Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine joints
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Ciência Rural |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000900602 |
Resumo: | ABSTRACT: Several studies, mainly in vitro, have shown that chondroitin sulfate (CS) and glucosamine (GlcN) do have chondro protective and anti-inflammatory actions. The aim of the present study was to investigate whether oral CS/GlcN supplementation has effects on the CS, hyaluronic acid (HA) and prostaglandin E2 (PGE2) concentrations on synovial fluid of equine osteoarthritic joints. Horses with mild osteoarthritis (OA) in tibiotarsal joint received daily PO doses of CS and GlcN (2.8/3.1 g) for 25 days. Synovial fluid (SF) and urine samples were collected before treatment (day 0), and every 7 days, until day 55 (30 days after the end of treatment). Urinary CS increased upon oral treatment, indicating that this compound was systemically distributed. Concerning the SF, CS concentration increased after the end of the treatment and returning to baseline afterwards, while HA and PGE2 concentrations did not change. Despite the systemic distribution, oral supplementation of CS/GlcNfor 25 days was insufficient as an anti-inflammatory support. However, it is possible to infer that there was an anabolic effect upon cartilage matrix. |
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Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine jointschondroitin sulfatehorseglucosamineosteoarthritissynovial fluidABSTRACT: Several studies, mainly in vitro, have shown that chondroitin sulfate (CS) and glucosamine (GlcN) do have chondro protective and anti-inflammatory actions. The aim of the present study was to investigate whether oral CS/GlcN supplementation has effects on the CS, hyaluronic acid (HA) and prostaglandin E2 (PGE2) concentrations on synovial fluid of equine osteoarthritic joints. Horses with mild osteoarthritis (OA) in tibiotarsal joint received daily PO doses of CS and GlcN (2.8/3.1 g) for 25 days. Synovial fluid (SF) and urine samples were collected before treatment (day 0), and every 7 days, until day 55 (30 days after the end of treatment). Urinary CS increased upon oral treatment, indicating that this compound was systemically distributed. Concerning the SF, CS concentration increased after the end of the treatment and returning to baseline afterwards, while HA and PGE2 concentrations did not change. Despite the systemic distribution, oral supplementation of CS/GlcNfor 25 days was insufficient as an anti-inflammatory support. However, it is possible to infer that there was an anabolic effect upon cartilage matrix.Universidade Federal de Santa Maria2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000900602Ciência Rural v.49 n.9 2019reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/0103-8478cr20180247info:eu-repo/semantics/openAccessMoreira,Juliana JunqueiraCoelho,Joyce MartinsMachado,Thais Sodré LimaMorais,Ana Paula LopesMichelacci,Yara MariaBaccarin,Raquel Yvonne Aranteseng2019-09-19T00:00:00ZRevista |
dc.title.none.fl_str_mv |
Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine joints |
title |
Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine joints |
spellingShingle |
Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine joints Moreira,Juliana Junqueira chondroitin sulfate horse glucosamine osteoarthritis synovial fluid |
title_short |
Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine joints |
title_full |
Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine joints |
title_fullStr |
Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine joints |
title_full_unstemmed |
Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine joints |
title_sort |
Oral glucosamine and chondroitin sulfate on synovial fluid biomarkers from osteoarthritic equine joints |
author |
Moreira,Juliana Junqueira |
author_facet |
Moreira,Juliana Junqueira Coelho,Joyce Martins Machado,Thais Sodré Lima Morais,Ana Paula Lopes Michelacci,Yara Maria Baccarin,Raquel Yvonne Arantes |
author_role |
author |
author2 |
Coelho,Joyce Martins Machado,Thais Sodré Lima Morais,Ana Paula Lopes Michelacci,Yara Maria Baccarin,Raquel Yvonne Arantes |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Moreira,Juliana Junqueira Coelho,Joyce Martins Machado,Thais Sodré Lima Morais,Ana Paula Lopes Michelacci,Yara Maria Baccarin,Raquel Yvonne Arantes |
dc.subject.por.fl_str_mv |
chondroitin sulfate horse glucosamine osteoarthritis synovial fluid |
topic |
chondroitin sulfate horse glucosamine osteoarthritis synovial fluid |
description |
ABSTRACT: Several studies, mainly in vitro, have shown that chondroitin sulfate (CS) and glucosamine (GlcN) do have chondro protective and anti-inflammatory actions. The aim of the present study was to investigate whether oral CS/GlcN supplementation has effects on the CS, hyaluronic acid (HA) and prostaglandin E2 (PGE2) concentrations on synovial fluid of equine osteoarthritic joints. Horses with mild osteoarthritis (OA) in tibiotarsal joint received daily PO doses of CS and GlcN (2.8/3.1 g) for 25 days. Synovial fluid (SF) and urine samples were collected before treatment (day 0), and every 7 days, until day 55 (30 days after the end of treatment). Urinary CS increased upon oral treatment, indicating that this compound was systemically distributed. Concerning the SF, CS concentration increased after the end of the treatment and returning to baseline afterwards, while HA and PGE2 concentrations did not change. Despite the systemic distribution, oral supplementation of CS/GlcNfor 25 days was insufficient as an anti-inflammatory support. However, it is possible to infer that there was an anabolic effect upon cartilage matrix. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000900602 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000900602 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0103-8478cr20180247 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.source.none.fl_str_mv |
Ciência Rural v.49 n.9 2019 reponame:Ciência Rural instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Ciência Rural |
collection |
Ciência Rural |
repository.name.fl_str_mv |
|
repository.mail.fl_str_mv |
|
_version_ |
1749140553967075328 |