Avaliação da concordância entre três métodos não invasivos (APRI, FIB-4 e Elastografia) para diagnóstico de fibrose em pacientes com hepatites virais e esquistossomose mansônica

• Autor(a) principal: Nascimento, Marco Antônio de Jesus
• Data de Publicação: 2017
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UFS
• Texto Completo: http://ri.ufs.br/jspui/handle/riufs/7455
• topic: Medicina; Saúde; Hepatite; Esquistossomose; Fibrose; Elastografia; Hepatitis; Schistosomiasis; CIENCIAS DA SAUDE::MEDICINA

Viral hepatitis and mansonic schistosomiasis are still very prevalente. The quantification of the degree of hepatic fibrosis in addition to a prognostic factor is an indication for the treatment of these pathologies. Given this, the aim of this study was to evaluate the correlation between three non-invasive methods for classification of hepatic fibrosis in patients with viral hepatitis and schistosomiasis. The sample was composed by: 31 patients with chronic hepatitis with HBV, 45 with HCV and 17 with schistosomiasis. Medical records were analyzed for collection of data related to sex, body mass index (BMI) and laboratory tests for analysis of biochemical markers. The evaluation was carried out through the hepatic fibrosis methods APRI, FIB-4 and Fibroscan (Kpa) and later correlation analysis by Spearman test (r). There was a predominance of males (64.4%) among patients with HCV and HBV (61.3%). HCV positive patients also presented highest average age (54.8 years) and high levels of AST and ALT. Positive correlation was observed between APRI and FIB-4 in patients of all groups; positive correlation between APRI and Fibroscan in patients with HCV and liver diseases together; and positive correlation between FIB-4 and Fibroscan in patients with HCV, schistosomiasis and liver diseases together. The data from this study suggest that although non-invasive methods present high correlation for fibrosis analysis in patients with hepatitis C, additional studies are needed in order to increase the security of those methods in other fibrosing hepatopathies