Multisystemic eosinophilic epitheliotropic disease in a horse in Brazil

Detalhes bibliográficos
Autor(a) principal: Laisse,Cláudio João Mourão
Data de Publicação: 2017
Outros Autores: Nascimento,Lismara Castro do, Panziera,Welden, Soares,Elizabeth Caldas, Fernandes,Denise Bicca, Westphalen,Júlio César, Sonne,Luciana, Pavarini,Saulo Petinatti, Driemeier,David
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Ciência Rural
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000500552
Resumo: ABSTRACT: Equine multisystemic eosinophilic epitheliotropic disease (MEED) is a rare disease, characterized by eosinophilia and eosinophilic infiltration of several organs. A 5-year-old horse presented pruritus, areas of alopecia, and moderate eosinophilia. The horse was treated with corticosteroids and antibiotics without substantial improvement; and after the disease progressed to fever, diarrhea, gastric reflux and progressive weight loss. Due to poor prognosis the horse was euthanized. Necropsy revealed poor body condition, multiple to coalescing foci of alopecia, with epidermal ulcerations and crusts on the head and distal parts of the limbs. The proximal duodenum was enlarged, with 3 intraluminal nodules. Histopathological evaluation revealed eosinophilic granulomas in the skin, oral mucosa, duodenum, pancreas, and mesenteric lymph nodes, which were associated with infiltrates of eosinophils, lymphocytes, macrophages, multinucleated giant cells, and occasional plasma cells, along with fibrovascular connective tissue proliferation. MEED should be included in the differential diagnosis of horses with skin lesions concomitant with clinical signs of gastrointestinal illness.
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spelling Multisystemic eosinophilic epitheliotropic disease in a horse in BrazilEosinophiliaeosinophilic granulomahistopathologyhorseABSTRACT: Equine multisystemic eosinophilic epitheliotropic disease (MEED) is a rare disease, characterized by eosinophilia and eosinophilic infiltration of several organs. A 5-year-old horse presented pruritus, areas of alopecia, and moderate eosinophilia. The horse was treated with corticosteroids and antibiotics without substantial improvement; and after the disease progressed to fever, diarrhea, gastric reflux and progressive weight loss. Due to poor prognosis the horse was euthanized. Necropsy revealed poor body condition, multiple to coalescing foci of alopecia, with epidermal ulcerations and crusts on the head and distal parts of the limbs. The proximal duodenum was enlarged, with 3 intraluminal nodules. Histopathological evaluation revealed eosinophilic granulomas in the skin, oral mucosa, duodenum, pancreas, and mesenteric lymph nodes, which were associated with infiltrates of eosinophils, lymphocytes, macrophages, multinucleated giant cells, and occasional plasma cells, along with fibrovascular connective tissue proliferation. MEED should be included in the differential diagnosis of horses with skin lesions concomitant with clinical signs of gastrointestinal illness.Universidade Federal de Santa Maria2017-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000500552Ciência Rural v.47 n.5 2017reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/0103-8478cr20160896info:eu-repo/semantics/openAccessLaisse,Cláudio João MourãoNascimento,Lismara Castro doPanziera,WeldenSoares,Elizabeth CaldasFernandes,Denise BiccaWestphalen,Júlio CésarSonne,LucianaPavarini,Saulo PetinattiDriemeier,Davideng2017-04-27T00:00:00ZRevista
dc.title.none.fl_str_mv Multisystemic eosinophilic epitheliotropic disease in a horse in Brazil
title Multisystemic eosinophilic epitheliotropic disease in a horse in Brazil
spellingShingle Multisystemic eosinophilic epitheliotropic disease in a horse in Brazil
Laisse,Cláudio João Mourão
Eosinophilia
eosinophilic granuloma
histopathology
horse
title_short Multisystemic eosinophilic epitheliotropic disease in a horse in Brazil
title_full Multisystemic eosinophilic epitheliotropic disease in a horse in Brazil
title_fullStr Multisystemic eosinophilic epitheliotropic disease in a horse in Brazil
title_full_unstemmed Multisystemic eosinophilic epitheliotropic disease in a horse in Brazil
title_sort Multisystemic eosinophilic epitheliotropic disease in a horse in Brazil
author Laisse,Cláudio João Mourão
author_facet Laisse,Cláudio João Mourão
Nascimento,Lismara Castro do
Panziera,Welden
Soares,Elizabeth Caldas
Fernandes,Denise Bicca
Westphalen,Júlio César
Sonne,Luciana
Pavarini,Saulo Petinatti
Driemeier,David
author_role author
author2 Nascimento,Lismara Castro do
Panziera,Welden
Soares,Elizabeth Caldas
Fernandes,Denise Bicca
Westphalen,Júlio César
Sonne,Luciana
Pavarini,Saulo Petinatti
Driemeier,David
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Laisse,Cláudio João Mourão
Nascimento,Lismara Castro do
Panziera,Welden
Soares,Elizabeth Caldas
Fernandes,Denise Bicca
Westphalen,Júlio César
Sonne,Luciana
Pavarini,Saulo Petinatti
Driemeier,David
dc.subject.por.fl_str_mv Eosinophilia
eosinophilic granuloma
histopathology
horse
topic Eosinophilia
eosinophilic granuloma
histopathology
horse
description ABSTRACT: Equine multisystemic eosinophilic epitheliotropic disease (MEED) is a rare disease, characterized by eosinophilia and eosinophilic infiltration of several organs. A 5-year-old horse presented pruritus, areas of alopecia, and moderate eosinophilia. The horse was treated with corticosteroids and antibiotics without substantial improvement; and after the disease progressed to fever, diarrhea, gastric reflux and progressive weight loss. Due to poor prognosis the horse was euthanized. Necropsy revealed poor body condition, multiple to coalescing foci of alopecia, with epidermal ulcerations and crusts on the head and distal parts of the limbs. The proximal duodenum was enlarged, with 3 intraluminal nodules. Histopathological evaluation revealed eosinophilic granulomas in the skin, oral mucosa, duodenum, pancreas, and mesenteric lymph nodes, which were associated with infiltrates of eosinophils, lymphocytes, macrophages, multinucleated giant cells, and occasional plasma cells, along with fibrovascular connective tissue proliferation. MEED should be included in the differential diagnosis of horses with skin lesions concomitant with clinical signs of gastrointestinal illness.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000500552
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000500552
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0103-8478cr20160896
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
publisher.none.fl_str_mv Universidade Federal de Santa Maria
dc.source.none.fl_str_mv Ciência Rural v.47 n.5 2017
reponame:Ciência Rural
instname:Universidade Federal de Santa Maria (UFSM)
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instname_str Universidade Federal de Santa Maria (UFSM)
instacron_str UFSM
institution UFSM
reponame_str Ciência Rural
collection Ciência Rural
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