CD4+CD25+ T lymphocytes and regulation of the immune system: perspectives for a pathophysiological understanding of sepsis

Detalhes bibliográficos
Autor(a) principal: Batista, Rodrigo Siqueira
Data de Publicação: 2012
Outros Autores: Gomes, Andréia Patrícia, Azevedo, Sarah Fumian Milward, Vitorino, Rodrigo Roger, Mendonça, Eduardo Gomes de, Sousa, Flávio Oliveira de, Oliveira, Alcione de Paiva, Cerqueira, Fábio Ribeiro, Paula, Sérgio Oliveira de, Oliveira, Maria Goreti de Almeida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: LOCUS Repositório Institucional da UFV
Texto Completo: http://dx.doi.org/10.1590/S0103-507X2012000300014
http://www.locus.ufv.br/handle/123456789/18965
Resumo: The systemic inflammatory response represents the core pathogenic event of sepsis, underlying clinical manifestations and laboratory findings in patients. Numerous studies have shown that CD4+CD25+ T lymphocytes, also known as regulatory T lymphocytes (Treg), participate in the development of sepsis due to their ability to suppress the immune response. The present article discusses the role of Treg lymphocytes in sepsis based on a specific search strategy (Latin American and Caribbean Health Sciences / Literatura Latino-americana e do Caribe em Ciências da Saúde - LILACS, PubMed, and Scientific Electronic Library Online - SciELO) focusing on two main topics: the participation of Treg cells in inflammation and immunity as well as perspectives in the computational physiological investigation of sepsis.
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spelling Batista, Rodrigo SiqueiraGomes, Andréia PatríciaAzevedo, Sarah Fumian MilwardVitorino, Rodrigo RogerMendonça, Eduardo Gomes deSousa, Flávio Oliveira deOliveira, Alcione de PaivaCerqueira, Fábio RibeiroPaula, Sérgio Oliveira deOliveira, Maria Goreti de Almeida2018-04-20T15:31:00Z2018-04-20T15:31:00Z2012-09-281982-4335http://dx.doi.org/10.1590/S0103-507X2012000300014http://www.locus.ufv.br/handle/123456789/18965The systemic inflammatory response represents the core pathogenic event of sepsis, underlying clinical manifestations and laboratory findings in patients. Numerous studies have shown that CD4+CD25+ T lymphocytes, also known as regulatory T lymphocytes (Treg), participate in the development of sepsis due to their ability to suppress the immune response. The present article discusses the role of Treg lymphocytes in sepsis based on a specific search strategy (Latin American and Caribbean Health Sciences / Literatura Latino-americana e do Caribe em Ciências da Saúde - LILACS, PubMed, and Scientific Electronic Library Online - SciELO) focusing on two main topics: the participation of Treg cells in inflammation and immunity as well as perspectives in the computational physiological investigation of sepsis.engRevista Brasileira de Terapia Intensivav. 24, n. 03, p. 294-301, July/Sept. 2012Regulatory T lymphocytesSepsis/pathophysiologySepsis/therapyInflammationImmunityComputer simulationCD4+CD25+ T lymphocytes and regulation of the immune system: perspectives for a pathophysiological understanding of sepsisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfinfo:eu-repo/semantics/openAccessreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINALartigo.pdfartigo.pdfTexto completoapplication/pdf126869https://locus.ufv.br//bitstream/123456789/18965/1/artigo.pdfdd0ec37423aacf3299a192eaa6d72420MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://locus.ufv.br//bitstream/123456789/18965/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILartigo.pdf.jpgartigo.pdf.jpgIM Thumbnailimage/jpeg4436https://locus.ufv.br//bitstream/123456789/18965/3/artigo.pdf.jpg748658479f3ad1aea5dcf8cb3eea2c25MD53123456789/189652018-04-20 23:00:33.194oai:locus.ufv.br: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Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452018-04-21T02:00:33LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false
dc.title.en.fl_str_mv CD4+CD25+ T lymphocytes and regulation of the immune system: perspectives for a pathophysiological understanding of sepsis
title CD4+CD25+ T lymphocytes and regulation of the immune system: perspectives for a pathophysiological understanding of sepsis
spellingShingle CD4+CD25+ T lymphocytes and regulation of the immune system: perspectives for a pathophysiological understanding of sepsis
Batista, Rodrigo Siqueira
Regulatory T lymphocytes
Sepsis/pathophysiology
Sepsis/therapy
Inflammation
Immunity
Computer simulation
title_short CD4+CD25+ T lymphocytes and regulation of the immune system: perspectives for a pathophysiological understanding of sepsis
title_full CD4+CD25+ T lymphocytes and regulation of the immune system: perspectives for a pathophysiological understanding of sepsis
title_fullStr CD4+CD25+ T lymphocytes and regulation of the immune system: perspectives for a pathophysiological understanding of sepsis
title_full_unstemmed CD4+CD25+ T lymphocytes and regulation of the immune system: perspectives for a pathophysiological understanding of sepsis
title_sort CD4+CD25+ T lymphocytes and regulation of the immune system: perspectives for a pathophysiological understanding of sepsis
author Batista, Rodrigo Siqueira
author_facet Batista, Rodrigo Siqueira
Gomes, Andréia Patrícia
Azevedo, Sarah Fumian Milward
Vitorino, Rodrigo Roger
Mendonça, Eduardo Gomes de
Sousa, Flávio Oliveira de
Oliveira, Alcione de Paiva
Cerqueira, Fábio Ribeiro
Paula, Sérgio Oliveira de
Oliveira, Maria Goreti de Almeida
author_role author
author2 Gomes, Andréia Patrícia
Azevedo, Sarah Fumian Milward
Vitorino, Rodrigo Roger
Mendonça, Eduardo Gomes de
Sousa, Flávio Oliveira de
Oliveira, Alcione de Paiva
Cerqueira, Fábio Ribeiro
Paula, Sérgio Oliveira de
Oliveira, Maria Goreti de Almeida
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Batista, Rodrigo Siqueira
Gomes, Andréia Patrícia
Azevedo, Sarah Fumian Milward
Vitorino, Rodrigo Roger
Mendonça, Eduardo Gomes de
Sousa, Flávio Oliveira de
Oliveira, Alcione de Paiva
Cerqueira, Fábio Ribeiro
Paula, Sérgio Oliveira de
Oliveira, Maria Goreti de Almeida
dc.subject.pt-BR.fl_str_mv Regulatory T lymphocytes
Sepsis/pathophysiology
Sepsis/therapy
Inflammation
Immunity
Computer simulation
topic Regulatory T lymphocytes
Sepsis/pathophysiology
Sepsis/therapy
Inflammation
Immunity
Computer simulation
description The systemic inflammatory response represents the core pathogenic event of sepsis, underlying clinical manifestations and laboratory findings in patients. Numerous studies have shown that CD4+CD25+ T lymphocytes, also known as regulatory T lymphocytes (Treg), participate in the development of sepsis due to their ability to suppress the immune response. The present article discusses the role of Treg lymphocytes in sepsis based on a specific search strategy (Latin American and Caribbean Health Sciences / Literatura Latino-americana e do Caribe em Ciências da Saúde - LILACS, PubMed, and Scientific Electronic Library Online - SciELO) focusing on two main topics: the participation of Treg cells in inflammation and immunity as well as perspectives in the computational physiological investigation of sepsis.
publishDate 2012
dc.date.issued.fl_str_mv 2012-09-28
dc.date.accessioned.fl_str_mv 2018-04-20T15:31:00Z
dc.date.available.fl_str_mv 2018-04-20T15:31:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0103-507X2012000300014
http://www.locus.ufv.br/handle/123456789/18965
dc.identifier.issn.none.fl_str_mv 1982-4335
identifier_str_mv 1982-4335
url http://dx.doi.org/10.1590/S0103-507X2012000300014
http://www.locus.ufv.br/handle/123456789/18965
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartofseries.pt-BR.fl_str_mv v. 24, n. 03, p. 294-301, July/Sept. 2012
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Revista Brasileira de Terapia Intensiva
publisher.none.fl_str_mv Revista Brasileira de Terapia Intensiva
dc.source.none.fl_str_mv reponame:LOCUS Repositório Institucional da UFV
instname:Universidade Federal de Viçosa (UFV)
instacron:UFV
instname_str Universidade Federal de Viçosa (UFV)
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reponame_str LOCUS Repositório Institucional da UFV
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