Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Ciência Rural |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000100114 |
Resumo: | ABSTRACT: The present study provides the first information about the safety of a new influenza viral vector vaccine expressing the Brucella ribosomal protein L7/L12 or Omp16 containing the adjuvant Montanide Gel01 in pregnant heifers. Immunization of pregnant heifers was conducted via the conjunctival (n=10) or subcutaneous (n=10) route using cross prime and booster vaccination schedules at an interval of 28 days. The vector vaccine was evaluated in comparison with positive control groups vaccinated with B. abortus S19 (n=10) or B. abortus RB51 (n=10) and a negative (PBS+Montanide Gel01; n=10) control group. Clinical studies, thermometry, assessment of local reactogenicity and observation of abortion showed that the vector vaccine via the conjunctival or subcutaneous route was completely safe for pregnant heifers compared to the commercial vaccines B. abortus S19 or B. abortus RB51. The only single adverse event was the formation of infiltration at the site of subcutaneous injection; this reaction was not observed for the conjunctival route. |
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Ciência rural (Online) |
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Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifersBrucella abortusvaccineinfluenza viral vectorsafetypregnant heiferthermometryreactogenicityabortionABSTRACT: The present study provides the first information about the safety of a new influenza viral vector vaccine expressing the Brucella ribosomal protein L7/L12 or Omp16 containing the adjuvant Montanide Gel01 in pregnant heifers. Immunization of pregnant heifers was conducted via the conjunctival (n=10) or subcutaneous (n=10) route using cross prime and booster vaccination schedules at an interval of 28 days. The vector vaccine was evaluated in comparison with positive control groups vaccinated with B. abortus S19 (n=10) or B. abortus RB51 (n=10) and a negative (PBS+Montanide Gel01; n=10) control group. Clinical studies, thermometry, assessment of local reactogenicity and observation of abortion showed that the vector vaccine via the conjunctival or subcutaneous route was completely safe for pregnant heifers compared to the commercial vaccines B. abortus S19 or B. abortus RB51. The only single adverse event was the formation of infiltration at the site of subcutaneous injection; this reaction was not observed for the conjunctival route.Universidade Federal de Santa Maria2016-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000100114Ciência Rural v.46 n.1 2016reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/0103-8478cr20150497info:eu-repo/semantics/openAccessTabynov,KaissarRyskeldinova,SholpanKydyrbayev,ZhailaubaySansyzbay,Abylaieng2016-01-20T00:00:00ZRevista |
dc.title.none.fl_str_mv |
Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers |
title |
Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers |
spellingShingle |
Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers Tabynov,Kaissar Brucella abortus vaccine influenza viral vector safety pregnant heifer thermometry reactogenicity abortion |
title_short |
Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers |
title_full |
Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers |
title_fullStr |
Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers |
title_full_unstemmed |
Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers |
title_sort |
Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers |
author |
Tabynov,Kaissar |
author_facet |
Tabynov,Kaissar Ryskeldinova,Sholpan Kydyrbayev,Zhailaubay Sansyzbay,Abylai |
author_role |
author |
author2 |
Ryskeldinova,Sholpan Kydyrbayev,Zhailaubay Sansyzbay,Abylai |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Tabynov,Kaissar Ryskeldinova,Sholpan Kydyrbayev,Zhailaubay Sansyzbay,Abylai |
dc.subject.por.fl_str_mv |
Brucella abortus vaccine influenza viral vector safety pregnant heifer thermometry reactogenicity abortion |
topic |
Brucella abortus vaccine influenza viral vector safety pregnant heifer thermometry reactogenicity abortion |
description |
ABSTRACT: The present study provides the first information about the safety of a new influenza viral vector vaccine expressing the Brucella ribosomal protein L7/L12 or Omp16 containing the adjuvant Montanide Gel01 in pregnant heifers. Immunization of pregnant heifers was conducted via the conjunctival (n=10) or subcutaneous (n=10) route using cross prime and booster vaccination schedules at an interval of 28 days. The vector vaccine was evaluated in comparison with positive control groups vaccinated with B. abortus S19 (n=10) or B. abortus RB51 (n=10) and a negative (PBS+Montanide Gel01; n=10) control group. Clinical studies, thermometry, assessment of local reactogenicity and observation of abortion showed that the vector vaccine via the conjunctival or subcutaneous route was completely safe for pregnant heifers compared to the commercial vaccines B. abortus S19 or B. abortus RB51. The only single adverse event was the formation of infiltration at the site of subcutaneous injection; this reaction was not observed for the conjunctival route. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000100114 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000100114 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0103-8478cr20150497 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.source.none.fl_str_mv |
Ciência Rural v.46 n.1 2016 reponame:Ciência Rural instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Ciência Rural |
collection |
Ciência Rural |
repository.name.fl_str_mv |
|
repository.mail.fl_str_mv |
|
_version_ |
1749140548581588992 |