In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs

Detalhes bibliográficos
Autor(a) principal: González,Luis Bustos
Data de Publicação: 2021
Outros Autores: Simirgiotis,Mario Juan, Parra,Claudio, Alfaro-Lira,Susana, Soto,Emilio, Echiburú-Chau,Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Ciência Rural
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000100402
Resumo: ABSTRACT: Cancer is still one of the leading causes of death worldwide. Many chemotherapeutics from plants have been tested in cancer, such as vinblastine and paclitaxel. The north of Chile, Arica & Parinacota region, is characterized by its vegetal biodiversity due to its unique geographical and climatological conditions, offering an unexplored and unique source of naturally-derived compounds. The present research has considered a screening of 26 highland herbs using an in vitro growth inhibition model in a panel of six cancer cell lines from different tissues. 5 of the 26 studied ethanolic extracts shows strong activity at least in one cell line when tested at 10 µg mL-1. We present a group of plants worthy to be evaluated as promissory extracts. This work is part of the systematic attempt to find new candidates to be used in cancer therapies.
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spelling In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubsGrowth Inhibitionanticancer activityhighland medicinal plantsethanolic extractbioprospectingnorthern ChileArica y ParinacotaABSTRACT: Cancer is still one of the leading causes of death worldwide. Many chemotherapeutics from plants have been tested in cancer, such as vinblastine and paclitaxel. The north of Chile, Arica & Parinacota region, is characterized by its vegetal biodiversity due to its unique geographical and climatological conditions, offering an unexplored and unique source of naturally-derived compounds. The present research has considered a screening of 26 highland herbs using an in vitro growth inhibition model in a panel of six cancer cell lines from different tissues. 5 of the 26 studied ethanolic extracts shows strong activity at least in one cell line when tested at 10 µg mL-1. We present a group of plants worthy to be evaluated as promissory extracts. This work is part of the systematic attempt to find new candidates to be used in cancer therapies.Universidade Federal de Santa Maria2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000100402Ciência Rural v.51 n.1 2021reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/0103-8478cr20190757info:eu-repo/semantics/openAccessGonzález,Luis BustosSimirgiotis,Mario JuanParra,ClaudioAlfaro-Lira,SusanaSoto,EmilioEchiburú-Chau,Carloseng2020-12-07T00:00:00ZRevista
dc.title.none.fl_str_mv In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs
title In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs
spellingShingle In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs
González,Luis Bustos
Growth Inhibition
anticancer activity
highland medicinal plants
ethanolic extract
bioprospecting
northern Chile
Arica y Parinacota
title_short In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs
title_full In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs
title_fullStr In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs
title_full_unstemmed In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs
title_sort In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs
author González,Luis Bustos
author_facet González,Luis Bustos
Simirgiotis,Mario Juan
Parra,Claudio
Alfaro-Lira,Susana
Soto,Emilio
Echiburú-Chau,Carlos
author_role author
author2 Simirgiotis,Mario Juan
Parra,Claudio
Alfaro-Lira,Susana
Soto,Emilio
Echiburú-Chau,Carlos
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv González,Luis Bustos
Simirgiotis,Mario Juan
Parra,Claudio
Alfaro-Lira,Susana
Soto,Emilio
Echiburú-Chau,Carlos
dc.subject.por.fl_str_mv Growth Inhibition
anticancer activity
highland medicinal plants
ethanolic extract
bioprospecting
northern Chile
Arica y Parinacota
topic Growth Inhibition
anticancer activity
highland medicinal plants
ethanolic extract
bioprospecting
northern Chile
Arica y Parinacota
description ABSTRACT: Cancer is still one of the leading causes of death worldwide. Many chemotherapeutics from plants have been tested in cancer, such as vinblastine and paclitaxel. The north of Chile, Arica & Parinacota region, is characterized by its vegetal biodiversity due to its unique geographical and climatological conditions, offering an unexplored and unique source of naturally-derived compounds. The present research has considered a screening of 26 highland herbs using an in vitro growth inhibition model in a panel of six cancer cell lines from different tissues. 5 of the 26 studied ethanolic extracts shows strong activity at least in one cell line when tested at 10 µg mL-1. We present a group of plants worthy to be evaluated as promissory extracts. This work is part of the systematic attempt to find new candidates to be used in cancer therapies.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000100402
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000100402
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0103-8478cr20190757
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
publisher.none.fl_str_mv Universidade Federal de Santa Maria
dc.source.none.fl_str_mv Ciência Rural v.51 n.1 2021
reponame:Ciência Rural
instname:Universidade Federal de Santa Maria (UFSM)
instacron:UFSM
instname_str Universidade Federal de Santa Maria (UFSM)
instacron_str UFSM
institution UFSM
reponame_str Ciência Rural
collection Ciência Rural
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1749140555266260992

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