Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach

Detalhes bibliográficos
Autor(a) principal: Venâncio, Antônio Medeiros
Data de Publicação: 2011
Outros Autores: Marchioro, Murilo, Estevam, Charles dos Santos, Melo, Mônica Santos de, Santana, Marília Trindade de, Onofre, Alexandre Sherlley Casimiro, Guimarães, Adriana Gibara, Oliveira, Makson Gleydson Brito de, Alves, Péricles Barreto, Pimentel, Hugo de Carvalho, Quintans-Júnior, Lucindo José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFS
Texto Completo: https://ri.ufs.br/handle/riufs/595
Resumo: The present study investigated the antinociceptive effects of Ocimum basilicum L. (Lamiaceae) leaf essential oil (LEO) and (-)-linalool (LIN) in formalin (2%)-, glutamate (25 µM)- and capsaicin (2.5 µg)- induced orofacial nociception models in mice. The involvement of these substances was further evaluated on the neuronal excitability of the hippocampal dentate gyrus. Male mice (n=8/group) were pretreated separately with LEO and by LIN (50, 100, and 200 mg/kg, i.p.), morphine (5 mg/kg, i.p.) and vehicle (saline + Tween 80 0.2%), before injection of nociceptive agent into the right upper lip (perinasal area). The LEO and LIN reduced the nociceptive face-rubbing behaviour in both phases on formalin test. LEO and LIN, at high doses, produced significantly antinociceptive effect in the capsaicin and glutamate tests. In hippocampal slices, LEO inhibited the population spike generated by stimulation of the hylus (antidromic stimulation), with an IC50 of 0.1±0.05 mg/mL. This response was reversibly blocked by lidocaine (0.5 mg/mL), a known voltage-dependent sodium channel antagonist and by LIN (0.5 mg/mL). Our results suggest that LEO and LIN modulate neurogenic and inflammatory pain in the tests of orofacial nociception induced by formalin, capsaicin and glutamate. Part of these effects may be associated with decreased peripheral and central neuronal excitability.
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spelling Venâncio, Antônio MedeirosMarchioro, MuriloEstevam, Charles dos SantosMelo, Mônica Santos deSantana, Marília Trindade deOnofre, Alexandre Sherlley CasimiroGuimarães, Adriana GibaraOliveira, Makson Gleydson Brito deAlves, Péricles BarretoPimentel, Hugo de CarvalhoQuintans-Júnior, Lucindo José2013-06-08T12:45:41Z2013-06-08T12:45:41Z2011-08VENANCIO, Antônio M. et al. Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach. Revista Brasileira de Farmacognosia, Curitiba, v. 21, n. 6, dez. 2011 . Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000600015&lng=en&nrm=iso>. Acesso em: 8 jun. 2013.0102-695Xhttps://ri.ufs.br/handle/riufs/595Creative Commons Attribution LicenseThe present study investigated the antinociceptive effects of Ocimum basilicum L. (Lamiaceae) leaf essential oil (LEO) and (-)-linalool (LIN) in formalin (2%)-, glutamate (25 µM)- and capsaicin (2.5 µg)- induced orofacial nociception models in mice. The involvement of these substances was further evaluated on the neuronal excitability of the hippocampal dentate gyrus. Male mice (n=8/group) were pretreated separately with LEO and by LIN (50, 100, and 200 mg/kg, i.p.), morphine (5 mg/kg, i.p.) and vehicle (saline + Tween 80 0.2%), before injection of nociceptive agent into the right upper lip (perinasal area). The LEO and LIN reduced the nociceptive face-rubbing behaviour in both phases on formalin test. LEO and LIN, at high doses, produced significantly antinociceptive effect in the capsaicin and glutamate tests. In hippocampal slices, LEO inhibited the population spike generated by stimulation of the hylus (antidromic stimulation), with an IC50 of 0.1±0.05 mg/mL. This response was reversibly blocked by lidocaine (0.5 mg/mL), a known voltage-dependent sodium channel antagonist and by LIN (0.5 mg/mL). Our results suggest that LEO and LIN modulate neurogenic and inflammatory pain in the tests of orofacial nociception induced by formalin, capsaicin and glutamate. Part of these effects may be associated with decreased peripheral and central neuronal excitability.Óleos essenciaisLinalolManjericãoOcimum basilicumNocicepção orofacialOcimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approachinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTHUMBNAILOcimumBasilicumLeaf.pdf.jpgOcimumBasilicumLeaf.pdf.jpgGenerated Thumbnailimage/jpeg1711https://ri.ufs.br/jspui/bitstream/riufs/595/4/OcimumBasilicumLeaf.pdf.jpg9bd8fb5baae4076ae44d0bfa4300d8dfMD54ORIGINALOcimumBasilicumLeaf.pdfOcimumBasilicumLeaf.pdfapplication/pdf805588https://ri.ufs.br/jspui/bitstream/riufs/595/1/OcimumBasilicumLeaf.pdf6484040fc32aab2daaaacd1c34843e5aMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://ri.ufs.br/jspui/bitstream/riufs/595/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTOcimumBasilicumLeaf.pdf.txtOcimumBasilicumLeaf.pdf.txtExtracted texttext/plain44992https://ri.ufs.br/jspui/bitstream/riufs/595/3/OcimumBasilicumLeaf.pdf.txt63029bbb88ce0e2b774344df68d0637aMD53riufs/5952013-06-09 02:00:07.189oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2013-06-09T05:00:07Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false
dc.title.pt_BR.fl_str_mv Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach
title Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach
spellingShingle Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach
Venâncio, Antônio Medeiros
Óleos essenciais
Linalol
Manjericão
Ocimum basilicum
Nocicepção orofacial
title_short Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach
title_full Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach
title_fullStr Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach
title_full_unstemmed Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach
title_sort Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach
author Venâncio, Antônio Medeiros
author_facet Venâncio, Antônio Medeiros
Marchioro, Murilo
Estevam, Charles dos Santos
Melo, Mônica Santos de
Santana, Marília Trindade de
Onofre, Alexandre Sherlley Casimiro
Guimarães, Adriana Gibara
Oliveira, Makson Gleydson Brito de
Alves, Péricles Barreto
Pimentel, Hugo de Carvalho
Quintans-Júnior, Lucindo José
author_role author
author2 Marchioro, Murilo
Estevam, Charles dos Santos
Melo, Mônica Santos de
Santana, Marília Trindade de
Onofre, Alexandre Sherlley Casimiro
Guimarães, Adriana Gibara
Oliveira, Makson Gleydson Brito de
Alves, Péricles Barreto
Pimentel, Hugo de Carvalho
Quintans-Júnior, Lucindo José
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Venâncio, Antônio Medeiros
Marchioro, Murilo
Estevam, Charles dos Santos
Melo, Mônica Santos de
Santana, Marília Trindade de
Onofre, Alexandre Sherlley Casimiro
Guimarães, Adriana Gibara
Oliveira, Makson Gleydson Brito de
Alves, Péricles Barreto
Pimentel, Hugo de Carvalho
Quintans-Júnior, Lucindo José
dc.subject.por.fl_str_mv Óleos essenciais
Linalol
Manjericão
Ocimum basilicum
Nocicepção orofacial
topic Óleos essenciais
Linalol
Manjericão
Ocimum basilicum
Nocicepção orofacial
description The present study investigated the antinociceptive effects of Ocimum basilicum L. (Lamiaceae) leaf essential oil (LEO) and (-)-linalool (LIN) in formalin (2%)-, glutamate (25 µM)- and capsaicin (2.5 µg)- induced orofacial nociception models in mice. The involvement of these substances was further evaluated on the neuronal excitability of the hippocampal dentate gyrus. Male mice (n=8/group) were pretreated separately with LEO and by LIN (50, 100, and 200 mg/kg, i.p.), morphine (5 mg/kg, i.p.) and vehicle (saline + Tween 80 0.2%), before injection of nociceptive agent into the right upper lip (perinasal area). The LEO and LIN reduced the nociceptive face-rubbing behaviour in both phases on formalin test. LEO and LIN, at high doses, produced significantly antinociceptive effect in the capsaicin and glutamate tests. In hippocampal slices, LEO inhibited the population spike generated by stimulation of the hylus (antidromic stimulation), with an IC50 of 0.1±0.05 mg/mL. This response was reversibly blocked by lidocaine (0.5 mg/mL), a known voltage-dependent sodium channel antagonist and by LIN (0.5 mg/mL). Our results suggest that LEO and LIN modulate neurogenic and inflammatory pain in the tests of orofacial nociception induced by formalin, capsaicin and glutamate. Part of these effects may be associated with decreased peripheral and central neuronal excitability.
publishDate 2011
dc.date.issued.fl_str_mv 2011-08
dc.date.accessioned.fl_str_mv 2013-06-08T12:45:41Z
dc.date.available.fl_str_mv 2013-06-08T12:45:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv VENANCIO, Antônio M. et al. Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach. Revista Brasileira de Farmacognosia, Curitiba, v. 21, n. 6, dez. 2011 . Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000600015&lng=en&nrm=iso>. Acesso em: 8 jun. 2013.
dc.identifier.uri.fl_str_mv https://ri.ufs.br/handle/riufs/595
dc.identifier.issn.none.fl_str_mv 0102-695X
dc.identifier.license.pt_BR.fl_str_mv Creative Commons Attribution License
identifier_str_mv VENANCIO, Antônio M. et al. Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach. Revista Brasileira de Farmacognosia, Curitiba, v. 21, n. 6, dez. 2011 . Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000600015&lng=en&nrm=iso>. Acesso em: 8 jun. 2013.
0102-695X
Creative Commons Attribution License
url https://ri.ufs.br/handle/riufs/595
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language eng
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instname_str Universidade Federal de Sergipe (UFS)
instacron_str UFS
institution UFS
reponame_str Repositório Institucional da UFS
collection Repositório Institucional da UFS
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