Vitamina C no soro e suco gástrico de pacientes dispépticos com e sem infecção por Helicobacter pylori
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Manancial - Repositório Digital da UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/5863 |
Resumo: | Introduction: Helicobater pylori interferes with vitamin C homeostasis and low levels of vitamin C may be a risk factor for H. pylori infection. Objective: to investigate the vitamin C serum and gastric juice levels of patients infected and non-infected by H. pylori. Additionally assess the association of vitamin C levels with H.pylori status, gastric pH and histological changes of gastric mucosa of dyspeptic patients with normal upper GI endoscopy. Methods: We studied 42 dyspeptic patients undergoing upper GI endoscopy had biopsies for diagnosis of H. pylori infection and gastric mucosa changes. We also collected 5 ml of blood (for dosage of serum vitamin C) and 10 ml of gastric juice. We measure pH of gastric juice. We used high-performance liquid chromatography to assess Vitamin C in serum and gastric juice. Results: The average age was 52 years (SD±11.8), 84.4% female, overweight BMI median 27,7) with adequate dietary intake of vitamin C. Twenty four (53.3%) patients had H. pylori infection. The median serum vitamin C levels in infected and non-infected was 3.9 and 3.4 μg (p = 0.59). The median gastric juice levels of vitamin C was 9,8 μg in infected and 18.4 μg in non-infected (p = 0.03). The histology showed normal mucosa in eight 8 (20%), chronic non-atrophic gastritis in 23 (55%) and chronic atrophic gastritis in 11 (26%) patients. There was no significant association of histology with Vitamin C serum levels (p = 0.26) or gastric (p = 0.29). Conclusion: Vitamin C serum levels were within the normal range, and most patients had adequate food ingestion of vitamin C. Serum levels of vitamin C were similar in individuals infected and non-infected while vitamin C levels in the gastric juice of patients infected were reduced compared with patients non-infected. Serum levels of vitamin C were higher in the gastric juice than in serum, regardless the patients were infected or not. |
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2016-11-182016-11-182015-06-10SILVA, Carina Siqueira Martelli da. Vitamin C in the serum and gastric juice of dyspeptic patients with and without Helicobacter pylori infection. 2015. 45 f. Dissertação (Mestrado em Medicina) - Universidade Federal de Santa Maria, Santa Maria, 2015.http://repositorio.ufsm.br/handle/1/5863Introduction: Helicobater pylori interferes with vitamin C homeostasis and low levels of vitamin C may be a risk factor for H. pylori infection. Objective: to investigate the vitamin C serum and gastric juice levels of patients infected and non-infected by H. pylori. Additionally assess the association of vitamin C levels with H.pylori status, gastric pH and histological changes of gastric mucosa of dyspeptic patients with normal upper GI endoscopy. Methods: We studied 42 dyspeptic patients undergoing upper GI endoscopy had biopsies for diagnosis of H. pylori infection and gastric mucosa changes. We also collected 5 ml of blood (for dosage of serum vitamin C) and 10 ml of gastric juice. We measure pH of gastric juice. We used high-performance liquid chromatography to assess Vitamin C in serum and gastric juice. Results: The average age was 52 years (SD±11.8), 84.4% female, overweight BMI median 27,7) with adequate dietary intake of vitamin C. Twenty four (53.3%) patients had H. pylori infection. The median serum vitamin C levels in infected and non-infected was 3.9 and 3.4 μg (p = 0.59). The median gastric juice levels of vitamin C was 9,8 μg in infected and 18.4 μg in non-infected (p = 0.03). The histology showed normal mucosa in eight 8 (20%), chronic non-atrophic gastritis in 23 (55%) and chronic atrophic gastritis in 11 (26%) patients. There was no significant association of histology with Vitamin C serum levels (p = 0.26) or gastric (p = 0.29). Conclusion: Vitamin C serum levels were within the normal range, and most patients had adequate food ingestion of vitamin C. Serum levels of vitamin C were similar in individuals infected and non-infected while vitamin C levels in the gastric juice of patients infected were reduced compared with patients non-infected. Serum levels of vitamin C were higher in the gastric juice than in serum, regardless the patients were infected or not.Introdução: A infecção por Helicobater pylori influencia na homeostase da vitamina C e níveis baixos da mesma podem determinar risco para a infecção. Objetivo: Investigar os níveis de vitamina C no soro e suco gástrico de pacientes infectados e não infectados por H. pylori e estudar sua associação com a infecção, com o pH gástrico e com as alterações anatomopatológicas da mucosa gástrica de pacientes dispépticos funcionais. Métodos: Foram estudados 42 pacientes dispépticos submetidos a endoscopia digestiva alta e biópsia para diagnóstico da infecção por H. pylori e de alterações anatomopatológicas da mucosa gástrica, classificadas de acordo com o Sistema Sidney. Aspirado suco gástrico com mensuração do pH e coleta de 5 ml de sangue para dosagem de vitamina C no soro. A dosagem da Vitamina C no soro e no suco gástrico foi realizada por cromatografia líquida de alta performance. Resultados: A idade média foi de 52 anos (DP±11,8), 84,4% do sexo feminino, com sobrepeso (IMC mediana=27,7), com adequada ingestão alimentar de vitamina C. Vinte e quatro (53,3%) pacientes apresentavam infecção por H. pylori. A mediana dos níveis de vitamina C no soro dos infectados foi 3,9 μg/ml e nos não infectados 3,4 μg/ml (p=0,59). A mediana dos níveis de vitamina C no suco gástrico foi 9,8 μg/ml nos infectados e 18,4 μg/ml nos não infectados (p=0,03). A histologia demonstrou mucosa normal em 8 (20%), gastrite crônica não atrófica em 23 (55%) e gastrite crônica atrófica em 11 (26%) pacientes, sem associação significativa com os níveis séricos (p=0,26) ou gástricos (p=0,29) da vitamina C. Conclusões: O nível sérico da vitamina C nos pacientes estudados esteve dentro dos valores de referência normais e o consumo de vitamina C foi adequado na maioria. Os níveis séricos da vitamina C foram semelhantes em indivíduos infectados e não infectados enquanto os níveis de vitamina C apresentaram-se reduzidos no suco gástrico dos pacientes infectados por H. pylori em comparação com os não infectados. Os níveis séricos de vitamina C foram mais altos no suco gástrico do que no soro, independentemente da condição de infectado ou não.application/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em Ciências da SaúdeUFSMBRMedicinaHelicobacter pyloriConsumo alimentarVitamina CH pyloriFood intakeVitamin CCNPQ::CIENCIAS DA SAUDEVitamina C no soro e suco gástrico de pacientes dispépticos com e sem infecção por Helicobacter pyloriVitamin C in the serum and gastric juice of dyspeptic patients with and without Helicobacter pylori infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisFagundes, Renato Borgeshttp://lattes.cnpq.br/5255286815018611Beck, Sandra Trevisanhttp://lattes.cnpq.br/4435727183593265Comim, Fabio Vasconcelloshttp://lattes.cnpq.br/5119233991388822http://lattes.cnpq.br/3982267745079456Silva, Carina Siqueira Martelli da400000000001400300300300500da89740b-62a5-4e0b-833d-55b5882db2883853b51d-4bfb-49f7-b369-8acba27a1000efc1f94d-0b34-46d2-9c0a-6edf5440f8901251088f-87d7-4b52-baa6-8e5739b3bf79info:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALSILVA, CARINA SIQUEIRA MARTELLI DA.pdfapplication/pdf519731http://repositorio.ufsm.br/bitstream/1/5863/1/SILVA%2c%20CARINA%20SIQUEIRA%20MARTELLI%20DA.pdf1a1603836a2d661d91ddc22c543c6f37MD51TEXTSILVA, CARINA SIQUEIRA MARTELLI DA.pdf.txtSILVA, CARINA SIQUEIRA MARTELLI DA.pdf.txtExtracted texttext/plain71089http://repositorio.ufsm.br/bitstream/1/5863/2/SILVA%2c%20CARINA%20SIQUEIRA%20MARTELLI%20DA.pdf.txt37dc5aec39417a7bdbb5a854cabf4c3eMD52THUMBNAILSILVA, CARINA SIQUEIRA MARTELLI DA.pdf.jpgSILVA, CARINA SIQUEIRA MARTELLI DA.pdf.jpgIM Thumbnailimage/jpeg4315http://repositorio.ufsm.br/bitstream/1/5863/3/SILVA%2c%20CARINA%20SIQUEIRA%20MARTELLI%20DA.pdf.jpg93176eaeac3374df699bbe5463ad968bMD531/58632022-04-12 10:35:44.4oai:repositorio.ufsm.br:1/5863Repositório Institucionalhttp://repositorio.ufsm.br/PUBhttp://repositorio.ufsm.br/oai/requestopendoar:39132022-04-12T13:35:44Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Vitamina C no soro e suco gástrico de pacientes dispépticos com e sem infecção por Helicobacter pylori |
dc.title.alternative.eng.fl_str_mv |
Vitamin C in the serum and gastric juice of dyspeptic patients with and without Helicobacter pylori infection |
title |
Vitamina C no soro e suco gástrico de pacientes dispépticos com e sem infecção por Helicobacter pylori |
spellingShingle |
Vitamina C no soro e suco gástrico de pacientes dispépticos com e sem infecção por Helicobacter pylori Silva, Carina Siqueira Martelli da Helicobacter pylori Consumo alimentar Vitamina C H pylori Food intake Vitamin C CNPQ::CIENCIAS DA SAUDE |
title_short |
Vitamina C no soro e suco gástrico de pacientes dispépticos com e sem infecção por Helicobacter pylori |
title_full |
Vitamina C no soro e suco gástrico de pacientes dispépticos com e sem infecção por Helicobacter pylori |
title_fullStr |
Vitamina C no soro e suco gástrico de pacientes dispépticos com e sem infecção por Helicobacter pylori |
title_full_unstemmed |
Vitamina C no soro e suco gástrico de pacientes dispépticos com e sem infecção por Helicobacter pylori |
title_sort |
Vitamina C no soro e suco gástrico de pacientes dispépticos com e sem infecção por Helicobacter pylori |
author |
Silva, Carina Siqueira Martelli da |
author_facet |
Silva, Carina Siqueira Martelli da |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Fagundes, Renato Borges |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/5255286815018611 |
dc.contributor.referee1.fl_str_mv |
Beck, Sandra Trevisan |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/4435727183593265 |
dc.contributor.referee2.fl_str_mv |
Comim, Fabio Vasconcellos |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/5119233991388822 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/3982267745079456 |
dc.contributor.author.fl_str_mv |
Silva, Carina Siqueira Martelli da |
contributor_str_mv |
Fagundes, Renato Borges Beck, Sandra Trevisan Comim, Fabio Vasconcellos |
dc.subject.por.fl_str_mv |
Helicobacter pylori Consumo alimentar Vitamina C |
topic |
Helicobacter pylori Consumo alimentar Vitamina C H pylori Food intake Vitamin C CNPQ::CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
H pylori Food intake Vitamin C |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS DA SAUDE |
description |
Introduction: Helicobater pylori interferes with vitamin C homeostasis and low levels of vitamin C may be a risk factor for H. pylori infection. Objective: to investigate the vitamin C serum and gastric juice levels of patients infected and non-infected by H. pylori. Additionally assess the association of vitamin C levels with H.pylori status, gastric pH and histological changes of gastric mucosa of dyspeptic patients with normal upper GI endoscopy. Methods: We studied 42 dyspeptic patients undergoing upper GI endoscopy had biopsies for diagnosis of H. pylori infection and gastric mucosa changes. We also collected 5 ml of blood (for dosage of serum vitamin C) and 10 ml of gastric juice. We measure pH of gastric juice. We used high-performance liquid chromatography to assess Vitamin C in serum and gastric juice. Results: The average age was 52 years (SD±11.8), 84.4% female, overweight BMI median 27,7) with adequate dietary intake of vitamin C. Twenty four (53.3%) patients had H. pylori infection. The median serum vitamin C levels in infected and non-infected was 3.9 and 3.4 μg (p = 0.59). The median gastric juice levels of vitamin C was 9,8 μg in infected and 18.4 μg in non-infected (p = 0.03). The histology showed normal mucosa in eight 8 (20%), chronic non-atrophic gastritis in 23 (55%) and chronic atrophic gastritis in 11 (26%) patients. There was no significant association of histology with Vitamin C serum levels (p = 0.26) or gastric (p = 0.29). Conclusion: Vitamin C serum levels were within the normal range, and most patients had adequate food ingestion of vitamin C. Serum levels of vitamin C were similar in individuals infected and non-infected while vitamin C levels in the gastric juice of patients infected were reduced compared with patients non-infected. Serum levels of vitamin C were higher in the gastric juice than in serum, regardless the patients were infected or not. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-06-10 |
dc.date.accessioned.fl_str_mv |
2016-11-18 |
dc.date.available.fl_str_mv |
2016-11-18 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
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masterThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVA, Carina Siqueira Martelli da. Vitamin C in the serum and gastric juice of dyspeptic patients with and without Helicobacter pylori infection. 2015. 45 f. Dissertação (Mestrado em Medicina) - Universidade Federal de Santa Maria, Santa Maria, 2015. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/5863 |
identifier_str_mv |
SILVA, Carina Siqueira Martelli da. Vitamin C in the serum and gastric juice of dyspeptic patients with and without Helicobacter pylori infection. 2015. 45 f. Dissertação (Mestrado em Medicina) - Universidade Federal de Santa Maria, Santa Maria, 2015. |
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http://repositorio.ufsm.br/handle/1/5863 |
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Universidade Federal de Santa Maria |
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UFSM |
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