Efeito agudo e crônico do etanol sobre as enzimas NTPDase, 5'-nucleotidase, acetilcolinesterase, peroxidação lipídica e comportamento em ratos
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações do UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/11089 |
Resumo: | Ethanol is one of the most used substance in different societies. This study was performed in order to clarify the acute and chronic effects of ethanol on biochemical and behavioral parameters in male Wistar rats. The acute treatment consisted of oral administration by gavage of 0.8, 2.0, 4.0, 6.0 and 8.0 g ethanol/kg. All rats were sacrificed one hour and thirty minutes post treatment. The results showed that acute treatment induced a biphasic or hormetic effect in platelet NTPDase and 5'-nucleotidase activities. The activity of the enzyme acetylcholinesterase was inhibited in cerebral cortex, cerebellum, hypothalamus, hippocampus and striatum in 6.0g/kg and 8.0g/kg treated-groups. Moreover the acute treatment increased lipid peroxidation in the blood serum, liver, kidney and brain structures. The open-field and elevated plus-maze behavior was few altered by acute treatment. The chronic treatment consisted of oral administration of 20% ethanol solution during 31 weeks as only source of fluid. Rats were sacrificed 48 hours after the end of the treatment. The results showed reduction of the weight of treated group and initial hepatic injury in histological evaluation. There was a reduction in platelet NTPDase activity with ATP or ADP as substrate, while the 5'-nucleotidase activity was increased. The activity of the enzyme acetylcholinesterase was increased in cerebellum, hypothalamus, hippocampus and striatum. Lipid peroxidation was increased in the blood serum, liver and kidney. Besides we observed that interruption of the treatment for 48 hours elicited an anxiogenic effect in open-field and elevated plus-maze. |
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2008-09-232008-09-232004-10-15DIAS, Glaecir Roseni Mundstock. Acute and chronic effects of ethanol on enzymes NTPDase, 5'-nucleotidase, acetylcholinesterase, lipid peroxidation and behavior in rats. 2004. 150 f. Dissertação (Mestrado em Bioquímica) - Universidade Federal de Santa Maria, Santa Maria, 2004.http://repositorio.ufsm.br/handle/1/11089Ethanol is one of the most used substance in different societies. This study was performed in order to clarify the acute and chronic effects of ethanol on biochemical and behavioral parameters in male Wistar rats. The acute treatment consisted of oral administration by gavage of 0.8, 2.0, 4.0, 6.0 and 8.0 g ethanol/kg. All rats were sacrificed one hour and thirty minutes post treatment. The results showed that acute treatment induced a biphasic or hormetic effect in platelet NTPDase and 5'-nucleotidase activities. The activity of the enzyme acetylcholinesterase was inhibited in cerebral cortex, cerebellum, hypothalamus, hippocampus and striatum in 6.0g/kg and 8.0g/kg treated-groups. Moreover the acute treatment increased lipid peroxidation in the blood serum, liver, kidney and brain structures. The open-field and elevated plus-maze behavior was few altered by acute treatment. The chronic treatment consisted of oral administration of 20% ethanol solution during 31 weeks as only source of fluid. Rats were sacrificed 48 hours after the end of the treatment. The results showed reduction of the weight of treated group and initial hepatic injury in histological evaluation. There was a reduction in platelet NTPDase activity with ATP or ADP as substrate, while the 5'-nucleotidase activity was increased. The activity of the enzyme acetylcholinesterase was increased in cerebellum, hypothalamus, hippocampus and striatum. Lipid peroxidation was increased in the blood serum, liver and kidney. Besides we observed that interruption of the treatment for 48 hours elicited an anxiogenic effect in open-field and elevated plus-maze.O etanol é uma das substâncias mais utilizadas nas diferentes sociedades. Esse estudo foi realizado com a finalidade de se esclarecerem os efeitos agudos e crônicos do etanol sobre parâmetros bioquímicos e comportamentais em ratos machos Wistar. O tratamento agudo consistiu na administração oral por gavagem de 0.8, 2.0, 4.0, 6.0 e 8.0 gramas de etanol/kg de peso corporal. Todos os ratos foram sacrificados uma hora e meia pós-tratamento. Os resultados demonstraram que o tratamento agudo com etanol induziu um efeito bifásico ou hormético sobre a atividade das enzimas NTPDase e 5'-nucleotidase de plaquetas. A atividade da enzima acetilcolinesterase foi inibida em córtex cerebral, cerebelo, hipotálamo, hipocampo e estriado nos grupos tratados com 6.0 g/kg e 8.0 g/kg. Além disso, o tratamento agudo aumentou a peroxidação lipídica em soro, fígado, rim e estruturas cerebrais. O comportamento em campo-aberto e no labirinto em cruz elevado foi pouco alterado pelo tratamento agudo. O tratamento crônico consistiu na administração de uma solução alcoólica 20% durante 31 semanas de tratamento, como única fonte de líquido. Os ratos foram sacrificados após 48 horas de interrupção do tratamento. Os resultados demonstraram redução do peso do grupo tratado e ocorrência de injúria hepática inicial na avaliação histológica. Houve uma diminuição da atividade da NTPDase, com os substratos ATP e ADP, enquanto que a atividade da 5'-nucleotidase foi aumentada. A atividade da enzima acetilcolinesterase aumentou em cerebelo, hipotálamo, hipocampo e estriado. A peroxidação lipídica aumentou em soro, fígado e rim. Além disso, observou-se que a interrupção por 48 horas induziu uma resposta ansiogênica evidenciada no campo-aberto e no labirinto em cruz elevado.Conselho Nacional de Desenvolvimento Científico e Tecnológicoapplication/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaUFSMBRBioquímicaBioquímicaEnzimasEtanolComportamentoCNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICAEfeito agudo e crônico do etanol sobre as enzimas NTPDase, 5'-nucleotidase, acetilcolinesterase, peroxidação lipídica e comportamento em ratosAcute and chronic effects of ethanol on enzymes NTPDase, 5'-nucleotidase, acetylcholinesterase, lipid peroxidation and behavior in ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisMorsch, Vera Maria Melchiorshttp://lattes.cnpq.br/1519648219507868Schetinger, Maria Rosa Chitolinahttp://lattes.cnpq.br/4401319386725357Bauermann, Liliane de Freitashttp://lattes.cnpq.br/5849925846135968Battastini, Ana Maria Oliveirahttp://lattes.cnpq.br/7400428082614215http://lattes.cnpq.br/9545668593318677Dias, Glaecir Roseni Mundstock20080000000240050050050050050005cf99a1-4e49-4daa-bb3b-26eee86569c134eea941-634c-40ad-920c-454ba67723abe31536a8-f5a8-4f54-b813-f9fc8b2e2686f89660ad-570e-4c5a-95c8-8554d6a597313cd76448-fb79-4eef-964a-72648182483cinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações do UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALGLAECIRMUNDSTOCKDIAS.pdfapplication/pdf1101660http://repositorio.ufsm.br/bitstream/1/11089/1/GLAECIRMUNDSTOCKDIAS.pdfb9d1b00d3c08a58f1da473aa76b40e8aMD51TEXTGLAECIRMUNDSTOCKDIAS.pdf.txtGLAECIRMUNDSTOCKDIAS.pdf.txtExtracted texttext/plain175508http://repositorio.ufsm.br/bitstream/1/11089/2/GLAECIRMUNDSTOCKDIAS.pdf.txt5e1a9124a283d20b8f82c8ab38da0c9aMD52THUMBNAILGLAECIRMUNDSTOCKDIAS.pdf.jpgGLAECIRMUNDSTOCKDIAS.pdf.jpgIM Thumbnailimage/jpeg6554http://repositorio.ufsm.br/bitstream/1/11089/3/GLAECIRMUNDSTOCKDIAS.pdf.jpg2e53998fc3c3b332ea7c541e72e885f5MD531/110892022-01-07 16:02:57.955oai:repositorio.ufsm.br:1/11089Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2022-01-07T19:02:57Biblioteca Digital de Teses e Dissertações do UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Efeito agudo e crônico do etanol sobre as enzimas NTPDase, 5'-nucleotidase, acetilcolinesterase, peroxidação lipídica e comportamento em ratos |
dc.title.alternative.eng.fl_str_mv |
Acute and chronic effects of ethanol on enzymes NTPDase, 5'-nucleotidase, acetylcholinesterase, lipid peroxidation and behavior in rats |
title |
Efeito agudo e crônico do etanol sobre as enzimas NTPDase, 5'-nucleotidase, acetilcolinesterase, peroxidação lipídica e comportamento em ratos |
spellingShingle |
Efeito agudo e crônico do etanol sobre as enzimas NTPDase, 5'-nucleotidase, acetilcolinesterase, peroxidação lipídica e comportamento em ratos Dias, Glaecir Roseni Mundstock Bioquímica Enzimas Etanol Comportamento CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
title_short |
Efeito agudo e crônico do etanol sobre as enzimas NTPDase, 5'-nucleotidase, acetilcolinesterase, peroxidação lipídica e comportamento em ratos |
title_full |
Efeito agudo e crônico do etanol sobre as enzimas NTPDase, 5'-nucleotidase, acetilcolinesterase, peroxidação lipídica e comportamento em ratos |
title_fullStr |
Efeito agudo e crônico do etanol sobre as enzimas NTPDase, 5'-nucleotidase, acetilcolinesterase, peroxidação lipídica e comportamento em ratos |
title_full_unstemmed |
Efeito agudo e crônico do etanol sobre as enzimas NTPDase, 5'-nucleotidase, acetilcolinesterase, peroxidação lipídica e comportamento em ratos |
title_sort |
Efeito agudo e crônico do etanol sobre as enzimas NTPDase, 5'-nucleotidase, acetilcolinesterase, peroxidação lipídica e comportamento em ratos |
author |
Dias, Glaecir Roseni Mundstock |
author_facet |
Dias, Glaecir Roseni Mundstock |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Morsch, Vera Maria Melchiors |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/1519648219507868 |
dc.contributor.advisor-co1.fl_str_mv |
Schetinger, Maria Rosa Chitolina |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/4401319386725357 |
dc.contributor.referee1.fl_str_mv |
Bauermann, Liliane de Freitas |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/5849925846135968 |
dc.contributor.referee2.fl_str_mv |
Battastini, Ana Maria Oliveira |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/7400428082614215 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9545668593318677 |
dc.contributor.author.fl_str_mv |
Dias, Glaecir Roseni Mundstock |
contributor_str_mv |
Morsch, Vera Maria Melchiors Schetinger, Maria Rosa Chitolina Bauermann, Liliane de Freitas Battastini, Ana Maria Oliveira |
dc.subject.por.fl_str_mv |
Bioquímica Enzimas Etanol Comportamento |
topic |
Bioquímica Enzimas Etanol Comportamento CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
description |
Ethanol is one of the most used substance in different societies. This study was performed in order to clarify the acute and chronic effects of ethanol on biochemical and behavioral parameters in male Wistar rats. The acute treatment consisted of oral administration by gavage of 0.8, 2.0, 4.0, 6.0 and 8.0 g ethanol/kg. All rats were sacrificed one hour and thirty minutes post treatment. The results showed that acute treatment induced a biphasic or hormetic effect in platelet NTPDase and 5'-nucleotidase activities. The activity of the enzyme acetylcholinesterase was inhibited in cerebral cortex, cerebellum, hypothalamus, hippocampus and striatum in 6.0g/kg and 8.0g/kg treated-groups. Moreover the acute treatment increased lipid peroxidation in the blood serum, liver, kidney and brain structures. The open-field and elevated plus-maze behavior was few altered by acute treatment. The chronic treatment consisted of oral administration of 20% ethanol solution during 31 weeks as only source of fluid. Rats were sacrificed 48 hours after the end of the treatment. The results showed reduction of the weight of treated group and initial hepatic injury in histological evaluation. There was a reduction in platelet NTPDase activity with ATP or ADP as substrate, while the 5'-nucleotidase activity was increased. The activity of the enzyme acetylcholinesterase was increased in cerebellum, hypothalamus, hippocampus and striatum. Lipid peroxidation was increased in the blood serum, liver and kidney. Besides we observed that interruption of the treatment for 48 hours elicited an anxiogenic effect in open-field and elevated plus-maze. |
publishDate |
2004 |
dc.date.issued.fl_str_mv |
2004-10-15 |
dc.date.accessioned.fl_str_mv |
2008-09-23 |
dc.date.available.fl_str_mv |
2008-09-23 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
DIAS, Glaecir Roseni Mundstock. Acute and chronic effects of ethanol on enzymes NTPDase, 5'-nucleotidase, acetylcholinesterase, lipid peroxidation and behavior in rats. 2004. 150 f. Dissertação (Mestrado em Bioquímica) - Universidade Federal de Santa Maria, Santa Maria, 2004. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/11089 |
identifier_str_mv |
DIAS, Glaecir Roseni Mundstock. Acute and chronic effects of ethanol on enzymes NTPDase, 5'-nucleotidase, acetylcholinesterase, lipid peroxidation and behavior in rats. 2004. 150 f. Dissertação (Mestrado em Bioquímica) - Universidade Federal de Santa Maria, Santa Maria, 2004. |
url |
http://repositorio.ufsm.br/handle/1/11089 |
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por |
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Universidade Federal de Santa Maria |
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