Purification, physicochemical properties, thermal analysis and antinociceptive effect of atranorin extracted from Cladina kalbii
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFS |
Texto Completo: | https://ri.ufs.br/handle/riufs/1506 |
Resumo: | Lichens and their secondary metabolites have attracted the interest of many researchers. Some species have been shown to contain substances with remarkable biologic activity, as antimicrobial, mainly against Gram positive bacteria; antineoplasic acting on solid and ascetic tumors, or in culture cells; antiviral; hypotensive; and spasmolytic effects. The aim of this study was to isolate and characterize atranorin, one of the major constituents which presents in Cladina kalbii (DES ABB.) AHTI., and analyze its antinociceptive effect. The antinociceptive activity was verified in acetic acid-induced writhing test and formalin test with mice. In this work it was observed that atranorin was effective in significant reducing (p<0.05) abdominal writhing at doses of 200 and 400 mg/kg (p.o.) by 52.6 and 61.3%, respectively, when compared to control group (vehicle). The formalin test showed in 200 and 400 mg/kg (p.o.) that atranorin injection was able to inhibit the inflammatory processes (second phase) dose dependently. |
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Melo, Marcelia Garcez Dória deAraújo, Adriano Antunes de SouzaRocha, Carla Paula LeiteAlmeida, Emyle Mayra Santana AlvesSiqueira, Rosana de SouzaBonjardim, Leonardo RigoldiQuintans-Júnior, Lucindo José2015-05-19T16:43:19Z2015-05-19T16:43:19Z2008-10MELO, M. G. D. et al. Purification, physicochemical properties, thermal analysis and antinociceptive effect of atranorin extracted from Cladina kalbii. Biological & Pharmaceutical Bulletin, Sapporo, v. 31, p. 1977-1980, out. 2008. Disponível em: <https://www.jstage.jst.go.jp/article/bpb/31/10/31_10_1977/_article>. Acesso em: 12 jun. 2013.1347-5215https://ri.ufs.br/handle/riufs/1506Lichens and their secondary metabolites have attracted the interest of many researchers. Some species have been shown to contain substances with remarkable biologic activity, as antimicrobial, mainly against Gram positive bacteria; antineoplasic acting on solid and ascetic tumors, or in culture cells; antiviral; hypotensive; and spasmolytic effects. The aim of this study was to isolate and characterize atranorin, one of the major constituents which presents in Cladina kalbii (DES ABB.) AHTI., and analyze its antinociceptive effect. The antinociceptive activity was verified in acetic acid-induced writhing test and formalin test with mice. In this work it was observed that atranorin was effective in significant reducing (p<0.05) abdominal writhing at doses of 200 and 400 mg/kg (p.o.) by 52.6 and 61.3%, respectively, when compared to control group (vehicle). The formalin test showed in 200 and 400 mg/kg (p.o.) that atranorin injection was able to inhibit the inflammatory processes (second phase) dose dependently.The Pharmaceutical Society of JapanCladina kalbiiAtividade antinociceptivaAnálise térmicaAtranorinaPurification, physicochemical properties, thermal analysis and antinociceptive effect of atranorin extracted from Cladina kalbiiinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTHUMBNAILPurificationPhysicochemicalProperties.pdf.jpgPurificationPhysicochemicalProperties.pdf.jpgGenerated Thumbnailimage/jpeg1863https://ri.ufs.br/jspui/bitstream/riufs/1506/4/PurificationPhysicochemicalProperties.pdf.jpg416d99f23c43cc9e8c707373a8ab8af9MD54ORIGINALPurificationPhysicochemicalProperties.pdfPurificationPhysicochemicalProperties.pdfapplication/pdf107234https://ri.ufs.br/jspui/bitstream/riufs/1506/1/PurificationPhysicochemicalProperties.pdfdebc3f7db516bd9b8e71a6355b0ad4a8MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://ri.ufs.br/jspui/bitstream/riufs/1506/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTPurificationPhysicochemicalProperties.pdf.txtPurificationPhysicochemicalProperties.pdf.txtExtracted texttext/plain16403https://ri.ufs.br/jspui/bitstream/riufs/1506/3/PurificationPhysicochemicalProperties.pdf.txtddb35f86c15d685841567acb8af4b08aMD53riufs/15062016-01-25 11:02:10.74oai:ufs.br:riufs/1506Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2016-01-25T14:02:10Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
dc.title.pt_BR.fl_str_mv |
Purification, physicochemical properties, thermal analysis and antinociceptive effect of atranorin extracted from Cladina kalbii |
title |
Purification, physicochemical properties, thermal analysis and antinociceptive effect of atranorin extracted from Cladina kalbii |
spellingShingle |
Purification, physicochemical properties, thermal analysis and antinociceptive effect of atranorin extracted from Cladina kalbii Melo, Marcelia Garcez Dória de Cladina kalbii Atividade antinociceptiva Análise térmica Atranorina |
title_short |
Purification, physicochemical properties, thermal analysis and antinociceptive effect of atranorin extracted from Cladina kalbii |
title_full |
Purification, physicochemical properties, thermal analysis and antinociceptive effect of atranorin extracted from Cladina kalbii |
title_fullStr |
Purification, physicochemical properties, thermal analysis and antinociceptive effect of atranorin extracted from Cladina kalbii |
title_full_unstemmed |
Purification, physicochemical properties, thermal analysis and antinociceptive effect of atranorin extracted from Cladina kalbii |
title_sort |
Purification, physicochemical properties, thermal analysis and antinociceptive effect of atranorin extracted from Cladina kalbii |
author |
Melo, Marcelia Garcez Dória de |
author_facet |
Melo, Marcelia Garcez Dória de Araújo, Adriano Antunes de Souza Rocha, Carla Paula Leite Almeida, Emyle Mayra Santana Alves Siqueira, Rosana de Souza Bonjardim, Leonardo Rigoldi Quintans-Júnior, Lucindo José |
author_role |
author |
author2 |
Araújo, Adriano Antunes de Souza Rocha, Carla Paula Leite Almeida, Emyle Mayra Santana Alves Siqueira, Rosana de Souza Bonjardim, Leonardo Rigoldi Quintans-Júnior, Lucindo José |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Melo, Marcelia Garcez Dória de Araújo, Adriano Antunes de Souza Rocha, Carla Paula Leite Almeida, Emyle Mayra Santana Alves Siqueira, Rosana de Souza Bonjardim, Leonardo Rigoldi Quintans-Júnior, Lucindo José |
dc.subject.por.fl_str_mv |
Cladina kalbii Atividade antinociceptiva Análise térmica Atranorina |
topic |
Cladina kalbii Atividade antinociceptiva Análise térmica Atranorina |
description |
Lichens and their secondary metabolites have attracted the interest of many researchers. Some species have been shown to contain substances with remarkable biologic activity, as antimicrobial, mainly against Gram positive bacteria; antineoplasic acting on solid and ascetic tumors, or in culture cells; antiviral; hypotensive; and spasmolytic effects. The aim of this study was to isolate and characterize atranorin, one of the major constituents which presents in Cladina kalbii (DES ABB.) AHTI., and analyze its antinociceptive effect. The antinociceptive activity was verified in acetic acid-induced writhing test and formalin test with mice. In this work it was observed that atranorin was effective in significant reducing (p<0.05) abdominal writhing at doses of 200 and 400 mg/kg (p.o.) by 52.6 and 61.3%, respectively, when compared to control group (vehicle). The formalin test showed in 200 and 400 mg/kg (p.o.) that atranorin injection was able to inhibit the inflammatory processes (second phase) dose dependently. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008-10 |
dc.date.accessioned.fl_str_mv |
2015-05-19T16:43:19Z |
dc.date.available.fl_str_mv |
2015-05-19T16:43:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MELO, M. G. D. et al. Purification, physicochemical properties, thermal analysis and antinociceptive effect of atranorin extracted from Cladina kalbii. Biological & Pharmaceutical Bulletin, Sapporo, v. 31, p. 1977-1980, out. 2008. Disponível em: <https://www.jstage.jst.go.jp/article/bpb/31/10/31_10_1977/_article>. Acesso em: 12 jun. 2013. |
dc.identifier.uri.fl_str_mv |
https://ri.ufs.br/handle/riufs/1506 |
dc.identifier.issn.none.fl_str_mv |
1347-5215 |
identifier_str_mv |
MELO, M. G. D. et al. Purification, physicochemical properties, thermal analysis and antinociceptive effect of atranorin extracted from Cladina kalbii. Biological & Pharmaceutical Bulletin, Sapporo, v. 31, p. 1977-1980, out. 2008. Disponível em: <https://www.jstage.jst.go.jp/article/bpb/31/10/31_10_1977/_article>. Acesso em: 12 jun. 2013. 1347-5215 |
url |
https://ri.ufs.br/handle/riufs/1506 |
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eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
The Pharmaceutical Society of Japan |
publisher.none.fl_str_mv |
The Pharmaceutical Society of Japan |
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reponame:Repositório Institucional da UFS instname:Universidade Federal de Sergipe (UFS) instacron:UFS |
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Universidade Federal de Sergipe (UFS) |
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UFS |
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UFS |
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Repositório Institucional da UFS |
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Repositório Institucional da UFS |
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