Reposicionamento dos antidepressivos fluoxetina e paroxetina e efeitos sinérgicos com ciprofloxacino frente bactérias multidroga resistentes
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Manancial - Repositório Digital da UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/22145 |
Resumo: | The growing need for effective antimicrobial agents for the treatment of multidrug-resistant bacteria (MDR), mainly caused by nosocomial infections, leads to the use of alternative alternatives. The repositioning or redirection of existing drugs and synergism with antibacterial drugs is a promising approach in the development of new antimicrobials. In this sense, the present study aimed, in the first article, to present new indications for use for antidepressant drugs selective serotonin reception (SSRI) fluoxetine and paroxetine. In this letter to the editor, 39 studies were analyzed, which describe different actions presented by these drugs. Fluoxetine showed 19 different activities in addition to its well-known antidepressant action, and paroxetine 10 new indications. The bacterial strains against which the two drugs were evaluated were also described, and the type of study, in vitro (standard strains or clinical isolates) or in vivo. In the second manuscript, the in vitro antibacterial activity of fluoxetine and paroxetine was evaluated alone and in combination with the antibacterial ciprofloxacin against 6 American Type Culture Collection (ATCC) standard strains and 70 MDR clinical isolates from a university hospital. The two antidepressants showed better antibacterial activity when compared to ciprofloxacin, in addition to being, separately, bactericidal against all as tested strains. In addition, the two drugs studied showed promising activity against Gram-negative (GN) and Gram-positive (GP), inferring the broader spectrum. When associated with ciprofloxacin, fluoxetine and paroxetine, they are diagnosed in the face of all MDR clinical isolates tested, highlighting that they were resistant to ciprofloxacin. Fluoxetine and paroxetine are promising alternative alternatives in the treatment of infectious diseases caused by MDR microorganisms, in addition to presenting different indications, as demonstrated in the literature. Both antidepressants take alternative approaches to redirect drugs, however, further studies are needed to elucidate the mechanisms of action involved. |
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Reposicionamento dos antidepressivos fluoxetina e paroxetina e efeitos sinérgicos com ciprofloxacino frente bactérias multidroga resistentesRepositioning of fluoxetine and paroxetine antidepressants and synergic effects with cyprofloxacine front resistant multi-drug bacteriaRedirecionamentoResistência bacterianaAtividade antibacterianaAntidepressivosFluoxetinaParoxetinaCiprofloxacinoSinergismoRedirectionBacterial resistanceAntibacterial activityAntidepressantsFluoxetineParoxetineCiprofloxacinSynergismCNPQ::CIENCIAS DA SAUDE::FARMACIAThe growing need for effective antimicrobial agents for the treatment of multidrug-resistant bacteria (MDR), mainly caused by nosocomial infections, leads to the use of alternative alternatives. The repositioning or redirection of existing drugs and synergism with antibacterial drugs is a promising approach in the development of new antimicrobials. In this sense, the present study aimed, in the first article, to present new indications for use for antidepressant drugs selective serotonin reception (SSRI) fluoxetine and paroxetine. In this letter to the editor, 39 studies were analyzed, which describe different actions presented by these drugs. Fluoxetine showed 19 different activities in addition to its well-known antidepressant action, and paroxetine 10 new indications. The bacterial strains against which the two drugs were evaluated were also described, and the type of study, in vitro (standard strains or clinical isolates) or in vivo. In the second manuscript, the in vitro antibacterial activity of fluoxetine and paroxetine was evaluated alone and in combination with the antibacterial ciprofloxacin against 6 American Type Culture Collection (ATCC) standard strains and 70 MDR clinical isolates from a university hospital. The two antidepressants showed better antibacterial activity when compared to ciprofloxacin, in addition to being, separately, bactericidal against all as tested strains. In addition, the two drugs studied showed promising activity against Gram-negative (GN) and Gram-positive (GP), inferring the broader spectrum. When associated with ciprofloxacin, fluoxetine and paroxetine, they are diagnosed in the face of all MDR clinical isolates tested, highlighting that they were resistant to ciprofloxacin. Fluoxetine and paroxetine are promising alternative alternatives in the treatment of infectious diseases caused by MDR microorganisms, in addition to presenting different indications, as demonstrated in the literature. Both antidepressants take alternative approaches to redirect drugs, however, further studies are needed to elucidate the mechanisms of action involved.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESA crescente necessidade de agentes antimicrobianos efetivos para o tratamento de bactérias multidroga resistentes (MDR) envolvidas principalmente em infecções hospitalares leva a utilização de estratégias alternativas. O reposicionamento ou redirecionamento de fármacos já existentes e o sinergismo com medicamentos antibacterianos é uma abordagem promissora no desenvolvimento de novos antimicrobianos. Nesse sentido, o presente estudo teve como objetivo, no primeiro artigo, apresentar novas indicações de uso para os fármacos antidepressivos inibidores seletivos da receptação de serotonina (ISRS) fluoxetina e paroxetina. Nesta carta ao editor foram analisados 39 estudos, os quais descrevem diferentes ações apresentadas por esses medicamentos. Fluoxetina apresentou 19 atividades distintas além de sua conhecida ação antidepressiva, e paroxetina 10 novas indicações. Foram descritas também as cepas bacterianas frente as quais os dois medicamentos foram avaliados, e o tipo de estudo, in vitro (cepas padrão ou isolados clínicos) ou in vivo. No segundo manuscrito, avaliou-se a atividade antibacteriana in vitro de fluoxetina e paroxetina isoladamente e em combinação com o antibacteriano ciprofloxacino frente a 6 cepas padrão American Type Culture Collection (ATCC) e 70 isolados clínicos MDR de um hospital universitário. Ambos antidepressivos apresentaram melhor atividade antibacteriana quando comparados com ciprofloxacino, além de, isoladamente, serem bactericidas frente a todas as cepas testadas. Além disso, os dois medicamentos estudados apresentaram promissora atividade frente a cepas Gram-negativas (GN) e Gram-positivas (GP), caracterizando espectro ampliado. Quando associados com ciprofloxacino, fluoxetina e paroxetina apresentaram sinergismo frente a todos isolados clínicos MDR testados, salientando-se que esses eram resistentes ao ciprofloxacino. Fluoxetina e paroxetina constituem alternativas promissoras no tratamento de doenças infecciosas causadas por microrganismos MDR, além de apresentarem diferentes indicações, como demonstrado na literatura. Ambos antidepressivos constituem abordagens alternativas no redirecionamento de fármacos, porém, são necessários estudos adicionais para elucidar os mecanismos de ação envolvidos.Universidade Federal de Santa MariaBrasilAnálises Clínicas e ToxicológicasUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da SaúdeHorner, Rosmarihttp://lattes.cnpq.br/5907084134183708Hörner, ManfredoPicoli, Simone UlrichFoletto, Vitória Segabinazzi2021-09-02T19:06:26Z2021-09-02T19:06:26Z2020-08-28info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://repositorio.ufsm.br/handle/1/22145porAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM2022-10-05T22:05:19Zoai:repositorio.ufsm.br:1/22145Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2022-10-05T22:05:19Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.none.fl_str_mv |
Reposicionamento dos antidepressivos fluoxetina e paroxetina e efeitos sinérgicos com ciprofloxacino frente bactérias multidroga resistentes Repositioning of fluoxetine and paroxetine antidepressants and synergic effects with cyprofloxacine front resistant multi-drug bacteria |
title |
Reposicionamento dos antidepressivos fluoxetina e paroxetina e efeitos sinérgicos com ciprofloxacino frente bactérias multidroga resistentes |
spellingShingle |
Reposicionamento dos antidepressivos fluoxetina e paroxetina e efeitos sinérgicos com ciprofloxacino frente bactérias multidroga resistentes Foletto, Vitória Segabinazzi Redirecionamento Resistência bacteriana Atividade antibacteriana Antidepressivos Fluoxetina Paroxetina Ciprofloxacino Sinergismo Redirection Bacterial resistance Antibacterial activity Antidepressants Fluoxetine Paroxetine Ciprofloxacin Synergism CNPQ::CIENCIAS DA SAUDE::FARMACIA |
title_short |
Reposicionamento dos antidepressivos fluoxetina e paroxetina e efeitos sinérgicos com ciprofloxacino frente bactérias multidroga resistentes |
title_full |
Reposicionamento dos antidepressivos fluoxetina e paroxetina e efeitos sinérgicos com ciprofloxacino frente bactérias multidroga resistentes |
title_fullStr |
Reposicionamento dos antidepressivos fluoxetina e paroxetina e efeitos sinérgicos com ciprofloxacino frente bactérias multidroga resistentes |
title_full_unstemmed |
Reposicionamento dos antidepressivos fluoxetina e paroxetina e efeitos sinérgicos com ciprofloxacino frente bactérias multidroga resistentes |
title_sort |
Reposicionamento dos antidepressivos fluoxetina e paroxetina e efeitos sinérgicos com ciprofloxacino frente bactérias multidroga resistentes |
author |
Foletto, Vitória Segabinazzi |
author_facet |
Foletto, Vitória Segabinazzi |
author_role |
author |
dc.contributor.none.fl_str_mv |
Horner, Rosmari http://lattes.cnpq.br/5907084134183708 Hörner, Manfredo Picoli, Simone Ulrich |
dc.contributor.author.fl_str_mv |
Foletto, Vitória Segabinazzi |
dc.subject.por.fl_str_mv |
Redirecionamento Resistência bacteriana Atividade antibacteriana Antidepressivos Fluoxetina Paroxetina Ciprofloxacino Sinergismo Redirection Bacterial resistance Antibacterial activity Antidepressants Fluoxetine Paroxetine Ciprofloxacin Synergism CNPQ::CIENCIAS DA SAUDE::FARMACIA |
topic |
Redirecionamento Resistência bacteriana Atividade antibacteriana Antidepressivos Fluoxetina Paroxetina Ciprofloxacino Sinergismo Redirection Bacterial resistance Antibacterial activity Antidepressants Fluoxetine Paroxetine Ciprofloxacin Synergism CNPQ::CIENCIAS DA SAUDE::FARMACIA |
description |
The growing need for effective antimicrobial agents for the treatment of multidrug-resistant bacteria (MDR), mainly caused by nosocomial infections, leads to the use of alternative alternatives. The repositioning or redirection of existing drugs and synergism with antibacterial drugs is a promising approach in the development of new antimicrobials. In this sense, the present study aimed, in the first article, to present new indications for use for antidepressant drugs selective serotonin reception (SSRI) fluoxetine and paroxetine. In this letter to the editor, 39 studies were analyzed, which describe different actions presented by these drugs. Fluoxetine showed 19 different activities in addition to its well-known antidepressant action, and paroxetine 10 new indications. The bacterial strains against which the two drugs were evaluated were also described, and the type of study, in vitro (standard strains or clinical isolates) or in vivo. In the second manuscript, the in vitro antibacterial activity of fluoxetine and paroxetine was evaluated alone and in combination with the antibacterial ciprofloxacin against 6 American Type Culture Collection (ATCC) standard strains and 70 MDR clinical isolates from a university hospital. The two antidepressants showed better antibacterial activity when compared to ciprofloxacin, in addition to being, separately, bactericidal against all as tested strains. In addition, the two drugs studied showed promising activity against Gram-negative (GN) and Gram-positive (GP), inferring the broader spectrum. When associated with ciprofloxacin, fluoxetine and paroxetine, they are diagnosed in the face of all MDR clinical isolates tested, highlighting that they were resistant to ciprofloxacin. Fluoxetine and paroxetine are promising alternative alternatives in the treatment of infectious diseases caused by MDR microorganisms, in addition to presenting different indications, as demonstrated in the literature. Both antidepressants take alternative approaches to redirect drugs, however, further studies are needed to elucidate the mechanisms of action involved. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-08-28 2021-09-02T19:06:26Z 2021-09-02T19:06:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/22145 |
url |
http://repositorio.ufsm.br/handle/1/22145 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Brasil Análises Clínicas e Toxicológicas UFSM Programa de Pós-Graduação em Ciências Farmacêuticas Centro de Ciências da Saúde |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Brasil Análises Clínicas e Toxicológicas UFSM Programa de Pós-Graduação em Ciências Farmacêuticas Centro de Ciências da Saúde |
dc.source.none.fl_str_mv |
reponame:Manancial - Repositório Digital da UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Manancial - Repositório Digital da UFSM |
collection |
Manancial - Repositório Digital da UFSM |
repository.name.fl_str_mv |
Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
atendimento.sib@ufsm.br||tedebc@gmail.com |
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1805922056964931584 |