Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFS |
Texto Completo: | http://www.hindawi.com/isrn/toxicology/2013/459530/abs/ https://ri.ufs.br/handle/riufs/619 |
Resumo: | Objective. To evaluate antinocicpetive and redox properties of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in in vivo and in vitro experimental models. Methods. Evaluation of the in vitro antioxidant activity of (+)-camphene, p-cymene, and geranyl acetate using different free radical-generating systems and evaluation of antinociceptive actions by acetic acid-induced writhing and formalin-induced nociception tests in mice. Results. p-Cymene has the strongest antinociceptive effect, but (+)-camphene and geranyl acetate also present significant activity at high doses (200 mg/kg). (+)-Camphene had the strongest antioxidant effect in vitro at TBARS and TRAP/TAR assays and also had the highest scavenging activities against different free radicals, such as hydroxyl and superoxide radicals. Sodium nitroprussiate-derived NO production was enhanced by (+)-camphene. Geranyl acetate and p-cymene also presented some antioxidant effects, but with a varying profile according the free radical-generating system studied. Conclusion. (+)-Camphene, p-cymene, and geranyl acetate may present pharmacological properties related to inflammation and pain-related processes, being potentially useful for development of new therapeutic strategies, with limited possibilities for p-cymene and geranyl acetate. |
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Quintans-Júnior, Lucindo JoséMoreira, José Cláudio FonsecaPasquali, Matheus Augusto De BittencourtRabie, Soheyla MohdPires, André SimõesSchroder, RafaelRabelo, Thallita KellySantos, João Paulo Almeida dosLima, Pollyana SouzaCavalcanti, Sócrates Cabral de HolandaAraújo, Adriano Antunes de SouzaQuintans, Jullyana de Souza SiqueiraGelain, Daniel Pens2013-06-21T23:22:23Z2013-06-21T23:22:23Z2013QUINTANS-JÚNIOR, L.J. et al. Antinociceptive activity and redox profile of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in experimental models. ISRN Toxicology, Cairo, v. 2013, 2013. Disponível em: <http://www.hindawi.com/isrn/toxicology/2013/459530/abs/>. Acesso em: 21 jun. 2013.2090-6196http://www.hindawi.com/isrn/toxicology/2013/459530/abs/https://ri.ufs.br/handle/riufs/619Creative Commons Attribution LicenseObjective. To evaluate antinocicpetive and redox properties of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in in vivo and in vitro experimental models. Methods. Evaluation of the in vitro antioxidant activity of (+)-camphene, p-cymene, and geranyl acetate using different free radical-generating systems and evaluation of antinociceptive actions by acetic acid-induced writhing and formalin-induced nociception tests in mice. Results. p-Cymene has the strongest antinociceptive effect, but (+)-camphene and geranyl acetate also present significant activity at high doses (200 mg/kg). (+)-Camphene had the strongest antioxidant effect in vitro at TBARS and TRAP/TAR assays and also had the highest scavenging activities against different free radicals, such as hydroxyl and superoxide radicals. Sodium nitroprussiate-derived NO production was enhanced by (+)-camphene. Geranyl acetate and p-cymene also presented some antioxidant effects, but with a varying profile according the free radical-generating system studied. Conclusion. (+)-Camphene, p-cymene, and geranyl acetate may present pharmacological properties related to inflammation and pain-related processes, being potentially useful for development of new therapeutic strategies, with limited possibilities for p-cymene and geranyl acetate.HindawiAtividade antinociceptivaMonoterpenosp-CimenoAcetato de geraniloAntinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Modelsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTHUMBNAILAntinociceptiveActivityMonoterpenes.pdf.jpgAntinociceptiveActivityMonoterpenes.pdf.jpgGenerated Thumbnailimage/jpeg1661https://ri.ufs.br/jspui/bitstream/riufs/619/4/AntinociceptiveActivityMonoterpenes.pdf.jpg4e78950665612259d4778d7fbebfe85fMD54ORIGINALAntinociceptiveActivityMonoterpenes.pdfAntinociceptiveActivityMonoterpenes.pdfapplication/pdf1627663https://ri.ufs.br/jspui/bitstream/riufs/619/1/AntinociceptiveActivityMonoterpenes.pdf580a538c6c7b365d0f697886ab19000cMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://ri.ufs.br/jspui/bitstream/riufs/619/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTAntinociceptiveActivityMonoterpenes.pdf.txtAntinociceptiveActivityMonoterpenes.pdf.txtExtracted texttext/plain46626https://ri.ufs.br/jspui/bitstream/riufs/619/3/AntinociceptiveActivityMonoterpenes.pdf.txt36b8227e893686c3fa5ddad090c0cf3dMD53riufs/6192013-12-20 16:50:09.652oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2013-12-20T19:50:09Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
dc.title.pt_BR.fl_str_mv |
Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models |
title |
Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models |
spellingShingle |
Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models Quintans-Júnior, Lucindo José Atividade antinociceptiva Monoterpenos p-Cimeno Acetato de geranilo |
title_short |
Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models |
title_full |
Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models |
title_fullStr |
Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models |
title_full_unstemmed |
Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models |
title_sort |
Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models |
author |
Quintans-Júnior, Lucindo José |
author_facet |
Quintans-Júnior, Lucindo José Moreira, José Cláudio Fonseca Pasquali, Matheus Augusto De Bittencourt Rabie, Soheyla Mohd Pires, André Simões Schroder, Rafael Rabelo, Thallita Kelly Santos, João Paulo Almeida dos Lima, Pollyana Souza Cavalcanti, Sócrates Cabral de Holanda Araújo, Adriano Antunes de Souza Quintans, Jullyana de Souza Siqueira Gelain, Daniel Pens |
author_role |
author |
author2 |
Moreira, José Cláudio Fonseca Pasquali, Matheus Augusto De Bittencourt Rabie, Soheyla Mohd Pires, André Simões Schroder, Rafael Rabelo, Thallita Kelly Santos, João Paulo Almeida dos Lima, Pollyana Souza Cavalcanti, Sócrates Cabral de Holanda Araújo, Adriano Antunes de Souza Quintans, Jullyana de Souza Siqueira Gelain, Daniel Pens |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Quintans-Júnior, Lucindo José Moreira, José Cláudio Fonseca Pasquali, Matheus Augusto De Bittencourt Rabie, Soheyla Mohd Pires, André Simões Schroder, Rafael Rabelo, Thallita Kelly Santos, João Paulo Almeida dos Lima, Pollyana Souza Cavalcanti, Sócrates Cabral de Holanda Araújo, Adriano Antunes de Souza Quintans, Jullyana de Souza Siqueira Gelain, Daniel Pens |
dc.subject.por.fl_str_mv |
Atividade antinociceptiva Monoterpenos p-Cimeno Acetato de geranilo |
topic |
Atividade antinociceptiva Monoterpenos p-Cimeno Acetato de geranilo |
description |
Objective. To evaluate antinocicpetive and redox properties of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in in vivo and in vitro experimental models. Methods. Evaluation of the in vitro antioxidant activity of (+)-camphene, p-cymene, and geranyl acetate using different free radical-generating systems and evaluation of antinociceptive actions by acetic acid-induced writhing and formalin-induced nociception tests in mice. Results. p-Cymene has the strongest antinociceptive effect, but (+)-camphene and geranyl acetate also present significant activity at high doses (200 mg/kg). (+)-Camphene had the strongest antioxidant effect in vitro at TBARS and TRAP/TAR assays and also had the highest scavenging activities against different free radicals, such as hydroxyl and superoxide radicals. Sodium nitroprussiate-derived NO production was enhanced by (+)-camphene. Geranyl acetate and p-cymene also presented some antioxidant effects, but with a varying profile according the free radical-generating system studied. Conclusion. (+)-Camphene, p-cymene, and geranyl acetate may present pharmacological properties related to inflammation and pain-related processes, being potentially useful for development of new therapeutic strategies, with limited possibilities for p-cymene and geranyl acetate. |
publishDate |
2013 |
dc.date.accessioned.fl_str_mv |
2013-06-21T23:22:23Z |
dc.date.available.fl_str_mv |
2013-06-21T23:22:23Z |
dc.date.issued.fl_str_mv |
2013 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
QUINTANS-JÚNIOR, L.J. et al. Antinociceptive activity and redox profile of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in experimental models. ISRN Toxicology, Cairo, v. 2013, 2013. Disponível em: <http://www.hindawi.com/isrn/toxicology/2013/459530/abs/>. Acesso em: 21 jun. 2013. |
dc.identifier.uri.fl_str_mv |
http://www.hindawi.com/isrn/toxicology/2013/459530/abs/ https://ri.ufs.br/handle/riufs/619 |
dc.identifier.issn.none.fl_str_mv |
2090-6196 |
dc.identifier.license.pt_BR.fl_str_mv |
Creative Commons Attribution License |
identifier_str_mv |
QUINTANS-JÚNIOR, L.J. et al. Antinociceptive activity and redox profile of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in experimental models. ISRN Toxicology, Cairo, v. 2013, 2013. Disponível em: <http://www.hindawi.com/isrn/toxicology/2013/459530/abs/>. Acesso em: 21 jun. 2013. 2090-6196 Creative Commons Attribution License |
url |
http://www.hindawi.com/isrn/toxicology/2013/459530/abs/ https://ri.ufs.br/handle/riufs/619 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Hindawi |
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Hindawi |
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reponame:Repositório Institucional da UFS instname:Universidade Federal de Sergipe (UFS) instacron:UFS |
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