Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs

Detalhes bibliográficos
Autor(a) principal: Lima,Tiago Barbalho
Data de Publicação: 2016
Outros Autores: Padua,Ivan Martinez, Kobashigawa,Karina Kamachi, Aldrovani,Marcela, Chacaltana,Flor Diana Yocoay Claros, Santo,Paloma do Espírito, Vieira,Lorena Carla, Barros Sobrinho,Alexandre Augusto Franchi, Cunha Junior,Armando Silva, Laus,José Luiz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Ciência Rural
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016001202216
Resumo: ABSTRACT: This study examined the efficacy of an intravitreal dexamethasone-loaded device for the control of postoperative ocular inflammation in dogs following phacoemulsification. Twenty dogs with bilateral mature senile cataracts were prepared for surgery using routine protocols. A biodegradable poly (lactic-co-glycolic acid) copolymer device was inserted through the pars plana into the vitreous chamber immediately before phacoemulsification (device group [DG], n=20). Following surgery, a conventional group (CG) received local and systemic steroids, mydriatics, and antibiotic therapy. The same treatment protocol was adopted in DG, except for steroids. All eyes were examined before surgery and at various times after phacoemulsification. Ultrasonography showed gradual device shrinkage, with only remnants remaining at postoperative day (POD) 60. Signs of uveitis were observed in 35% of the DG on POD 7, but by POD 14, 50% of eyes showed signs of uveitis and these eyes required local steroid therapy. The intraocular pressure (IOP) was higher in the DG than in the CG immediately after surgery. IOP did not differ on POD 7 and POD 14, but was lower during the late postoperative period (POD 30 to 90). Flare values were greater in the DG than in the CG immediately following surgery, but showed no subsequent differences. In summary, the intravitreal dexamethasone device did not adequately control intraocular inflammation in dogs undergoing phacoemulsification.
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spelling Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogsdogcataract surgeryinflammationPLGAdexamethasoneABSTRACT: This study examined the efficacy of an intravitreal dexamethasone-loaded device for the control of postoperative ocular inflammation in dogs following phacoemulsification. Twenty dogs with bilateral mature senile cataracts were prepared for surgery using routine protocols. A biodegradable poly (lactic-co-glycolic acid) copolymer device was inserted through the pars plana into the vitreous chamber immediately before phacoemulsification (device group [DG], n=20). Following surgery, a conventional group (CG) received local and systemic steroids, mydriatics, and antibiotic therapy. The same treatment protocol was adopted in DG, except for steroids. All eyes were examined before surgery and at various times after phacoemulsification. Ultrasonography showed gradual device shrinkage, with only remnants remaining at postoperative day (POD) 60. Signs of uveitis were observed in 35% of the DG on POD 7, but by POD 14, 50% of eyes showed signs of uveitis and these eyes required local steroid therapy. The intraocular pressure (IOP) was higher in the DG than in the CG immediately after surgery. IOP did not differ on POD 7 and POD 14, but was lower during the late postoperative period (POD 30 to 90). Flare values were greater in the DG than in the CG immediately following surgery, but showed no subsequent differences. In summary, the intravitreal dexamethasone device did not adequately control intraocular inflammation in dogs undergoing phacoemulsification.Universidade Federal de Santa Maria2016-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016001202216Ciência Rural v.46 n.12 2016reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/0103-8478cr20160179info:eu-repo/semantics/openAccessLima,Tiago BarbalhoPadua,Ivan MartinezKobashigawa,Karina KamachiAldrovani,MarcelaChacaltana,Flor Diana Yocoay ClarosSanto,Paloma do EspíritoVieira,Lorena CarlaBarros Sobrinho,Alexandre Augusto FranchiCunha Junior,Armando SilvaLaus,José Luizeng2016-10-20T00:00:00ZRevista
dc.title.none.fl_str_mv Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs
title Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs
spellingShingle Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs
Lima,Tiago Barbalho
dog
cataract surgery
inflammation
PLGA
dexamethasone
title_short Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs
title_full Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs
title_fullStr Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs
title_full_unstemmed Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs
title_sort Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs
author Lima,Tiago Barbalho
author_facet Lima,Tiago Barbalho
Padua,Ivan Martinez
Kobashigawa,Karina Kamachi
Aldrovani,Marcela
Chacaltana,Flor Diana Yocoay Claros
Santo,Paloma do Espírito
Vieira,Lorena Carla
Barros Sobrinho,Alexandre Augusto Franchi
Cunha Junior,Armando Silva
Laus,José Luiz
author_role author
author2 Padua,Ivan Martinez
Kobashigawa,Karina Kamachi
Aldrovani,Marcela
Chacaltana,Flor Diana Yocoay Claros
Santo,Paloma do Espírito
Vieira,Lorena Carla
Barros Sobrinho,Alexandre Augusto Franchi
Cunha Junior,Armando Silva
Laus,José Luiz
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima,Tiago Barbalho
Padua,Ivan Martinez
Kobashigawa,Karina Kamachi
Aldrovani,Marcela
Chacaltana,Flor Diana Yocoay Claros
Santo,Paloma do Espírito
Vieira,Lorena Carla
Barros Sobrinho,Alexandre Augusto Franchi
Cunha Junior,Armando Silva
Laus,José Luiz
dc.subject.por.fl_str_mv dog
cataract surgery
inflammation
PLGA
dexamethasone
topic dog
cataract surgery
inflammation
PLGA
dexamethasone
description ABSTRACT: This study examined the efficacy of an intravitreal dexamethasone-loaded device for the control of postoperative ocular inflammation in dogs following phacoemulsification. Twenty dogs with bilateral mature senile cataracts were prepared for surgery using routine protocols. A biodegradable poly (lactic-co-glycolic acid) copolymer device was inserted through the pars plana into the vitreous chamber immediately before phacoemulsification (device group [DG], n=20). Following surgery, a conventional group (CG) received local and systemic steroids, mydriatics, and antibiotic therapy. The same treatment protocol was adopted in DG, except for steroids. All eyes were examined before surgery and at various times after phacoemulsification. Ultrasonography showed gradual device shrinkage, with only remnants remaining at postoperative day (POD) 60. Signs of uveitis were observed in 35% of the DG on POD 7, but by POD 14, 50% of eyes showed signs of uveitis and these eyes required local steroid therapy. The intraocular pressure (IOP) was higher in the DG than in the CG immediately after surgery. IOP did not differ on POD 7 and POD 14, but was lower during the late postoperative period (POD 30 to 90). Flare values were greater in the DG than in the CG immediately following surgery, but showed no subsequent differences. In summary, the intravitreal dexamethasone device did not adequately control intraocular inflammation in dogs undergoing phacoemulsification.
publishDate 2016
dc.date.none.fl_str_mv 2016-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016001202216
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016001202216
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0103-8478cr20160179
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
publisher.none.fl_str_mv Universidade Federal de Santa Maria
dc.source.none.fl_str_mv Ciência Rural v.46 n.12 2016
reponame:Ciência Rural
instname:Universidade Federal de Santa Maria (UFSM)
instacron:UFSM
instname_str Universidade Federal de Santa Maria (UFSM)
instacron_str UFSM
institution UFSM
reponame_str Ciência Rural
collection Ciência Rural
repository.name.fl_str_mv
repository.mail.fl_str_mv
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