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Detalhes bibliográficos
Autor(a) principal: Vanessa Fontana, Vanessa Fontana
Data de Publicação: 2006
Outros Autores: Puhl, Ana Cristina, Pedrini, Fernanda, Falkenberg, Miriam, Jaime Cofre, Jaime Cofre
Tipo de documento: Artigo
Idioma: por
Título da fonte: Biotemas (Online)
Texto Completo: https://periodicos.ufsc.br/index.php/biotemas/article/view/21180
Resumo: The concept of gene is in crisis. Does it affect pharmacogenetics and pharmacogenomics? It is well known that the efficacy of certain drugs varies from individual to individual, depending in part on variation in the genes that encode drug metabolizing enzymes or target proteins. Like many other branches of the biomedical sciences, pharmacogenetics has been invigorated by recent advances in genomics, which has led to expectations that the safety and efficacy of medicines will soon be notably improved by persona- lization of therapeutics based on genetic data. Here we discuss how the crisis of the molecular gene concept affects the premise traced by pharmaco- genetics and how the sprouting of new paradigms in molecular and developmental biology points out the impossibility of reducing biological complexity to a DNA strand and single nucleotide polymorphism, affectingthe main aim of pharmacotherapy which is to provide the right drug for the right patient at the right dose.
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spelling .O conceito de gene está em crise. A farmacogenética e a farmacogenômica também?The concept of gene is in crisis. Does it affect pharmacogenetics and pharmacogenomics? It is well known that the efficacy of certain drugs varies from individual to individual, depending in part on variation in the genes that encode drug metabolizing enzymes or target proteins. Like many other branches of the biomedical sciences, pharmacogenetics has been invigorated by recent advances in genomics, which has led to expectations that the safety and efficacy of medicines will soon be notably improved by persona- lization of therapeutics based on genetic data. Here we discuss how the crisis of the molecular gene concept affects the premise traced by pharmaco- genetics and how the sprouting of new paradigms in molecular and developmental biology points out the impossibility of reducing biological complexity to a DNA strand and single nucleotide polymorphism, affectingthe main aim of pharmacotherapy which is to provide the right drug for the right patient at the right dose.Sabe-se bem que a eficácia de determinados fármacos varia de indivíduo para indivíduo, dependendo em parte da variação dos genes que codificam as proteínas alvos ou enzimas metabolizadoras. A farmacogenética, como muitos outros ramos das ciências biomédicas, foi impulsionada pelos avanços recentes da genômica, que conduziram às expectativas de que a segurança e a eficácia dos medicamentos seriam melhoradas notavelmente pela personalização da terapêutica, com base nos  dados genéticos dos pacientes. Neste trabalho discutimos como a crise do conceito molecular do gene afeta a premissa seguida pela farmaco genética e como o surgimento   de novos paradigmas na biologia molecular  e do desenvolvimento sinalizam  a impossibilidade de reduzir a complexidade biológica a uma fita de ADN ou a polimorfismos de único nucleotídeo, afetando as perspectivas de indivi- dualizar a farmacoterapia nos moldes idealizados, com o medica mento certo, na dose certa, para cada paciente.Universidade Federal de Santa Catarina2006-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.ufsc.br/index.php/biotemas/article/view/21180Biotemas; v. 19 n. 3 (2006); 87-962175-79250103-1643reponame:Biotemas (Online)instname:Universidade Federal de Santa Catarina (UFSC)instacron:UFSCporhttps://periodicos.ufsc.br/index.php/biotemas/article/view/21180/19160Copyright (c) 2006 Vanessa Fontana Vanessa Fontana, Ana Cristina Puhl, Fernanda Pedrini, Miriam Falkenberg, Jaime Cofre Jaime Cofrehttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessVanessa Fontana, Vanessa FontanaPuhl, Ana CristinaPedrini, FernandaFalkenberg, MiriamJaime Cofre, Jaime Cofre2022-11-21T11:46:41Zoai:periodicos.ufsc.br:article/21180Revistahttp://www.biotemas.ufsc.br/index.htmPUBhttps://periodicos.ufsc.br/index.php/biotemas/oai||carlospinto@ccb.ufsc.br2175-79250103-1643opendoar:2022-11-21T11:46:41Biotemas (Online) - Universidade Federal de Santa Catarina (UFSC)false
dc.title.none.fl_str_mv .
O conceito de gene está em crise. A farmacogenética e a farmacogenômica também?
title .
spellingShingle .
Vanessa Fontana, Vanessa Fontana
title_short .
title_full .
title_fullStr .
title_full_unstemmed .
title_sort .
author Vanessa Fontana, Vanessa Fontana
author_facet Vanessa Fontana, Vanessa Fontana
Puhl, Ana Cristina
Pedrini, Fernanda
Falkenberg, Miriam
Jaime Cofre, Jaime Cofre
author_role author
author2 Puhl, Ana Cristina
Pedrini, Fernanda
Falkenberg, Miriam
Jaime Cofre, Jaime Cofre
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Vanessa Fontana, Vanessa Fontana
Puhl, Ana Cristina
Pedrini, Fernanda
Falkenberg, Miriam
Jaime Cofre, Jaime Cofre
description The concept of gene is in crisis. Does it affect pharmacogenetics and pharmacogenomics? It is well known that the efficacy of certain drugs varies from individual to individual, depending in part on variation in the genes that encode drug metabolizing enzymes or target proteins. Like many other branches of the biomedical sciences, pharmacogenetics has been invigorated by recent advances in genomics, which has led to expectations that the safety and efficacy of medicines will soon be notably improved by persona- lization of therapeutics based on genetic data. Here we discuss how the crisis of the molecular gene concept affects the premise traced by pharmaco- genetics and how the sprouting of new paradigms in molecular and developmental biology points out the impossibility of reducing biological complexity to a DNA strand and single nucleotide polymorphism, affectingthe main aim of pharmacotherapy which is to provide the right drug for the right patient at the right dose.
publishDate 2006
dc.date.none.fl_str_mv 2006-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.ufsc.br/index.php/biotemas/article/view/21180
url https://periodicos.ufsc.br/index.php/biotemas/article/view/21180
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.ufsc.br/index.php/biotemas/article/view/21180/19160
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Santa Catarina
publisher.none.fl_str_mv Universidade Federal de Santa Catarina
dc.source.none.fl_str_mv Biotemas; v. 19 n. 3 (2006); 87-96
2175-7925
0103-1643
reponame:Biotemas (Online)
instname:Universidade Federal de Santa Catarina (UFSC)
instacron:UFSC
instname_str Universidade Federal de Santa Catarina (UFSC)
instacron_str UFSC
institution UFSC
reponame_str Biotemas (Online)
collection Biotemas (Online)
repository.name.fl_str_mv Biotemas (Online) - Universidade Federal de Santa Catarina (UFSC)
repository.mail.fl_str_mv ||carlospinto@ccb.ufsc.br
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