Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models

Detalhes bibliográficos
Autor(a) principal: Quintans-Júnior, Lucindo José
Data de Publicação: 2013
Outros Autores: Moreira, José Cláudio Fonseca, Pasquali, Matheus Augusto De Bittencourt, Rabie, Soheyla Mohd, Pires, André Simões, Schroder, Rafael, Rabelo, Thallita Kelly, Santos, João Paulo Almeida dos, Lima, Pollyana Souza, Cavalcanti, Sócrates Cabral de Holanda, Araújo, Adriano Antunes de Souza, Quintans, Jullyana de Souza Siqueira, Gelain, Daniel Pens
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFS
Texto Completo: http://www.hindawi.com/isrn/toxicology/2013/459530/abs/
https://ri.ufs.br/handle/riufs/619
Resumo: Objective. To evaluate antinocicpetive and redox properties of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in in vivo and in vitro experimental models. Methods. Evaluation of the in vitro antioxidant activity of (+)-camphene, p-cymene, and geranyl acetate using different free radical-generating systems and evaluation of antinociceptive actions by acetic acid-induced writhing and formalin-induced nociception tests in mice. Results. p-Cymene has the strongest antinociceptive effect, but (+)-camphene and geranyl acetate also present significant activity at high doses (200 mg/kg). (+)-Camphene had the strongest antioxidant effect in vitro at TBARS and TRAP/TAR assays and also had the highest scavenging activities against different free radicals, such as hydroxyl and superoxide radicals. Sodium nitroprussiate-derived NO production was enhanced by (+)-camphene. Geranyl acetate and p-cymene also presented some antioxidant effects, but with a varying profile according the free radical-generating system studied. Conclusion. (+)-Camphene, p-cymene, and geranyl acetate may present pharmacological properties related to inflammation and pain-related processes, being potentially useful for development of new therapeutic strategies, with limited possibilities for p-cymene and geranyl acetate.
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spelling Quintans-Júnior, Lucindo JoséMoreira, José Cláudio FonsecaPasquali, Matheus Augusto De BittencourtRabie, Soheyla MohdPires, André SimõesSchroder, RafaelRabelo, Thallita KellySantos, João Paulo Almeida dosLima, Pollyana SouzaCavalcanti, Sócrates Cabral de HolandaAraújo, Adriano Antunes de SouzaQuintans, Jullyana de Souza SiqueiraGelain, Daniel Pens2013-06-21T23:22:23Z2013-06-21T23:22:23Z2013QUINTANS-JÚNIOR, L.J. et al. Antinociceptive activity and redox profile of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in experimental models. ISRN Toxicology, Cairo, v. 2013, 2013. Disponível em: <http://www.hindawi.com/isrn/toxicology/2013/459530/abs/>. Acesso em: 21 jun. 2013.2090-6196http://www.hindawi.com/isrn/toxicology/2013/459530/abs/https://ri.ufs.br/handle/riufs/619Creative Commons Attribution LicenseObjective. To evaluate antinocicpetive and redox properties of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in in vivo and in vitro experimental models. Methods. Evaluation of the in vitro antioxidant activity of (+)-camphene, p-cymene, and geranyl acetate using different free radical-generating systems and evaluation of antinociceptive actions by acetic acid-induced writhing and formalin-induced nociception tests in mice. Results. p-Cymene has the strongest antinociceptive effect, but (+)-camphene and geranyl acetate also present significant activity at high doses (200 mg/kg). (+)-Camphene had the strongest antioxidant effect in vitro at TBARS and TRAP/TAR assays and also had the highest scavenging activities against different free radicals, such as hydroxyl and superoxide radicals. Sodium nitroprussiate-derived NO production was enhanced by (+)-camphene. Geranyl acetate and p-cymene also presented some antioxidant effects, but with a varying profile according the free radical-generating system studied. Conclusion. (+)-Camphene, p-cymene, and geranyl acetate may present pharmacological properties related to inflammation and pain-related processes, being potentially useful for development of new therapeutic strategies, with limited possibilities for p-cymene and geranyl acetate.HindawiAtividade antinociceptivaMonoterpenosp-CimenoAcetato de geraniloAntinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Modelsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTHUMBNAILAntinociceptiveActivityMonoterpenes.pdf.jpgAntinociceptiveActivityMonoterpenes.pdf.jpgGenerated Thumbnailimage/jpeg1661https://ri.ufs.br/jspui/bitstream/riufs/619/4/AntinociceptiveActivityMonoterpenes.pdf.jpg4e78950665612259d4778d7fbebfe85fMD54ORIGINALAntinociceptiveActivityMonoterpenes.pdfAntinociceptiveActivityMonoterpenes.pdfapplication/pdf1627663https://ri.ufs.br/jspui/bitstream/riufs/619/1/AntinociceptiveActivityMonoterpenes.pdf580a538c6c7b365d0f697886ab19000cMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://ri.ufs.br/jspui/bitstream/riufs/619/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTAntinociceptiveActivityMonoterpenes.pdf.txtAntinociceptiveActivityMonoterpenes.pdf.txtExtracted texttext/plain46626https://ri.ufs.br/jspui/bitstream/riufs/619/3/AntinociceptiveActivityMonoterpenes.pdf.txt36b8227e893686c3fa5ddad090c0cf3dMD53riufs/6192013-12-20 16:50:09.652oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2013-12-20T19:50:09Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false
dc.title.pt_BR.fl_str_mv Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models
title Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models
spellingShingle Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models
Quintans-Júnior, Lucindo José
Atividade antinociceptiva
Monoterpenos
p-Cimeno
Acetato de geranilo
title_short Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models
title_full Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models
title_fullStr Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models
title_full_unstemmed Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models
title_sort Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models
author Quintans-Júnior, Lucindo José
author_facet Quintans-Júnior, Lucindo José
Moreira, José Cláudio Fonseca
Pasquali, Matheus Augusto De Bittencourt
Rabie, Soheyla Mohd
Pires, André Simões
Schroder, Rafael
Rabelo, Thallita Kelly
Santos, João Paulo Almeida dos
Lima, Pollyana Souza
Cavalcanti, Sócrates Cabral de Holanda
Araújo, Adriano Antunes de Souza
Quintans, Jullyana de Souza Siqueira
Gelain, Daniel Pens
author_role author
author2 Moreira, José Cláudio Fonseca
Pasquali, Matheus Augusto De Bittencourt
Rabie, Soheyla Mohd
Pires, André Simões
Schroder, Rafael
Rabelo, Thallita Kelly
Santos, João Paulo Almeida dos
Lima, Pollyana Souza
Cavalcanti, Sócrates Cabral de Holanda
Araújo, Adriano Antunes de Souza
Quintans, Jullyana de Souza Siqueira
Gelain, Daniel Pens
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Quintans-Júnior, Lucindo José
Moreira, José Cláudio Fonseca
Pasquali, Matheus Augusto De Bittencourt
Rabie, Soheyla Mohd
Pires, André Simões
Schroder, Rafael
Rabelo, Thallita Kelly
Santos, João Paulo Almeida dos
Lima, Pollyana Souza
Cavalcanti, Sócrates Cabral de Holanda
Araújo, Adriano Antunes de Souza
Quintans, Jullyana de Souza Siqueira
Gelain, Daniel Pens
dc.subject.por.fl_str_mv Atividade antinociceptiva
Monoterpenos
p-Cimeno
Acetato de geranilo
topic Atividade antinociceptiva
Monoterpenos
p-Cimeno
Acetato de geranilo
description Objective. To evaluate antinocicpetive and redox properties of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in in vivo and in vitro experimental models. Methods. Evaluation of the in vitro antioxidant activity of (+)-camphene, p-cymene, and geranyl acetate using different free radical-generating systems and evaluation of antinociceptive actions by acetic acid-induced writhing and formalin-induced nociception tests in mice. Results. p-Cymene has the strongest antinociceptive effect, but (+)-camphene and geranyl acetate also present significant activity at high doses (200 mg/kg). (+)-Camphene had the strongest antioxidant effect in vitro at TBARS and TRAP/TAR assays and also had the highest scavenging activities against different free radicals, such as hydroxyl and superoxide radicals. Sodium nitroprussiate-derived NO production was enhanced by (+)-camphene. Geranyl acetate and p-cymene also presented some antioxidant effects, but with a varying profile according the free radical-generating system studied. Conclusion. (+)-Camphene, p-cymene, and geranyl acetate may present pharmacological properties related to inflammation and pain-related processes, being potentially useful for development of new therapeutic strategies, with limited possibilities for p-cymene and geranyl acetate.
publishDate 2013
dc.date.accessioned.fl_str_mv 2013-06-21T23:22:23Z
dc.date.available.fl_str_mv 2013-06-21T23:22:23Z
dc.date.issued.fl_str_mv 2013
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv QUINTANS-JÚNIOR, L.J. et al. Antinociceptive activity and redox profile of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in experimental models. ISRN Toxicology, Cairo, v. 2013, 2013. Disponível em: <http://www.hindawi.com/isrn/toxicology/2013/459530/abs/>. Acesso em: 21 jun. 2013.
dc.identifier.uri.fl_str_mv http://www.hindawi.com/isrn/toxicology/2013/459530/abs/
https://ri.ufs.br/handle/riufs/619
dc.identifier.issn.none.fl_str_mv 2090-6196
dc.identifier.license.pt_BR.fl_str_mv Creative Commons Attribution License
identifier_str_mv QUINTANS-JÚNIOR, L.J. et al. Antinociceptive activity and redox profile of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in experimental models. ISRN Toxicology, Cairo, v. 2013, 2013. Disponível em: <http://www.hindawi.com/isrn/toxicology/2013/459530/abs/>. Acesso em: 21 jun. 2013.
2090-6196
Creative Commons Attribution License
url http://www.hindawi.com/isrn/toxicology/2013/459530/abs/
https://ri.ufs.br/handle/riufs/619
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFS
instname:Universidade Federal de Sergipe (UFS)
instacron:UFS
instname_str Universidade Federal de Sergipe (UFS)
instacron_str UFS
institution UFS
reponame_str Repositório Institucional da UFS
collection Repositório Institucional da UFS
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