Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Ciência Rural |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016001202216 |
Resumo: | ABSTRACT: This study examined the efficacy of an intravitreal dexamethasone-loaded device for the control of postoperative ocular inflammation in dogs following phacoemulsification. Twenty dogs with bilateral mature senile cataracts were prepared for surgery using routine protocols. A biodegradable poly (lactic-co-glycolic acid) copolymer device was inserted through the pars plana into the vitreous chamber immediately before phacoemulsification (device group [DG], n=20). Following surgery, a conventional group (CG) received local and systemic steroids, mydriatics, and antibiotic therapy. The same treatment protocol was adopted in DG, except for steroids. All eyes were examined before surgery and at various times after phacoemulsification. Ultrasonography showed gradual device shrinkage, with only remnants remaining at postoperative day (POD) 60. Signs of uveitis were observed in 35% of the DG on POD 7, but by POD 14, 50% of eyes showed signs of uveitis and these eyes required local steroid therapy. The intraocular pressure (IOP) was higher in the DG than in the CG immediately after surgery. IOP did not differ on POD 7 and POD 14, but was lower during the late postoperative period (POD 30 to 90). Flare values were greater in the DG than in the CG immediately following surgery, but showed no subsequent differences. In summary, the intravitreal dexamethasone device did not adequately control intraocular inflammation in dogs undergoing phacoemulsification. |
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Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogsdogcataract surgeryinflammationPLGAdexamethasoneABSTRACT: This study examined the efficacy of an intravitreal dexamethasone-loaded device for the control of postoperative ocular inflammation in dogs following phacoemulsification. Twenty dogs with bilateral mature senile cataracts were prepared for surgery using routine protocols. A biodegradable poly (lactic-co-glycolic acid) copolymer device was inserted through the pars plana into the vitreous chamber immediately before phacoemulsification (device group [DG], n=20). Following surgery, a conventional group (CG) received local and systemic steroids, mydriatics, and antibiotic therapy. The same treatment protocol was adopted in DG, except for steroids. All eyes were examined before surgery and at various times after phacoemulsification. Ultrasonography showed gradual device shrinkage, with only remnants remaining at postoperative day (POD) 60. Signs of uveitis were observed in 35% of the DG on POD 7, but by POD 14, 50% of eyes showed signs of uveitis and these eyes required local steroid therapy. The intraocular pressure (IOP) was higher in the DG than in the CG immediately after surgery. IOP did not differ on POD 7 and POD 14, but was lower during the late postoperative period (POD 30 to 90). Flare values were greater in the DG than in the CG immediately following surgery, but showed no subsequent differences. In summary, the intravitreal dexamethasone device did not adequately control intraocular inflammation in dogs undergoing phacoemulsification.Universidade Federal de Santa Maria2016-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016001202216Ciência Rural v.46 n.12 2016reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/0103-8478cr20160179info:eu-repo/semantics/openAccessLima,Tiago BarbalhoPadua,Ivan MartinezKobashigawa,Karina KamachiAldrovani,MarcelaChacaltana,Flor Diana Yocoay ClarosSanto,Paloma do EspíritoVieira,Lorena CarlaBarros Sobrinho,Alexandre Augusto FranchiCunha Junior,Armando SilvaLaus,José Luizeng2016-10-20T00:00:00ZRevista |
dc.title.none.fl_str_mv |
Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs |
title |
Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs |
spellingShingle |
Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs Lima,Tiago Barbalho dog cataract surgery inflammation PLGA dexamethasone |
title_short |
Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs |
title_full |
Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs |
title_fullStr |
Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs |
title_full_unstemmed |
Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs |
title_sort |
Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs |
author |
Lima,Tiago Barbalho |
author_facet |
Lima,Tiago Barbalho Padua,Ivan Martinez Kobashigawa,Karina Kamachi Aldrovani,Marcela Chacaltana,Flor Diana Yocoay Claros Santo,Paloma do Espírito Vieira,Lorena Carla Barros Sobrinho,Alexandre Augusto Franchi Cunha Junior,Armando Silva Laus,José Luiz |
author_role |
author |
author2 |
Padua,Ivan Martinez Kobashigawa,Karina Kamachi Aldrovani,Marcela Chacaltana,Flor Diana Yocoay Claros Santo,Paloma do Espírito Vieira,Lorena Carla Barros Sobrinho,Alexandre Augusto Franchi Cunha Junior,Armando Silva Laus,José Luiz |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lima,Tiago Barbalho Padua,Ivan Martinez Kobashigawa,Karina Kamachi Aldrovani,Marcela Chacaltana,Flor Diana Yocoay Claros Santo,Paloma do Espírito Vieira,Lorena Carla Barros Sobrinho,Alexandre Augusto Franchi Cunha Junior,Armando Silva Laus,José Luiz |
dc.subject.por.fl_str_mv |
dog cataract surgery inflammation PLGA dexamethasone |
topic |
dog cataract surgery inflammation PLGA dexamethasone |
description |
ABSTRACT: This study examined the efficacy of an intravitreal dexamethasone-loaded device for the control of postoperative ocular inflammation in dogs following phacoemulsification. Twenty dogs with bilateral mature senile cataracts were prepared for surgery using routine protocols. A biodegradable poly (lactic-co-glycolic acid) copolymer device was inserted through the pars plana into the vitreous chamber immediately before phacoemulsification (device group [DG], n=20). Following surgery, a conventional group (CG) received local and systemic steroids, mydriatics, and antibiotic therapy. The same treatment protocol was adopted in DG, except for steroids. All eyes were examined before surgery and at various times after phacoemulsification. Ultrasonography showed gradual device shrinkage, with only remnants remaining at postoperative day (POD) 60. Signs of uveitis were observed in 35% of the DG on POD 7, but by POD 14, 50% of eyes showed signs of uveitis and these eyes required local steroid therapy. The intraocular pressure (IOP) was higher in the DG than in the CG immediately after surgery. IOP did not differ on POD 7 and POD 14, but was lower during the late postoperative period (POD 30 to 90). Flare values were greater in the DG than in the CG immediately following surgery, but showed no subsequent differences. In summary, the intravitreal dexamethasone device did not adequately control intraocular inflammation in dogs undergoing phacoemulsification. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016001202216 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016001202216 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0103-8478cr20160179 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.source.none.fl_str_mv |
Ciência Rural v.46 n.12 2016 reponame:Ciência Rural instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Ciência Rural |
collection |
Ciência Rural |
repository.name.fl_str_mv |
|
repository.mail.fl_str_mv |
|
_version_ |
1749140550837075968 |