Behavioral teratogenicity induced by maternal food restriction: maternal cannibalism and poor reflex development in offspring
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Biotemas (Online) |
Texto Completo: | https://periodicos.ufsc.br/index.php/biotemas/article/view/2175-7925.2014v27n2p185 |
Resumo: | http://dx.doi.org/10.5007/2175-7925.2014v27n2p185Recent studies have attributed the presence of several toxic chemicals during pregnancy to maternal malnutrition. A deficit in maternal nutritional status may be crucial for the development of teratogenicity. However, nowadays, the concept of teratogenesis is not restricted to structural abnormalities, but, also, to functional changes, such as, for instance, those observed in behavior. This study investigated the effects of maternal food restriction (FR) during pregnancy on the physical, behavioral, and reflex development of offspring. Pregnant female rats underwent feed restriction at different levels (15, 40, 55, and 70% of the daily feed intake when compared to the control group), starting on gestation day 6 (GD6) until GD17; the control group received food ad libitum. After birth, the physical and neurobehavioral development of offspring were assessed. The results showed that, except for weight reduction, the physical development of offsprings from the FR groups did not differ from that of the control group. However, the experimental groups showed deficits in neurological reflexes, particularly with regard to negative geotaxis and palmar reflex. In general activity, the offspring of the FR group 40% (E40) and E55 showed low frequencies of locomotion and rearing and long periods of immobility. The results show that maternal FR during pregnancy promotes neurological disorders in offspring, but it does not affect physical development, showing the importance of behavioral assessments. |
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Behavioral teratogenicity induced by maternal food restriction: maternal cannibalism and poor reflex development in offspringhttp://dx.doi.org/10.5007/2175-7925.2014v27n2p185Recent studies have attributed the presence of several toxic chemicals during pregnancy to maternal malnutrition. A deficit in maternal nutritional status may be crucial for the development of teratogenicity. However, nowadays, the concept of teratogenesis is not restricted to structural abnormalities, but, also, to functional changes, such as, for instance, those observed in behavior. This study investigated the effects of maternal food restriction (FR) during pregnancy on the physical, behavioral, and reflex development of offspring. Pregnant female rats underwent feed restriction at different levels (15, 40, 55, and 70% of the daily feed intake when compared to the control group), starting on gestation day 6 (GD6) until GD17; the control group received food ad libitum. After birth, the physical and neurobehavioral development of offspring were assessed. The results showed that, except for weight reduction, the physical development of offsprings from the FR groups did not differ from that of the control group. However, the experimental groups showed deficits in neurological reflexes, particularly with regard to negative geotaxis and palmar reflex. In general activity, the offspring of the FR group 40% (E40) and E55 showed low frequencies of locomotion and rearing and long periods of immobility. The results show that maternal FR during pregnancy promotes neurological disorders in offspring, but it does not affect physical development, showing the importance of behavioral assessments.Universidade Federal de Santa Catarina2014-01-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.ufsc.br/index.php/biotemas/article/view/2175-7925.2014v27n2p18510.5007/2175-7925.2014v27n2p185Biotemas; v. 27 n. 2 (2014); 185-1922175-79250103-1643reponame:Biotemas (Online)instname:Universidade Federal de Santa Catarina (UFSC)instacron:UFSCenghttps://periodicos.ufsc.br/index.php/biotemas/article/view/2175-7925.2014v27n2p185/26616Copyright (c) 2014 Esther Lopes Ricci, Maria Martha Bernardi, Silvana Lima Górniak, Helenice Souza Spinosainfo:eu-repo/semantics/openAccessRicci, Esther LopesBernardi, Maria MarthaGórniak, Silvana LimaSpinosa, Helenice Souza2014-05-09T15:45:11Zoai:periodicos.ufsc.br:article/28434Revistahttp://www.biotemas.ufsc.br/index.htmPUBhttps://periodicos.ufsc.br/index.php/biotemas/oai||carlospinto@ccb.ufsc.br2175-79250103-1643opendoar:2014-05-09T15:45:11Biotemas (Online) - Universidade Federal de Santa Catarina (UFSC)false |
dc.title.none.fl_str_mv |
Behavioral teratogenicity induced by maternal food restriction: maternal cannibalism and poor reflex development in offspring |
title |
Behavioral teratogenicity induced by maternal food restriction: maternal cannibalism and poor reflex development in offspring |
spellingShingle |
Behavioral teratogenicity induced by maternal food restriction: maternal cannibalism and poor reflex development in offspring Ricci, Esther Lopes |
title_short |
Behavioral teratogenicity induced by maternal food restriction: maternal cannibalism and poor reflex development in offspring |
title_full |
Behavioral teratogenicity induced by maternal food restriction: maternal cannibalism and poor reflex development in offspring |
title_fullStr |
Behavioral teratogenicity induced by maternal food restriction: maternal cannibalism and poor reflex development in offspring |
title_full_unstemmed |
Behavioral teratogenicity induced by maternal food restriction: maternal cannibalism and poor reflex development in offspring |
title_sort |
Behavioral teratogenicity induced by maternal food restriction: maternal cannibalism and poor reflex development in offspring |
author |
Ricci, Esther Lopes |
author_facet |
Ricci, Esther Lopes Bernardi, Maria Martha Górniak, Silvana Lima Spinosa, Helenice Souza |
author_role |
author |
author2 |
Bernardi, Maria Martha Górniak, Silvana Lima Spinosa, Helenice Souza |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Ricci, Esther Lopes Bernardi, Maria Martha Górniak, Silvana Lima Spinosa, Helenice Souza |
description |
http://dx.doi.org/10.5007/2175-7925.2014v27n2p185Recent studies have attributed the presence of several toxic chemicals during pregnancy to maternal malnutrition. A deficit in maternal nutritional status may be crucial for the development of teratogenicity. However, nowadays, the concept of teratogenesis is not restricted to structural abnormalities, but, also, to functional changes, such as, for instance, those observed in behavior. This study investigated the effects of maternal food restriction (FR) during pregnancy on the physical, behavioral, and reflex development of offspring. Pregnant female rats underwent feed restriction at different levels (15, 40, 55, and 70% of the daily feed intake when compared to the control group), starting on gestation day 6 (GD6) until GD17; the control group received food ad libitum. After birth, the physical and neurobehavioral development of offspring were assessed. The results showed that, except for weight reduction, the physical development of offsprings from the FR groups did not differ from that of the control group. However, the experimental groups showed deficits in neurological reflexes, particularly with regard to negative geotaxis and palmar reflex. In general activity, the offspring of the FR group 40% (E40) and E55 showed low frequencies of locomotion and rearing and long periods of immobility. The results show that maternal FR during pregnancy promotes neurological disorders in offspring, but it does not affect physical development, showing the importance of behavioral assessments. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01-29 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.ufsc.br/index.php/biotemas/article/view/2175-7925.2014v27n2p185 10.5007/2175-7925.2014v27n2p185 |
url |
https://periodicos.ufsc.br/index.php/biotemas/article/view/2175-7925.2014v27n2p185 |
identifier_str_mv |
10.5007/2175-7925.2014v27n2p185 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://periodicos.ufsc.br/index.php/biotemas/article/view/2175-7925.2014v27n2p185/26616 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Catarina |
publisher.none.fl_str_mv |
Universidade Federal de Santa Catarina |
dc.source.none.fl_str_mv |
Biotemas; v. 27 n. 2 (2014); 185-192 2175-7925 0103-1643 reponame:Biotemas (Online) instname:Universidade Federal de Santa Catarina (UFSC) instacron:UFSC |
instname_str |
Universidade Federal de Santa Catarina (UFSC) |
instacron_str |
UFSC |
institution |
UFSC |
reponame_str |
Biotemas (Online) |
collection |
Biotemas (Online) |
repository.name.fl_str_mv |
Biotemas (Online) - Universidade Federal de Santa Catarina (UFSC) |
repository.mail.fl_str_mv |
||carlospinto@ccb.ufsc.br |
_version_ |
1799940553009266688 |