Effects of meloxicam administered by different routes to control experimental uveitis in dogs
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Ciência Rural |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782009000700024 |
Resumo: | Efficacy of meloxicam, administered by different routes was studied in experimental uveitis in dogs. Anterior chamber paracenteses was accomplished at two different moments (M0 and M1), with a five hour interval among them. At M0 and M1, 0.2mL of aqueous humor was collected and total protein and prostaglandin E2 (PGE2) quantitation was determined. Four groups were formed (n=5), which received meloxicam at the end of M0. by the following routes: subcutaneous (GIm), subconjunctival (GII), and topical (GIII). A fourth group that received no treatment was instituted (Control). Conjunctival histopathology of the GII was performed. Results were evaluated statistically (P≤0.05). In all groups, protein and PGE2 values enhanced significantly in M1. Protein and PGE2 values did not change significantly between groups at M1. Inflammatory exudate of acute character and mild hemorrhage were seen at histopathology, after meloxicam administration. Meloxicam were unable to inhibit PGE2 synthesis and the protein influx to the anterior chamber by any of the tested routes. |
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Ciência rural (Online) |
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Effects of meloxicam administered by different routes to control experimental uveitis in dogsuveitismeloxicamtotal proteinprostaglandin E2dogsEfficacy of meloxicam, administered by different routes was studied in experimental uveitis in dogs. Anterior chamber paracenteses was accomplished at two different moments (M0 and M1), with a five hour interval among them. At M0 and M1, 0.2mL of aqueous humor was collected and total protein and prostaglandin E2 (PGE2) quantitation was determined. Four groups were formed (n=5), which received meloxicam at the end of M0. by the following routes: subcutaneous (GIm), subconjunctival (GII), and topical (GIII). A fourth group that received no treatment was instituted (Control). Conjunctival histopathology of the GII was performed. Results were evaluated statistically (P≤0.05). In all groups, protein and PGE2 values enhanced significantly in M1. Protein and PGE2 values did not change significantly between groups at M1. Inflammatory exudate of acute character and mild hemorrhage were seen at histopathology, after meloxicam administration. Meloxicam were unable to inhibit PGE2 synthesis and the protein influx to the anterior chamber by any of the tested routes.Universidade Federal de Santa Maria2009-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782009000700024Ciência Rural v.39 n.7 2009reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/S0103-84782009005000154info:eu-repo/semantics/openAccessRibeiro,Alexandre PintoEscobar,AndréMotheo,Tathiana FergunsonGodoy,Guilherme SeleraLaus,José Luizeng2009-11-16T00:00:00ZRevista |
dc.title.none.fl_str_mv |
Effects of meloxicam administered by different routes to control experimental uveitis in dogs |
title |
Effects of meloxicam administered by different routes to control experimental uveitis in dogs |
spellingShingle |
Effects of meloxicam administered by different routes to control experimental uveitis in dogs Ribeiro,Alexandre Pinto uveitis meloxicam total protein prostaglandin E2 dogs |
title_short |
Effects of meloxicam administered by different routes to control experimental uveitis in dogs |
title_full |
Effects of meloxicam administered by different routes to control experimental uveitis in dogs |
title_fullStr |
Effects of meloxicam administered by different routes to control experimental uveitis in dogs |
title_full_unstemmed |
Effects of meloxicam administered by different routes to control experimental uveitis in dogs |
title_sort |
Effects of meloxicam administered by different routes to control experimental uveitis in dogs |
author |
Ribeiro,Alexandre Pinto |
author_facet |
Ribeiro,Alexandre Pinto Escobar,André Motheo,Tathiana Fergunson Godoy,Guilherme Selera Laus,José Luiz |
author_role |
author |
author2 |
Escobar,André Motheo,Tathiana Fergunson Godoy,Guilherme Selera Laus,José Luiz |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Ribeiro,Alexandre Pinto Escobar,André Motheo,Tathiana Fergunson Godoy,Guilherme Selera Laus,José Luiz |
dc.subject.por.fl_str_mv |
uveitis meloxicam total protein prostaglandin E2 dogs |
topic |
uveitis meloxicam total protein prostaglandin E2 dogs |
description |
Efficacy of meloxicam, administered by different routes was studied in experimental uveitis in dogs. Anterior chamber paracenteses was accomplished at two different moments (M0 and M1), with a five hour interval among them. At M0 and M1, 0.2mL of aqueous humor was collected and total protein and prostaglandin E2 (PGE2) quantitation was determined. Four groups were formed (n=5), which received meloxicam at the end of M0. by the following routes: subcutaneous (GIm), subconjunctival (GII), and topical (GIII). A fourth group that received no treatment was instituted (Control). Conjunctival histopathology of the GII was performed. Results were evaluated statistically (P≤0.05). In all groups, protein and PGE2 values enhanced significantly in M1. Protein and PGE2 values did not change significantly between groups at M1. Inflammatory exudate of acute character and mild hemorrhage were seen at histopathology, after meloxicam administration. Meloxicam were unable to inhibit PGE2 synthesis and the protein influx to the anterior chamber by any of the tested routes. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782009000700024 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782009000700024 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-84782009005000154 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.source.none.fl_str_mv |
Ciência Rural v.39 n.7 2009 reponame:Ciência Rural instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Ciência Rural |
collection |
Ciência Rural |
repository.name.fl_str_mv |
|
repository.mail.fl_str_mv |
|
_version_ |
1749140534641819648 |