Indoxil sulfato urinário (Indican) em crianças e adolescentes com doença falciforme: avaliação de disbiose intestinal e fatores associados
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFS |
Texto Completo: | http://ri.ufs.br/jspui/handle/riufs/13072 |
Resumo: | Introduction: Urinary indoxyl sulfate (Indican) is an organic acid derived from the amino acid tryptophan from diet that is metabolised by intestinal bacteria through tryptophanases. Indican is present in low urine in healthy individuals and a high level of urinary indican is an indication of bacterial overgrowth in the small intestine. Sickle cell disease (SCD) is one of the most prevalent genetic diseases worldwide. It is an autosomal recessive disorder, with acute vaso-occlusive crisis being its most common manifestation. Intestinal dysbiosis is defined as intestinal microbiota (IM) imbalance and may be present in SCD. Objective: To verify the occurrence of intestinal dysbiosis in patients with SCD, with and without hydroxyurea. Methods: This is a sectional study conducted between January 2018 and March 2019, involving 98 children and adolescents (05 to 18 years), divided into three groups: G1. SCD patients with hydroxyurea; G2 SCD patients without hydroxyurea; G3 control (individuals without SCD). Urine examination (Indican) was performed to assess intestinal dysbiosis, parasitological stool, anthropometric indices, Rome IV criteria, Bristol stool scale, and socioeconomic and demographic status. Results: It was found the presence of intestinal dysbiosis among the participants, being 74% in G1, 76% in G2 and 65% in G3. Variables such as type of delivery, time of breastfeeding and functional constipation were associated with Indican concentrations, regardless of the presence of the SCD between the groups. Conclusion: High urinary Indican concentrations were observed in patients with SCD, as well as in the control group, indicating intestinal dysbiosis, with no significant difference. |
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Zuin, Beatriz MascarenhasCipolotti, Rosana2020-03-19T19:38:33Z2020-03-19T19:38:33Z2019-08-21ZUIN, Beatriz Mascarenhas. Indoxil sulfato urinário (Indican) em crianças e adolescentes com doença falciforme: avaliação de disbiose intestinal e fatores associados. 2019. 66 f. Dissertação (Mestrado em Ciências da Saúde) – Universidade Federal de Sergipe, Aracaju, 2019.http://ri.ufs.br/jspui/handle/riufs/13072Introduction: Urinary indoxyl sulfate (Indican) is an organic acid derived from the amino acid tryptophan from diet that is metabolised by intestinal bacteria through tryptophanases. Indican is present in low urine in healthy individuals and a high level of urinary indican is an indication of bacterial overgrowth in the small intestine. Sickle cell disease (SCD) is one of the most prevalent genetic diseases worldwide. It is an autosomal recessive disorder, with acute vaso-occlusive crisis being its most common manifestation. Intestinal dysbiosis is defined as intestinal microbiota (IM) imbalance and may be present in SCD. Objective: To verify the occurrence of intestinal dysbiosis in patients with SCD, with and without hydroxyurea. Methods: This is a sectional study conducted between January 2018 and March 2019, involving 98 children and adolescents (05 to 18 years), divided into three groups: G1. SCD patients with hydroxyurea; G2 SCD patients without hydroxyurea; G3 control (individuals without SCD). Urine examination (Indican) was performed to assess intestinal dysbiosis, parasitological stool, anthropometric indices, Rome IV criteria, Bristol stool scale, and socioeconomic and demographic status. Results: It was found the presence of intestinal dysbiosis among the participants, being 74% in G1, 76% in G2 and 65% in G3. Variables such as type of delivery, time of breastfeeding and functional constipation were associated with Indican concentrations, regardless of the presence of the SCD between the groups. Conclusion: High urinary Indican concentrations were observed in patients with SCD, as well as in the control group, indicating intestinal dysbiosis, with no significant difference.Introdução: O indoxil sulfato urinário (Indican) é um ácido orgânico derivado do aminoácido triptofano proveniente da dieta, que é metabolizado por bactérias intestinais por meio de triptofanases. O Indican está presente na urina em níveis baixos em indivíduos saudáveis e um nível elevado de indican urinário é indicação de supercrescimento bacteriano no intestino delgado. A doença falciforme (DF) é uma das doenças genéticas mais prevalentes em todo o mundo. Trata-se de uma alteração autossômica recessiva, sendo a crise vaso-oclusiva aguda sua manifestação mais comum. Disbiose intestinal é definida como o desequilíbrio da microbiota intestinal (MI) e pode estar presente na DF. Objetivo: Verificar a ocorrência de disbiose intestinal em pacientes com DF, com e sem uso de hidroxiureia. Métodos: Trata-se de um estudo seccional, conduzido entre janeiro de 2018 e março de 2019, envolvendo 98 crianças e adolescentes (05 a 18 anos), divididos em três grupos: G1. pacientes com DF em uso de hidroxiúreia; G2. pacientes com DF sem uso de hidroxiuréia; G3. controle (indivíduos sem DF). Foi realizado exame de urina (Indican) para avaliar DI, parasitológico de fezes, avaliação de índices antropométricos, critérios de Roma IV, Escala de fezes Bristol e situação socioeconômica e demográfica. Resultados: Verificou-se a presença de disbiose intestinal entre os participantes, sendo 74% no G1, 76% no G2 e 65% no G3. Observou-se que variáveis como tipo de parto, tempo de amamentação e constipação funcional estiveram associadas às concentrações do Indican, independente da presença de DF entre os grupos. Conclusão: Foram observadas altas concentrações urinárias de Indican em pacientes com DF, assim como no grupo controle, sendo indicativo de disbiose intestinal, sem diferença significativa.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESAracajuporDoença falciformeDisbioseMicrobiotaEstado nutricionalTriptofanoMicrobiota intestinalConstipação intestinalIntestinal microbiotaDysbiosisSickle cell diseaseNutritional statusTryptophanConstipationCIENCIAS DA SAUDEIndoxil sulfato urinário (Indican) em crianças e adolescentes com doença falciforme: avaliação de disbiose intestinal e fatores associadosUrinary indoxyl sulfate (indican) in children and adolescents with sickle cell disease: evaluation of intestinal dysbiosis and associated factors.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisPós-Graduação em Ciências da SaúdeUniversidade Federal de Sergipereponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTEXTBEATRIZ_MASCARENHAS_ZUIN.pdf.txtBEATRIZ_MASCARENHAS_ZUIN.pdf.txtExtracted texttext/plain114812https://ri.ufs.br/jspui/bitstream/riufs/13072/3/BEATRIZ_MASCARENHAS_ZUIN.pdf.txt5b62bcc9f144578faee0bc16500d13c2MD53THUMBNAILBEATRIZ_MASCARENHAS_ZUIN.pdf.jpgBEATRIZ_MASCARENHAS_ZUIN.pdf.jpgGenerated Thumbnailimage/jpeg1178https://ri.ufs.br/jspui/bitstream/riufs/13072/4/BEATRIZ_MASCARENHAS_ZUIN.pdf.jpgbdb9aaf95783d322c7460f082a57c952MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81475https://ri.ufs.br/jspui/bitstream/riufs/13072/1/license.txt098cbbf65c2c15e1fb2e49c5d306a44cMD51ORIGINALBEATRIZ_MASCARENHAS_ZUIN.pdfBEATRIZ_MASCARENHAS_ZUIN.pdfapplication/pdf1818417https://ri.ufs.br/jspui/bitstream/riufs/13072/2/BEATRIZ_MASCARENHAS_ZUIN.pdf8ebc5a9335672b37038d3b12faf9609aMD52riufs/130722020-03-19 16:38:35.071oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2020-03-19T19:38:35Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
dc.title.pt_BR.fl_str_mv |
Indoxil sulfato urinário (Indican) em crianças e adolescentes com doença falciforme: avaliação de disbiose intestinal e fatores associados |
dc.title.alternative.eng.fl_str_mv |
Urinary indoxyl sulfate (indican) in children and adolescents with sickle cell disease: evaluation of intestinal dysbiosis and associated factors. |
title |
Indoxil sulfato urinário (Indican) em crianças e adolescentes com doença falciforme: avaliação de disbiose intestinal e fatores associados |
spellingShingle |
Indoxil sulfato urinário (Indican) em crianças e adolescentes com doença falciforme: avaliação de disbiose intestinal e fatores associados Zuin, Beatriz Mascarenhas Doença falciforme Disbiose Microbiota Estado nutricional Triptofano Microbiota intestinal Constipação intestinal Intestinal microbiota Dysbiosis Sickle cell disease Nutritional status Tryptophan Constipation CIENCIAS DA SAUDE |
title_short |
Indoxil sulfato urinário (Indican) em crianças e adolescentes com doença falciforme: avaliação de disbiose intestinal e fatores associados |
title_full |
Indoxil sulfato urinário (Indican) em crianças e adolescentes com doença falciforme: avaliação de disbiose intestinal e fatores associados |
title_fullStr |
Indoxil sulfato urinário (Indican) em crianças e adolescentes com doença falciforme: avaliação de disbiose intestinal e fatores associados |
title_full_unstemmed |
Indoxil sulfato urinário (Indican) em crianças e adolescentes com doença falciforme: avaliação de disbiose intestinal e fatores associados |
title_sort |
Indoxil sulfato urinário (Indican) em crianças e adolescentes com doença falciforme: avaliação de disbiose intestinal e fatores associados |
author |
Zuin, Beatriz Mascarenhas |
author_facet |
Zuin, Beatriz Mascarenhas |
author_role |
author |
dc.contributor.author.fl_str_mv |
Zuin, Beatriz Mascarenhas |
dc.contributor.advisor1.fl_str_mv |
Cipolotti, Rosana |
contributor_str_mv |
Cipolotti, Rosana |
dc.subject.por.fl_str_mv |
Doença falciforme Disbiose Microbiota Estado nutricional Triptofano Microbiota intestinal Constipação intestinal |
topic |
Doença falciforme Disbiose Microbiota Estado nutricional Triptofano Microbiota intestinal Constipação intestinal Intestinal microbiota Dysbiosis Sickle cell disease Nutritional status Tryptophan Constipation CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
Intestinal microbiota Dysbiosis Sickle cell disease Nutritional status Tryptophan Constipation |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Introduction: Urinary indoxyl sulfate (Indican) is an organic acid derived from the amino acid tryptophan from diet that is metabolised by intestinal bacteria through tryptophanases. Indican is present in low urine in healthy individuals and a high level of urinary indican is an indication of bacterial overgrowth in the small intestine. Sickle cell disease (SCD) is one of the most prevalent genetic diseases worldwide. It is an autosomal recessive disorder, with acute vaso-occlusive crisis being its most common manifestation. Intestinal dysbiosis is defined as intestinal microbiota (IM) imbalance and may be present in SCD. Objective: To verify the occurrence of intestinal dysbiosis in patients with SCD, with and without hydroxyurea. Methods: This is a sectional study conducted between January 2018 and March 2019, involving 98 children and adolescents (05 to 18 years), divided into three groups: G1. SCD patients with hydroxyurea; G2 SCD patients without hydroxyurea; G3 control (individuals without SCD). Urine examination (Indican) was performed to assess intestinal dysbiosis, parasitological stool, anthropometric indices, Rome IV criteria, Bristol stool scale, and socioeconomic and demographic status. Results: It was found the presence of intestinal dysbiosis among the participants, being 74% in G1, 76% in G2 and 65% in G3. Variables such as type of delivery, time of breastfeeding and functional constipation were associated with Indican concentrations, regardless of the presence of the SCD between the groups. Conclusion: High urinary Indican concentrations were observed in patients with SCD, as well as in the control group, indicating intestinal dysbiosis, with no significant difference. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019-08-21 |
dc.date.accessioned.fl_str_mv |
2020-03-19T19:38:33Z |
dc.date.available.fl_str_mv |
2020-03-19T19:38:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ZUIN, Beatriz Mascarenhas. Indoxil sulfato urinário (Indican) em crianças e adolescentes com doença falciforme: avaliação de disbiose intestinal e fatores associados. 2019. 66 f. Dissertação (Mestrado em Ciências da Saúde) – Universidade Federal de Sergipe, Aracaju, 2019. |
dc.identifier.uri.fl_str_mv |
http://ri.ufs.br/jspui/handle/riufs/13072 |
identifier_str_mv |
ZUIN, Beatriz Mascarenhas. Indoxil sulfato urinário (Indican) em crianças e adolescentes com doença falciforme: avaliação de disbiose intestinal e fatores associados. 2019. 66 f. Dissertação (Mestrado em Ciências da Saúde) – Universidade Federal de Sergipe, Aracaju, 2019. |
url |
http://ri.ufs.br/jspui/handle/riufs/13072 |
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por |
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openAccess |
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Pós-Graduação em Ciências da Saúde |
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Universidade Federal de Sergipe |
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