Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae)

Detalhes bibliográficos
Autor(a) principal: Santos, Roberta Tancredi dos [UNIFESP]
Data de Publicação: 2012
Outros Autores: Hiramoto, Liliane Lumi [UNIFESP], Lago, Joao Henrique Ghilardi [UNIFESP], Sartorelli, Patricia [UNIFESP], Tempone, André Gustavo [UNIFESP], Pinto, Erika Gracielle
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://repositorio.unifesp.br/handle/11600/6908
http://dx.doi.org/10.1590/S0100-40422012001100025
Resumo: MeOH extract from the leaves of Plectranthus barbatus Andrews (Lamiaceae), showed in vitro anti-trypanosomal activity. The bioassay-guided fractionation resulted in the isolation of a gallic acid derivative, identified as 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG), after thorough NMR and MS spectral analysis. Finally, this compound was tested against trypomastigote forms of T. cruzi and displayed an EC50 value of 67 µM, at least 6.6-fold more effective than the standard drug benznidazole. This is the first occurrence of PGG in the Plectranthus genus and the first anti-parasitic activity described for PGG in the literature.
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spelling Santos, Roberta Tancredi dos [UNIFESP]Hiramoto, Liliane Lumi [UNIFESP]Lago, Joao Henrique Ghilardi [UNIFESP]Sartorelli, Patricia [UNIFESP]Tempone, André Gustavo [UNIFESP]Pinto, Erika GracielleUniversidade Federal de São Paulo (UNIFESP)Instituto Adolfo Lutz Departamento de ParasitologiaUniversidade de São Paulo (USP)Instituto Plantarum de Estudos da Flora2015-06-14T13:43:32Z2015-06-14T13:43:32Z2012-01-01SANTOS, Roberta Tancredi dos et al . Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae). Quím. Nova, São Paulo , v. 35, n. 11, p. 2229-2332, 20120100-4042http://repositorio.unifesp.br/handle/11600/6908http://dx.doi.org/10.1590/S0100-40422012001100025S0100-40422012001100025.pdfS0100-4042201200110002510.1590/S0100-40422012001100025WOS:000312034600025MeOH extract from the leaves of Plectranthus barbatus Andrews (Lamiaceae), showed in vitro anti-trypanosomal activity. The bioassay-guided fractionation resulted in the isolation of a gallic acid derivative, identified as 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG), after thorough NMR and MS spectral analysis. Finally, this compound was tested against trypomastigote forms of T. cruzi and displayed an EC50 value of 67 µM, at least 6.6-fold more effective than the standard drug benznidazole. This is the first occurrence of PGG in the Plectranthus genus and the first anti-parasitic activity described for PGG in the literature.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Federal de São Paulo (UNIFESP) Instituto de Ciências Ambientais, Químicas e FarmacêuticasInstituto Adolfo Lutz Departamento de ParasitologiaUniversidade de São Paulo Instituto de Medicina Tropical de São PauloInstituto Plantarum de Estudos da FloraUNIFESP, Instituto de Ciências Ambientais, Químicas e FarmacêuticasSciELO2229-2332engSociedade Brasileira de QuímicaQuímica NovaPlectranthus barbatus1,2,3,4,6-penta-O-galloyl-β-D-glucoseanti-trypanosomal activityAnti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-40422012001100025.pdfapplication/pdf234697${dspace.ui.url}/bitstream/11600/6908/1/S0100-40422012001100025.pdf9d4ff9f14ff1330734aadb03daf256a4MD51open accessTEXTS0100-40422012001100025.pdf.txtS0100-40422012001100025.pdf.txtExtracted texttext/plain19250${dspace.ui.url}/bitstream/11600/6908/9/S0100-40422012001100025.pdf.txt8b7a4fd861635d92bf0c28bbd88e6c6dMD59open accessTHUMBNAILS0100-40422012001100025.pdf.jpgS0100-40422012001100025.pdf.jpgIM Thumbnailimage/jpeg6532${dspace.ui.url}/bitstream/11600/6908/11/S0100-40422012001100025.pdf.jpgd31df06605c6417699797f322756c8fcMD511open access11600/69082023-06-05 19:35:41.985open accessoai:repositorio.unifesp.br:11600/6908Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:35:41Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae)
title Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae)
spellingShingle Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae)
Santos, Roberta Tancredi dos [UNIFESP]
Plectranthus barbatus
1,2,3,4,6-penta-O-galloyl-β-D-glucose
anti-trypanosomal activity
title_short Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae)
title_full Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae)
title_fullStr Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae)
title_full_unstemmed Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae)
title_sort Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae)
author Santos, Roberta Tancredi dos [UNIFESP]
author_facet Santos, Roberta Tancredi dos [UNIFESP]
Hiramoto, Liliane Lumi [UNIFESP]
Lago, Joao Henrique Ghilardi [UNIFESP]
Sartorelli, Patricia [UNIFESP]
Tempone, André Gustavo [UNIFESP]
Pinto, Erika Gracielle
author_role author
author2 Hiramoto, Liliane Lumi [UNIFESP]
Lago, Joao Henrique Ghilardi [UNIFESP]
Sartorelli, Patricia [UNIFESP]
Tempone, André Gustavo [UNIFESP]
Pinto, Erika Gracielle
author2_role author
author
author
author
author
dc.contributor.institution.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Instituto Adolfo Lutz Departamento de Parasitologia
Universidade de São Paulo (USP)
Instituto Plantarum de Estudos da Flora
dc.contributor.author.fl_str_mv Santos, Roberta Tancredi dos [UNIFESP]
Hiramoto, Liliane Lumi [UNIFESP]
Lago, Joao Henrique Ghilardi [UNIFESP]
Sartorelli, Patricia [UNIFESP]
Tempone, André Gustavo [UNIFESP]
Pinto, Erika Gracielle
dc.subject.eng.fl_str_mv Plectranthus barbatus
1,2,3,4,6-penta-O-galloyl-β-D-glucose
anti-trypanosomal activity
topic Plectranthus barbatus
1,2,3,4,6-penta-O-galloyl-β-D-glucose
anti-trypanosomal activity
description MeOH extract from the leaves of Plectranthus barbatus Andrews (Lamiaceae), showed in vitro anti-trypanosomal activity. The bioassay-guided fractionation resulted in the isolation of a gallic acid derivative, identified as 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG), after thorough NMR and MS spectral analysis. Finally, this compound was tested against trypomastigote forms of T. cruzi and displayed an EC50 value of 67 µM, at least 6.6-fold more effective than the standard drug benznidazole. This is the first occurrence of PGG in the Plectranthus genus and the first anti-parasitic activity described for PGG in the literature.
publishDate 2012
dc.date.issued.fl_str_mv 2012-01-01
dc.date.accessioned.fl_str_mv 2015-06-14T13:43:32Z
dc.date.available.fl_str_mv 2015-06-14T13:43:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.fl_str_mv SANTOS, Roberta Tancredi dos et al . Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae). Quím. Nova, São Paulo , v. 35, n. 11, p. 2229-2332, 2012
dc.identifier.uri.fl_str_mv http://repositorio.unifesp.br/handle/11600/6908
http://dx.doi.org/10.1590/S0100-40422012001100025
dc.identifier.issn.none.fl_str_mv 0100-4042
dc.identifier.file.none.fl_str_mv S0100-40422012001100025.pdf
dc.identifier.scielo.none.fl_str_mv S0100-40422012001100025
dc.identifier.doi.none.fl_str_mv 10.1590/S0100-40422012001100025
dc.identifier.wos.none.fl_str_mv WOS:000312034600025
identifier_str_mv SANTOS, Roberta Tancredi dos et al . Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae). Quím. Nova, São Paulo , v. 35, n. 11, p. 2229-2332, 2012
0100-4042
S0100-40422012001100025.pdf
S0100-40422012001100025
10.1590/S0100-40422012001100025
WOS:000312034600025
url http://repositorio.unifesp.br/handle/11600/6908
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
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instname:Universidade Federal de São Paulo (UNIFESP)
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