of meloxicam) was given if the dog had DIVAS > 70 mm or GCMPS > 3,5. B0.4 had a higher DIVAS II score compared with N1.0, at 2 (p = 0,038) and 3 hours (p = 0,002), and with N0.5 at 3 hours (p = 0,003). There was no difference in DIVAS I, III and GCMPS scores between treatments. Rescue analgesia was required in thirty-four bitches. The number of analgesic rescues (p = 0,813) and total dose of morphine given as rescue (p = 0,763) were not different between groups. Preemptive administration of nalbuphine, butorphanol and morphine produce similar postoperative analgesia with great possibility of analgesic rescue in the first 6 hours, therefore, over this period, regular and interactive evaluations should be performed to ensure adequate analgesia in bitches submitted to ovariohysterectomy.application/pdfporUniversidade Federal Rural do Rio de JaneiroPrograma de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas)UFRRJBrasilInstituto de VeterináriaAnalgesiaAgonista-antagonistaCãoEscala de dorOpioideAnalgesiaAgonist-antagonistDogOpioidPain scaleMedicina VeterináriaNalbufina, butorfanol e morfina no controle da dor pós-operatória imediata em cadelas submetidas a ovariohisterectomia eletivaNalbuphine, butorphanol and morphine for the control of early postoperative pain in canine elective ovariohysterectomyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisAUBRUN, F.; SALVI, N.; CORIAT, P.; RIOU, B. 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American Journal of Veterinary Research, v. 54, p. 976–983, 1993. WILSON, D. V.; EVANS, A. T.; MILLER, R. Effects of preanesthetic administration ofmorphine on gastroesophageal reflux and regurgitation during anesthesia in dogs. American Journal of Veterinary Research, v. 66, p. 386–390, 2005. ZANUZZO, F. S.; TEIXEIRA-NETO, F. J.; TEIXEIRA, L. R.; DINIZ, M. S.; SOUZA, V. L.; THOMAZINI, C. M.; STEAGALL, P. V. Analgesic and antihyperalgesic effects of dipyrone, meloxicam or a dipyrone-meloxicam combination in bitches undergoing ovariohysterectomy. Veterinary Journal, v. 205, p. 33–37, 2015.https://tede.ufrrj.br/retrieve/66581/2018%20-%20Viviane%20Horta%20Gomes%20%286%29.pdf.jpghttps://tede.ufrrj.br/jspui/handle/jspui/5002Submitted by Leticia Schettini (leticia@ufrrj.br) on 2021-09-01T18:51:54Z No. of bitstreams: 1 2018 - Viviane Horta Gomes (6).pdf: 835054 bytes, checksum: 73187d3b1797750f7f4e5e4321b23dd5 (MD5)Made available in DSpace on 2021-09-01T18:51:55Z (GMT). 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dc.title.por.fl_str_mv Nalbufina, butorfanol e morfina no controle da dor pós-operatória imediata em cadelas submetidas a ovariohisterectomia eletiva
dc.title.alternative.eng.fl_str_mv Nalbuphine, butorphanol and morphine for the control of early postoperative pain in canine elective ovariohysterectomy
title Nalbufina, butorfanol e morfina no controle da dor pós-operatória imediata em cadelas submetidas a ovariohisterectomia eletiva
spellingShingle Nalbufina, butorfanol e morfina no controle da dor pós-operatória imediata em cadelas submetidas a ovariohisterectomia eletiva
Gomes, Viviane Horta
Analgesia
Agonista-antagonista
Cão
Escala de dor
Opioide
Analgesia
Agonist-antagonist
Dog
Opioid
Pain scale
Medicina Veterinária
title_short Nalbufina, butorfanol e morfina no controle da dor pós-operatória imediata em cadelas submetidas a ovariohisterectomia eletiva
title_full Nalbufina, butorfanol e morfina no controle da dor pós-operatória imediata em cadelas submetidas a ovariohisterectomia eletiva
title_fullStr Nalbufina, butorfanol e morfina no controle da dor pós-operatória imediata em cadelas submetidas a ovariohisterectomia eletiva
title_full_unstemmed Nalbufina, butorfanol e morfina no controle da dor pós-operatória imediata em cadelas submetidas a ovariohisterectomia eletiva
title_sort Nalbufina, butorfanol e morfina no controle da dor pós-operatória imediata em cadelas submetidas a ovariohisterectomia eletiva
author Gomes, Viviane Horta
author_facet Gomes, Viviane Horta
author_role author
dc.contributor.author.fl_str_mv Gomes, Viviane Horta
dc.contributor.advisor1.fl_str_mv Silva, Marta Fernanda Albuquerque da
dc.contributor.advisor1ID.fl_str_mv 0544591266946007
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/0544591266946007
dc.contributor.referee1.fl_str_mv Paiva, Jonimar Pereira
dc.contributor.referee1ID.fl_str_mv 0555358847663175
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/0555358847663175
dc.contributor.referee2.fl_str_mv Abreu, Mariana Boechat de
dc.contributor.referee2ID.fl_str_mv 0171700191037164
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/0171700191037164
dc.contributor.referee3.fl_str_mv Moreno, Juan Carlos Duque
dc.contributor.referee3ID.fl_str_mv 8509640024284103
dc.contributor.referee3Lattes.fl_str_mv http://lattes.cnpq.br/8509640024284103
dc.contributor.referee4.fl_str_mv Santos, Paulo Sergio Patto dos
dc.contributor.referee4ID.fl_str_mv 5331938962896664
dc.contributor.referee4Lattes.fl_str_mv http://lattes.cnpq.br/5331938962896664
dc.contributor.authorID.fl_str_mv 8842502819385308
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/8842502819385308
contributor_str_mv Silva, Marta Fernanda Albuquerque da
Paiva, Jonimar Pereira
Abreu, Mariana Boechat de
Moreno, Juan Carlos Duque
Santos, Paulo Sergio Patto dos
dc.subject.por.fl_str_mv Analgesia
Agonista-antagonista
Cão
Escala de dor
Opioide
topic Analgesia
Agonista-antagonista
Cão
Escala de dor
Opioide
Analgesia
Agonist-antagonist
Dog
Opioid
Pain scale
Medicina Veterinária
dc.subject.eng.fl_str_mv Analgesia
Agonist-antagonist
Dog
Opioid
Pain scale
dc.subject.cnpq.fl_str_mv Medicina Veterinária
description Os opioides são utilizados no manejo da dor perioperatória, formando a base do plano analgésico balanceado. O objetivo deste estudo foi comparar a eficácia analgésica da nalbufina, butorfanol e morfina no pós-operatório imediato, em cadelas submetidas a ovariohisterectomia eletiva. Quarenta e oito cadelas hígidas de diferentes raças foram distribuídas de forma aleatória em quatro tratamentos: nalbufina 0,5 mg kg-1(N0.5) e 1,0 mg kg-1 (N1.0), butorfanol 0,4 mg kg-1(B0.4) ou morfina 0,2 mg kg-1(M0.2) associados à acepromazina 0,02 mg kg-1 , por via intravenosa (IV). A anestesia foi induzida com propofol e mantida com isofluorano. A Escala Analógica Visual Dinâmica e Interativa (DIVAS, 0–100 mm), fases I (DIVAS I), II (DIVAS II) e III (DIVAS III), e a Escala de Dor Composta de Glasgow Modificada (GCMPS, 0–10) foram utilizadas para avaliar a dor antes da administração dos fármacos (BL), 1, 2, 3, 4, 5 e 6 horas após a extubação. O resgateanalgésico (0,2 mg kg-1 IV de morfina combinada a 0,2 mg kg-1 IV de meloxicam) foi administrado se o cão apresentasse DIVAS > 70 mm ou GCMPS > 3,5. B0.4 apresentou maior escore em DIVAS II comparado ao N1.0, nas horas 2 (p = 0,038) e 3 (p = 0,002), e ao N0.5, na hora 3 (p = 0,003). Não houve diferença em DIVAS I, III e GCMPS entre os tratamentos. Trinta e quatro cadelas necessitaram de resgate analgésico. Não houve diferença entre os grupos em relação a número de resgates analgésicos (p = 0,813) e a dose total de morfina administrada como resgate (p = 0,763). A administração preemptiva de nalbufina, butorfanol e morfina promove similar analgesia pós-operatória com grande possibilidade de resgate analgésico nas 6 primeiras horas, dessa forma, nesse período devem ser realizadas avaliações regulares e interativas para garantir analgesia adequada às cadelas submetidas a ovariohisterectomia.
publishDate 2018
dc.date.issued.fl_str_mv 2018-08-21
dc.date.accessioned.fl_str_mv 2023-12-21T18:57:54Z
dc.date.available.fl_str_mv 2023-12-21T18:57:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOMES, Viviane Horta. Nalbufina, butorfanol e morfina no controle da dor pós-operatória imediata em cadelas submetidas a ovariohisterectomia eletiva. 2018. 51 f. Tese (Mestrado em Medicina Veterinária) - Instituto de Veterinária, Departamento de Medicina e Cirurgia Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2018.
dc.identifier.uri.fl_str_mv https://rima.ufrrj.br/jspui/handle/20.500.14407/10137
identifier_str_mv GOMES, Viviane Horta. Nalbufina, butorfanol e morfina no controle da dor pós-operatória imediata em cadelas submetidas a ovariohisterectomia eletiva. 2018. 51 f. Tese (Mestrado em Medicina Veterinária) - Instituto de Veterinária, Departamento de Medicina e Cirurgia Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2018.
url https://rima.ufrrj.br/jspui/handle/20.500.14407/10137
dc.language.iso.fl_str_mv por
language por
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