Effect of maternal diabetes on female offspring
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Einstein (São Paulo) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082014000400413 |
Resumo: | Objective To evaluate the effect of maternal diabetes on the blood pressure and kidney function of female offspring, as well as if such changes exacerbate during pregnancy.MethodsDiabetes mellitus was induced in female rats with the administration of streptozotocin in a single dose, one week before mating. During pregnancy, blood pressure was measured through plethysmography. On the 20th day of pregnancy, the animals were placed for 24 hours in metabolic cages to obtain urine samples. After the animals were removed from the cages, blood samples were withdrawn. One month after pregnancy, new blood and urine sample were collected. Kidney function was evaluated through proteinuria, plasma urea, plasma creatinine, creatinine excretion rate, urinary flow, and creatinine clearance.Results The female offspring from diabetic mothers showed an increase in blood pressure, and a decrease in glomerular filtration rate in relation to the control group.Conclusion Hyperglycemia during pregnancy was capable of causing an increase in blood pressure and kidney dysfunction in the female offspring. |
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Einstein (São Paulo) |
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Effect of maternal diabetes on female offspringPregnancy, animalFetal developmentDiabetes mellitus, experimentalHypertensionUreaCreatinineStreptozocin/administration & dosageObjective To evaluate the effect of maternal diabetes on the blood pressure and kidney function of female offspring, as well as if such changes exacerbate during pregnancy.MethodsDiabetes mellitus was induced in female rats with the administration of streptozotocin in a single dose, one week before mating. During pregnancy, blood pressure was measured through plethysmography. On the 20th day of pregnancy, the animals were placed for 24 hours in metabolic cages to obtain urine samples. After the animals were removed from the cages, blood samples were withdrawn. One month after pregnancy, new blood and urine sample were collected. Kidney function was evaluated through proteinuria, plasma urea, plasma creatinine, creatinine excretion rate, urinary flow, and creatinine clearance.Results The female offspring from diabetic mothers showed an increase in blood pressure, and a decrease in glomerular filtration rate in relation to the control group.Conclusion Hyperglycemia during pregnancy was capable of causing an increase in blood pressure and kidney dysfunction in the female offspring.Instituto Israelita de Ensino e Pesquisa Albert Einstein2014-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082014000400413einstein (São Paulo) v.12 n.4 2014reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.1590/S1679-45082014AO3200info:eu-repo/semantics/openAccessMartins,Juliana de OliveiraPanício,Maurício IsaacDantas,Marcos Paulo SuehiroGomes,Guiomar Nascimentoeng2015-09-10T00:00:00Zoai:scielo:S1679-45082014000400413Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2015-09-10T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false |
dc.title.none.fl_str_mv |
Effect of maternal diabetes on female offspring |
title |
Effect of maternal diabetes on female offspring |
spellingShingle |
Effect of maternal diabetes on female offspring Martins,Juliana de Oliveira Pregnancy, animal Fetal development Diabetes mellitus, experimental Hypertension Urea Creatinine Streptozocin/administration & dosage |
title_short |
Effect of maternal diabetes on female offspring |
title_full |
Effect of maternal diabetes on female offspring |
title_fullStr |
Effect of maternal diabetes on female offspring |
title_full_unstemmed |
Effect of maternal diabetes on female offspring |
title_sort |
Effect of maternal diabetes on female offspring |
author |
Martins,Juliana de Oliveira |
author_facet |
Martins,Juliana de Oliveira Panício,Maurício Isaac Dantas,Marcos Paulo Suehiro Gomes,Guiomar Nascimento |
author_role |
author |
author2 |
Panício,Maurício Isaac Dantas,Marcos Paulo Suehiro Gomes,Guiomar Nascimento |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Martins,Juliana de Oliveira Panício,Maurício Isaac Dantas,Marcos Paulo Suehiro Gomes,Guiomar Nascimento |
dc.subject.por.fl_str_mv |
Pregnancy, animal Fetal development Diabetes mellitus, experimental Hypertension Urea Creatinine Streptozocin/administration & dosage |
topic |
Pregnancy, animal Fetal development Diabetes mellitus, experimental Hypertension Urea Creatinine Streptozocin/administration & dosage |
description |
Objective To evaluate the effect of maternal diabetes on the blood pressure and kidney function of female offspring, as well as if such changes exacerbate during pregnancy.MethodsDiabetes mellitus was induced in female rats with the administration of streptozotocin in a single dose, one week before mating. During pregnancy, blood pressure was measured through plethysmography. On the 20th day of pregnancy, the animals were placed for 24 hours in metabolic cages to obtain urine samples. After the animals were removed from the cages, blood samples were withdrawn. One month after pregnancy, new blood and urine sample were collected. Kidney function was evaluated through proteinuria, plasma urea, plasma creatinine, creatinine excretion rate, urinary flow, and creatinine clearance.Results The female offspring from diabetic mothers showed an increase in blood pressure, and a decrease in glomerular filtration rate in relation to the control group.Conclusion Hyperglycemia during pregnancy was capable of causing an increase in blood pressure and kidney dysfunction in the female offspring. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082014000400413 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082014000400413 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1679-45082014AO3200 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
dc.source.none.fl_str_mv |
einstein (São Paulo) v.12 n.4 2014 reponame:Einstein (São Paulo) instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) instacron:IIEPAE |
instname_str |
Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
instacron_str |
IIEPAE |
institution |
IIEPAE |
reponame_str |
Einstein (São Paulo) |
collection |
Einstein (São Paulo) |
repository.name.fl_str_mv |
Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
repository.mail.fl_str_mv |
||revista@einstein.br |
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1752129907506282496 |