p-Cymene attenuates cancer pain via inhibitory pathways and modulation of calcium currents
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31822 |
Resumo: | Foundation for Research and Technological Innovation Support of the State of Sergipe (Fundação de Apoio à Pesquisa e Inovação Tecnológica do Estado de Sergipe/ FAPITEC/SE), the National Council of Technological and Scientific Development (Conselho Nacional de Desenvolvimento Científico e Tecnológico/CNPq/Brazil 449667/2014-6) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES/Brazil). |
| id |
CRUZ_33ca63333122abb3f2fcc9cc6fc7da77 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/31822 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Santos, Wagner B. R.Melo, Marlange Almeida de OliveiraAlves, Rafael da SilvaBrito, Renan Guedes deRabelo, Thallita KellyPrado, Lindaura da SilvaSilva, Virginia K. dos S.Bezerra, Daniel PereiraMenezes Filho, José E. R. deSouza, Diego S.Vasconcelos, Carla Maria Lins deScotti, LucianaScotti, Marcus TulliusLucca Júnior, Waldecy deQuintans Júnior, Lucindo JoséGuimarães, Adriana Gibara2019-02-21T16:56:34Z2019-02-21T16:56:34Z2019SANTOS, W. B. R. et al. p-Cymene attenuates cancer pain via inhibitory pathways and modulation of calcium currents. Phytomedicine, p-1-33, 2019.0944-7113https://www.arca.fiocruz.br/handle/icict/3182210.1016/j.phymed.2019.152836Foundation for Research and Technological Innovation Support of the State of Sergipe (Fundação de Apoio à Pesquisa e Inovação Tecnológica do Estado de Sergipe/ FAPITEC/SE), the National Council of Technological and Scientific Development (Conselho Nacional de Desenvolvimento Científico e Tecnológico/CNPq/Brazil 449667/2014-6) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES/Brazil).Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil.Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil.Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil.Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil.Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil.Federal University of Sergipe. Postgraduate Program in Sciences Applied to Health. Lagarto, SE, Brazil.Federal University of Sergipe. Department of Odontology. Lagarto, SE, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil.Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil.Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil.Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil.Federal University of Paraíba. João Pessoa, PB, Brazil.Federal University of Paraíba. João Pessoa, PB, Brazil.Federal University of Sergipe. Department of Morphology. São Cristóvão, SE, Brazil.Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil.Federal University of Sergipe. Department of Health Education. Lagarto, SE, Brazil.Oncological pain is one of the most prevalent and difficult-to-treat symptoms in patients with cancer. p-cymene (PC) is a monoterpene found in more than 100 different plant species, endowed with various pharmacological properties - particularly antinociceptive. Hypothesis/Purpose: PC has antinociceptive effect in a model of oncologic pain due to the activation of the descending inhibitory pathway of pain. Study Design: A pre-clinical, longitudinal, blind and randomized study. Methods: Male Swiss mice were induced with S180 cells in the right hind paw, then treated daily with PC (12.5, 25 and 50 mg/kg, s.c.) and screened for mechanical hyperalgesia, spontaneous nociception, nociception induced by non-noxious palpation, tumor growth, changes in the neuromuscular function and existence of bone degradation in the tumor area. The effect of PC on Ca2+ currents (electrophysiological records), histological and neurochemical changes (immunofluorescence for Fos) were also evaluated. Results: PC reduced (p < 0.05) the mechanical hyperalgesia, the spontaneous (p < 0.001) and non-noxious palpation (p < 0.001) nociceptions, not changing the tumor development, neuromuscular function or histopathological aspects of the paw affected. PC reduced Fos expression in the spinal cord (p < 0.001) and increased this expression in the PAG (p < 0.05) and in the NRM (p < 0.01). PC decreased the density of calcium channel currents (p < 0.05). These results suggest the antinociceptive effect of PC on oncologic pain, probably acting in both ascending and descending pain pathways, and modulating the calcium channel currents in order to exert its effects.engElsevierProdutos naturaisMonoterpenosAntinociceptivoHiperalgesiaCâncerNatural productsMonoterpenesAntinociceptiveHyperalgesiaCancerp-Cymene attenuates cancer pain via inhibitory pathways and modulation of calcium currentsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31822/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSantos W. p-Cymene attenuates cancer...2019.pdfSantos W. p-Cymene attenuates cancer...2019.pdfapplication/pdf1762545https://www.arca.fiocruz.br/bitstream/icict/31822/2/Santos%20W.%20p-Cymene%20attenuates%20cancer...2019.pdf064ac1c31e28301c1b88f4d3f133643eMD52TEXTSantos W. p-Cymene attenuates cancer...2019.pdf.txtSantos W. p-Cymene attenuates cancer...2019.pdf.txtExtracted texttext/plain45026https://www.arca.fiocruz.br/bitstream/icict/31822/3/Santos%20W.%20p-Cymene%20attenuates%20cancer...2019.pdf.txt4d6e476ae7d8b8f614f281c9257146b2MD53icict/318222019-02-24 12:31:26.281oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-02-24T15:31:26Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
p-Cymene attenuates cancer pain via inhibitory pathways and modulation of calcium currents |
| title |
p-Cymene attenuates cancer pain via inhibitory pathways and modulation of calcium currents |
| spellingShingle |
p-Cymene attenuates cancer pain via inhibitory pathways and modulation of calcium currents Santos, Wagner B. R. Produtos naturais Monoterpenos Antinociceptivo Hiperalgesia Câncer Natural products Monoterpenes Antinociceptive Hyperalgesia Cancer |
| title_short |
p-Cymene attenuates cancer pain via inhibitory pathways and modulation of calcium currents |
| title_full |
p-Cymene attenuates cancer pain via inhibitory pathways and modulation of calcium currents |
| title_fullStr |
p-Cymene attenuates cancer pain via inhibitory pathways and modulation of calcium currents |
| title_full_unstemmed |
p-Cymene attenuates cancer pain via inhibitory pathways and modulation of calcium currents |
| title_sort |
p-Cymene attenuates cancer pain via inhibitory pathways and modulation of calcium currents |
| author |
Santos, Wagner B. R. |
| author_facet |
Santos, Wagner B. R. Melo, Marlange Almeida de Oliveira Alves, Rafael da Silva Brito, Renan Guedes de Rabelo, Thallita Kelly Prado, Lindaura da Silva Silva, Virginia K. dos S. Bezerra, Daniel Pereira Menezes Filho, José E. R. de Souza, Diego S. Vasconcelos, Carla Maria Lins de Scotti, Luciana Scotti, Marcus Tullius Lucca Júnior, Waldecy de Quintans Júnior, Lucindo José Guimarães, Adriana Gibara |
| author_role |
author |
| author2 |
Melo, Marlange Almeida de Oliveira Alves, Rafael da Silva Brito, Renan Guedes de Rabelo, Thallita Kelly Prado, Lindaura da Silva Silva, Virginia K. dos S. Bezerra, Daniel Pereira Menezes Filho, José E. R. de Souza, Diego S. Vasconcelos, Carla Maria Lins de Scotti, Luciana Scotti, Marcus Tullius Lucca Júnior, Waldecy de Quintans Júnior, Lucindo José Guimarães, Adriana Gibara |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Santos, Wagner B. R. Melo, Marlange Almeida de Oliveira Alves, Rafael da Silva Brito, Renan Guedes de Rabelo, Thallita Kelly Prado, Lindaura da Silva Silva, Virginia K. dos S. Bezerra, Daniel Pereira Menezes Filho, José E. R. de Souza, Diego S. Vasconcelos, Carla Maria Lins de Scotti, Luciana Scotti, Marcus Tullius Lucca Júnior, Waldecy de Quintans Júnior, Lucindo José Guimarães, Adriana Gibara |
| dc.subject.other.pt_BR.fl_str_mv |
Produtos naturais Monoterpenos Antinociceptivo Hiperalgesia Câncer |
| topic |
Produtos naturais Monoterpenos Antinociceptivo Hiperalgesia Câncer Natural products Monoterpenes Antinociceptive Hyperalgesia Cancer |
| dc.subject.en.pt_BR.fl_str_mv |
Natural products Monoterpenes Antinociceptive Hyperalgesia Cancer |
| description |
Foundation for Research and Technological Innovation Support of the State of Sergipe (Fundação de Apoio à Pesquisa e Inovação Tecnológica do Estado de Sergipe/ FAPITEC/SE), the National Council of Technological and Scientific Development (Conselho Nacional de Desenvolvimento Científico e Tecnológico/CNPq/Brazil 449667/2014-6) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES/Brazil). |
| publishDate |
2019 |
| dc.date.accessioned.fl_str_mv |
2019-02-21T16:56:34Z |
| dc.date.available.fl_str_mv |
2019-02-21T16:56:34Z |
| dc.date.issued.fl_str_mv |
2019 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
SANTOS, W. B. R. et al. p-Cymene attenuates cancer pain via inhibitory pathways and modulation of calcium currents. Phytomedicine, p-1-33, 2019. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/31822 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0944-7113 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.1016/j.phymed.2019.152836 |
| identifier_str_mv |
SANTOS, W. B. R. et al. p-Cymene attenuates cancer pain via inhibitory pathways and modulation of calcium currents. Phytomedicine, p-1-33, 2019. 0944-7113 10.1016/j.phymed.2019.152836 |
| url |
https://www.arca.fiocruz.br/handle/icict/31822 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/31822/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/31822/2/Santos%20W.%20p-Cymene%20attenuates%20cancer...2019.pdf https://www.arca.fiocruz.br/bitstream/icict/31822/3/Santos%20W.%20p-Cymene%20attenuates%20cancer...2019.pdf.txt |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 064ac1c31e28301c1b88f4d3f133643e 4d6e476ae7d8b8f614f281c9257146b2 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1798324821794226176 |