Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission

Detalhes bibliográficos
Autor(a) principal: Quintans-Júnior, Lucindo José
Data de Publicação: 2009
Outros Autores: Silva, Davi Alves da, Quintans, Jullyana de Souza Siqueira, Araújo, Adriano Antunes de Souza, Guimarães, Adriana Gibara, Araújo, Rafael A. N., Araújo, Demetrius Antonio Machado de, Souza, Maria de Fátima Vanderlei, Gutierrez, Stanley Juan Chavez, Barbosa Filho, José Maria, Almeida, Reinaldo Nobrega de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UFS
Texto Completo: https://ri.ufs.br/handle/riufs/592
Resumo: AIM: In the present study we verified the anticonvulsant properties of the new tryptamine analogue, N-salicyloyltryptamine (NST), in rodents. METHODS AND RESULTS: In the evaluation of the anticonvulsant activity, NST protected the animals from the incidence of seizures induced by pentylenetetrazole (PTZ) and picrotoxin (PIC), in doses of 100 and 200 mg/kg. NST (100 and 200 mg/kg, i.p.) significantly eliminated the extensor reflex of maximal electric-induced seizure tests in 40% of the experimental animals. However, in the PTZ model FLU (10 mg/kg, i.p.), an antagonist of the benzodiazepine (BZD) site in the GABAA-BZD receptor complex, inhibited the prolongation of seizure latency induced by NST. CONCLUSION: Our results demonstrated an anticonvulsant activity of the new analogue that could be, at least in part, associated to the involvement of the GABAergic mechanism._________________________________________________________________________________________ RESUMO: OBJETIVO: O presente estudo buscou avaliar o possível efeito anticonvulsivante do novo análogo da triptamina, N-saliciloiltriptamina (NST), em roedores. MÉTODOS E RESULTADOS: Na avaliação do efeito anticonvulsivante, os animais tratados com NST (100 e 200 mg/kg, i.p.) foram protegidos de maneira estatisticamente significativa (p<0,05) quanto a latência e incidência do aparecimento das convulsões induzidas pela administração do pentilenotetrazol (PTZ) e da picrotoxina (PIC). O efeito protetor do NST nas convulsões induzidas pelo PTZ foi revertido pela administração do flumazenil (10 mg/kg, i.p.), um antagonista dos receptores GABA-benzodiazepínicos (GABAA-BZD). A administração de NST (100 e 200 mg/kg, i.p.) protegeu de forma estatisticamente significativa (p < 0,05) os animais no teste das convulsões induzidas pelo eletrochoque-auricular em camundongos. CONCLUSÃO: Os resultados do presente estudo sugerem que o efeito anticonvulsivante de NST está associado, pelo menos em parte, ao sistema GABAérgico.
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spelling Quintans-Júnior, Lucindo JoséSilva, Davi Alves daQuintans, Jullyana de Souza SiqueiraAraújo, Adriano Antunes de SouzaGuimarães, Adriana GibaraAraújo, Rafael A. N.Araújo, Demetrius Antonio Machado deSouza, Maria de Fátima VanderleiGutierrez, Stanley Juan ChavezBarbosa Filho, José MariaAlmeida, Reinaldo Nobrega de2013-06-07T23:06:37Z2013-06-07T23:06:37Z2009-12QUINTANS-JUNIOR, Lucindo J. et al. Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission. Journal of Epilepsy and Clinical Neurophysiology, Porto Alegre, v. 15, n. 4, dez. 2009. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492009000400005&lng=pt&nrm=iso>. Acesso em: 7 jun. 2013.1676-2649https://ri.ufs.br/handle/riufs/592Creative Commons Attribution LicenseAIM: In the present study we verified the anticonvulsant properties of the new tryptamine analogue, N-salicyloyltryptamine (NST), in rodents. METHODS AND RESULTS: In the evaluation of the anticonvulsant activity, NST protected the animals from the incidence of seizures induced by pentylenetetrazole (PTZ) and picrotoxin (PIC), in doses of 100 and 200 mg/kg. NST (100 and 200 mg/kg, i.p.) significantly eliminated the extensor reflex of maximal electric-induced seizure tests in 40% of the experimental animals. However, in the PTZ model FLU (10 mg/kg, i.p.), an antagonist of the benzodiazepine (BZD) site in the GABAA-BZD receptor complex, inhibited the prolongation of seizure latency induced by NST. CONCLUSION: Our results demonstrated an anticonvulsant activity of the new analogue that could be, at least in part, associated to the involvement of the GABAergic mechanism._________________________________________________________________________________________ RESUMO: OBJETIVO: O presente estudo buscou avaliar o possível efeito anticonvulsivante do novo análogo da triptamina, N-saliciloiltriptamina (NST), em roedores. MÉTODOS E RESULTADOS: Na avaliação do efeito anticonvulsivante, os animais tratados com NST (100 e 200 mg/kg, i.p.) foram protegidos de maneira estatisticamente significativa (p<0,05) quanto a latência e incidência do aparecimento das convulsões induzidas pela administração do pentilenotetrazol (PTZ) e da picrotoxina (PIC). O efeito protetor do NST nas convulsões induzidas pelo PTZ foi revertido pela administração do flumazenil (10 mg/kg, i.p.), um antagonista dos receptores GABA-benzodiazepínicos (GABAA-BZD). A administração de NST (100 e 200 mg/kg, i.p.) protegeu de forma estatisticamente significativa (p < 0,05) os animais no teste das convulsões induzidas pelo eletrochoque-auricular em camundongos. CONCLUSÃO: Os resultados do presente estudo sugerem que o efeito anticonvulsivante de NST está associado, pelo menos em parte, ao sistema GABAérgico.Atividade anticonvulsivanteN-saliciloiltriptaminaFlumazenilPentylenetetrazoleGABAAnticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmissionPropriedade anticonvulsivante da N-saliciloiltriptamina: evidências do envolvimento do sistema GABAérgicoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleporreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTHUMBNAILAnticonvulsantGabaergic.pdf.jpgAnticonvulsantGabaergic.pdf.jpgGenerated Thumbnailimage/jpeg1463https://ri.ufs.br/jspui/bitstream/riufs/592/4/AnticonvulsantGabaergic.pdf.jpg0d07bf062e01864cdc35fc70d8d7e454MD54ORIGINALAnticonvulsantGabaergic.pdfAnticonvulsantGabaergic.pdfapplication/pdf209932https://ri.ufs.br/jspui/bitstream/riufs/592/1/AnticonvulsantGabaergic.pdfecce4795322816dda3ecdeb16bdfdc03MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://ri.ufs.br/jspui/bitstream/riufs/592/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTAnticonvulsantGabaergic.pdf.txtAnticonvulsantGabaergic.pdf.txtExtracted texttext/plain19998https://ri.ufs.br/jspui/bitstream/riufs/592/3/AnticonvulsantGabaergic.pdf.txt2bd5877ef29e80871f8d8e6409afc407MD53riufs/5922014-09-17 18:57:21.682oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2014-09-17T21:57:21Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false
dc.title.pt_BR.fl_str_mv Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission
dc.title.alternative.pt_BR.fl_str_mv Propriedade anticonvulsivante da N-saliciloiltriptamina: evidências do envolvimento do sistema GABAérgico
title Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission
spellingShingle Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission
Quintans-Júnior, Lucindo José
Atividade anticonvulsivante
N-saliciloiltriptamina
Flumazenil
Pentylenetetrazole
GABA
title_short Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission
title_full Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission
title_fullStr Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission
title_full_unstemmed Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission
title_sort Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission
author Quintans-Júnior, Lucindo José
author_facet Quintans-Júnior, Lucindo José
Silva, Davi Alves da
Quintans, Jullyana de Souza Siqueira
Araújo, Adriano Antunes de Souza
Guimarães, Adriana Gibara
Araújo, Rafael A. N.
Araújo, Demetrius Antonio Machado de
Souza, Maria de Fátima Vanderlei
Gutierrez, Stanley Juan Chavez
Barbosa Filho, José Maria
Almeida, Reinaldo Nobrega de
author_role author
author2 Silva, Davi Alves da
Quintans, Jullyana de Souza Siqueira
Araújo, Adriano Antunes de Souza
Guimarães, Adriana Gibara
Araújo, Rafael A. N.
Araújo, Demetrius Antonio Machado de
Souza, Maria de Fátima Vanderlei
Gutierrez, Stanley Juan Chavez
Barbosa Filho, José Maria
Almeida, Reinaldo Nobrega de
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Quintans-Júnior, Lucindo José
Silva, Davi Alves da
Quintans, Jullyana de Souza Siqueira
Araújo, Adriano Antunes de Souza
Guimarães, Adriana Gibara
Araújo, Rafael A. N.
Araújo, Demetrius Antonio Machado de
Souza, Maria de Fátima Vanderlei
Gutierrez, Stanley Juan Chavez
Barbosa Filho, José Maria
Almeida, Reinaldo Nobrega de
dc.subject.por.fl_str_mv Atividade anticonvulsivante
N-saliciloiltriptamina
Flumazenil
Pentylenetetrazole
GABA
topic Atividade anticonvulsivante
N-saliciloiltriptamina
Flumazenil
Pentylenetetrazole
GABA
description AIM: In the present study we verified the anticonvulsant properties of the new tryptamine analogue, N-salicyloyltryptamine (NST), in rodents. METHODS AND RESULTS: In the evaluation of the anticonvulsant activity, NST protected the animals from the incidence of seizures induced by pentylenetetrazole (PTZ) and picrotoxin (PIC), in doses of 100 and 200 mg/kg. NST (100 and 200 mg/kg, i.p.) significantly eliminated the extensor reflex of maximal electric-induced seizure tests in 40% of the experimental animals. However, in the PTZ model FLU (10 mg/kg, i.p.), an antagonist of the benzodiazepine (BZD) site in the GABAA-BZD receptor complex, inhibited the prolongation of seizure latency induced by NST. CONCLUSION: Our results demonstrated an anticonvulsant activity of the new analogue that could be, at least in part, associated to the involvement of the GABAergic mechanism._________________________________________________________________________________________ RESUMO: OBJETIVO: O presente estudo buscou avaliar o possível efeito anticonvulsivante do novo análogo da triptamina, N-saliciloiltriptamina (NST), em roedores. MÉTODOS E RESULTADOS: Na avaliação do efeito anticonvulsivante, os animais tratados com NST (100 e 200 mg/kg, i.p.) foram protegidos de maneira estatisticamente significativa (p<0,05) quanto a latência e incidência do aparecimento das convulsões induzidas pela administração do pentilenotetrazol (PTZ) e da picrotoxina (PIC). O efeito protetor do NST nas convulsões induzidas pelo PTZ foi revertido pela administração do flumazenil (10 mg/kg, i.p.), um antagonista dos receptores GABA-benzodiazepínicos (GABAA-BZD). A administração de NST (100 e 200 mg/kg, i.p.) protegeu de forma estatisticamente significativa (p < 0,05) os animais no teste das convulsões induzidas pelo eletrochoque-auricular em camundongos. CONCLUSÃO: Os resultados do presente estudo sugerem que o efeito anticonvulsivante de NST está associado, pelo menos em parte, ao sistema GABAérgico.
publishDate 2009
dc.date.issued.fl_str_mv 2009-12
dc.date.accessioned.fl_str_mv 2013-06-07T23:06:37Z
dc.date.available.fl_str_mv 2013-06-07T23:06:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv QUINTANS-JUNIOR, Lucindo J. et al. Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission. Journal of Epilepsy and Clinical Neurophysiology, Porto Alegre, v. 15, n. 4, dez. 2009. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492009000400005&lng=pt&nrm=iso>. Acesso em: 7 jun. 2013.
dc.identifier.uri.fl_str_mv https://ri.ufs.br/handle/riufs/592
dc.identifier.issn.none.fl_str_mv 1676-2649
dc.identifier.license.pt_BR.fl_str_mv Creative Commons Attribution License
identifier_str_mv QUINTANS-JUNIOR, Lucindo J. et al. Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of central GABAergic neurotransmission. Journal of Epilepsy and Clinical Neurophysiology, Porto Alegre, v. 15, n. 4, dez. 2009. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492009000400005&lng=pt&nrm=iso>. Acesso em: 7 jun. 2013.
1676-2649
Creative Commons Attribution License
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instname_str Universidade Federal de Sergipe (UFS)
instacron_str UFS
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reponame_str Repositório Institucional da UFS
collection Repositório Institucional da UFS
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