Potenciais interações medicamentosas no tratamento da leucemia linfóide aguda
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional Manancial UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/28151 |
Resumo: | Leukemia is the most frequent type of cancer in children, being considered the second most common cause of child mortality in Brazil. Acute Lymphocytic Leukemia (ALL) represents 75% of all types of acute leukemia in children. Its treatment is long and complex, being polypharmacy a very common characteristic, what contributes to the occurrence of possible drug interactions. The aim of this study was to carry out an inventory regarding the potential drug interactions that result from the combination of the different pharmacological agents used in the beginning of ALL treatment. It is as descriptive study with quantitative data analysis, and were included all patients admitted to the Pediatric Haemato-Oncology service at Hospital Universitário de Santa Maria, in Santa Maria, Rio Grande do Sul, Brazil, between April 2012 and April 2014, for the treatment of ALL. The daily prescriptions of all participating patients were assessed and all the co-administered medication was included for the analysis of potential drug interactions by using the Micromedexelectronic database. The sample corresponded to 869 prescriptions and 4481 prescribed drugs. Sixty-six distinct drugs were identified and the presence of potential drug interactions was verified in 100% of the samples, in a total of 758 potentially interactive combinations, during the first hospitalization. 60,8% of these combinations were classified as of major severity. Most drugs used belong to the class of anti-infectives, and Sulfamethoxazole/Trimethoprim was the most used drug. It was possible to observe that the entire sample was exposed to polypharmacy and to potentially interactive combinations during the first stage of the treatment, thus evidencing the relationship between polypharmacy and the risk of drug interactions. The confirmation of a significant number of potentially interactive combinations, most of them of major severity, reaffirms the need for the multiprofessional team to improve their practice in the sense of expanding their knowledge regarding this subject, aiming at improving the quality of the service offered and reducing the harm for patients. |
id |
UFSM-20_5e5b0852b5a389b391fcf64016333f59 |
---|---|
oai_identifier_str |
oai:repositorio.ufsm.br:1/28151 |
network_acronym_str |
UFSM-20 |
network_name_str |
Repositório Institucional Manancial UFSM |
repository_id_str |
3913 |
spelling |
2023-03-10T15:12:35Z2023-03-10T15:12:35Z2015-03-31http://repositorio.ufsm.br/handle/1/28151Leukemia is the most frequent type of cancer in children, being considered the second most common cause of child mortality in Brazil. Acute Lymphocytic Leukemia (ALL) represents 75% of all types of acute leukemia in children. Its treatment is long and complex, being polypharmacy a very common characteristic, what contributes to the occurrence of possible drug interactions. The aim of this study was to carry out an inventory regarding the potential drug interactions that result from the combination of the different pharmacological agents used in the beginning of ALL treatment. It is as descriptive study with quantitative data analysis, and were included all patients admitted to the Pediatric Haemato-Oncology service at Hospital Universitário de Santa Maria, in Santa Maria, Rio Grande do Sul, Brazil, between April 2012 and April 2014, for the treatment of ALL. The daily prescriptions of all participating patients were assessed and all the co-administered medication was included for the analysis of potential drug interactions by using the Micromedexelectronic database. The sample corresponded to 869 prescriptions and 4481 prescribed drugs. Sixty-six distinct drugs were identified and the presence of potential drug interactions was verified in 100% of the samples, in a total of 758 potentially interactive combinations, during the first hospitalization. 60,8% of these combinations were classified as of major severity. Most drugs used belong to the class of anti-infectives, and Sulfamethoxazole/Trimethoprim was the most used drug. It was possible to observe that the entire sample was exposed to polypharmacy and to potentially interactive combinations during the first stage of the treatment, thus evidencing the relationship between polypharmacy and the risk of drug interactions. The confirmation of a significant number of potentially interactive combinations, most of them of major severity, reaffirms the need for the multiprofessional team to improve their practice in the sense of expanding their knowledge regarding this subject, aiming at improving the quality of the service offered and reducing the harm for patients.Na infância, as leucemias são os tipos mais frequentes de câncer e este é considerado a segunda causa de morte nessa faixa etária no Brasil. A Leucemia Linfóide Aguda (LLA) representa 75% de todas as leucemias agudas infantis. Seu tratamento é longo e complexo, sendo comum a presença da polifarmácia, o que favorece a ocorência de possíveis interações medicamentosas. Este estudo teve por objetivo identificar potenciais interações decorrentes da combinação dos diferentes agentes farmacológicos utilizados no início do tratamento da LLA. Trata-se de um estudo descritivo, com tratamento quantitativo dos dados. Foram considerados todos os pacientes que internaram no serviço de hemato-oncologia pediátrica do Hospital Universitário de Santa Maria no período de abril de 2012 a abril de 2014, para tratamento de LLA. Foram avaliadas as prescrições diárias de todos os pacientes da amostra e todas as medicações co-administradas foram incluídas para análise de potenciais interações medicamentosas, utilizando-se a base de dados eletrônica Micromedex. A amostra correspondeu a 869 prescrições e um total de 4481 medicamentos prescritos. Foram identificados 66 medicamentos distintos e em 100% da amostra foi constatada presença de potenciais interações medicamentosas, totalizando 758 combinações potencialmente interativas, durante o período da primeira internação. 60,8% dessas combinações foram classificadas como sendo de gavidade maior. A maioria dos medicamentos utilizados pertence a classe dos inti-infecciosos e o fármaco mais usado foi Sulfametoxazol/Trimetoprima. Foi possí vel concluir que a totalidade da amostra foi exposta à polifarmácia e à combinações potencialmente interativas durante a primeira fase do tratamento, evidenciando assim a relação entre polifarmácia e risco de interações medicamentosas. A constatação de um expressivo número de combinações potencialmente interativas, sendo a maioria de gravidade maior, reafirma a necessidade de a equipe multiprofissional aprimorar sua prática, no sentido de ampliar seus conhecimentos a respeito da temática, visando a melhoria da qualidade do serviço prestado e a redução de danos ao paciente.porUniversidade Federal de Santa MariaCentro de Ciências da SaúdePrograma de Pós-Graduação em Ciências da SaúdeUFSMBrasilCiências da SaúdeAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessInterações de medicamentosPolifarmáciaLeucemia linfóide agudaDrug interactionsPolypharmacyAcute lymphocytic leukemiaCNPQ::CIENCIAS DA SAUDEPotenciais interações medicamentosas no tratamento da leucemia linfóide agudaPotential drug interactions in the treatment of acute lymphocytic leukemiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisCampos, Marli Matiko Anraku dehttp://lattes.cnpq.br/6421182991125434Magnago, Tânia Solange Bosi de SouzaBeck, Sandra Trevisanhttp://lattes.cnpq.br/3049977334692822Soccal, Daiana Carvalho400000000001600600600600600ac8e430f-6a47-4d8e-91cd-2fd828e1aa37713ff597-e12e-40b3-a2fa-2fec07da345faaf29c69-343a-4e95-899d-c81ef833fc9fff109cf6-4409-4de1-964c-747a898bcd42reponame:Repositório Institucional Manancial UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALDIS_PPGCS_2015_SOCCAL_DAIANA.pdfDIS_PPGCS_2015_SOCCAL_DAIANA.pdfDissertação de Mestradoapplication/pdf951688http://repositorio.ufsm.br/bitstream/1/28151/1/DIS_PPGCS_2015_SOCCAL_DAIANA.pdfb58aeecac3d55f123f6e939e15fff305MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805http://repositorio.ufsm.br/bitstream/1/28151/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81956http://repositorio.ufsm.br/bitstream/1/28151/3/license.txt2f0571ecee68693bd5cd3f17c1e075dfMD531/281512023-03-10 12:12:35.502oai:repositorio.ufsm.br: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ório Institucionalhttp://repositorio.ufsm.br/PUBhttp://repositorio.ufsm.br/oai/requestouvidoria@ufsm.bropendoar:39132023-03-10T15:12:35Repositório Institucional Manancial UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Potenciais interações medicamentosas no tratamento da leucemia linfóide aguda |
dc.title.alternative.eng.fl_str_mv |
Potential drug interactions in the treatment of acute lymphocytic leukemia |
title |
Potenciais interações medicamentosas no tratamento da leucemia linfóide aguda |
spellingShingle |
Potenciais interações medicamentosas no tratamento da leucemia linfóide aguda Soccal, Daiana Carvalho Interações de medicamentos Polifarmácia Leucemia linfóide aguda Drug interactions Polypharmacy Acute lymphocytic leukemia CNPQ::CIENCIAS DA SAUDE |
title_short |
Potenciais interações medicamentosas no tratamento da leucemia linfóide aguda |
title_full |
Potenciais interações medicamentosas no tratamento da leucemia linfóide aguda |
title_fullStr |
Potenciais interações medicamentosas no tratamento da leucemia linfóide aguda |
title_full_unstemmed |
Potenciais interações medicamentosas no tratamento da leucemia linfóide aguda |
title_sort |
Potenciais interações medicamentosas no tratamento da leucemia linfóide aguda |
author |
Soccal, Daiana Carvalho |
author_facet |
Soccal, Daiana Carvalho |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Campos, Marli Matiko Anraku de |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/6421182991125434 |
dc.contributor.referee1.fl_str_mv |
Magnago, Tânia Solange Bosi de Souza |
dc.contributor.referee2.fl_str_mv |
Beck, Sandra Trevisan |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/3049977334692822 |
dc.contributor.author.fl_str_mv |
Soccal, Daiana Carvalho |
contributor_str_mv |
Campos, Marli Matiko Anraku de Magnago, Tânia Solange Bosi de Souza Beck, Sandra Trevisan |
dc.subject.por.fl_str_mv |
Interações de medicamentos Polifarmácia Leucemia linfóide aguda |
topic |
Interações de medicamentos Polifarmácia Leucemia linfóide aguda Drug interactions Polypharmacy Acute lymphocytic leukemia CNPQ::CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
Drug interactions Polypharmacy Acute lymphocytic leukemia |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS DA SAUDE |
description |
Leukemia is the most frequent type of cancer in children, being considered the second most common cause of child mortality in Brazil. Acute Lymphocytic Leukemia (ALL) represents 75% of all types of acute leukemia in children. Its treatment is long and complex, being polypharmacy a very common characteristic, what contributes to the occurrence of possible drug interactions. The aim of this study was to carry out an inventory regarding the potential drug interactions that result from the combination of the different pharmacological agents used in the beginning of ALL treatment. It is as descriptive study with quantitative data analysis, and were included all patients admitted to the Pediatric Haemato-Oncology service at Hospital Universitário de Santa Maria, in Santa Maria, Rio Grande do Sul, Brazil, between April 2012 and April 2014, for the treatment of ALL. The daily prescriptions of all participating patients were assessed and all the co-administered medication was included for the analysis of potential drug interactions by using the Micromedexelectronic database. The sample corresponded to 869 prescriptions and 4481 prescribed drugs. Sixty-six distinct drugs were identified and the presence of potential drug interactions was verified in 100% of the samples, in a total of 758 potentially interactive combinations, during the first hospitalization. 60,8% of these combinations were classified as of major severity. Most drugs used belong to the class of anti-infectives, and Sulfamethoxazole/Trimethoprim was the most used drug. It was possible to observe that the entire sample was exposed to polypharmacy and to potentially interactive combinations during the first stage of the treatment, thus evidencing the relationship between polypharmacy and the risk of drug interactions. The confirmation of a significant number of potentially interactive combinations, most of them of major severity, reaffirms the need for the multiprofessional team to improve their practice in the sense of expanding their knowledge regarding this subject, aiming at improving the quality of the service offered and reducing the harm for patients. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-03-31 |
dc.date.accessioned.fl_str_mv |
2023-03-10T15:12:35Z |
dc.date.available.fl_str_mv |
2023-03-10T15:12:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/28151 |
url |
http://repositorio.ufsm.br/handle/1/28151 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
400000000001 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 600 |
dc.relation.authority.fl_str_mv |
ac8e430f-6a47-4d8e-91cd-2fd828e1aa37 713ff597-e12e-40b3-a2fa-2fec07da345f aaf29c69-343a-4e95-899d-c81ef833fc9f ff109cf6-4409-4de1-964c-747a898bcd42 |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências da Saúde |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Ciências da Saúde |
dc.publisher.initials.fl_str_mv |
UFSM |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Ciências da Saúde |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências da Saúde |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional Manancial UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Repositório Institucional Manancial UFSM |
collection |
Repositório Institucional Manancial UFSM |
bitstream.url.fl_str_mv |
http://repositorio.ufsm.br/bitstream/1/28151/1/DIS_PPGCS_2015_SOCCAL_DAIANA.pdf http://repositorio.ufsm.br/bitstream/1/28151/2/license_rdf http://repositorio.ufsm.br/bitstream/1/28151/3/license.txt |
bitstream.checksum.fl_str_mv |
b58aeecac3d55f123f6e939e15fff305 4460e5956bc1d1639be9ae6146a50347 2f0571ecee68693bd5cd3f17c1e075df |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional Manancial UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
ouvidoria@ufsm.br |
_version_ |
1808854717057466368 |