Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine joints

Detalhes bibliográficos
Autor(a) principal: Moreira,Juliana Junqueira
Data de Publicação: 2019
Outros Autores: Coelho,Joyce Martins, Machado,Thais Sodré Lima, Morais,Ana Paula Lopes, Michelacci,Yara Maria, Baccarin,Raquel Yvonne Arantes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Ciência Rural
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000900602
Resumo: ABSTRACT: Several studies, mainly in vitro, have shown that chondroitin sulfate (CS) and glucosamine (GlcN) do have chondro protective and anti-inflammatory actions. The aim of the present study was to investigate whether oral CS/GlcN supplementation has effects on the CS, hyaluronic acid (HA) and prostaglandin E2 (PGE2) concentrations on synovial fluid of equine osteoarthritic joints. Horses with mild osteoarthritis (OA) in tibiotarsal joint received daily PO doses of CS and GlcN (2.8/3.1 g) for 25 days. Synovial fluid (SF) and urine samples were collected before treatment (day 0), and every 7 days, until day 55 (30 days after the end of treatment). Urinary CS increased upon oral treatment, indicating that this compound was systemically distributed. Concerning the SF, CS concentration increased after the end of the treatment and returning to baseline afterwards, while HA and PGE2 concentrations did not change. Despite the systemic distribution, oral supplementation of CS/GlcNfor 25 days was insufficient as an anti-inflammatory support. However, it is possible to infer that there was an anabolic effect upon cartilage matrix.
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spelling Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine jointschondroitin sulfatehorseglucosamineosteoarthritissynovial fluidABSTRACT: Several studies, mainly in vitro, have shown that chondroitin sulfate (CS) and glucosamine (GlcN) do have chondro protective and anti-inflammatory actions. The aim of the present study was to investigate whether oral CS/GlcN supplementation has effects on the CS, hyaluronic acid (HA) and prostaglandin E2 (PGE2) concentrations on synovial fluid of equine osteoarthritic joints. Horses with mild osteoarthritis (OA) in tibiotarsal joint received daily PO doses of CS and GlcN (2.8/3.1 g) for 25 days. Synovial fluid (SF) and urine samples were collected before treatment (day 0), and every 7 days, until day 55 (30 days after the end of treatment). Urinary CS increased upon oral treatment, indicating that this compound was systemically distributed. Concerning the SF, CS concentration increased after the end of the treatment and returning to baseline afterwards, while HA and PGE2 concentrations did not change. Despite the systemic distribution, oral supplementation of CS/GlcNfor 25 days was insufficient as an anti-inflammatory support. However, it is possible to infer that there was an anabolic effect upon cartilage matrix.Universidade Federal de Santa Maria2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000900602Ciência Rural v.49 n.9 2019reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/0103-8478cr20180247info:eu-repo/semantics/openAccessMoreira,Juliana JunqueiraCoelho,Joyce MartinsMachado,Thais Sodré LimaMorais,Ana Paula LopesMichelacci,Yara MariaBaccarin,Raquel Yvonne Aranteseng2019-09-19T00:00:00ZRevista
dc.title.none.fl_str_mv Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine joints
title Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine joints
spellingShingle Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine joints
Moreira,Juliana Junqueira
chondroitin sulfate
horse
glucosamine
osteoarthritis
synovial fluid
title_short Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine joints
title_full Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine joints
title_fullStr Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine joints
title_full_unstemmed Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine joints
title_sort Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine joints
author Moreira,Juliana Junqueira
author_facet Moreira,Juliana Junqueira
Coelho,Joyce Martins
Machado,Thais Sodré Lima
Morais,Ana Paula Lopes
Michelacci,Yara Maria
Baccarin,Raquel Yvonne Arantes
author_role author
author2 Coelho,Joyce Martins
Machado,Thais Sodré Lima
Morais,Ana Paula Lopes
Michelacci,Yara Maria
Baccarin,Raquel Yvonne Arantes
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Moreira,Juliana Junqueira
Coelho,Joyce Martins
Machado,Thais Sodré Lima
Morais,Ana Paula Lopes
Michelacci,Yara Maria
Baccarin,Raquel Yvonne Arantes
dc.subject.por.fl_str_mv chondroitin sulfate
horse
glucosamine
osteoarthritis
synovial fluid
topic chondroitin sulfate
horse
glucosamine
osteoarthritis
synovial fluid
description ABSTRACT: Several studies, mainly in vitro, have shown that chondroitin sulfate (CS) and glucosamine (GlcN) do have chondro protective and anti-inflammatory actions. The aim of the present study was to investigate whether oral CS/GlcN supplementation has effects on the CS, hyaluronic acid (HA) and prostaglandin E2 (PGE2) concentrations on synovial fluid of equine osteoarthritic joints. Horses with mild osteoarthritis (OA) in tibiotarsal joint received daily PO doses of CS and GlcN (2.8/3.1 g) for 25 days. Synovial fluid (SF) and urine samples were collected before treatment (day 0), and every 7 days, until day 55 (30 days after the end of treatment). Urinary CS increased upon oral treatment, indicating that this compound was systemically distributed. Concerning the SF, CS concentration increased after the end of the treatment and returning to baseline afterwards, while HA and PGE2 concentrations did not change. Despite the systemic distribution, oral supplementation of CS/GlcNfor 25 days was insufficient as an anti-inflammatory support. However, it is possible to infer that there was an anabolic effect upon cartilage matrix.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000900602
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000900602
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0103-8478cr20180247
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
publisher.none.fl_str_mv Universidade Federal de Santa Maria
dc.source.none.fl_str_mv Ciência Rural v.49 n.9 2019
reponame:Ciência Rural
instname:Universidade Federal de Santa Maria (UFSM)
instacron:UFSM
instname_str Universidade Federal de Santa Maria (UFSM)
instacron_str UFSM
institution UFSM
reponame_str Ciência Rural
collection Ciência Rural
repository.name.fl_str_mv
repository.mail.fl_str_mv
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