Minimum alveolar concentration of isoflurane in dogs administered a single intramuscular injection of racemic or S (+)-ketamine after premedication with acepromazine-morphine

Detalhes bibliográficos
Autor(a) principal: Bressan,Thais Feres
Data de Publicação: 2017
Outros Autores: Monteiro,Eduardo Raposo, Coelho,Karina, Monteiro,Betânia Souza, Campagnol,Daniela
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Ciência Rural
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000100601
Resumo: ABSTRACT: The present study evaluated the minimum alveolar concentration of isoflurane (ISOMAC) in twenty three dogs premedicated with acepromazine (0.02mgkg-1) and morphine (0.5mgkg-1) and administered racemic (RK) or S(+)-ketamine (SK). Dogs randomly received a single dose (3mgkg-1, IM) of either RK or SK 15minutes after anesthetic induction with propofol. The ISOMAC was determined by the up-and-down method. Approximately 20 minutes after administration of RK or SK, a surgical noxious stimulus was applied and the response evaluated. The ISOMAC was 0.50±0.01% in the RK group (n=10) and 0.31±0.04% in the SK group (n=13). The ISOMAC was 38% lower in the SK group compared to the RK group. Results of the present study revealed that in dogs premedicated with acepromazine and morphine, IM administration of 3mgkg-1 ketamine approximately 20 minutes before the noxious stimulus produced clinically important reduction in the ISOMAC and the MAC-sparing effect was significantly greater with SK compared to RK.
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spelling Minimum alveolar concentration of isoflurane in dogs administered a single intramuscular injection of racemic or S (+)-ketamine after premedication with acepromazine-morphinedissociative anesthesiaMACNMDA antagonistphencyclidine derivativepreemptive analgesiaABSTRACT: The present study evaluated the minimum alveolar concentration of isoflurane (ISOMAC) in twenty three dogs premedicated with acepromazine (0.02mgkg-1) and morphine (0.5mgkg-1) and administered racemic (RK) or S(+)-ketamine (SK). Dogs randomly received a single dose (3mgkg-1, IM) of either RK or SK 15minutes after anesthetic induction with propofol. The ISOMAC was determined by the up-and-down method. Approximately 20 minutes after administration of RK or SK, a surgical noxious stimulus was applied and the response evaluated. The ISOMAC was 0.50±0.01% in the RK group (n=10) and 0.31±0.04% in the SK group (n=13). The ISOMAC was 38% lower in the SK group compared to the RK group. Results of the present study revealed that in dogs premedicated with acepromazine and morphine, IM administration of 3mgkg-1 ketamine approximately 20 minutes before the noxious stimulus produced clinically important reduction in the ISOMAC and the MAC-sparing effect was significantly greater with SK compared to RK.Universidade Federal de Santa Maria2017-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000100601Ciência Rural v.47 n.1 2017reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/0103-8478cr20160027info:eu-repo/semantics/openAccessBressan,Thais FeresMonteiro,Eduardo RaposoCoelho,KarinaMonteiro,Betânia SouzaCampagnol,Danielaeng2016-11-21T00:00:00ZRevista
dc.title.none.fl_str_mv Minimum alveolar concentration of isoflurane in dogs administered a single intramuscular injection of racemic or S (+)-ketamine after premedication with acepromazine-morphine
title Minimum alveolar concentration of isoflurane in dogs administered a single intramuscular injection of racemic or S (+)-ketamine after premedication with acepromazine-morphine
spellingShingle Minimum alveolar concentration of isoflurane in dogs administered a single intramuscular injection of racemic or S (+)-ketamine after premedication with acepromazine-morphine
Bressan,Thais Feres
dissociative anesthesia
MAC
NMDA antagonist
phencyclidine derivative
preemptive analgesia
title_short Minimum alveolar concentration of isoflurane in dogs administered a single intramuscular injection of racemic or S (+)-ketamine after premedication with acepromazine-morphine
title_full Minimum alveolar concentration of isoflurane in dogs administered a single intramuscular injection of racemic or S (+)-ketamine after premedication with acepromazine-morphine
title_fullStr Minimum alveolar concentration of isoflurane in dogs administered a single intramuscular injection of racemic or S (+)-ketamine after premedication with acepromazine-morphine
title_full_unstemmed Minimum alveolar concentration of isoflurane in dogs administered a single intramuscular injection of racemic or S (+)-ketamine after premedication with acepromazine-morphine
title_sort Minimum alveolar concentration of isoflurane in dogs administered a single intramuscular injection of racemic or S (+)-ketamine after premedication with acepromazine-morphine
author Bressan,Thais Feres
author_facet Bressan,Thais Feres
Monteiro,Eduardo Raposo
Coelho,Karina
Monteiro,Betânia Souza
Campagnol,Daniela
author_role author
author2 Monteiro,Eduardo Raposo
Coelho,Karina
Monteiro,Betânia Souza
Campagnol,Daniela
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Bressan,Thais Feres
Monteiro,Eduardo Raposo
Coelho,Karina
Monteiro,Betânia Souza
Campagnol,Daniela
dc.subject.por.fl_str_mv dissociative anesthesia
MAC
NMDA antagonist
phencyclidine derivative
preemptive analgesia
topic dissociative anesthesia
MAC
NMDA antagonist
phencyclidine derivative
preemptive analgesia
description ABSTRACT: The present study evaluated the minimum alveolar concentration of isoflurane (ISOMAC) in twenty three dogs premedicated with acepromazine (0.02mgkg-1) and morphine (0.5mgkg-1) and administered racemic (RK) or S(+)-ketamine (SK). Dogs randomly received a single dose (3mgkg-1, IM) of either RK or SK 15minutes after anesthetic induction with propofol. The ISOMAC was determined by the up-and-down method. Approximately 20 minutes after administration of RK or SK, a surgical noxious stimulus was applied and the response evaluated. The ISOMAC was 0.50±0.01% in the RK group (n=10) and 0.31±0.04% in the SK group (n=13). The ISOMAC was 38% lower in the SK group compared to the RK group. Results of the present study revealed that in dogs premedicated with acepromazine and morphine, IM administration of 3mgkg-1 ketamine approximately 20 minutes before the noxious stimulus produced clinically important reduction in the ISOMAC and the MAC-sparing effect was significantly greater with SK compared to RK.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000100601
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000100601
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0103-8478cr20160027
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
publisher.none.fl_str_mv Universidade Federal de Santa Maria
dc.source.none.fl_str_mv Ciência Rural v.47 n.1 2017
reponame:Ciência Rural
instname:Universidade Federal de Santa Maria (UFSM)
instacron:UFSM
instname_str Universidade Federal de Santa Maria (UFSM)
instacron_str UFSM
institution UFSM
reponame_str Ciência Rural
collection Ciência Rural
repository.name.fl_str_mv
repository.mail.fl_str_mv
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