Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFS |
Texto Completo: | https://ri.ufs.br/handle/riufs/592 |
Resumo: | AIM: In the present study we verified the anticonvulsant properties of the new tryptamine analogue, N-salicyloyltryptamine (NST), in rodents. METHODS AND RESULTS: In the evaluation of the anticonvulsant activity, NST protected the animals from the incidence of seizures induced by pentylenetetrazole (PTZ) and picrotoxin (PIC), in doses of 100 and 200 mg/kg. NST (100 and 200 mg/kg, i.p.) significantly eliminated the extensor reflex of maximal electric-induced seizure tests in 40% of the experimental animals. However, in the PTZ model FLU (10 mg/kg, i.p.), an antagonist of the benzodiazepine (BZD) site in the GABAA-BZD receptor complex, inhibited the prolongation of seizure latency induced by NST. CONCLUSION: Our results demonstrated an anticonvulsant activity of the new analogue that could be, at least in part, associated to the involvement of the GABAergic mechanism._________________________________________________________________________________________ RESUMO: OBJETIVO: O presente estudo buscou avaliar o possível efeito anticonvulsivante do novo análogo da triptamina, N-saliciloiltriptamina (NST), em roedores. MÉTODOS E RESULTADOS: Na avaliação do efeito anticonvulsivante, os animais tratados com NST (100 e 200 mg/kg, i.p.) foram protegidos de maneira estatisticamente significativa (p<0,05) quanto a latência e incidência do aparecimento das convulsões induzidas pela administração do pentilenotetrazol (PTZ) e da picrotoxina (PIC). O efeito protetor do NST nas convulsões induzidas pelo PTZ foi revertido pela administração do flumazenil (10 mg/kg, i.p.), um antagonista dos receptores GABA-benzodiazepínicos (GABAA-BZD). A administração de NST (100 e 200 mg/kg, i.p.) protegeu de forma estatisticamente significativa (p < 0,05) os animais no teste das convulsões induzidas pelo eletrochoque-auricular em camundongos. CONCLUSÃO: Os resultados do presente estudo sugerem que o efeito anticonvulsivante de NST está associado, pelo menos em parte, ao sistema GABAérgico. |
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Quintans-Júnior, Lucindo JoséSilva, Davi Alves daQuintans, Jullyana de Souza SiqueiraAraújo, Adriano Antunes de SouzaGuimarães, Adriana GibaraAraújo, Rafael A. N.Araújo, Demetrius Antonio Machado deSouza, Maria de Fátima VanderleiGutierrez, Stanley Juan ChavezBarbosa Filho, José MariaAlmeida, Reinaldo Nobrega de2013-06-07T23:06:37Z2013-06-07T23:06:37Z2009-12QUINTANS-JUNIOR, Lucindo J. et al. Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission. Journal of Epilepsy and Clinical Neurophysiology, Porto Alegre, v. 15, n. 4, dez. 2009. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492009000400005&lng=pt&nrm=iso>. Acesso em: 7 jun. 2013.1676-2649https://ri.ufs.br/handle/riufs/592Creative Commons Attribution LicenseAIM: In the present study we verified the anticonvulsant properties of the new tryptamine analogue, N-salicyloyltryptamine (NST), in rodents. METHODS AND RESULTS: In the evaluation of the anticonvulsant activity, NST protected the animals from the incidence of seizures induced by pentylenetetrazole (PTZ) and picrotoxin (PIC), in doses of 100 and 200 mg/kg. NST (100 and 200 mg/kg, i.p.) significantly eliminated the extensor reflex of maximal electric-induced seizure tests in 40% of the experimental animals. However, in the PTZ model FLU (10 mg/kg, i.p.), an antagonist of the benzodiazepine (BZD) site in the GABAA-BZD receptor complex, inhibited the prolongation of seizure latency induced by NST. CONCLUSION: Our results demonstrated an anticonvulsant activity of the new analogue that could be, at least in part, associated to the involvement of the GABAergic mechanism._________________________________________________________________________________________ RESUMO: OBJETIVO: O presente estudo buscou avaliar o possível efeito anticonvulsivante do novo análogo da triptamina, N-saliciloiltriptamina (NST), em roedores. MÉTODOS E RESULTADOS: Na avaliação do efeito anticonvulsivante, os animais tratados com NST (100 e 200 mg/kg, i.p.) foram protegidos de maneira estatisticamente significativa (p<0,05) quanto a latência e incidência do aparecimento das convulsões induzidas pela administração do pentilenotetrazol (PTZ) e da picrotoxina (PIC). O efeito protetor do NST nas convulsões induzidas pelo PTZ foi revertido pela administração do flumazenil (10 mg/kg, i.p.), um antagonista dos receptores GABA-benzodiazepínicos (GABAA-BZD). A administração de NST (100 e 200 mg/kg, i.p.) protegeu de forma estatisticamente significativa (p < 0,05) os animais no teste das convulsões induzidas pelo eletrochoque-auricular em camundongos. CONCLUSÃO: Os resultados do presente estudo sugerem que o efeito anticonvulsivante de NST está associado, pelo menos em parte, ao sistema GABAérgico.Atividade anticonvulsivanteN-saliciloiltriptaminaFlumazenilPentylenetetrazoleGABAAnticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmissionPropriedade anticonvulsivante da N-saliciloiltriptamina: evidências do envolvimento do sistema GABAérgicoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleporreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTHUMBNAILAnticonvulsantGabaergic.pdf.jpgAnticonvulsantGabaergic.pdf.jpgGenerated Thumbnailimage/jpeg1463https://ri.ufs.br/jspui/bitstream/riufs/592/4/AnticonvulsantGabaergic.pdf.jpg0d07bf062e01864cdc35fc70d8d7e454MD54ORIGINALAnticonvulsantGabaergic.pdfAnticonvulsantGabaergic.pdfapplication/pdf209932https://ri.ufs.br/jspui/bitstream/riufs/592/1/AnticonvulsantGabaergic.pdfecce4795322816dda3ecdeb16bdfdc03MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://ri.ufs.br/jspui/bitstream/riufs/592/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTAnticonvulsantGabaergic.pdf.txtAnticonvulsantGabaergic.pdf.txtExtracted texttext/plain19998https://ri.ufs.br/jspui/bitstream/riufs/592/3/AnticonvulsantGabaergic.pdf.txt2bd5877ef29e80871f8d8e6409afc407MD53riufs/5922014-09-17 18:57:21.682oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2014-09-17T21:57:21Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
dc.title.pt_BR.fl_str_mv |
Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission |
dc.title.alternative.pt_BR.fl_str_mv |
Propriedade anticonvulsivante da N-saliciloiltriptamina: evidências do envolvimento do sistema GABAérgico |
title |
Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission |
spellingShingle |
Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission Quintans-Júnior, Lucindo José Atividade anticonvulsivante N-saliciloiltriptamina Flumazenil Pentylenetetrazole GABA |
title_short |
Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission |
title_full |
Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission |
title_fullStr |
Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission |
title_full_unstemmed |
Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission |
title_sort |
Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission |
author |
Quintans-Júnior, Lucindo José |
author_facet |
Quintans-Júnior, Lucindo José Silva, Davi Alves da Quintans, Jullyana de Souza Siqueira Araújo, Adriano Antunes de Souza Guimarães, Adriana Gibara Araújo, Rafael A. N. Araújo, Demetrius Antonio Machado de Souza, Maria de Fátima Vanderlei Gutierrez, Stanley Juan Chavez Barbosa Filho, José Maria Almeida, Reinaldo Nobrega de |
author_role |
author |
author2 |
Silva, Davi Alves da Quintans, Jullyana de Souza Siqueira Araújo, Adriano Antunes de Souza Guimarães, Adriana Gibara Araújo, Rafael A. N. Araújo, Demetrius Antonio Machado de Souza, Maria de Fátima Vanderlei Gutierrez, Stanley Juan Chavez Barbosa Filho, José Maria Almeida, Reinaldo Nobrega de |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Quintans-Júnior, Lucindo José Silva, Davi Alves da Quintans, Jullyana de Souza Siqueira Araújo, Adriano Antunes de Souza Guimarães, Adriana Gibara Araújo, Rafael A. N. Araújo, Demetrius Antonio Machado de Souza, Maria de Fátima Vanderlei Gutierrez, Stanley Juan Chavez Barbosa Filho, José Maria Almeida, Reinaldo Nobrega de |
dc.subject.por.fl_str_mv |
Atividade anticonvulsivante N-saliciloiltriptamina Flumazenil Pentylenetetrazole GABA |
topic |
Atividade anticonvulsivante N-saliciloiltriptamina Flumazenil Pentylenetetrazole GABA |
description |
AIM: In the present study we verified the anticonvulsant properties of the new tryptamine analogue, N-salicyloyltryptamine (NST), in rodents. METHODS AND RESULTS: In the evaluation of the anticonvulsant activity, NST protected the animals from the incidence of seizures induced by pentylenetetrazole (PTZ) and picrotoxin (PIC), in doses of 100 and 200 mg/kg. NST (100 and 200 mg/kg, i.p.) significantly eliminated the extensor reflex of maximal electric-induced seizure tests in 40% of the experimental animals. However, in the PTZ model FLU (10 mg/kg, i.p.), an antagonist of the benzodiazepine (BZD) site in the GABAA-BZD receptor complex, inhibited the prolongation of seizure latency induced by NST. CONCLUSION: Our results demonstrated an anticonvulsant activity of the new analogue that could be, at least in part, associated to the involvement of the GABAergic mechanism._________________________________________________________________________________________ RESUMO: OBJETIVO: O presente estudo buscou avaliar o possível efeito anticonvulsivante do novo análogo da triptamina, N-saliciloiltriptamina (NST), em roedores. MÉTODOS E RESULTADOS: Na avaliação do efeito anticonvulsivante, os animais tratados com NST (100 e 200 mg/kg, i.p.) foram protegidos de maneira estatisticamente significativa (p<0,05) quanto a latência e incidência do aparecimento das convulsões induzidas pela administração do pentilenotetrazol (PTZ) e da picrotoxina (PIC). O efeito protetor do NST nas convulsões induzidas pelo PTZ foi revertido pela administração do flumazenil (10 mg/kg, i.p.), um antagonista dos receptores GABA-benzodiazepínicos (GABAA-BZD). A administração de NST (100 e 200 mg/kg, i.p.) protegeu de forma estatisticamente significativa (p < 0,05) os animais no teste das convulsões induzidas pelo eletrochoque-auricular em camundongos. CONCLUSÃO: Os resultados do presente estudo sugerem que o efeito anticonvulsivante de NST está associado, pelo menos em parte, ao sistema GABAérgico. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009-12 |
dc.date.accessioned.fl_str_mv |
2013-06-07T23:06:37Z |
dc.date.available.fl_str_mv |
2013-06-07T23:06:37Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
QUINTANS-JUNIOR, Lucindo J. et al. Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission. Journal of Epilepsy and Clinical Neurophysiology, Porto Alegre, v. 15, n. 4, dez. 2009. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492009000400005&lng=pt&nrm=iso>. Acesso em: 7 jun. 2013. |
dc.identifier.uri.fl_str_mv |
https://ri.ufs.br/handle/riufs/592 |
dc.identifier.issn.none.fl_str_mv |
1676-2649 |
dc.identifier.license.pt_BR.fl_str_mv |
Creative Commons Attribution License |
identifier_str_mv |
QUINTANS-JUNIOR, Lucindo J. et al. Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission. Journal of Epilepsy and Clinical Neurophysiology, Porto Alegre, v. 15, n. 4, dez. 2009. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492009000400005&lng=pt&nrm=iso>. Acesso em: 7 jun. 2013. 1676-2649 Creative Commons Attribution License |
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https://ri.ufs.br/handle/riufs/592 |
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