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Data de Publicação: | 2006 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Biotemas (Online) |
Texto Completo: | https://periodicos.ufsc.br/index.php/biotemas/article/view/21180 |
Resumo: | The concept of gene is in crisis. Does it affect pharmacogenetics and pharmacogenomics? It is well known that the efficacy of certain drugs varies from individual to individual, depending in part on variation in the genes that encode drug metabolizing enzymes or target proteins. Like many other branches of the biomedical sciences, pharmacogenetics has been invigorated by recent advances in genomics, which has led to expectations that the safety and efficacy of medicines will soon be notably improved by persona- lization of therapeutics based on genetic data. Here we discuss how the crisis of the molecular gene concept affects the premise traced by pharmaco- genetics and how the sprouting of new paradigms in molecular and developmental biology points out the impossibility of reducing biological complexity to a DNA strand and single nucleotide polymorphism, affectingthe main aim of pharmacotherapy which is to provide the right drug for the right patient at the right dose. |
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.O conceito de gene está em crise. A farmacogenética e a farmacogenômica também?The concept of gene is in crisis. Does it affect pharmacogenetics and pharmacogenomics? It is well known that the efficacy of certain drugs varies from individual to individual, depending in part on variation in the genes that encode drug metabolizing enzymes or target proteins. Like many other branches of the biomedical sciences, pharmacogenetics has been invigorated by recent advances in genomics, which has led to expectations that the safety and efficacy of medicines will soon be notably improved by persona- lization of therapeutics based on genetic data. Here we discuss how the crisis of the molecular gene concept affects the premise traced by pharmaco- genetics and how the sprouting of new paradigms in molecular and developmental biology points out the impossibility of reducing biological complexity to a DNA strand and single nucleotide polymorphism, affectingthe main aim of pharmacotherapy which is to provide the right drug for the right patient at the right dose.Sabe-se bem que a eficácia de determinados fármacos varia de indivíduo para indivíduo, dependendo em parte da variação dos genes que codificam as proteínas alvos ou enzimas metabolizadoras. A farmacogenética, como muitos outros ramos das ciências biomédicas, foi impulsionada pelos avanços recentes da genômica, que conduziram às expectativas de que a segurança e a eficácia dos medicamentos seriam melhoradas notavelmente pela personalização da terapêutica, com base nos dados genéticos dos pacientes. Neste trabalho discutimos como a crise do conceito molecular do gene afeta a premissa seguida pela farmaco genética e como o surgimento de novos paradigmas na biologia molecular e do desenvolvimento sinalizam a impossibilidade de reduzir a complexidade biológica a uma fita de ADN ou a polimorfismos de único nucleotídeo, afetando as perspectivas de indivi- dualizar a farmacoterapia nos moldes idealizados, com o medica mento certo, na dose certa, para cada paciente.Universidade Federal de Santa Catarina2006-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.ufsc.br/index.php/biotemas/article/view/21180Biotemas; v. 19 n. 3 (2006); 87-962175-79250103-1643reponame:Biotemas (Online)instname:Universidade Federal de Santa Catarina (UFSC)instacron:UFSCporhttps://periodicos.ufsc.br/index.php/biotemas/article/view/21180/19160Copyright (c) 2006 Vanessa Fontana Vanessa Fontana, Ana Cristina Puhl, Fernanda Pedrini, Miriam Falkenberg, Jaime Cofre Jaime Cofrehttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessVanessa Fontana, Vanessa FontanaPuhl, Ana CristinaPedrini, FernandaFalkenberg, MiriamJaime Cofre, Jaime Cofre2022-11-21T11:46:41Zoai:periodicos.ufsc.br:article/21180Revistahttp://www.biotemas.ufsc.br/index.htmPUBhttps://periodicos.ufsc.br/index.php/biotemas/oai||carlospinto@ccb.ufsc.br2175-79250103-1643opendoar:2022-11-21T11:46:41Biotemas (Online) - Universidade Federal de Santa Catarina (UFSC)false |
dc.title.none.fl_str_mv |
. O conceito de gene está em crise. A farmacogenética e a farmacogenômica também? |
title |
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spellingShingle |
. Vanessa Fontana, Vanessa Fontana |
title_short |
. |
title_full |
. |
title_fullStr |
. |
title_full_unstemmed |
. |
title_sort |
. |
author |
Vanessa Fontana, Vanessa Fontana |
author_facet |
Vanessa Fontana, Vanessa Fontana Puhl, Ana Cristina Pedrini, Fernanda Falkenberg, Miriam Jaime Cofre, Jaime Cofre |
author_role |
author |
author2 |
Puhl, Ana Cristina Pedrini, Fernanda Falkenberg, Miriam Jaime Cofre, Jaime Cofre |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Vanessa Fontana, Vanessa Fontana Puhl, Ana Cristina Pedrini, Fernanda Falkenberg, Miriam Jaime Cofre, Jaime Cofre |
description |
The concept of gene is in crisis. Does it affect pharmacogenetics and pharmacogenomics? It is well known that the efficacy of certain drugs varies from individual to individual, depending in part on variation in the genes that encode drug metabolizing enzymes or target proteins. Like many other branches of the biomedical sciences, pharmacogenetics has been invigorated by recent advances in genomics, which has led to expectations that the safety and efficacy of medicines will soon be notably improved by persona- lization of therapeutics based on genetic data. Here we discuss how the crisis of the molecular gene concept affects the premise traced by pharmaco- genetics and how the sprouting of new paradigms in molecular and developmental biology points out the impossibility of reducing biological complexity to a DNA strand and single nucleotide polymorphism, affectingthe main aim of pharmacotherapy which is to provide the right drug for the right patient at the right dose. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.ufsc.br/index.php/biotemas/article/view/21180 |
url |
https://periodicos.ufsc.br/index.php/biotemas/article/view/21180 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.ufsc.br/index.php/biotemas/article/view/21180/19160 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Catarina |
publisher.none.fl_str_mv |
Universidade Federal de Santa Catarina |
dc.source.none.fl_str_mv |
Biotemas; v. 19 n. 3 (2006); 87-96 2175-7925 0103-1643 reponame:Biotemas (Online) instname:Universidade Federal de Santa Catarina (UFSC) instacron:UFSC |
instname_str |
Universidade Federal de Santa Catarina (UFSC) |
instacron_str |
UFSC |
institution |
UFSC |
reponame_str |
Biotemas (Online) |
collection |
Biotemas (Online) |
repository.name.fl_str_mv |
Biotemas (Online) - Universidade Federal de Santa Catarina (UFSC) |
repository.mail.fl_str_mv |
||carlospinto@ccb.ufsc.br |
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1799940550883803136 |