Avaliação neuropsicológica e dos marcadores inflamatórios nos pacientes com epilepsia

Detalhes bibliográficos
Autor(a) principal: Arend, Josi
Data de Publicação: 2015
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Manancial - Repositório Digital da UFSM
dARK ID: ark:/26339/001300000nv86
Texto Completo: http://repositorio.ufsm.br/handle/1/9023
Resumo: The epilepsy is a neurological disorder manifested by recurrent unprovoked seizures, resulting in harmful effects on the patients. Epileptic seizures are generated from hypersincronic abnormal discharges of neurons, eventually resulting in irreversible damage. The consequences involve damages in the neurobiological, neurochemical, cognitive and psychological scopes. As a result, the objective of this study was to investigate the cognitive function (NEUPSILIN test), depression score (Hamilton Rating Scale) and inflammatory markers (TNF, IL1β, AChE), cell death (caspase 3) and DNA damage (PicoGreen) in epileptic patients, compared to individuals without the disease. The results showed significant memory damages in patients with epilepsy, as well as a high depression score. The inflammatory markers, cell death and DNA damage also were showed high. In addition, there was not observed significant correlation when were compared the seizures duration with memory impairment and depression score. There was also no significant correlation when comparing the depression scores and the enzyme acetylcholinesterase activity with memory impairment. In this way, the results of this study suggest that the neurophysiological changes caused by the epilepsy may be responsible for the memory damages and higher rates of depression in patients. Furthermore, it can be suggested that the seizures contribute to the development of neuroinflammation, releasing inflammatory mediators and, by this way, initiating a apoptotic cascade that culminates in the DNA damage.
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spelling Avaliação neuropsicológica e dos marcadores inflamatórios nos pacientes com epilepsiaNeuropsychological assessment and analysis of inflammatory markers in patients with epilepsyEpilepsiaMemóriaDepressãoInflamaçãoApoptoseDano ao DNAPerfil neuropsicológicoEpilepsyMemoryDepressionInflammationApoptosisDNA damageNeuropsychological profileCNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIAThe epilepsy is a neurological disorder manifested by recurrent unprovoked seizures, resulting in harmful effects on the patients. Epileptic seizures are generated from hypersincronic abnormal discharges of neurons, eventually resulting in irreversible damage. The consequences involve damages in the neurobiological, neurochemical, cognitive and psychological scopes. As a result, the objective of this study was to investigate the cognitive function (NEUPSILIN test), depression score (Hamilton Rating Scale) and inflammatory markers (TNF, IL1β, AChE), cell death (caspase 3) and DNA damage (PicoGreen) in epileptic patients, compared to individuals without the disease. The results showed significant memory damages in patients with epilepsy, as well as a high depression score. The inflammatory markers, cell death and DNA damage also were showed high. In addition, there was not observed significant correlation when were compared the seizures duration with memory impairment and depression score. There was also no significant correlation when comparing the depression scores and the enzyme acetylcholinesterase activity with memory impairment. In this way, the results of this study suggest that the neurophysiological changes caused by the epilepsy may be responsible for the memory damages and higher rates of depression in patients. Furthermore, it can be suggested that the seizures contribute to the development of neuroinflammation, releasing inflammatory mediators and, by this way, initiating a apoptotic cascade that culminates in the DNA damage.A epilepsia é um distúrbio neurológico manifestado por recorrência de crises não provocadas, resultando em efeitos prejudiciais sobre os pacientes. As crises epilépticas são geradas a partir de descargas hipersincrônicas anormais dos neurônios, eventualmente resultando em danos irreversíveis. As consequências envolvem prejuízo no âmbito neurobiológico, neuroquímico, cognitivo e psicológico. Em virtude disso, o objetivo do presente estudo foi investigar a função cognitiva (teste NEUPSILIN), escore de depressão (Escala de Hamilton) e marcadores inflamatórios (TNFα, IL1β, AChE), de morte celular (caspase 3) e dano ao DNA (picogreen), em pacientes epilépticos, comparando com indivíduos sem a doença. Os resultados mostraram um prejuízo de memória significativo nos pacientes com epilepsia, bem como um elevado escore de depressão. Os marcadores inflamatórios, de morte celular e dano ao DNA também se apresentaram elevados. Além disso, não foi observada uma correlação significativa quando comparado o tempo de duração das crises epilépticas com o prejuízo da memória e o escore de depressão. Também não houve correlação significativa quando se comparou o escore de depressão e a atividade da enzima acetilcolinesterase com o prejuízo da memória. Desta maneira, os resultados deste estudo sugerem que as alterações neurofisiológicas provocadas pela epilepsia possam ser as responsáveis pelo prejuízo da memória e índices mais elevados de depressão nos pacientes. Além disso, pôde-se sugerir que as crises epilépticas contribuem para o desenvolvimento da neuroinflamação, liberando os mediadores inflamatórios e, desta forma, iniciando uma cascata apoptótica que culmina no dano ao DNA.Universidade Federal de Santa MariaBRFarmacologiaUFSMPrograma de Pós-Graduação em FarmacologiaFighera, Michele Rechiahttp://lattes.cnpq.br/8583392747509231Souza, Mauren Assis dehttp://lattes.cnpq.br/1571752069730472Premaor, Melissa Orlandinhttp://lattes.cnpq.br/1919693261808995Arend, Josi2016-03-302016-03-302015-08-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfapplication/pdfAREND, Josi. Neuropsychological assessment and analysis of inflammatory markers in patients with epilepsy. 2015. 89 f. Dissertação (Mestrado em Farmácia) - Universidade Federal de Santa Maria, Santa Maria, 2015.http://repositorio.ufsm.br/handle/1/9023ark:/26339/001300000nv86porinfo:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM2022-04-06T17:01:44Zoai:repositorio.ufsm.br:1/9023Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2022-04-06T17:01:44Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false
dc.title.none.fl_str_mv Avaliação neuropsicológica e dos marcadores inflamatórios nos pacientes com epilepsia
Neuropsychological assessment and analysis of inflammatory markers in patients with epilepsy
title Avaliação neuropsicológica e dos marcadores inflamatórios nos pacientes com epilepsia
spellingShingle Avaliação neuropsicológica e dos marcadores inflamatórios nos pacientes com epilepsia
Arend, Josi
Epilepsia
Memória
Depressão
Inflamação
Apoptose
Dano ao DNA
Perfil neuropsicológico
Epilepsy
Memory
Depression
Inflammation
Apoptosis
DNA damage
Neuropsychological profile
CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA
title_short Avaliação neuropsicológica e dos marcadores inflamatórios nos pacientes com epilepsia
title_full Avaliação neuropsicológica e dos marcadores inflamatórios nos pacientes com epilepsia
title_fullStr Avaliação neuropsicológica e dos marcadores inflamatórios nos pacientes com epilepsia
title_full_unstemmed Avaliação neuropsicológica e dos marcadores inflamatórios nos pacientes com epilepsia
title_sort Avaliação neuropsicológica e dos marcadores inflamatórios nos pacientes com epilepsia
author Arend, Josi
author_facet Arend, Josi
author_role author
dc.contributor.none.fl_str_mv Fighera, Michele Rechia
http://lattes.cnpq.br/8583392747509231
Souza, Mauren Assis de
http://lattes.cnpq.br/1571752069730472
Premaor, Melissa Orlandin
http://lattes.cnpq.br/1919693261808995
dc.contributor.author.fl_str_mv Arend, Josi
dc.subject.por.fl_str_mv Epilepsia
Memória
Depressão
Inflamação
Apoptose
Dano ao DNA
Perfil neuropsicológico
Epilepsy
Memory
Depression
Inflammation
Apoptosis
DNA damage
Neuropsychological profile
CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA
topic Epilepsia
Memória
Depressão
Inflamação
Apoptose
Dano ao DNA
Perfil neuropsicológico
Epilepsy
Memory
Depression
Inflammation
Apoptosis
DNA damage
Neuropsychological profile
CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA
description The epilepsy is a neurological disorder manifested by recurrent unprovoked seizures, resulting in harmful effects on the patients. Epileptic seizures are generated from hypersincronic abnormal discharges of neurons, eventually resulting in irreversible damage. The consequences involve damages in the neurobiological, neurochemical, cognitive and psychological scopes. As a result, the objective of this study was to investigate the cognitive function (NEUPSILIN test), depression score (Hamilton Rating Scale) and inflammatory markers (TNF, IL1β, AChE), cell death (caspase 3) and DNA damage (PicoGreen) in epileptic patients, compared to individuals without the disease. The results showed significant memory damages in patients with epilepsy, as well as a high depression score. The inflammatory markers, cell death and DNA damage also were showed high. In addition, there was not observed significant correlation when were compared the seizures duration with memory impairment and depression score. There was also no significant correlation when comparing the depression scores and the enzyme acetylcholinesterase activity with memory impairment. In this way, the results of this study suggest that the neurophysiological changes caused by the epilepsy may be responsible for the memory damages and higher rates of depression in patients. Furthermore, it can be suggested that the seizures contribute to the development of neuroinflammation, releasing inflammatory mediators and, by this way, initiating a apoptotic cascade that culminates in the DNA damage.
publishDate 2015
dc.date.none.fl_str_mv 2015-08-31
2016-03-30
2016-03-30
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv AREND, Josi. Neuropsychological assessment and analysis of inflammatory markers in patients with epilepsy. 2015. 89 f. Dissertação (Mestrado em Farmácia) - Universidade Federal de Santa Maria, Santa Maria, 2015.
http://repositorio.ufsm.br/handle/1/9023
dc.identifier.dark.fl_str_mv ark:/26339/001300000nv86
identifier_str_mv AREND, Josi. Neuropsychological assessment and analysis of inflammatory markers in patients with epilepsy. 2015. 89 f. Dissertação (Mestrado em Farmácia) - Universidade Federal de Santa Maria, Santa Maria, 2015.
ark:/26339/001300000nv86
url http://repositorio.ufsm.br/handle/1/9023
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
BR
Farmacologia
UFSM
Programa de Pós-Graduação em Farmacologia
publisher.none.fl_str_mv Universidade Federal de Santa Maria
BR
Farmacologia
UFSM
Programa de Pós-Graduação em Farmacologia
dc.source.none.fl_str_mv reponame:Manancial - Repositório Digital da UFSM
instname:Universidade Federal de Santa Maria (UFSM)
instacron:UFSM
instname_str Universidade Federal de Santa Maria (UFSM)
instacron_str UFSM
institution UFSM
reponame_str Manancial - Repositório Digital da UFSM
collection Manancial - Repositório Digital da UFSM
repository.name.fl_str_mv Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)
repository.mail.fl_str_mv atendimento.sib@ufsm.br||tedebc@gmail.com
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