Bioassay-guided evaluation of antinociceptive effect of N-salicyloyltryptamine: a behavioral and electrophysiological approach

• Autor(a) principal: Quintans-Júnior, Lucindo José
• Data de Publicação: 2010
• Outros Autores: Silva, Davi Antas, Quintans, Jullyana de Souza Siqueira, Araújo, Adriano Antunes de Souza, Siqueira, Rosana de Souza, Bonjardim, Leonardo Rigoldi, Santana, Josimari Melo de, Lucca Júnior, Waldecy de, Souza, Maria Fátima Vanderlei, Gutierrez, Stanley Juan Chavez, Barbosa Filho, José Maria, Santana Filho, Valter, Araújo, Demetrius Antonio Machado de, Almeida, Reinaldo Nobrega de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFS
• Texto Completo: https://ri.ufs.br/handle/riufs/622
• topic: Avaliação biomonitorada; Atividade antinociceptiva; N-saliciloiltriptamina

We investigated the antinociceptive and nerve excitability effects of the N-salicyloyltryptamine (NST) NST-treated mice exhibited a significant decrease in the number of writhes when 100 and 200 mg/kg (i.p.) were administered (i.p.). This effect was not antagonized by naloxone (1.5 mg/kg, i.p.). NST inhibited the licking response of the injected paw when 100 and 200 mg/kg were administered (i.p.) to mice in the first and second phases of the formalin test. Because the antinociceptive effects could be associated with neuronal excitability inhibition, we performed the single sucrose gap technique and showed that NST (3.57 mM) significantly reduced (29.2%) amplitude of the compound action potential (CAP) suggesting a sodium channel effect induced by NST. Our results demonstrated an antinociceptive activity of the NST that could be, at least in part, associated to the reduction of the action potential amplitude. NST might represent an important tool for pain management.