Síntese de complexo polieletrolítico supramolecular κ-carragena-quitosana ancorado com Β-CD para sistema de liberação controlada do fármaco sulfadiazina de prata
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFS |
Texto Completo: | https://ri.ufs.br/jspui/handle/riufs/14754 |
Resumo: | The search for controlled drug delivery mechanisms has been relevant in recent decades, with the aim of establishing more efficient therapeutic alternatives. In this work, a supramolecular polyelectrolytic complex (SPEC) between the biopolymers, κcarrageenan (CRG) chitosan (CS) functionalized with β-CD, in the stoichiometric ratio 4.25:1 obtained after determining the isoelectric point, was complexed to the sulfadiazine of silver (SDZ-Ag), a specific antibiotic for the treatment of burns and skin lesions. The samples were characterized by FTIR, DSC, TG, SEM and zeta potential techniques, which confirmed the formation of the polymeric complex. In this work, SDZ-Ag was used as a model drug and the association with supramolecular polyelectrolytic complexes was also studied by computational molecular modeling, using a semi-empirical method. The DRS and MET analyzes showed that the drug's Ag+ ions were reduced to different average sizes (12, 35 and 53 nm) through silver metallic non-structures. In vitro tests using Gram-positive strains: Staphylococcus aureus (ATCC 25923), Enterococcus durans/hirae (SS1225 / IAL 03/10) and Gram-negative: Klebsiella pneumoniae (ATCC 700603), Escherichia coli (ATCC 25922) and Enterobacter aerogenes (ATCC 13048), were used to evaluate the antimicrobial and kinetic profile of SPEC, observing drug release in 24 hours and pure SDZ in 5.5 hours. Finally, this work shows that the CDchitosan/carrageenan supramolecular polyelectrolyte complexes have an expressive potential to be applied as a polymer-based system for controlled drug release. |
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Evangelista, Thamasia Fernanda de SáAlmeida, Luís Eduardo2021-11-18T20:39:34Z2021-11-18T20:39:34Z2020-03-03EVANGELISTA, Thamasia Fernanda de Sá. Síntese de complexo polieletrolítico supramolecular κ-carragena-quitosana ancorado com Β-CD para sistema de liberação controlada do fármaco sulfadiazina de prata. 2020. 122 f. Tese (Doutorado em Ciência e Engenharia de Materiais) - Universidade Federal de Sergipe, São Cristóvão, SE, 2020.https://ri.ufs.br/jspui/handle/riufs/14754The search for controlled drug delivery mechanisms has been relevant in recent decades, with the aim of establishing more efficient therapeutic alternatives. In this work, a supramolecular polyelectrolytic complex (SPEC) between the biopolymers, κcarrageenan (CRG) chitosan (CS) functionalized with β-CD, in the stoichiometric ratio 4.25:1 obtained after determining the isoelectric point, was complexed to the sulfadiazine of silver (SDZ-Ag), a specific antibiotic for the treatment of burns and skin lesions. The samples were characterized by FTIR, DSC, TG, SEM and zeta potential techniques, which confirmed the formation of the polymeric complex. In this work, SDZ-Ag was used as a model drug and the association with supramolecular polyelectrolytic complexes was also studied by computational molecular modeling, using a semi-empirical method. The DRS and MET analyzes showed that the drug's Ag+ ions were reduced to different average sizes (12, 35 and 53 nm) through silver metallic non-structures. In vitro tests using Gram-positive strains: Staphylococcus aureus (ATCC 25923), Enterococcus durans/hirae (SS1225 / IAL 03/10) and Gram-negative: Klebsiella pneumoniae (ATCC 700603), Escherichia coli (ATCC 25922) and Enterobacter aerogenes (ATCC 13048), were used to evaluate the antimicrobial and kinetic profile of SPEC, observing drug release in 24 hours and pure SDZ in 5.5 hours. Finally, this work shows that the CDchitosan/carrageenan supramolecular polyelectrolyte complexes have an expressive potential to be applied as a polymer-based system for controlled drug release.A busca por mecanismos de liberação controlada de fármacos tem sido relevante nas últimas décadas, com o objetivo de estabelecer alternativas terapêuticas mais eficientes. Neste trabalho, um complexo polieletrolítico supramolecular (SPEC) entre os biopolímeros, κ-carragena (CRG) quitosana (CS) funcionalizada com β-CD, na razão estequiométrica 4,25:1 obtidos após determinado o ponto isoelétrico, foi complexado à sulfadiazina de prata (SDZ-Ag), um antibiótico específico para o tratamento de queimaduras e lesões na pele. As amostras foram caracterizadas pelas técnicas de FTIR, DSC, TG, MEV e potencial zeta, que confirmaram a formação do SPEC. Neste trabalho, a SDZ-Ag foi utilizada como fármaco modelo e a associação com o SPEC foi estudada também por modelagem molecular computacional, utilizando um método semiempírico. As análises DRS e MET mostraram que os íons Ag+ do fármaco foram reduzidos para diferentes tamanhos médios (12, 35 e 53 nm) através de nanoestruturas metálicas de prata. Testes in vitro usando cepas Gram-positivas: Staphylococcus aureus (ATCC 25923), Enterococcus durans/hirae (SS1225/ IAL 03/10) e Gram-negativas: Klebsiella pneumoniae (ATCC 700603), Escherichia coli (ATCC 25922) e Enterobacter aerogenes (ATCC 13048), foram utilizadas para avaliar o perfil antimicrobiano e cinético do SPEC, observando liberação do fármaco em 24 horas e SDZ pura em 5,5 horas. Finalmente, este trabalho mostra que os complexos de polieletrólitos supramoleculares de CD-quitosana/carragena possuem um potencial expressivo para serem aplicados como um sistema à base de polímeros para liberação controlada de fármacos.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESSão Cristóvão, SEporEngenharia de materiaisBiopolímerosMicro-organismosAntibióticosSulfadiazina de prataBiomaterialsInclusion complexesAntimicrobial activityENGENHARIAS::ENGENHARIA DE MATERIAIS E METALURGICASíntese de complexo polieletrolítico supramolecular κ-carragena-quitosana ancorado com Β-CD para sistema de liberação controlada do fármaco sulfadiazina de pratainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisPós-Graduação em Ciência e Engenharia de MateriaisUniversidade Federal de Sergipereponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain; charset=utf-81475https://ri.ufs.br/jspui/bitstream/riufs/14754/1/license.txt098cbbf65c2c15e1fb2e49c5d306a44cMD51ORIGINALTHAMASIA_FERNANDA_SA_EVANGELISTA.pdfTHAMASIA_FERNANDA_SA_EVANGELISTA.pdfapplication/pdf3727214https://ri.ufs.br/jspui/bitstream/riufs/14754/2/THAMASIA_FERNANDA_SA_EVANGELISTA.pdfe02de775dfe27f00ff378e0d9cdcc20eMD52TEXTTHAMASIA_FERNANDA_SA_EVANGELISTA.pdf.txtTHAMASIA_FERNANDA_SA_EVANGELISTA.pdf.txtExtracted texttext/plain158905https://ri.ufs.br/jspui/bitstream/riufs/14754/3/THAMASIA_FERNANDA_SA_EVANGELISTA.pdf.txt0d6ba495eb03caf8e49bee76291a0bd2MD53THUMBNAILTHAMASIA_FERNANDA_SA_EVANGELISTA.pdf.jpgTHAMASIA_FERNANDA_SA_EVANGELISTA.pdf.jpgGenerated Thumbnailimage/jpeg1285https://ri.ufs.br/jspui/bitstream/riufs/14754/4/THAMASIA_FERNANDA_SA_EVANGELISTA.pdf.jpg33ed7f443f5333a24fcab827400b1ac0MD54riufs/147542021-11-18 17:39:34.695oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2021-11-18T20:39:34Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
dc.title.pt_BR.fl_str_mv |
Síntese de complexo polieletrolítico supramolecular κ-carragena-quitosana ancorado com Β-CD para sistema de liberação controlada do fármaco sulfadiazina de prata |
title |
Síntese de complexo polieletrolítico supramolecular κ-carragena-quitosana ancorado com Β-CD para sistema de liberação controlada do fármaco sulfadiazina de prata |
spellingShingle |
Síntese de complexo polieletrolítico supramolecular κ-carragena-quitosana ancorado com Β-CD para sistema de liberação controlada do fármaco sulfadiazina de prata Evangelista, Thamasia Fernanda de Sá Engenharia de materiais Biopolímeros Micro-organismos Antibióticos Sulfadiazina de prata Biomaterials Inclusion complexes Antimicrobial activity ENGENHARIAS::ENGENHARIA DE MATERIAIS E METALURGICA |
title_short |
Síntese de complexo polieletrolítico supramolecular κ-carragena-quitosana ancorado com Β-CD para sistema de liberação controlada do fármaco sulfadiazina de prata |
title_full |
Síntese de complexo polieletrolítico supramolecular κ-carragena-quitosana ancorado com Β-CD para sistema de liberação controlada do fármaco sulfadiazina de prata |
title_fullStr |
Síntese de complexo polieletrolítico supramolecular κ-carragena-quitosana ancorado com Β-CD para sistema de liberação controlada do fármaco sulfadiazina de prata |
title_full_unstemmed |
Síntese de complexo polieletrolítico supramolecular κ-carragena-quitosana ancorado com Β-CD para sistema de liberação controlada do fármaco sulfadiazina de prata |
title_sort |
Síntese de complexo polieletrolítico supramolecular κ-carragena-quitosana ancorado com Β-CD para sistema de liberação controlada do fármaco sulfadiazina de prata |
author |
Evangelista, Thamasia Fernanda de Sá |
author_facet |
Evangelista, Thamasia Fernanda de Sá |
author_role |
author |
dc.contributor.author.fl_str_mv |
Evangelista, Thamasia Fernanda de Sá |
dc.contributor.advisor1.fl_str_mv |
Almeida, Luís Eduardo |
contributor_str_mv |
Almeida, Luís Eduardo |
dc.subject.por.fl_str_mv |
Engenharia de materiais Biopolímeros Micro-organismos Antibióticos Sulfadiazina de prata |
topic |
Engenharia de materiais Biopolímeros Micro-organismos Antibióticos Sulfadiazina de prata Biomaterials Inclusion complexes Antimicrobial activity ENGENHARIAS::ENGENHARIA DE MATERIAIS E METALURGICA |
dc.subject.eng.fl_str_mv |
Biomaterials Inclusion complexes Antimicrobial activity |
dc.subject.cnpq.fl_str_mv |
ENGENHARIAS::ENGENHARIA DE MATERIAIS E METALURGICA |
description |
The search for controlled drug delivery mechanisms has been relevant in recent decades, with the aim of establishing more efficient therapeutic alternatives. In this work, a supramolecular polyelectrolytic complex (SPEC) between the biopolymers, κcarrageenan (CRG) chitosan (CS) functionalized with β-CD, in the stoichiometric ratio 4.25:1 obtained after determining the isoelectric point, was complexed to the sulfadiazine of silver (SDZ-Ag), a specific antibiotic for the treatment of burns and skin lesions. The samples were characterized by FTIR, DSC, TG, SEM and zeta potential techniques, which confirmed the formation of the polymeric complex. In this work, SDZ-Ag was used as a model drug and the association with supramolecular polyelectrolytic complexes was also studied by computational molecular modeling, using a semi-empirical method. The DRS and MET analyzes showed that the drug's Ag+ ions were reduced to different average sizes (12, 35 and 53 nm) through silver metallic non-structures. In vitro tests using Gram-positive strains: Staphylococcus aureus (ATCC 25923), Enterococcus durans/hirae (SS1225 / IAL 03/10) and Gram-negative: Klebsiella pneumoniae (ATCC 700603), Escherichia coli (ATCC 25922) and Enterobacter aerogenes (ATCC 13048), were used to evaluate the antimicrobial and kinetic profile of SPEC, observing drug release in 24 hours and pure SDZ in 5.5 hours. Finally, this work shows that the CDchitosan/carrageenan supramolecular polyelectrolyte complexes have an expressive potential to be applied as a polymer-based system for controlled drug release. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-03-03 |
dc.date.accessioned.fl_str_mv |
2021-11-18T20:39:34Z |
dc.date.available.fl_str_mv |
2021-11-18T20:39:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
EVANGELISTA, Thamasia Fernanda de Sá. Síntese de complexo polieletrolítico supramolecular κ-carragena-quitosana ancorado com Β-CD para sistema de liberação controlada do fármaco sulfadiazina de prata. 2020. 122 f. Tese (Doutorado em Ciência e Engenharia de Materiais) - Universidade Federal de Sergipe, São Cristóvão, SE, 2020. |
dc.identifier.uri.fl_str_mv |
https://ri.ufs.br/jspui/handle/riufs/14754 |
identifier_str_mv |
EVANGELISTA, Thamasia Fernanda de Sá. Síntese de complexo polieletrolítico supramolecular κ-carragena-quitosana ancorado com Β-CD para sistema de liberação controlada do fármaco sulfadiazina de prata. 2020. 122 f. Tese (Doutorado em Ciência e Engenharia de Materiais) - Universidade Federal de Sergipe, São Cristóvão, SE, 2020. |
url |
https://ri.ufs.br/jspui/handle/riufs/14754 |
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Pós-Graduação em Ciência e Engenharia de Materiais |
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Universidade Federal de Sergipe |
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