Lymphocyte polarization: Pathophysiological relevance of Th9 and Th17

• Autor(a) principal: Degasperi, Giovanna Rosa
• Data de Publicação: 2018
• Outros Autores: Camargo, Ricardo Cunha, Ribeiro, Taynara Cristina Silva, Rodrigues, Thais Costa Reis, Barille, Giovanna
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Saúde (Santa Maria)
• Texto Completo: https://periodicos.ufsm.br/revistasaude/article/view/32689
• topic: T-Lymphocytes; Interleukins; Transcription factors; Regulatory T Lymphocytes; Polarização de células T; Interleucinas; Fatores de transcrição; Th17; Th9; Células T reguladoras

The polarization of TCD4+ cells is one of the most important mechanisms of the immune response. Each of the subtypes or cell patterns are derived from the polarization due to the interaction of TCD4+ naive cells as antigens presented by antigen-presenting cells. The expression of certain transcription factors and the production of specific interleukins constitute the identity of each one of them. In addition to the Th1 and Th2 already described, the role of the Th17 and Th9 polarizations are increasingly present in the initiation of several pathologies and are a promising way to outline possible therapeutic strategies. For the bibliographic review of the descriptive exploratory type, the databases Scielo, PubMed, Lilacs and Bireme.