Cyclooxygenase-2 expression in epithelial neoplasms and its relevance as a targeted therapy in dogs

Detalhes bibliográficos
Autor(a) principal: Cunha,Rúbia Monteiro de Castro
Data de Publicação: 2016
Outros Autores: Horta,Rodrigo dos Santos, Lavalle,Gleidice Eunice, Araújo,Roberto Baracat
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Ciência Rural
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000601050
Resumo: ABSTRACT: Targeted therapy of neoplasms is an emergent approach in human and veterinary medicine. Cyclooxygenase (COX) is a class of catalytic enzymes related to the formation of inflammatory mediators. COX-2 is expressed constitutively in a few body tissues, but it may be induced in specific pathophysiologic conditions, such as cancer. COX-2 expression in neoplams may be considered a potential predictive factor, due to the possible association of selective COX-2 inhibitors in adjuvant treatments. This scientific communication has the objective to report COX-2 expression in seven neoplasms of dogs and the usage of adjuvant treatment with COX-2 selective inhibitors as an effective and feasible option in cancer treatment.
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spelling Cyclooxygenase-2 expression in epithelial neoplasms and its relevance as a targeted therapy in dogscancercarcinomaimmunohistochemistryantineoplastic drugs.ABSTRACT: Targeted therapy of neoplasms is an emergent approach in human and veterinary medicine. Cyclooxygenase (COX) is a class of catalytic enzymes related to the formation of inflammatory mediators. COX-2 is expressed constitutively in a few body tissues, but it may be induced in specific pathophysiologic conditions, such as cancer. COX-2 expression in neoplams may be considered a potential predictive factor, due to the possible association of selective COX-2 inhibitors in adjuvant treatments. This scientific communication has the objective to report COX-2 expression in seven neoplasms of dogs and the usage of adjuvant treatment with COX-2 selective inhibitors as an effective and feasible option in cancer treatment.Universidade Federal de Santa Maria2016-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000601050Ciência Rural v.46 n.6 2016reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/0103-8478cr20150794info:eu-repo/semantics/openAccessCunha,Rúbia Monteiro de CastroHorta,Rodrigo dos SantosLavalle,Gleidice EuniceAraújo,Roberto Baracateng2016-05-03T00:00:00ZRevista
dc.title.none.fl_str_mv Cyclooxygenase-2 expression in epithelial neoplasms and its relevance as a targeted therapy in dogs
title Cyclooxygenase-2 expression in epithelial neoplasms and its relevance as a targeted therapy in dogs
spellingShingle Cyclooxygenase-2 expression in epithelial neoplasms and its relevance as a targeted therapy in dogs
Cunha,Rúbia Monteiro de Castro
cancer
carcinoma
immunohistochemistry
antineoplastic drugs.
title_short Cyclooxygenase-2 expression in epithelial neoplasms and its relevance as a targeted therapy in dogs
title_full Cyclooxygenase-2 expression in epithelial neoplasms and its relevance as a targeted therapy in dogs
title_fullStr Cyclooxygenase-2 expression in epithelial neoplasms and its relevance as a targeted therapy in dogs
title_full_unstemmed Cyclooxygenase-2 expression in epithelial neoplasms and its relevance as a targeted therapy in dogs
title_sort Cyclooxygenase-2 expression in epithelial neoplasms and its relevance as a targeted therapy in dogs
author Cunha,Rúbia Monteiro de Castro
author_facet Cunha,Rúbia Monteiro de Castro
Horta,Rodrigo dos Santos
Lavalle,Gleidice Eunice
Araújo,Roberto Baracat
author_role author
author2 Horta,Rodrigo dos Santos
Lavalle,Gleidice Eunice
Araújo,Roberto Baracat
author2_role author
author
author
dc.contributor.author.fl_str_mv Cunha,Rúbia Monteiro de Castro
Horta,Rodrigo dos Santos
Lavalle,Gleidice Eunice
Araújo,Roberto Baracat
dc.subject.por.fl_str_mv cancer
carcinoma
immunohistochemistry
antineoplastic drugs.
topic cancer
carcinoma
immunohistochemistry
antineoplastic drugs.
description ABSTRACT: Targeted therapy of neoplasms is an emergent approach in human and veterinary medicine. Cyclooxygenase (COX) is a class of catalytic enzymes related to the formation of inflammatory mediators. COX-2 is expressed constitutively in a few body tissues, but it may be induced in specific pathophysiologic conditions, such as cancer. COX-2 expression in neoplams may be considered a potential predictive factor, due to the possible association of selective COX-2 inhibitors in adjuvant treatments. This scientific communication has the objective to report COX-2 expression in seven neoplasms of dogs and the usage of adjuvant treatment with COX-2 selective inhibitors as an effective and feasible option in cancer treatment.
publishDate 2016
dc.date.none.fl_str_mv 2016-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000601050
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000601050
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0103-8478cr20150794
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
publisher.none.fl_str_mv Universidade Federal de Santa Maria
dc.source.none.fl_str_mv Ciência Rural v.46 n.6 2016
reponame:Ciência Rural
instname:Universidade Federal de Santa Maria (UFSM)
instacron:UFSM
instname_str Universidade Federal de Santa Maria (UFSM)
instacron_str UFSM
institution UFSM
reponame_str Ciência Rural
collection Ciência Rural
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1749140550399819776

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