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Detalhes bibliográficos
Autor(a) principal: Bernardes, Eliane
Data de Publicação: 1993
Outros Autores: Mastro, Nélida Lúcia del
Tipo de documento: Artigo
Idioma: por
Título da fonte: Biotemas (Online)
Texto Completo: https://periodicos.ufsc.br/index.php/biotemas/article/view/22717
Resumo: The use of radiomodifying that alter the radiation effect, protecting or sensitizing cells and organisms, presents great interest in tumor radiotherapy. Glutathione (GSH) can be described as the major endogen radioprotector. The diethylmaleate (DEM) is a drug able to block intracellular GSH. This work aims at the establishment of the radiomodifyng competence of DEM administered in two different vehicles, peanut oil and aqueous ethanolic solution by the analysis of mouse survival curves as well as the relative percentagens of serum proteins. Groups of animals were previously injected intraperitoneally with 0.3 ml of 418 and 150 uM DEM respectively in each one of the vehicles one hour before irradiated with an 60Co acute dose of 9 Gy. The survival of mice was followed during 30 days and electrophoretic profiles of serum proteins 1,3 and 7 days after irradiation. The results showed that the action of DEM on muose radio sensivity depends on the vehicles used, considering that both media showed a radiomodifier action.
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spelling .Influência do dietilmaleato na sobrevida e no nível de proteínas séricas de camundongos irradiados com cobaltoThe use of radiomodifying that alter the radiation effect, protecting or sensitizing cells and organisms, presents great interest in tumor radiotherapy. Glutathione (GSH) can be described as the major endogen radioprotector. The diethylmaleate (DEM) is a drug able to block intracellular GSH. This work aims at the establishment of the radiomodifyng competence of DEM administered in two different vehicles, peanut oil and aqueous ethanolic solution by the analysis of mouse survival curves as well as the relative percentagens of serum proteins. Groups of animals were previously injected intraperitoneally with 0.3 ml of 418 and 150 uM DEM respectively in each one of the vehicles one hour before irradiated with an 60Co acute dose of 9 Gy. The survival of mice was followed during 30 days and electrophoretic profiles of serum proteins 1,3 and 7 days after irradiation. The results showed that the action of DEM on muose radio sensivity depends on the vehicles used, considering that both media showed a radiomodifier action.O uso de drogas radiomodificadoras que alteram o efeito da radiação, protegendo ou sensibilizando células ou organismos, apresenta grande interesse nos casos de radioterapia de tumores. A glutationa (GSH) pode ser considerada o principal radioprotetor endógeno. O dietilmaleato (DEM) é uma substância que bloqueia o GSH intracelular. O objetivo deste trabalho visa estabelecer a competência radiomodificadora do DEM em dois veículos, óleo de amendoim e solução de etanol, ao reduzir o nível de GSH intracelular, por meio da análise das curvas de sobrevida de camundongos irradiados e a nível de percentagens relativas de proteínas séricas. Grupos de animais foram previamente injetados intraperitonealmente com 0,3ml de solução de DEM (418 e 150 uM) nos dois veículos e irradiados com dose aguda de 9 Gy (60Co), uma hora após a injeção. A sobrevida dos camundongos foi acompanhada durante 30 dias e os perfis eletroforéticos das proteínas séricas 1,3 e 7 dias respectivamente após a irradiação. A análise dos resultados mostra que a ação do DEM na radiossensibilidade de camundongos depende do veículo utilizado, já que os próprios veículos apresentam ação radiomodificadora.Universidade Federal de Santa Catarina1993-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.ufsc.br/index.php/biotemas/article/view/2271710.5007/%xBiotemas; v. 6 n. 1 (1993); 19-302175-79250103-1643reponame:Biotemas (Online)instname:Universidade Federal de Santa Catarina (UFSC)instacron:UFSCporhttps://periodicos.ufsc.br/index.php/biotemas/article/view/22717/20681Copyright (c) 1993 Eliane Bernardes, Nélida Lúcia del Mastroinfo:eu-repo/semantics/openAccessBernardes, ElianeMastro, Nélida Lúcia del2012-01-24T14:11:31Zoai:periodicos.ufsc.br:article/22717Revistahttp://www.biotemas.ufsc.br/index.htmPUBhttps://periodicos.ufsc.br/index.php/biotemas/oai||carlospinto@ccb.ufsc.br2175-79250103-1643opendoar:2012-01-24T14:11:31Biotemas (Online) - Universidade Federal de Santa Catarina (UFSC)false
dc.title.none.fl_str_mv .
Influência do dietilmaleato na sobrevida e no nível de proteínas séricas de camundongos irradiados com cobalto
title .
spellingShingle .
Bernardes, Eliane
title_short .
title_full .
title_fullStr .
title_full_unstemmed .
title_sort .
author Bernardes, Eliane
author_facet Bernardes, Eliane
Mastro, Nélida Lúcia del
author_role author
author2 Mastro, Nélida Lúcia del
author2_role author
dc.contributor.author.fl_str_mv Bernardes, Eliane
Mastro, Nélida Lúcia del
description The use of radiomodifying that alter the radiation effect, protecting or sensitizing cells and organisms, presents great interest in tumor radiotherapy. Glutathione (GSH) can be described as the major endogen radioprotector. The diethylmaleate (DEM) is a drug able to block intracellular GSH. This work aims at the establishment of the radiomodifyng competence of DEM administered in two different vehicles, peanut oil and aqueous ethanolic solution by the analysis of mouse survival curves as well as the relative percentagens of serum proteins. Groups of animals were previously injected intraperitoneally with 0.3 ml of 418 and 150 uM DEM respectively in each one of the vehicles one hour before irradiated with an 60Co acute dose of 9 Gy. The survival of mice was followed during 30 days and electrophoretic profiles of serum proteins 1,3 and 7 days after irradiation. The results showed that the action of DEM on muose radio sensivity depends on the vehicles used, considering that both media showed a radiomodifier action.
publishDate 1993
dc.date.none.fl_str_mv 1993-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.ufsc.br/index.php/biotemas/article/view/22717
10.5007/%x
url https://periodicos.ufsc.br/index.php/biotemas/article/view/22717
identifier_str_mv 10.5007/%x
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.ufsc.br/index.php/biotemas/article/view/22717/20681
dc.rights.driver.fl_str_mv Copyright (c) 1993 Eliane Bernardes, Nélida Lúcia del Mastro
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 1993 Eliane Bernardes, Nélida Lúcia del Mastro
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Santa Catarina
publisher.none.fl_str_mv Universidade Federal de Santa Catarina
dc.source.none.fl_str_mv Biotemas; v. 6 n. 1 (1993); 19-30
2175-7925
0103-1643
reponame:Biotemas (Online)
instname:Universidade Federal de Santa Catarina (UFSC)
instacron:UFSC
instname_str Universidade Federal de Santa Catarina (UFSC)
instacron_str UFSC
institution UFSC
reponame_str Biotemas (Online)
collection Biotemas (Online)
repository.name.fl_str_mv Biotemas (Online) - Universidade Federal de Santa Catarina (UFSC)
repository.mail.fl_str_mv ||carlospinto@ccb.ufsc.br
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