Screening of antibacterial extracts from plants native to the Brazilian Amazon Rain Forest and Atlantic Forest
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S0100-879X2004000300015 http://repositorio.unifesp.br/handle/11600/2031 |
Resumo: | More than 20% of the world's biodiversity is located in Brazilian forests and only a few plant extracts have been evaluated for potential antibacterial activity. In the present study, 705 organic and aqueous extracts of plants obtained from different Amazon Rain Forest and Atlantic Forest plants were screened for antibacterial activity at 100 µg/ml, using a microdilution broth assay against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Escherichia coli. One extract, VO581, was active against S. aureus (minimum inhibitory concentration (MIC) = 140 µg/ml and minimal bactericidal concentration (MBC) = 160 µg/ml, organic extract obtained from stems) and two extracts were active against E. faecalis, SM053 (MIC = 80 µg/ml and MBC = 90 µg/ml, organic extract obtained from aerial parts), and MY841 (MIC = 30 µg/ml and MBC = 50 µg/ml, organic extract obtained from stems). The most active fractions are being fractionated to identify their active substances. Higher concentrations of other extracts are currently being evaluated against the same microorganisms. |
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Repositório Institucional da UNIFESP |
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Screening of antibacterial extracts from plants native to the Brazilian Amazon Rain Forest and Atlantic ForestPlant extractAntibacterial activityScreeningAmazon Rain ForestAtlantic ForestMore than 20% of the world's biodiversity is located in Brazilian forests and only a few plant extracts have been evaluated for potential antibacterial activity. In the present study, 705 organic and aqueous extracts of plants obtained from different Amazon Rain Forest and Atlantic Forest plants were screened for antibacterial activity at 100 µg/ml, using a microdilution broth assay against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Escherichia coli. One extract, VO581, was active against S. aureus (minimum inhibitory concentration (MIC) = 140 µg/ml and minimal bactericidal concentration (MBC) = 160 µg/ml, organic extract obtained from stems) and two extracts were active against E. faecalis, SM053 (MIC = 80 µg/ml and MBC = 90 µg/ml, organic extract obtained from aerial parts), and MY841 (MIC = 30 µg/ml and MBC = 50 µg/ml, organic extract obtained from stems). The most active fractions are being fractionated to identify their active substances. Higher concentrations of other extracts are currently being evaluated against the same microorganisms.Universidade Paulista Laboratório de ExtraçãoUniversidade Federal de São Paulo (UNIFESP) Laboratório Especial de Microbiologia ClínicaUniversidade Federal do Maranhão Centro de Ciências Biológicas e da SaúdeUNIFESP, Laboratório Especial de Microbiologia ClínicaSciELOAssociação Brasileira de Divulgação CientíficaUniversidade Paulista Laboratório de ExtraçãoUniversidade Federal de São Paulo (UNIFESP)Universidade Federal do Maranhão Centro de Ciências Biológicas e da SaúdeSuffredini, I.b.Sader, Helio Silva [UNIFESP]Gonçalves, Azizedite GuedesReis, Adriana O. [UNIFESP]Gales, Ana Cristina [UNIFESP]Varella, Antonio DrauzioYounes, Riad Naim2015-06-14T13:30:20Z2015-06-14T13:30:20Z2004-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion379-384application/pdfhttp://dx.doi.org/10.1590/S0100-879X2004000300015Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 37, n. 3, p. 379-384, 2004.10.1590/S0100-879X2004000300015S0100-879X2004000300015.pdf0100-879XS0100-879X2004000300015http://repositorio.unifesp.br/handle/11600/2031WOS:000220371600015engBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-06T23:57:21Zoai:repositorio.unifesp.br/:11600/2031Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-06T23:57:21Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Screening of antibacterial extracts from plants native to the Brazilian Amazon Rain Forest and Atlantic Forest |
title |
Screening of antibacterial extracts from plants native to the Brazilian Amazon Rain Forest and Atlantic Forest |
spellingShingle |
Screening of antibacterial extracts from plants native to the Brazilian Amazon Rain Forest and Atlantic Forest Suffredini, I.b. Plant extract Antibacterial activity Screening Amazon Rain Forest Atlantic Forest |
title_short |
Screening of antibacterial extracts from plants native to the Brazilian Amazon Rain Forest and Atlantic Forest |
title_full |
Screening of antibacterial extracts from plants native to the Brazilian Amazon Rain Forest and Atlantic Forest |
title_fullStr |
Screening of antibacterial extracts from plants native to the Brazilian Amazon Rain Forest and Atlantic Forest |
title_full_unstemmed |
Screening of antibacterial extracts from plants native to the Brazilian Amazon Rain Forest and Atlantic Forest |
title_sort |
Screening of antibacterial extracts from plants native to the Brazilian Amazon Rain Forest and Atlantic Forest |
author |
Suffredini, I.b. |
author_facet |
Suffredini, I.b. Sader, Helio Silva [UNIFESP] Gonçalves, Azizedite Guedes Reis, Adriana O. [UNIFESP] Gales, Ana Cristina [UNIFESP] Varella, Antonio Drauzio Younes, Riad Naim |
author_role |
author |
author2 |
Sader, Helio Silva [UNIFESP] Gonçalves, Azizedite Guedes Reis, Adriana O. [UNIFESP] Gales, Ana Cristina [UNIFESP] Varella, Antonio Drauzio Younes, Riad Naim |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Paulista Laboratório de Extração Universidade Federal de São Paulo (UNIFESP) Universidade Federal do Maranhão Centro de Ciências Biológicas e da Saúde |
dc.contributor.author.fl_str_mv |
Suffredini, I.b. Sader, Helio Silva [UNIFESP] Gonçalves, Azizedite Guedes Reis, Adriana O. [UNIFESP] Gales, Ana Cristina [UNIFESP] Varella, Antonio Drauzio Younes, Riad Naim |
dc.subject.por.fl_str_mv |
Plant extract Antibacterial activity Screening Amazon Rain Forest Atlantic Forest |
topic |
Plant extract Antibacterial activity Screening Amazon Rain Forest Atlantic Forest |
description |
More than 20% of the world's biodiversity is located in Brazilian forests and only a few plant extracts have been evaluated for potential antibacterial activity. In the present study, 705 organic and aqueous extracts of plants obtained from different Amazon Rain Forest and Atlantic Forest plants were screened for antibacterial activity at 100 µg/ml, using a microdilution broth assay against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Escherichia coli. One extract, VO581, was active against S. aureus (minimum inhibitory concentration (MIC) = 140 µg/ml and minimal bactericidal concentration (MBC) = 160 µg/ml, organic extract obtained from stems) and two extracts were active against E. faecalis, SM053 (MIC = 80 µg/ml and MBC = 90 µg/ml, organic extract obtained from aerial parts), and MY841 (MIC = 30 µg/ml and MBC = 50 µg/ml, organic extract obtained from stems). The most active fractions are being fractionated to identify their active substances. Higher concentrations of other extracts are currently being evaluated against the same microorganisms. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-03-01 2015-06-14T13:30:20Z 2015-06-14T13:30:20Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0100-879X2004000300015 Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 37, n. 3, p. 379-384, 2004. 10.1590/S0100-879X2004000300015 S0100-879X2004000300015.pdf 0100-879X S0100-879X2004000300015 http://repositorio.unifesp.br/handle/11600/2031 WOS:000220371600015 |
url |
http://dx.doi.org/10.1590/S0100-879X2004000300015 http://repositorio.unifesp.br/handle/11600/2031 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 37, n. 3, p. 379-384, 2004. 10.1590/S0100-879X2004000300015 S0100-879X2004000300015.pdf 0100-879X S0100-879X2004000300015 WOS:000220371600015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
379-384 application/pdf |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268404208500736 |