Efeito clínico do plasma rico em plaquetas, autólogo e homólogo, em gel, na cicatrização cutânea em equinos
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional Manancial UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/24292 |
Resumo: | In equine medicine, cutaneous injuries, especially distal limb, are part of the main challenges and their resolutions involve high costs, with impacts both on the individual, reducing their quality of life, and economic, for the breeders and owners of these animals. There are numerous studies demonstrating the use of PRP and its effectiveness in the healing of these injuries, but in these studies the blood of the animal itself to be treated is used, and the PRP is performed at the same time of application. Due to the reality of the veterinarian who works in the field of bringing barriers to the implementation of this process, and its use depending on numerous applications, this study aims to measure the feasibility of using homologous blood to carry out the application of PRP in order to facilitate the completion of the process. The objectives of this study were to evaluate, through macroscopy and microscopy, the healing process of wounds in horses, treated with autologous and homologous PRP. Six horses were selected, 5 animals were submitted to surgical wounds, and in each animal three wounds were made, which were treated with autologous PPR, homologous PRP and saline solution, and the 6th animal served as a universal donor for the treatment with homologous PRP. There was no statistical difference in the reduction of the lesion area at 15 and 30 days of treatment (p > 0.05), even though visually the groups treated with the different forms of PRP were smaller than those of the control group. As for the macroscopic evaluations, no wound presented secretion as well as signs of infection, no animal also presented exuberant granulation tissue. Homologous PRP was as efficient as autologous PRP in its ability to increase wound healing speed, allowing healing of very similar quality and without any adverse effects. |
id |
UFSM-20_501dabd120abee1e123a5b785b10fdcd |
---|---|
oai_identifier_str |
oai:repositorio.ufsm.br:1/24292 |
network_acronym_str |
UFSM-20 |
network_name_str |
Repositório Institucional Manancial UFSM |
repository_id_str |
3913 |
spelling |
2022-05-05T17:52:56Z2022-05-05T17:52:56Z2022-03-10http://repositorio.ufsm.br/handle/1/24292In equine medicine, cutaneous injuries, especially distal limb, are part of the main challenges and their resolutions involve high costs, with impacts both on the individual, reducing their quality of life, and economic, for the breeders and owners of these animals. There are numerous studies demonstrating the use of PRP and its effectiveness in the healing of these injuries, but in these studies the blood of the animal itself to be treated is used, and the PRP is performed at the same time of application. Due to the reality of the veterinarian who works in the field of bringing barriers to the implementation of this process, and its use depending on numerous applications, this study aims to measure the feasibility of using homologous blood to carry out the application of PRP in order to facilitate the completion of the process. The objectives of this study were to evaluate, through macroscopy and microscopy, the healing process of wounds in horses, treated with autologous and homologous PRP. Six horses were selected, 5 animals were submitted to surgical wounds, and in each animal three wounds were made, which were treated with autologous PPR, homologous PRP and saline solution, and the 6th animal served as a universal donor for the treatment with homologous PRP. There was no statistical difference in the reduction of the lesion area at 15 and 30 days of treatment (p > 0.05), even though visually the groups treated with the different forms of PRP were smaller than those of the control group. As for the macroscopic evaluations, no wound presented secretion as well as signs of infection, no animal also presented exuberant granulation tissue. Homologous PRP was as efficient as autologous PRP in its ability to increase wound healing speed, allowing healing of very similar quality and without any adverse effects.Lesões cutâneas, principalmente em porções distais de membros fazem parte dos principais desafios em medicina equina, sendo suas resoluções custosas, com impactos tanto no indivíduo, reduzindo sua qualidade de vida, quanto econômicos, para os criadores e proprietários destes animais. Existem inúmeras pesquisas demonstrando o uso do plasma rico em plaquetas (PRP) e sua eficácia na cicatrização dessas lesões, porém nestas pesquisas utiliza-se o sangue do próprio animal a ser tratado, sendo o PRP realizado no mesmo momento da aplicação. Devido a realidade do Médico veterinário que trabalha a campo trazer barreiras para a realização deste processo, e a sua utilização depender de inúmeras aplicações, este estudo tem a finalidade de mensurar a viabilidade da utilização de sangue homólogo para a realização da aplicação do PRP a fim de facilitar a realização do processo. Os objetivos deste estudo foram avaliar através da macroscopia e microscopia o processo de cicatrização de feridas em equinos, tratadas por PRP autólogo e homólogo. Foram selecionados 6 equinos sendo que 5 animais foram submetidos à realização de feridas de forma cirúrgica, em cada animal foram realizadas três feridas, as quais foram tratadas com PPR autólogo, PRP homólogo e solução fisiológica. O 6º animal serviu de doador universal para o tratamento com PRP homólogo. Não houve diferença estatística na diminuição da área de lesão aos 15 e 30 dias de tratamento (p > 0.05), comparando todos os grupos, mesmo que visualmente os grupos tratados com as diferentes formas de PRP apresentavam-se menores que as do grupo controle. Quanto às avaliações macroscópicas nenhuma ferida apresentou secreção assim como indícios de infecção, nenhum animal apresentou também tecido de granulação exuberante. O PRP homólogo foi tão eficiente quanto o PRP autólogo na capacidade de aumentar a velocidade de cicatrização das feridas, permitindo uma cicatrização de qualidade muito semelhante e sem qualquer efeito adverso.porUniversidade Federal de Santa MariaCentro de Ciências RuraisPrograma de Pós-Graduação em Medicina VeterináriaUFSMBrasilMedicina VeterináriaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessFeridas cutâneasPlasma rico em plaquetasCicatrizaçãoSkin woundsPlatelet-rich plasmaHealingCNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIAEfeito clínico do plasma rico em plaquetas, autólogo e homólogo, em gel, na cicatrização cutânea em equinosClinical effect of platelet rich plasma gel, autologous and homologous, on skin healing in horsesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisDe La Côrte, Flávio Desessardshttp://lattes.cnpq.br/4040388452531898Pereira, Roberta Carneiro da FontouraPozzobon, RicardoAzevedo, Marcos da Silvahttp://lattes.cnpq.br/3181971672235210Mucha, João Vicente Gonçales5005000000076006006006006006007d696fdf-546c-4c47-9f54-d36a1cf7e6b1cc57c8a7-6ec2-40a7-acff-17170842bd2af3f02d04-4339-4be8-b437-4f6f51aecf0c37653533-ef4b-4dce-aa33-e55cfe63b0ccefcaf41a-1b83-4e35-a828-583541d22f79reponame:Repositório Institucional Manancial UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMLICENSElicense.txtlicense.txttext/plain; charset=utf-81956http://repositorio.ufsm.br/bitstream/1/24292/3/license.txt2f0571ecee68693bd5cd3f17c1e075dfMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805http://repositorio.ufsm.br/bitstream/1/24292/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52ORIGINALDIS_PPGMV_2022_MUCHA_JOÃO.pdfDIS_PPGMV_2022_MUCHA_JOÃO.pdfDissertação de mestradoapplication/pdf1145290http://repositorio.ufsm.br/bitstream/1/24292/1/DIS_PPGMV_2022_MUCHA_JO%c3%83O.pdf21231e9eb5c0814deb570e34f9858d9eMD511/242922022-05-05 14:54:20.655oai:repositorio.ufsm.br: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ório Institucionalhttp://repositorio.ufsm.br/PUBhttp://repositorio.ufsm.br/oai/requestouvidoria@ufsm.bropendoar:39132022-05-05T17:54:20Repositório Institucional Manancial UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Efeito clínico do plasma rico em plaquetas, autólogo e homólogo, em gel, na cicatrização cutânea em equinos |
dc.title.alternative.eng.fl_str_mv |
Clinical effect of platelet rich plasma gel, autologous and homologous, on skin healing in horses |
title |
Efeito clínico do plasma rico em plaquetas, autólogo e homólogo, em gel, na cicatrização cutânea em equinos |
spellingShingle |
Efeito clínico do plasma rico em plaquetas, autólogo e homólogo, em gel, na cicatrização cutânea em equinos Mucha, João Vicente Gonçales Feridas cutâneas Plasma rico em plaquetas Cicatrização Skin wounds Platelet-rich plasma Healing CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
title_short |
Efeito clínico do plasma rico em plaquetas, autólogo e homólogo, em gel, na cicatrização cutânea em equinos |
title_full |
Efeito clínico do plasma rico em plaquetas, autólogo e homólogo, em gel, na cicatrização cutânea em equinos |
title_fullStr |
Efeito clínico do plasma rico em plaquetas, autólogo e homólogo, em gel, na cicatrização cutânea em equinos |
title_full_unstemmed |
Efeito clínico do plasma rico em plaquetas, autólogo e homólogo, em gel, na cicatrização cutânea em equinos |
title_sort |
Efeito clínico do plasma rico em plaquetas, autólogo e homólogo, em gel, na cicatrização cutânea em equinos |
author |
Mucha, João Vicente Gonçales |
author_facet |
Mucha, João Vicente Gonçales |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
De La Côrte, Flávio Desessards |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/4040388452531898 |
dc.contributor.advisor-co1.fl_str_mv |
Pereira, Roberta Carneiro da Fontoura |
dc.contributor.referee1.fl_str_mv |
Pozzobon, Ricardo |
dc.contributor.referee2.fl_str_mv |
Azevedo, Marcos da Silva |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/3181971672235210 |
dc.contributor.author.fl_str_mv |
Mucha, João Vicente Gonçales |
contributor_str_mv |
De La Côrte, Flávio Desessards Pereira, Roberta Carneiro da Fontoura Pozzobon, Ricardo Azevedo, Marcos da Silva |
dc.subject.por.fl_str_mv |
Feridas cutâneas Plasma rico em plaquetas Cicatrização |
topic |
Feridas cutâneas Plasma rico em plaquetas Cicatrização Skin wounds Platelet-rich plasma Healing CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
dc.subject.eng.fl_str_mv |
Skin wounds Platelet-rich plasma Healing |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
description |
In equine medicine, cutaneous injuries, especially distal limb, are part of the main challenges and their resolutions involve high costs, with impacts both on the individual, reducing their quality of life, and economic, for the breeders and owners of these animals. There are numerous studies demonstrating the use of PRP and its effectiveness in the healing of these injuries, but in these studies the blood of the animal itself to be treated is used, and the PRP is performed at the same time of application. Due to the reality of the veterinarian who works in the field of bringing barriers to the implementation of this process, and its use depending on numerous applications, this study aims to measure the feasibility of using homologous blood to carry out the application of PRP in order to facilitate the completion of the process. The objectives of this study were to evaluate, through macroscopy and microscopy, the healing process of wounds in horses, treated with autologous and homologous PRP. Six horses were selected, 5 animals were submitted to surgical wounds, and in each animal three wounds were made, which were treated with autologous PPR, homologous PRP and saline solution, and the 6th animal served as a universal donor for the treatment with homologous PRP. There was no statistical difference in the reduction of the lesion area at 15 and 30 days of treatment (p > 0.05), even though visually the groups treated with the different forms of PRP were smaller than those of the control group. As for the macroscopic evaluations, no wound presented secretion as well as signs of infection, no animal also presented exuberant granulation tissue. Homologous PRP was as efficient as autologous PRP in its ability to increase wound healing speed, allowing healing of very similar quality and without any adverse effects. |
publishDate |
2022 |
dc.date.accessioned.fl_str_mv |
2022-05-05T17:52:56Z |
dc.date.available.fl_str_mv |
2022-05-05T17:52:56Z |
dc.date.issued.fl_str_mv |
2022-03-10 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/24292 |
url |
http://repositorio.ufsm.br/handle/1/24292 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
500500000007 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 600 600 |
dc.relation.authority.fl_str_mv |
7d696fdf-546c-4c47-9f54-d36a1cf7e6b1 cc57c8a7-6ec2-40a7-acff-17170842bd2a f3f02d04-4339-4be8-b437-4f6f51aecf0c 37653533-ef4b-4dce-aa33-e55cfe63b0cc efcaf41a-1b83-4e35-a828-583541d22f79 |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências Rurais |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Medicina Veterinária |
dc.publisher.initials.fl_str_mv |
UFSM |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Medicina Veterinária |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências Rurais |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional Manancial UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Repositório Institucional Manancial UFSM |
collection |
Repositório Institucional Manancial UFSM |
bitstream.url.fl_str_mv |
http://repositorio.ufsm.br/bitstream/1/24292/3/license.txt http://repositorio.ufsm.br/bitstream/1/24292/2/license_rdf http://repositorio.ufsm.br/bitstream/1/24292/1/DIS_PPGMV_2022_MUCHA_JO%c3%83O.pdf |
bitstream.checksum.fl_str_mv |
2f0571ecee68693bd5cd3f17c1e075df 4460e5956bc1d1639be9ae6146a50347 21231e9eb5c0814deb570e34f9858d9e |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional Manancial UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
ouvidoria@ufsm.br |
_version_ |
1808854710452486144 |