Effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary rats

• Autor(a) principal: Gomez, Rossana Anelice
• Data de Publicação: 2012
• Outros Autores: de Arruda, Miguel, Pinhero Ramos, Fabio, Cossio Bolaños, Marco Antonio
• Tipo de documento: Artigo
• Idioma: spa
• Título da fonte: Revista Brasileira de Cineantropometria & Desempenho Humano (Online)
• Texto Completo: https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2012v14n3p324

L-carnitine, considered to be of great value in metabolic processes, plays an important role in the mitochondrial β-oxidation process. It may be used to improve athletic performance and to maintain a higher workload during exercise. This study aimed to investigate the effect of L-carnitine supplementation on muscle fatigue in sciatic nerve-gastrocnemius muscle preparations in sedentary and trained rats. The animals were divided into 4 groups: non-supplemented sedentary (NSS), supplemented sedentary (SS), non-supplemented trained (NST), and supplemented trained (ST) rats. The animals were trained in daily 1-h sessions (5 days/week) and received chronic oral L-carnitine supplementation (1 mg/mL) for 4 weeks. Muscle fatigue was determined by supramaximal tetanic stimulation of the sciatic nerve (50 Hz). Time values for strength reduction were significantly different (p<0.05) between NSS vs. SS and NST vs. ST rats. No significant differences were observed between SS vs. ST and NST vs. NSS rats. These findings demonstrate that L-carnitine lengthen the time required for induction of muscle fatigue.