Rastreio ultrassonográfico de carcinoma hepatocelular em pacientes cirróticos: preditores de mortalidade, efeitos no estadiamento e sobrevida

• Autor(a) principal: Figueiredo, Luís Felipe da Costa
• Data de Publicação: 2019
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UFS
• Texto Completo: https://ri.ufs.br/jspui/handle/riufs/14731
• topic: Carcinoma hepatocelular; Fatores de Risco; Programas de Rastreamento; Sobrevida; Hepatocellular Carcinoma; Risk Factors; Mass Screening; Survival

Cirrhosis is the major risk factor for hepatocellular carcinoma. Cirrhotic patients should be screened. Prognosis depends on staging at diagnosis. Variables such as serum alpha-fetoprotein, total bilirubin and albumin levels may be predictors of mortality. The objective was to evaluate the impact of screening for hepatocellular carcinoma on cirrhotic patients and search for independent predictors of mortality in this pathology. This work is a retrospective cohort in which 150 patients diagnosed with hepatocellular carcinoma were studied. Divided into screening and control groups. This work evaluated staging and treatment at diagnosis, survival and variables as predictors of mortality. In screening group 73.33% were in early stage and 60% had received a curative thera-peutic proposal against 25.19% and 22.96%, respectively, in control group. As mortality predictors, we obtained serum alphafetoprotein dosage (relative risk: 3.66; 95% confidence interval: 1.64 - 8.17; p = 0.002) and total bilirubins (relative risk: 2.40; 95% confidence interval: 1.16 - 4.96; p = 0.018). In conclusion, semi-annual ultrasound screening is an efficient method for the diagnosis of early-stage HCC. Serum alfafetoprotein and total bilirubin levels can be used as independent predictors of mortality.