Mammary fibroadenomatoid hyperplasia in a heifer

• Autor(a) principal: Silva,Lorena Ferreira
• Data de Publicação: 2017
• Outros Autores: Silva,Luiz Antonio Franco da, Rabelo,Rogério Elias, Silva,Wanessa Patrícia Rodrigues da, Cassali,Geovanni Dantas, Gonçalves,Aline De Biasi Bassani, Sant’Ana,Fabiano José Ferreira de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Ciência Rural
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000600552
• topic: mammary hyperplasia; estrogen; progesterone; diseases of cattle

ABSTRACT: This manuscript described the anatomopathological and immunohistochemical findings in a rare case of mammary fibroadenomatoid hyperplasia in a 12-month-old Holstein heifer. A yellow, multilobulated, firm 20cm x 9cm x 6.5cm mass affecting the right quarters of the udder was observed. Total mastectomy was performed. Microscopic evaluation revealed severe hyperplasia of the mammary epithelium and numerous well-differentiated and mildly pleomorphic acini. Additionally, moderate proliferation of the fibrous connective tissue and the myoepithelial cells near the proliferating acini was evident. About 50% of the proliferating epithelial cells showed positive nuclear labeling for estrogen and progesterone receptors, and approximately one-third were positive for Ki-67. In addition, the myoepithelial cells exhibited diffuse nuclear immunoreactivity for p63. Based on the clinical, morphologic, and immunohistochemical findings, a diagnosis of mammary fibroadenomatoid hyperplasia with probable influence of ovarian steroids was made.