Effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary rats
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | spa |
Título da fonte: | Revista Brasileira de Cineantropometria & Desempenho Humano (Online) |
Texto Completo: | https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2012v14n3p324 |
Resumo: | L-carnitine, considered to be of great value in metabolic processes, plays an important role in the mitochondrial β-oxidation process. It may be used to improve athletic performance and to maintain a higher workload during exercise. This study aimed to investigate the effect of L-carnitine supplementation on muscle fatigue in sciatic nerve-gastrocnemius muscle preparations in sedentary and trained rats. The animals were divided into 4 groups: non-supplemented sedentary (NSS), supplemented sedentary (SS), non-supplemented trained (NST), and supplemented trained (ST) rats. The animals were trained in daily 1-h sessions (5 days/week) and received chronic oral L-carnitine supplementation (1 mg/mL) for 4 weeks. Muscle fatigue was determined by supramaximal tetanic stimulation of the sciatic nerve (50 Hz). Time values for strength reduction were significantly different (p<0.05) between NSS vs. SS and NST vs. ST rats. No significant differences were observed between SS vs. ST and NST vs. NSS rats. These findings demonstrate that L-carnitine lengthen the time required for induction of muscle fatigue. |
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Revista Brasileira de Cineantropometria & Desempenho Humano (Online) |
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Effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary ratsEfectos de la suplementación de carnitina sobre el nivel de fatiga muscular del gastrocnemio de ratas entrenadas y sedentáriasL-carnitine, considered to be of great value in metabolic processes, plays an important role in the mitochondrial β-oxidation process. It may be used to improve athletic performance and to maintain a higher workload during exercise. This study aimed to investigate the effect of L-carnitine supplementation on muscle fatigue in sciatic nerve-gastrocnemius muscle preparations in sedentary and trained rats. The animals were divided into 4 groups: non-supplemented sedentary (NSS), supplemented sedentary (SS), non-supplemented trained (NST), and supplemented trained (ST) rats. The animals were trained in daily 1-h sessions (5 days/week) and received chronic oral L-carnitine supplementation (1 mg/mL) for 4 weeks. Muscle fatigue was determined by supramaximal tetanic stimulation of the sciatic nerve (50 Hz). Time values for strength reduction were significantly different (p<0.05) between NSS vs. SS and NST vs. ST rats. No significant differences were observed between SS vs. ST and NST vs. NSS rats. These findings demonstrate that L-carnitine lengthen the time required for induction of muscle fatigue.La L-carnitina tiene un gran valor en procesos metabolicos al cumplir un papel importante en el proceso de β-oxidacion mitocondrial, por lo cual, podria ser usada para mejorar el rendimiento atletico y mantener una carga de trabajo. Este trabajo tuvo por objetivo evaluar los efectos de la suplementacion de L-carnitina y del entrenamiento en el tiempo necesario a la induccion de la fatiga muscular en preparaciones in situ del nervio ciatico y musculo gastronemio en ratas. Cuatro grupos de animales fueron constituidos: sedentario no suplementado (SNS), sedentario suplementado (SS), entrenado no suplementado (ENS) y entrenado suplementado (ES). El entrenamiento fue realizado en sesiones diarias (1h/5dias/semana) y con suplementacion oral cronica de L-Carnitina (1mg/ml) por 4 semanas. La fatiga muscular fue obtenida mediante estimulacion supramaximal tetanica del nervio ciatico (50 Hz). Los valores del tiempo para la reduccion de fuerza fueron significativamente diferentes (p<0,05) entre los grupos SNS vs SS y ENS vs ES, respectivamente. Sin embargo, no hubo diferencias significativas entre los grupos ESvs SS y ENS vs SNS. Estos resultados demuestran que la L-carnitina prolongo el tempo necesario para la reduccion de fuerza a nivel del musculo gastrocnemio.Universidade Federal de Santa Catarina. Florianópolis, SC. Brasil2012-04-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion"Avaliado por Pares",ExperimentalAvaliado por ParesExperimentalapplication/pdfhttps://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2012v14n3p32410.1590/1980-0037.2012v14n3p324Brazilian Journal of Kinanthropometry and Human Performance; Vol. 14 No. 3 (2012); 324-332Revista Brasileira de Cineantropometria e Desempenho Humano; v. 14 n. 3 (2012); 324-3321980-00371415-8426reponame:Revista Brasileira de Cineantropometria & Desempenho Humano (Online)instname:Universidade Federal de Santa Catarina (UFSC)instacron:UFSCspahttps://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2012v14n3p324/21742Gomez, Rossana Anelicede Arruda, MiguelPinhero Ramos, FabioCossio Bolaños, Marco Antonioinfo:eu-repo/semantics/openAccess2022-11-21T14:14:54Zoai:periodicos.ufsc.br:article/19207Revistahttps://periodicos.ufsc.br/index.php/rbcdh/PUBhttps://periodicos.ufsc.br/index.php/rbcdh/oairbcdh@contato.ufsc.br || portaldeperiodicos.bu@contato.ufsc.br1980-00371415-8426opendoar:2022-11-21T14:14:54Revista Brasileira de Cineantropometria & Desempenho Humano (Online) - Universidade Federal de Santa Catarina (UFSC)false |
dc.title.none.fl_str_mv |
Effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary rats Efectos de la suplementación de carnitina sobre el nivel de fatiga muscular del gastrocnemio de ratas entrenadas y sedentárias |
title |
Effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary rats |
spellingShingle |
Effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary rats Gomez, Rossana Anelice |
title_short |
Effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary rats |
title_full |
Effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary rats |
title_fullStr |
Effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary rats |
title_full_unstemmed |
Effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary rats |
title_sort |
Effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary rats |
author |
Gomez, Rossana Anelice |
author_facet |
Gomez, Rossana Anelice de Arruda, Miguel Pinhero Ramos, Fabio Cossio Bolaños, Marco Antonio |
author_role |
author |
author2 |
de Arruda, Miguel Pinhero Ramos, Fabio Cossio Bolaños, Marco Antonio |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Gomez, Rossana Anelice de Arruda, Miguel Pinhero Ramos, Fabio Cossio Bolaños, Marco Antonio |
description |
L-carnitine, considered to be of great value in metabolic processes, plays an important role in the mitochondrial β-oxidation process. It may be used to improve athletic performance and to maintain a higher workload during exercise. This study aimed to investigate the effect of L-carnitine supplementation on muscle fatigue in sciatic nerve-gastrocnemius muscle preparations in sedentary and trained rats. The animals were divided into 4 groups: non-supplemented sedentary (NSS), supplemented sedentary (SS), non-supplemented trained (NST), and supplemented trained (ST) rats. The animals were trained in daily 1-h sessions (5 days/week) and received chronic oral L-carnitine supplementation (1 mg/mL) for 4 weeks. Muscle fatigue was determined by supramaximal tetanic stimulation of the sciatic nerve (50 Hz). Time values for strength reduction were significantly different (p<0.05) between NSS vs. SS and NST vs. ST rats. No significant differences were observed between SS vs. ST and NST vs. NSS rats. These findings demonstrate that L-carnitine lengthen the time required for induction of muscle fatigue. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-04-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion "Avaliado por Pares", Experimental Avaliado por Pares Experimental |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2012v14n3p324 10.1590/1980-0037.2012v14n3p324 |
url |
https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2012v14n3p324 |
identifier_str_mv |
10.1590/1980-0037.2012v14n3p324 |
dc.language.iso.fl_str_mv |
spa |
language |
spa |
dc.relation.none.fl_str_mv |
https://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2012v14n3p324/21742 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Catarina. Florianópolis, SC. Brasil |
publisher.none.fl_str_mv |
Universidade Federal de Santa Catarina. Florianópolis, SC. Brasil |
dc.source.none.fl_str_mv |
Brazilian Journal of Kinanthropometry and Human Performance; Vol. 14 No. 3 (2012); 324-332 Revista Brasileira de Cineantropometria e Desempenho Humano; v. 14 n. 3 (2012); 324-332 1980-0037 1415-8426 reponame:Revista Brasileira de Cineantropometria & Desempenho Humano (Online) instname:Universidade Federal de Santa Catarina (UFSC) instacron:UFSC |
instname_str |
Universidade Federal de Santa Catarina (UFSC) |
instacron_str |
UFSC |
institution |
UFSC |
reponame_str |
Revista Brasileira de Cineantropometria & Desempenho Humano (Online) |
collection |
Revista Brasileira de Cineantropometria & Desempenho Humano (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cineantropometria & Desempenho Humano (Online) - Universidade Federal de Santa Catarina (UFSC) |
repository.mail.fl_str_mv |
rbcdh@contato.ufsc.br || portaldeperiodicos.bu@contato.ufsc.br |
_version_ |
1789435122414518272 |