In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Ciência Rural |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000100402 |
Resumo: | ABSTRACT: Cancer is still one of the leading causes of death worldwide. Many chemotherapeutics from plants have been tested in cancer, such as vinblastine and paclitaxel. The north of Chile, Arica & Parinacota region, is characterized by its vegetal biodiversity due to its unique geographical and climatological conditions, offering an unexplored and unique source of naturally-derived compounds. The present research has considered a screening of 26 highland herbs using an in vitro growth inhibition model in a panel of six cancer cell lines from different tissues. 5 of the 26 studied ethanolic extracts shows strong activity at least in one cell line when tested at 10 µg mL-1. We present a group of plants worthy to be evaluated as promissory extracts. This work is part of the systematic attempt to find new candidates to be used in cancer therapies. |
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In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubsGrowth Inhibitionanticancer activityhighland medicinal plantsethanolic extractbioprospectingnorthern ChileArica y ParinacotaABSTRACT: Cancer is still one of the leading causes of death worldwide. Many chemotherapeutics from plants have been tested in cancer, such as vinblastine and paclitaxel. The north of Chile, Arica & Parinacota region, is characterized by its vegetal biodiversity due to its unique geographical and climatological conditions, offering an unexplored and unique source of naturally-derived compounds. The present research has considered a screening of 26 highland herbs using an in vitro growth inhibition model in a panel of six cancer cell lines from different tissues. 5 of the 26 studied ethanolic extracts shows strong activity at least in one cell line when tested at 10 µg mL-1. We present a group of plants worthy to be evaluated as promissory extracts. This work is part of the systematic attempt to find new candidates to be used in cancer therapies.Universidade Federal de Santa Maria2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000100402Ciência Rural v.51 n.1 2021reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/0103-8478cr20190757info:eu-repo/semantics/openAccessGonzález,Luis BustosSimirgiotis,Mario JuanParra,ClaudioAlfaro-Lira,SusanaSoto,EmilioEchiburú-Chau,Carloseng2020-12-07T00:00:00ZRevista |
dc.title.none.fl_str_mv |
In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs |
title |
In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs |
spellingShingle |
In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs González,Luis Bustos Growth Inhibition anticancer activity highland medicinal plants ethanolic extract bioprospecting northern Chile Arica y Parinacota |
title_short |
In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs |
title_full |
In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs |
title_fullStr |
In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs |
title_full_unstemmed |
In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs |
title_sort |
In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs |
author |
González,Luis Bustos |
author_facet |
González,Luis Bustos Simirgiotis,Mario Juan Parra,Claudio Alfaro-Lira,Susana Soto,Emilio Echiburú-Chau,Carlos |
author_role |
author |
author2 |
Simirgiotis,Mario Juan Parra,Claudio Alfaro-Lira,Susana Soto,Emilio Echiburú-Chau,Carlos |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
González,Luis Bustos Simirgiotis,Mario Juan Parra,Claudio Alfaro-Lira,Susana Soto,Emilio Echiburú-Chau,Carlos |
dc.subject.por.fl_str_mv |
Growth Inhibition anticancer activity highland medicinal plants ethanolic extract bioprospecting northern Chile Arica y Parinacota |
topic |
Growth Inhibition anticancer activity highland medicinal plants ethanolic extract bioprospecting northern Chile Arica y Parinacota |
description |
ABSTRACT: Cancer is still one of the leading causes of death worldwide. Many chemotherapeutics from plants have been tested in cancer, such as vinblastine and paclitaxel. The north of Chile, Arica & Parinacota region, is characterized by its vegetal biodiversity due to its unique geographical and climatological conditions, offering an unexplored and unique source of naturally-derived compounds. The present research has considered a screening of 26 highland herbs using an in vitro growth inhibition model in a panel of six cancer cell lines from different tissues. 5 of the 26 studied ethanolic extracts shows strong activity at least in one cell line when tested at 10 µg mL-1. We present a group of plants worthy to be evaluated as promissory extracts. This work is part of the systematic attempt to find new candidates to be used in cancer therapies. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000100402 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000100402 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0103-8478cr20190757 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.source.none.fl_str_mv |
Ciência Rural v.51 n.1 2021 reponame:Ciência Rural instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Ciência Rural |
collection |
Ciência Rural |
repository.name.fl_str_mv |
|
repository.mail.fl_str_mv |
|
_version_ |
1749140555266260992 |