Prevalência de marcadores sorológicos dos vírus das Hepatites B (VHB) e C (VHC) em indivíduos infectados por Schistosoma mansoni no bairro Santa Maria, Aracaju/SE

Detalhes bibliográficos
Autor(a) principal: Santos, Márcio Bezerra
Data de Publicação: 2012
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFS
Texto Completo: https://ri.ufs.br/handle/riufs/3246
Resumo: The Schistosomiasis is a parasitic disease, severe, chronic waterborne and development, whose etiologic agent is Schistosoma mansoni. It occurs in 74 countries with 207 million people infected and 700 million in risky areas. In Brazil, data indicate a prevalence of eight million. The Schistosomiasis can be exacerbated when patients are carriers of the Hepatitis B Virus (HBV) and C (HCV), resulting in simultaneous evolution of both pathologies. In Brazil, the prevalence of co-infection with HBV/HCV and S. mansoni found in studies ranged from 13.6% to 40% for HBV and 0.5% to 19.66% for the HCV. On this basis, this research aimed to identify the prevalence of serological markers of HBV and HCV and risky factors in individuals carrying the S. mansoni in the Santa Maria neighborhood, Aracaju, state of Sergipe. We conducted a cross-sectional epidemiological study. Data were collected for each patient by means of a questionnaire investigation. This questionnaire included variables identifying the subject of the research participants and variables that included the epidemiological risky factors for infection with HBV or HCV. We collected serum samples of research participants and forwarded to the laboratory testing to identify serological markers of hepatitis B and C: Total Anti-HBc IgG, Anti-HBs, HBsAg and Anti-HCV. All procedures performed using the technique of chemiluminescence immunoassay using the ARCHITECT assay for each serological marker following the protocols established by the laboratory equipment manufacturer SYSTEM ARCHITECT. In addition, we carried out the analysis of spatial distribution of co-infection in the district through the program using the TerraView Kernel intensity estimation. It was found that 16 individuals had contact with HBV (9.41%), one of these was positive for HBsAg. Only Thirty-two samples (18.82%) were positive for the marker Anti-HBs. Three samples were positive for anti-HCV (1.76%), and also a positive for Anti-HBc. The main risks of HBV and HCV infection were related to parenteral interventions of health services, as well as sexual activity without condom use in the case of HBV. Spatial analysis of cases of co-infection (Schistosomiasis and Hepatitis) allowed the visualization of areas of higher concentration of these infections, as well as those that are exposed to different degrees of risk of transmission. The survey results allow to offer, the municipal health services, a tool to facilitate the understanding of the spatial distribution of schistosomiasis and hepatitis (B and C) in Santa Maria neighborhood. Although our values are above the estimated prevalence for the Brazilian population and the Northeast, we can t infer that the individuals with Schistosomiasis are more susceptible to infection with HBV or HCV, since the risky factors were the means of risky transmission of causative agents of hepatitis and not infected with S. mansoni.
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spelling Santos, Márcio Bezerrahttp://lattes.cnpq.br/3116321756193947Araújo, Karina Conceição Gomes Machado dehttp://lattes.cnpq.br/20526879721900132017-09-25T13:59:16Z2017-09-25T13:59:16Z2012-07-19https://ri.ufs.br/handle/riufs/3246The Schistosomiasis is a parasitic disease, severe, chronic waterborne and development, whose etiologic agent is Schistosoma mansoni. It occurs in 74 countries with 207 million people infected and 700 million in risky areas. In Brazil, data indicate a prevalence of eight million. The Schistosomiasis can be exacerbated when patients are carriers of the Hepatitis B Virus (HBV) and C (HCV), resulting in simultaneous evolution of both pathologies. In Brazil, the prevalence of co-infection with HBV/HCV and S. mansoni found in studies ranged from 13.6% to 40% for HBV and 0.5% to 19.66% for the HCV. On this basis, this research aimed to identify the prevalence of serological markers of HBV and HCV and risky factors in individuals carrying the S. mansoni in the Santa Maria neighborhood, Aracaju, state of Sergipe. We conducted a cross-sectional epidemiological study. Data were collected for each patient by means of a questionnaire investigation. This questionnaire included variables identifying the subject of the research participants and variables that included the epidemiological risky factors for infection with HBV or HCV. We collected serum samples of research participants and forwarded to the laboratory testing to identify serological markers of hepatitis B and C: Total Anti-HBc IgG, Anti-HBs, HBsAg and Anti-HCV. All procedures performed using the technique of chemiluminescence immunoassay using the ARCHITECT assay for each serological marker following the protocols established by the laboratory equipment manufacturer SYSTEM ARCHITECT. In addition, we carried out the analysis of spatial distribution of co-infection in the district through the program using the TerraView Kernel intensity estimation. It was found that 16 individuals had contact with HBV (9.41%), one of these was positive for HBsAg. Only Thirty-two samples (18.82%) were positive for the marker Anti-HBs. Three samples were positive for anti-HCV (1.76%), and also a positive for Anti-HBc. The main risks of HBV and HCV infection were related to parenteral interventions of health services, as well as sexual activity without condom use in the case of HBV. Spatial analysis of cases of co-infection (Schistosomiasis and Hepatitis) allowed the visualization of areas of higher concentration of these infections, as well as those that are exposed to different degrees of risk of transmission. The survey results allow to offer, the municipal health services, a tool to facilitate the understanding of the spatial distribution of schistosomiasis and hepatitis (B and C) in Santa Maria neighborhood. Although our values are above the estimated prevalence for the Brazilian population and the Northeast, we can t infer that the individuals with Schistosomiasis are more susceptible to infection with HBV or HCV, since the risky factors were the means of risky transmission of causative agents of hepatitis and not infected with S. mansoni.A Esquistossomose Mansônica é uma doença parasitária grave, de veiculação hídrica e evolução crônica, cujo agente etiológico é o Schistosoma mansoni. Ocorre em 74 países, com 207 milhões de pessoas infectadas e 700 milhões em áreas de risco. No Brasil, dados indicam uma prevalência de oito milhões. A Esquistossomose pode ser agravada quando os pacientes são portadores dos Vírus das Hepatites B (VHB) e C (VHC), resultando na evolução simultânea de ambas as patologias. No Brasil, As prevalências da co-infecção VHB/VHC e S. mansoni encontradas nos estudos realizados variaram de 13,6% a 40% para o HBV e de 0,5% a 19,66% para o HCV. Com base nisso, esta pesquisa objetivou identificar a prevalência de marcadores sorológicos do VHB e VHC e os fatores de risco em indivíduos portadores do S. mansoni no Bairro Santa Maria, Aracaju/SE. Foi realizado um estudo epidemiológico do tipo transversal. Coletaram-se dados de cada paciente por meio de um questionário investigativo. Este questionário contemplou variáveis de identificação do sujeito participante da pesquisa e variáveis epidemiológicas que incluíram os fatores de risco para infecção pelo HBV ou HCV. Foram coletadas alíquotas de soro dos participantes da pesquisa e encaminhadas para a realização das análises laboratoriais para identificação de marcadores sorológicos dos Vírus das Hepatites B e C: Anti-HBc Total IgG, Anti-HBs, HBsAg e Anti-HCV. Todos os procedimentos realizados utilizaram a técnica de Imunoensaio Quimioluminescente através do Ensaio ARCHITECT para cada marcador sorológico seguindo os protocolos de análises laboratoriais estabelecidos pelo fabricante do equipamento ARCHITECT SYSTEM. Além disso, realizou-se a análise espacial da distribuição da co-infecção no bairro através do programa TerraView utilizando o estimador de intensidade Kernel. Constatou-se que 16 indivíduos tiveram contato com o HBV (9,41%), desses um foi positivo para HBsAg. Apenas Trinta e duas amostras (18,82%) foram positivas para o marcador Anti-HBs. Três amostras foram positivas para Anti-HCV (1,76%), sendo uma também positiva para Anti-HBc. Os principais riscos de infecção pelo HBV e HCV foram relacionados às intervenções parenterais dos serviços de saúde, assim como à atividade sexual sem uso de preservativo, no caso do HBV. A análise espacial dos casos de co-infecção (Esquistossomose e Hepatite) permitiu a visualização de áreas de maior concentração dessas infecções, assim como as que são expostas a diferentes graus de risco de transmissão. Os resultados da pesquisa possibilitam oferecer, aos serviços municipais de saúde, um instrumento que facilite a compreensão da distribuição espacial da Esquistossomose e Hepatites (B e C) no bairro Santa Maria. Embora nossos valores sejam acima da prevalência estimada para a população brasileira e da região nordeste, não podemos inferir que os indivíduos portadores da Esquistossomose são mais susceptíveis à infecção pelo HBV ou HCV, uma vez que, os fatores de risco foram as vias de risco de transmissão de agentes causadores de hepatite e não a infecção pelo S. mansoni.Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorapplication/pdfporUniversidade Federal de SergipePós-Graduação em Biologia ParasitáriaUFSBREpidemiologiaVírus da hepatite BVírus da hepatite CSchistosoma masoniEpidemiologyHepatitis B virusHepatitis C virusSchistosomiasisCNPQ::CIENCIAS BIOLOGICASPrevalência de marcadores sorológicos dos vírus das Hepatites B (VHB) e C (VHC) em indivíduos infectados por Schistosoma mansoni no bairro Santa Maria, Aracaju/SEPREVALENCE OF SEROLOGICAL MARKERS OF HEPATITIS B VIRUS (HBV) AND C (HCV) IN INDIVIDUALS INFECTED WITH SCHISTOSOMA MANSONI IN THE NEIGHBORHOOD SANTA MARIA, ARACAJU, STATE OF SERGIPE.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSORIGINALMARCIO_BEZERRA_SANTOS.pdfapplication/pdf2690226https://ri.ufs.br/jspui/bitstream/riufs/3246/1/MARCIO_BEZERRA_SANTOS.pdfde8a06eac85e24b301ab6d21b343d0e6MD51TEXTMARCIO_BEZERRA_SANTOS.pdf.txtMARCIO_BEZERRA_SANTOS.pdf.txtExtracted texttext/plain229088https://ri.ufs.br/jspui/bitstream/riufs/3246/2/MARCIO_BEZERRA_SANTOS.pdf.txt84c4f81b81bd91e337ed7e7f1117e495MD52THUMBNAILMARCIO_BEZERRA_SANTOS.pdf.jpgMARCIO_BEZERRA_SANTOS.pdf.jpgGenerated Thumbnailimage/jpeg1275https://ri.ufs.br/jspui/bitstream/riufs/3246/3/MARCIO_BEZERRA_SANTOS.pdf.jpgd0d04d70ab5a38fa6d628399d44fadfeMD53riufs/32462017-11-24 21:27:54.563oai:ufs.br:riufs/3246Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2017-11-25T00:27:54Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false
dc.title.por.fl_str_mv Prevalência de marcadores sorológicos dos vírus das Hepatites B (VHB) e C (VHC) em indivíduos infectados por Schistosoma mansoni no bairro Santa Maria, Aracaju/SE
dc.title.alternative.eng.fl_str_mv PREVALENCE OF SEROLOGICAL MARKERS OF HEPATITIS B VIRUS (HBV) AND C (HCV) IN INDIVIDUALS INFECTED WITH SCHISTOSOMA MANSONI IN THE NEIGHBORHOOD SANTA MARIA, ARACAJU, STATE OF SERGIPE.
title Prevalência de marcadores sorológicos dos vírus das Hepatites B (VHB) e C (VHC) em indivíduos infectados por Schistosoma mansoni no bairro Santa Maria, Aracaju/SE
spellingShingle Prevalência de marcadores sorológicos dos vírus das Hepatites B (VHB) e C (VHC) em indivíduos infectados por Schistosoma mansoni no bairro Santa Maria, Aracaju/SE
Santos, Márcio Bezerra
Epidemiologia
Vírus da hepatite B
Vírus da hepatite C
Schistosoma masoni
Epidemiology
Hepatitis B virus
Hepatitis C virus
Schistosomiasis
CNPQ::CIENCIAS BIOLOGICAS
title_short Prevalência de marcadores sorológicos dos vírus das Hepatites B (VHB) e C (VHC) em indivíduos infectados por Schistosoma mansoni no bairro Santa Maria, Aracaju/SE
title_full Prevalência de marcadores sorológicos dos vírus das Hepatites B (VHB) e C (VHC) em indivíduos infectados por Schistosoma mansoni no bairro Santa Maria, Aracaju/SE
title_fullStr Prevalência de marcadores sorológicos dos vírus das Hepatites B (VHB) e C (VHC) em indivíduos infectados por Schistosoma mansoni no bairro Santa Maria, Aracaju/SE
title_full_unstemmed Prevalência de marcadores sorológicos dos vírus das Hepatites B (VHB) e C (VHC) em indivíduos infectados por Schistosoma mansoni no bairro Santa Maria, Aracaju/SE
title_sort Prevalência de marcadores sorológicos dos vírus das Hepatites B (VHB) e C (VHC) em indivíduos infectados por Schistosoma mansoni no bairro Santa Maria, Aracaju/SE
author Santos, Márcio Bezerra
author_facet Santos, Márcio Bezerra
author_role author
dc.contributor.author.fl_str_mv Santos, Márcio Bezerra
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3116321756193947
dc.contributor.advisor1.fl_str_mv Araújo, Karina Conceição Gomes Machado de
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/2052687972190013
contributor_str_mv Araújo, Karina Conceição Gomes Machado de
dc.subject.por.fl_str_mv Epidemiologia
Vírus da hepatite B
Vírus da hepatite C
Schistosoma masoni
topic Epidemiologia
Vírus da hepatite B
Vírus da hepatite C
Schistosoma masoni
Epidemiology
Hepatitis B virus
Hepatitis C virus
Schistosomiasis
CNPQ::CIENCIAS BIOLOGICAS
dc.subject.eng.fl_str_mv Epidemiology
Hepatitis B virus
Hepatitis C virus
Schistosomiasis
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS BIOLOGICAS
description The Schistosomiasis is a parasitic disease, severe, chronic waterborne and development, whose etiologic agent is Schistosoma mansoni. It occurs in 74 countries with 207 million people infected and 700 million in risky areas. In Brazil, data indicate a prevalence of eight million. The Schistosomiasis can be exacerbated when patients are carriers of the Hepatitis B Virus (HBV) and C (HCV), resulting in simultaneous evolution of both pathologies. In Brazil, the prevalence of co-infection with HBV/HCV and S. mansoni found in studies ranged from 13.6% to 40% for HBV and 0.5% to 19.66% for the HCV. On this basis, this research aimed to identify the prevalence of serological markers of HBV and HCV and risky factors in individuals carrying the S. mansoni in the Santa Maria neighborhood, Aracaju, state of Sergipe. We conducted a cross-sectional epidemiological study. Data were collected for each patient by means of a questionnaire investigation. This questionnaire included variables identifying the subject of the research participants and variables that included the epidemiological risky factors for infection with HBV or HCV. We collected serum samples of research participants and forwarded to the laboratory testing to identify serological markers of hepatitis B and C: Total Anti-HBc IgG, Anti-HBs, HBsAg and Anti-HCV. All procedures performed using the technique of chemiluminescence immunoassay using the ARCHITECT assay for each serological marker following the protocols established by the laboratory equipment manufacturer SYSTEM ARCHITECT. In addition, we carried out the analysis of spatial distribution of co-infection in the district through the program using the TerraView Kernel intensity estimation. It was found that 16 individuals had contact with HBV (9.41%), one of these was positive for HBsAg. Only Thirty-two samples (18.82%) were positive for the marker Anti-HBs. Three samples were positive for anti-HCV (1.76%), and also a positive for Anti-HBc. The main risks of HBV and HCV infection were related to parenteral interventions of health services, as well as sexual activity without condom use in the case of HBV. Spatial analysis of cases of co-infection (Schistosomiasis and Hepatitis) allowed the visualization of areas of higher concentration of these infections, as well as those that are exposed to different degrees of risk of transmission. The survey results allow to offer, the municipal health services, a tool to facilitate the understanding of the spatial distribution of schistosomiasis and hepatitis (B and C) in Santa Maria neighborhood. Although our values are above the estimated prevalence for the Brazilian population and the Northeast, we can t infer that the individuals with Schistosomiasis are more susceptible to infection with HBV or HCV, since the risky factors were the means of risky transmission of causative agents of hepatitis and not infected with S. mansoni.
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