Body fat and lipid profile of monozygotic twins discordant for insulin resistance
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Cineantropometria & Desempenho Humano (Online) |
Texto Completo: | https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2016v18n6p690 |
Resumo: | The study investigated alterations in body fat and metabolic profile of adolescent monozygotic twins, resulting from discordance for insulin resistance, adjusted for physical activity, physical fitness and heredity. Thirty-eight pairs of monozygotic twins were assessed for anthropometric measurements to estimate body fat. Physical fitness was estimated with treadmill test and use of ergospirometer. Daily physical activity was estimated from the daily count of steps measured by a pedometer during 3 days. Fasting blood samples were used to determine blood glucose, insulin, lipid parameters. The Homa-IR and HOMA-β indexes were calculated. Twins with measures higher than 2.5 were considered insulin resistant. When both brothers were below or above cutoffs, the pair was allocated to the concordant group. When one brother was insulin resistant and the other was not, the pair was allocated in the discordant group. Twins were compared using paired test. In the discordant group, it was observed that insulin-resistant twins had higher birth weight values, bodyweight, BMI, waist circumference, body fat percentage, body fat (sum of skinfolds), Homa-β index and lower HDL compared to their corresponding pair. Insulin-resistant twins showed higher values in anthropometry and body composition, as well as in the glycemia and insulin index and lower HDL. These events may have been unchained by metabolic alterations possibly originating from gestational stage, however, modulated by body composition. |
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Body fat and lipid profile of monozygotic twins discordant for insulin resistanceGordura corporal e perfil lipídico de gêmeos monozigóticos discordantes para resistência à insulina The study investigated alterations in body fat and metabolic profile of adolescent monozygotic twins, resulting from discordance for insulin resistance, adjusted for physical activity, physical fitness and heredity. Thirty-eight pairs of monozygotic twins were assessed for anthropometric measurements to estimate body fat. Physical fitness was estimated with treadmill test and use of ergospirometer. Daily physical activity was estimated from the daily count of steps measured by a pedometer during 3 days. Fasting blood samples were used to determine blood glucose, insulin, lipid parameters. The Homa-IR and HOMA-β indexes were calculated. Twins with measures higher than 2.5 were considered insulin resistant. When both brothers were below or above cutoffs, the pair was allocated to the concordant group. When one brother was insulin resistant and the other was not, the pair was allocated in the discordant group. Twins were compared using paired test. In the discordant group, it was observed that insulin-resistant twins had higher birth weight values, bodyweight, BMI, waist circumference, body fat percentage, body fat (sum of skinfolds), Homa-β index and lower HDL compared to their corresponding pair. Insulin-resistant twins showed higher values in anthropometry and body composition, as well as in the glycemia and insulin index and lower HDL. These events may have been unchained by metabolic alterations possibly originating from gestational stage, however, modulated by body composition. O objetivo do estudo foi investigar alterações na composição corporal e perfil metabólico de gêmeos monozigóticos adolescentes, decorrentes da discordância para resistência à insulina, ajustados para atividade física, aptidão cardiorrespiratória e hereditariedade. Participaram do estudo 38 pares de gêmeos monozigóticos (11 a 17 anos). Foram obtidas as medidas antropométricas de massa corporal (MC), estatura, circunferência da cintura (CC) e espessuras de dobras cutâneas (EDC). Todos os gêmeos foram submetidos a teste de esforço máximo em esteira rolante com análise direta dos gases (VO2máx), avaliação da atividade física diária por meio de pedômetros, a coleta de sangue em jejum para estimativa da glicemia, insulina e perfil lipídico, e posterior estimativa do índice HOMA-RI e HOMA-β. Os pares onde os irmãos apresentavam-se ambos abaixo ou acima do ponto de corte (Homa-RI < 2,5) foram alocados no grupo concordante (GC). Quando um irmão era resistente e outro não resistente à insulina, este par foi alocado no grupo discordante (GD). Foi observado, no GD, que os gêmeos resistentes à insulina, apresentavam maiores valores de peso de nascimento, MC, IMC, CC, percentual de gordura, adiposidade corporal (soma EDC) e índice Homa-β, além de menor valor de HDL comparados aos seus pares correspondentes. Jovens resistentes à insulina apresentaram valores superiores na antropometria e composição corporal, bem como, índices glicêmicos e insulínicos e menor HDL. Estes eventos podem ter sido desencadeados pelas alterações metabólicas possivelmente originadas na fase gestacional, porém, moduladas pela composição corporal.Universidade Federal de Santa Catarina. Florianópolis, SC. Brasil2016-02-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion"Avaliado por Pares",Original paperAvaliado por ParesArtigos Originaisapplication/pdfhttps://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2016v18n6p69010.1590/1980-0037.2016v18n6p690Brazilian Journal of Kinanthropometry and Human Performance; Vol. 18 No. 6 (2016); 690-699Revista Brasileira de Cineantropometria e Desempenho Humano; v. 18 n. 6 (2016); 690-6991980-00371415-8426reponame:Revista Brasileira de Cineantropometria & Desempenho Humano (Online)instname:Universidade Federal de Santa Catarina (UFSC)instacron:UFSCenghttps://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2016v18n6p690/33556Copyright (c) 2017 Revista Brasileira de Cineantropometria e Desempenho Humanoinfo:eu-repo/semantics/openAccessCavazzotto, Timothy GustavoQueiroga, Marcos RobertoFerreira, Sandra AiresKokubun, EduardoBueno, Maria Raquel de OliveiraSerassuelo Junior, Helio2018-12-05T10:26:43Zoai:periodicos.ufsc.br:article/44443Revistahttps://periodicos.ufsc.br/index.php/rbcdh/PUBhttps://periodicos.ufsc.br/index.php/rbcdh/oairbcdh@contato.ufsc.br || portaldeperiodicos.bu@contato.ufsc.br1980-00371415-8426opendoar:2018-12-05T10:26:43Revista Brasileira de Cineantropometria & Desempenho Humano (Online) - Universidade Federal de Santa Catarina (UFSC)false |
dc.title.none.fl_str_mv |
Body fat and lipid profile of monozygotic twins discordant for insulin resistance Gordura corporal e perfil lipídico de gêmeos monozigóticos discordantes para resistência à insulina |
title |
Body fat and lipid profile of monozygotic twins discordant for insulin resistance |
spellingShingle |
Body fat and lipid profile of monozygotic twins discordant for insulin resistance Cavazzotto, Timothy Gustavo |
title_short |
Body fat and lipid profile of monozygotic twins discordant for insulin resistance |
title_full |
Body fat and lipid profile of monozygotic twins discordant for insulin resistance |
title_fullStr |
Body fat and lipid profile of monozygotic twins discordant for insulin resistance |
title_full_unstemmed |
Body fat and lipid profile of monozygotic twins discordant for insulin resistance |
title_sort |
Body fat and lipid profile of monozygotic twins discordant for insulin resistance |
author |
Cavazzotto, Timothy Gustavo |
author_facet |
Cavazzotto, Timothy Gustavo Queiroga, Marcos Roberto Ferreira, Sandra Aires Kokubun, Eduardo Bueno, Maria Raquel de Oliveira Serassuelo Junior, Helio |
author_role |
author |
author2 |
Queiroga, Marcos Roberto Ferreira, Sandra Aires Kokubun, Eduardo Bueno, Maria Raquel de Oliveira Serassuelo Junior, Helio |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Cavazzotto, Timothy Gustavo Queiroga, Marcos Roberto Ferreira, Sandra Aires Kokubun, Eduardo Bueno, Maria Raquel de Oliveira Serassuelo Junior, Helio |
description |
The study investigated alterations in body fat and metabolic profile of adolescent monozygotic twins, resulting from discordance for insulin resistance, adjusted for physical activity, physical fitness and heredity. Thirty-eight pairs of monozygotic twins were assessed for anthropometric measurements to estimate body fat. Physical fitness was estimated with treadmill test and use of ergospirometer. Daily physical activity was estimated from the daily count of steps measured by a pedometer during 3 days. Fasting blood samples were used to determine blood glucose, insulin, lipid parameters. The Homa-IR and HOMA-β indexes were calculated. Twins with measures higher than 2.5 were considered insulin resistant. When both brothers were below or above cutoffs, the pair was allocated to the concordant group. When one brother was insulin resistant and the other was not, the pair was allocated in the discordant group. Twins were compared using paired test. In the discordant group, it was observed that insulin-resistant twins had higher birth weight values, bodyweight, BMI, waist circumference, body fat percentage, body fat (sum of skinfolds), Homa-β index and lower HDL compared to their corresponding pair. Insulin-resistant twins showed higher values in anthropometry and body composition, as well as in the glycemia and insulin index and lower HDL. These events may have been unchained by metabolic alterations possibly originating from gestational stage, however, modulated by body composition. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-02-13 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion "Avaliado por Pares", Original paper Avaliado por Pares Artigos Originais |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2016v18n6p690 10.1590/1980-0037.2016v18n6p690 |
url |
https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2016v18n6p690 |
identifier_str_mv |
10.1590/1980-0037.2016v18n6p690 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2016v18n6p690/33556 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2017 Revista Brasileira de Cineantropometria e Desempenho Humano info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2017 Revista Brasileira de Cineantropometria e Desempenho Humano |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Catarina. Florianópolis, SC. Brasil |
publisher.none.fl_str_mv |
Universidade Federal de Santa Catarina. Florianópolis, SC. Brasil |
dc.source.none.fl_str_mv |
Brazilian Journal of Kinanthropometry and Human Performance; Vol. 18 No. 6 (2016); 690-699 Revista Brasileira de Cineantropometria e Desempenho Humano; v. 18 n. 6 (2016); 690-699 1980-0037 1415-8426 reponame:Revista Brasileira de Cineantropometria & Desempenho Humano (Online) instname:Universidade Federal de Santa Catarina (UFSC) instacron:UFSC |
instname_str |
Universidade Federal de Santa Catarina (UFSC) |
instacron_str |
UFSC |
institution |
UFSC |
reponame_str |
Revista Brasileira de Cineantropometria & Desempenho Humano (Online) |
collection |
Revista Brasileira de Cineantropometria & Desempenho Humano (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cineantropometria & Desempenho Humano (Online) - Universidade Federal de Santa Catarina (UFSC) |
repository.mail.fl_str_mv |
rbcdh@contato.ufsc.br || portaldeperiodicos.bu@contato.ufsc.br |
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1789435124545224704 |