Physical exercise, inflammatory process and adaptive condition: an overview.
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng por |
Título da fonte: | Revista Brasileira de Cineantropometria & Desempenho Humano (Online) |
Texto Completo: | https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2011v13n4p320 |
Resumo: | Physical exercise induces inflammation, a physiological response that is part of immune system activity and promotes tissue remodeling after exercise overload. The activation of the inflammatory process is local and systemic and is mediated by different cells and secreted compounds. The objective is to reestablish organ homeostasis after a single bout of exercise or after several exercise sessions. The acute-phase response involves the combined actions of activated leukocytes, cytokines, acute-phase proteins, hormones, and other signaling molecules that control the response to an exercise session and guide the adaptations resulting from training. This review provides an overview of the inflammatory process related to exercise and literature data regarding markers of inflammation in response to different experimental protocols. The results obtained indicate distinct inflammatory responses to acute and chronic exercise. In general, acute exercise induces a proinflammatory response characterized by transient leukocytosis (neutrophilia, monocytosis, and lymphocytosis), followed by a partial cellular immunosuppressive state. An increase in serum concentrations of creatine kinase, C-reactive protein and cell adhesion molecules is also observed, in addition to an increased secretion of cortisol and cytokines. In contrast, chronic exercise results in a local and systemic anti-inflammatory response that promotes tissue adaptation and protects the organism against the development of chronic inflammatory diseases and against the effects of non-functional overtraining, a condition in which a systemic and chronic proinflammatory and pro-oxidant state seems to prevail. |
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Physical exercise, inflammatory process and adaptive condition: an overview.Exercício físico, processo inflamatório e adaptação: uma visão geralPhysical exercise induces inflammation, a physiological response that is part of immune system activity and promotes tissue remodeling after exercise overload. The activation of the inflammatory process is local and systemic and is mediated by different cells and secreted compounds. The objective is to reestablish organ homeostasis after a single bout of exercise or after several exercise sessions. The acute-phase response involves the combined actions of activated leukocytes, cytokines, acute-phase proteins, hormones, and other signaling molecules that control the response to an exercise session and guide the adaptations resulting from training. This review provides an overview of the inflammatory process related to exercise and literature data regarding markers of inflammation in response to different experimental protocols. The results obtained indicate distinct inflammatory responses to acute and chronic exercise. In general, acute exercise induces a proinflammatory response characterized by transient leukocytosis (neutrophilia, monocytosis, and lymphocytosis), followed by a partial cellular immunosuppressive state. An increase in serum concentrations of creatine kinase, C-reactive protein and cell adhesion molecules is also observed, in addition to an increased secretion of cortisol and cytokines. In contrast, chronic exercise results in a local and systemic anti-inflammatory response that promotes tissue adaptation and protects the organism against the development of chronic inflammatory diseases and against the effects of non-functional overtraining, a condition in which a systemic and chronic proinflammatory and pro-oxidant state seems to prevail.O exercício físico induz inflamação, evento que ocorre para promover o reparo e remodelamento tecidual após o trauma. A ativação do processo inflamatório é local e sistêmico, valendo-se para isso de diversas células e componentes secretados. O objetivoé restabelecer a homeostasia orgânica após uma única sessão ou após diversas sessões de exercícios. A resposta de fase aguda consiste de ações integradas entre leucócitos, citocinas, proteínas de fase aguda, hormônios e outras moléculas sinalizadoras que controlam a resposta tanto a uma sessão de exercícios como também direcionam as adaptações decorrentes do treinamento. Nessa revisão, apresentaremos um panorama geral sobre inflamação e exercício físico, e os dados na literatura sobre marcadores de inflamação em resposta a diferentes protocolos experimentais. Os resultados obtidos apontam respostas distintas sobre o processo inflamatório em relação aos efeitos agudos ou crônicos dos exercícios. De forma geral, uma única sessão de exercício físico intenso induz um estado pró-inflamatório, representado por leucocitose transitória, em decorrência de neutrofilia, monocitose e linfocitose, seguida de supressão parcial da imunidade celular. Também têm sido observados aumentos nas concentrações séricas da enzima creatina quinase, proteína C-reativa e moléculas de adesão celular, além do aumento na secreção de cortisol e citocinas. Já o treinamento físico sistematizado pode levar a um estado anti-inflamatório local e sistêmico. Esse ambiente anti-inflamatório viabilizaria a adaptação e, ao mesmo tempo, protegeria o organismo contra o desenvolvimento de patologias inflamatórias crônicas e dos efeitos nocivos do overtraining, quando parece prevalecer um estado pró-inflamatório e pró-oxidante crônico e sistêmico.Universidade Federal de Santa Catarina. Florianópolis, SC. Brasil2011-06-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion"Avaliado por Pares","Artigo Solicitado"Overview"Avaliado por Pares", "Artigo Solicitado"Revisão de Literaturaapplication/pdfapplication/pdfhttps://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2011v13n4p32010.1590/1980-0037.2011v13n4p320Brazilian Journal of Kinanthropometry and Human Performance; Vol. 13 No. 4 (2011); 320-328Revista Brasileira de Cineantropometria e Desempenho Humano; v. 13 n. 4 (2011); 320-3281980-00371415-8426reponame:Revista Brasileira de Cineantropometria & Desempenho Humano (Online)instname:Universidade Federal de Santa Catarina (UFSC)instacron:UFSCengporhttps://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2011v13n4p320/18055https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2011v13n4p320/17908Silva, Fernando Oliveira Catanho daMacedo, Denise Vazinfo:eu-repo/semantics/openAccess2022-11-21T14:14:54Zoai:periodicos.ufsc.br:article/19602Revistahttps://periodicos.ufsc.br/index.php/rbcdh/PUBhttps://periodicos.ufsc.br/index.php/rbcdh/oairbcdh@contato.ufsc.br || portaldeperiodicos.bu@contato.ufsc.br1980-00371415-8426opendoar:2022-11-21T14:14:54Revista Brasileira de Cineantropometria & Desempenho Humano (Online) - Universidade Federal de Santa Catarina (UFSC)false |
dc.title.none.fl_str_mv |
Physical exercise, inflammatory process and adaptive condition: an overview. Exercício físico, processo inflamatório e adaptação: uma visão geral |
title |
Physical exercise, inflammatory process and adaptive condition: an overview. |
spellingShingle |
Physical exercise, inflammatory process and adaptive condition: an overview. Silva, Fernando Oliveira Catanho da |
title_short |
Physical exercise, inflammatory process and adaptive condition: an overview. |
title_full |
Physical exercise, inflammatory process and adaptive condition: an overview. |
title_fullStr |
Physical exercise, inflammatory process and adaptive condition: an overview. |
title_full_unstemmed |
Physical exercise, inflammatory process and adaptive condition: an overview. |
title_sort |
Physical exercise, inflammatory process and adaptive condition: an overview. |
author |
Silva, Fernando Oliveira Catanho da |
author_facet |
Silva, Fernando Oliveira Catanho da Macedo, Denise Vaz |
author_role |
author |
author2 |
Macedo, Denise Vaz |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Silva, Fernando Oliveira Catanho da Macedo, Denise Vaz |
description |
Physical exercise induces inflammation, a physiological response that is part of immune system activity and promotes tissue remodeling after exercise overload. The activation of the inflammatory process is local and systemic and is mediated by different cells and secreted compounds. The objective is to reestablish organ homeostasis after a single bout of exercise or after several exercise sessions. The acute-phase response involves the combined actions of activated leukocytes, cytokines, acute-phase proteins, hormones, and other signaling molecules that control the response to an exercise session and guide the adaptations resulting from training. This review provides an overview of the inflammatory process related to exercise and literature data regarding markers of inflammation in response to different experimental protocols. The results obtained indicate distinct inflammatory responses to acute and chronic exercise. In general, acute exercise induces a proinflammatory response characterized by transient leukocytosis (neutrophilia, monocytosis, and lymphocytosis), followed by a partial cellular immunosuppressive state. An increase in serum concentrations of creatine kinase, C-reactive protein and cell adhesion molecules is also observed, in addition to an increased secretion of cortisol and cytokines. In contrast, chronic exercise results in a local and systemic anti-inflammatory response that promotes tissue adaptation and protects the organism against the development of chronic inflammatory diseases and against the effects of non-functional overtraining, a condition in which a systemic and chronic proinflammatory and pro-oxidant state seems to prevail. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-06-15 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion "Avaliado por Pares","Artigo Solicitado" Overview "Avaliado por Pares", "Artigo Solicitado" Revisão de Literatura |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2011v13n4p320 10.1590/1980-0037.2011v13n4p320 |
url |
https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2011v13n4p320 |
identifier_str_mv |
10.1590/1980-0037.2011v13n4p320 |
dc.language.iso.fl_str_mv |
eng por |
language |
eng por |
dc.relation.none.fl_str_mv |
https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2011v13n4p320/18055 https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2011v13n4p320/17908 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Catarina. Florianópolis, SC. Brasil |
publisher.none.fl_str_mv |
Universidade Federal de Santa Catarina. Florianópolis, SC. Brasil |
dc.source.none.fl_str_mv |
Brazilian Journal of Kinanthropometry and Human Performance; Vol. 13 No. 4 (2011); 320-328 Revista Brasileira de Cineantropometria e Desempenho Humano; v. 13 n. 4 (2011); 320-328 1980-0037 1415-8426 reponame:Revista Brasileira de Cineantropometria & Desempenho Humano (Online) instname:Universidade Federal de Santa Catarina (UFSC) instacron:UFSC |
instname_str |
Universidade Federal de Santa Catarina (UFSC) |
instacron_str |
UFSC |
institution |
UFSC |
reponame_str |
Revista Brasileira de Cineantropometria & Desempenho Humano (Online) |
collection |
Revista Brasileira de Cineantropometria & Desempenho Humano (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cineantropometria & Desempenho Humano (Online) - Universidade Federal de Santa Catarina (UFSC) |
repository.mail.fl_str_mv |
rbcdh@contato.ufsc.br || portaldeperiodicos.bu@contato.ufsc.br |
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1789435122431295488 |