Fenótipos aberrantes em leucemia mieloide aguda e sua relação com prognóstico e sobrevida : uma revisão sistemática
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | |
Tipo de documento: | Trabalho de conclusão de curso |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFS |
Texto Completo: | http://ri.ufs.br/jspui/handle/riufs/10718 |
Resumo: | Acute myeloid leukemia is a hematologic malignancy highly associated with poor prognosis and low survival rate. Aberrant phenotypes detected by immunophenotyping have been associated with a worse clinical course of the disease, specially, when related with prognosis and survival rate. The aim of this systematic review was to evaluate the influence of aberrant markers in prognosis and survival of acute myeloid leukemia. Materials and methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic review of PubMed, Scopus, Science Direct, Web of Science and Cochrane Library was carried out through 1998 to 2016. Results: We included 16 studies on this systematic review, which the aberrant phenotype expression of 30 markers were detected by flow cytometry using samples of 2,000 patients. From all those, the expression of nine aberrant markers were related to prognosis, and five had shown negative impact on prognosis in AML. This systematic review studied the following markers CD7, CD82, CD34, CD19, CD56, CD98, CD90, CD123, and CD15. Conclusions: The prognosis implication of aberrant antigen remains controversy and new studies are essential for a better understanding of leukemia features. In order to lead to higher rates of complete remission, the development of a target therapy is becoming prominent. |
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Trindade, Louise DantasPinheiro, Lucio Henrique SousaLima, Dulce Marta Schimieguel Mascarenhas2019-03-20T13:43:00Z2019-03-20T13:43:00Z2017-01-26Trindade, Louise Dantas; Pinheiro, Lucio Henrique Sousa. Fenótipos aberrantes em leucemia mieloide aguda e sua relação com prognóstico e sobrevida : uma revisão sistemática. São Cristóvão, SE, 2017. Monografia (graduação em Farmácia) – Departamento de Farmácia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Sergipe, São Cristóvão, 2017http://ri.ufs.br/jspui/handle/riufs/10718Acute myeloid leukemia is a hematologic malignancy highly associated with poor prognosis and low survival rate. Aberrant phenotypes detected by immunophenotyping have been associated with a worse clinical course of the disease, specially, when related with prognosis and survival rate. The aim of this systematic review was to evaluate the influence of aberrant markers in prognosis and survival of acute myeloid leukemia. Materials and methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic review of PubMed, Scopus, Science Direct, Web of Science and Cochrane Library was carried out through 1998 to 2016. Results: We included 16 studies on this systematic review, which the aberrant phenotype expression of 30 markers were detected by flow cytometry using samples of 2,000 patients. From all those, the expression of nine aberrant markers were related to prognosis, and five had shown negative impact on prognosis in AML. This systematic review studied the following markers CD7, CD82, CD34, CD19, CD56, CD98, CD90, CD123, and CD15. Conclusions: The prognosis implication of aberrant antigen remains controversy and new studies are essential for a better understanding of leukemia features. In order to lead to higher rates of complete remission, the development of a target therapy is becoming prominent.São Cristóvão, SEporFarmáciaEnsino de farmáciaLeucemia mieloide agudaPrognósticoAberrant phenotypesAcute myeloid leukemiaPrognosisSurvivalCIENCIAS DA SAUDE::FARMACIAFenótipos aberrantes em leucemia mieloide aguda e sua relação com prognóstico e sobrevida : uma revisão sistemáticaAberrant phenotypes in acute myeloid leukemia and its relationship with prognosis and survival: a systematic reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisUniversidade Federal de SergipeDFA - Departamento de Farmácia – São Cristóvão - Presencialreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTEXTLouise_Dantas_Trindade.pdf.txtLouise_Dantas_Trindade.pdf.txtExtracted texttext/plain65731https://ri.ufs.br/jspui/bitstream/riufs/10718/3/Louise_Dantas_Trindade.pdf.txt8017d54883b7d6c7f08a4cdd239f8406MD53THUMBNAILLouise_Dantas_Trindade.pdf.jpgLouise_Dantas_Trindade.pdf.jpgGenerated Thumbnailimage/jpeg1398https://ri.ufs.br/jspui/bitstream/riufs/10718/4/Louise_Dantas_Trindade.pdf.jpg9ebef0feabe293d85ca23c161af6d8e4MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81475https://ri.ufs.br/jspui/bitstream/riufs/10718/1/license.txt098cbbf65c2c15e1fb2e49c5d306a44cMD51ORIGINALLouise_Dantas_Trindade.pdfLouise_Dantas_Trindade.pdfapplication/pdf1362998https://ri.ufs.br/jspui/bitstream/riufs/10718/2/Louise_Dantas_Trindade.pdf38ef159aeaf55673fb8c11107b94c804MD52riufs/107182019-03-20 10:43:36.142oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2019-03-20T13:43:36Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
dc.title.pt_BR.fl_str_mv |
Fenótipos aberrantes em leucemia mieloide aguda e sua relação com prognóstico e sobrevida : uma revisão sistemática |
dc.title.alternative.eng.fl_str_mv |
Aberrant phenotypes in acute myeloid leukemia and its relationship with prognosis and survival: a systematic review |
title |
Fenótipos aberrantes em leucemia mieloide aguda e sua relação com prognóstico e sobrevida : uma revisão sistemática |
spellingShingle |
Fenótipos aberrantes em leucemia mieloide aguda e sua relação com prognóstico e sobrevida : uma revisão sistemática Trindade, Louise Dantas Farmácia Ensino de farmácia Leucemia mieloide aguda Prognóstico Aberrant phenotypes Acute myeloid leukemia Prognosis Survival CIENCIAS DA SAUDE::FARMACIA |
title_short |
Fenótipos aberrantes em leucemia mieloide aguda e sua relação com prognóstico e sobrevida : uma revisão sistemática |
title_full |
Fenótipos aberrantes em leucemia mieloide aguda e sua relação com prognóstico e sobrevida : uma revisão sistemática |
title_fullStr |
Fenótipos aberrantes em leucemia mieloide aguda e sua relação com prognóstico e sobrevida : uma revisão sistemática |
title_full_unstemmed |
Fenótipos aberrantes em leucemia mieloide aguda e sua relação com prognóstico e sobrevida : uma revisão sistemática |
title_sort |
Fenótipos aberrantes em leucemia mieloide aguda e sua relação com prognóstico e sobrevida : uma revisão sistemática |
author |
Trindade, Louise Dantas |
author_facet |
Trindade, Louise Dantas Pinheiro, Lucio Henrique Sousa |
author_role |
author |
author2 |
Pinheiro, Lucio Henrique Sousa |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Trindade, Louise Dantas Pinheiro, Lucio Henrique Sousa |
dc.contributor.advisor1.fl_str_mv |
Lima, Dulce Marta Schimieguel Mascarenhas |
contributor_str_mv |
Lima, Dulce Marta Schimieguel Mascarenhas |
dc.subject.por.fl_str_mv |
Farmácia Ensino de farmácia Leucemia mieloide aguda Prognóstico |
topic |
Farmácia Ensino de farmácia Leucemia mieloide aguda Prognóstico Aberrant phenotypes Acute myeloid leukemia Prognosis Survival CIENCIAS DA SAUDE::FARMACIA |
dc.subject.eng.fl_str_mv |
Aberrant phenotypes Acute myeloid leukemia Prognosis Survival |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::FARMACIA |
description |
Acute myeloid leukemia is a hematologic malignancy highly associated with poor prognosis and low survival rate. Aberrant phenotypes detected by immunophenotyping have been associated with a worse clinical course of the disease, specially, when related with prognosis and survival rate. The aim of this systematic review was to evaluate the influence of aberrant markers in prognosis and survival of acute myeloid leukemia. Materials and methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic review of PubMed, Scopus, Science Direct, Web of Science and Cochrane Library was carried out through 1998 to 2016. Results: We included 16 studies on this systematic review, which the aberrant phenotype expression of 30 markers were detected by flow cytometry using samples of 2,000 patients. From all those, the expression of nine aberrant markers were related to prognosis, and five had shown negative impact on prognosis in AML. This systematic review studied the following markers CD7, CD82, CD34, CD19, CD56, CD98, CD90, CD123, and CD15. Conclusions: The prognosis implication of aberrant antigen remains controversy and new studies are essential for a better understanding of leukemia features. In order to lead to higher rates of complete remission, the development of a target therapy is becoming prominent. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017-01-26 |
dc.date.accessioned.fl_str_mv |
2019-03-20T13:43:00Z |
dc.date.available.fl_str_mv |
2019-03-20T13:43:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
format |
bachelorThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Trindade, Louise Dantas; Pinheiro, Lucio Henrique Sousa. Fenótipos aberrantes em leucemia mieloide aguda e sua relação com prognóstico e sobrevida : uma revisão sistemática. São Cristóvão, SE, 2017. Monografia (graduação em Farmácia) – Departamento de Farmácia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Sergipe, São Cristóvão, 2017 |
dc.identifier.uri.fl_str_mv |
http://ri.ufs.br/jspui/handle/riufs/10718 |
identifier_str_mv |
Trindade, Louise Dantas; Pinheiro, Lucio Henrique Sousa. Fenótipos aberrantes em leucemia mieloide aguda e sua relação com prognóstico e sobrevida : uma revisão sistemática. São Cristóvão, SE, 2017. Monografia (graduação em Farmácia) – Departamento de Farmácia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Sergipe, São Cristóvão, 2017 |
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Universidade Federal de Sergipe |
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DFA - Departamento de Farmácia – São Cristóvão - Presencial |
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