Efeitos de um dispositivo intravítreo de dexametasona na inflamação ocular após facoemulsificação em cães

• Autor(a) principal: Lima, Tiago Barbalho [UNESP]
• Data de Publicação: 2016
• Outros Autores: Padua, Ivan Martinez [UNESP], Kobashigawa, Karina Kamachi [UNESP], Aldrovani, Marcela [UNESP], Chacaltana, Flor Diana Yocoay Claros [UNESP], Santo, Paloma Do Espírito [UNESP], Vieira, Lorena Carla, Barros Sobrinho, Alexandre Augusto Franchi [UNESP], Cunha Junior, Armando Silva, Laus, José Luiz [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1590/0103-8478cr20160179; http://hdl.handle.net/11449/178377
• topic: Cataract surgery; Dexamethasone; Dog; Inflammation; PLGA

This study examined the efficacy of an intravitreal dexamethasone-loaded device for the control of postoperative ocular inflammation in dogs following phacoemulsification. Twenty dogs with bilateral mature senile cataracts were prepared for surgery using routine protocols. A biodegradable poly (lactic-coglycolic acid) copolymer device was inserted through the pars plana into the vitreous chamber immediately before phacoemulsification (device group [DG], n=20). Following surgery, a conventional group (CG) received local and systemic steroids, mydriatics, and antibiotic therapy. The same treatment protocol was adopted in DG, except for steroids. All eyes were examined before surgery and at various times after phacoemulsification. Ultrasonography showed gradual device shrinkage, with only remnants remaining at postoperative day (POD) 60. Signs of uveitis were observed in 35% of the DG on POD 7, but by POD 14, 50% of eyes showed signs of uveitis and these eyes required local steroid therapy. The intraocular pressure (IOP) was higher in the DG than in the CG immediately after surgery. IOP did not differ on POD 7 and POD 14, but was lower during the late postoperative period (POD 30 to 90). Flare values were greater in the DG than in the CG immediately following surgery, but showed no subsequent differences. In summary, the intravitreal dexamethasone device did not adequately control intraocular inflammation in dogs undergoing phacoemulsification.