Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae)
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/6908 http://dx.doi.org/10.1590/S0100-40422012001100025 |
Resumo: | MeOH extract from the leaves of Plectranthus barbatus Andrews (Lamiaceae), showed in vitro anti-trypanosomal activity. The bioassay-guided fractionation resulted in the isolation of a gallic acid derivative, identified as 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG), after thorough NMR and MS spectral analysis. Finally, this compound was tested against trypomastigote forms of T. cruzi and displayed an EC50 value of 67 µM, at least 6.6-fold more effective than the standard drug benznidazole. This is the first occurrence of PGG in the Plectranthus genus and the first anti-parasitic activity described for PGG in the literature. |
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Santos, Roberta Tancredi dos [UNIFESP]Hiramoto, Liliane Lumi [UNIFESP]Lago, Joao Henrique Ghilardi [UNIFESP]Sartorelli, Patricia [UNIFESP]Tempone, André Gustavo [UNIFESP]Pinto, Erika GracielleUniversidade Federal de São Paulo (UNIFESP)Instituto Adolfo Lutz Departamento de ParasitologiaUniversidade de São Paulo (USP)Instituto Plantarum de Estudos da Flora2015-06-14T13:43:32Z2015-06-14T13:43:32Z2012-01-01SANTOS, Roberta Tancredi dos et al . Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae). Quím. Nova, São Paulo , v. 35, n. 11, p. 2229-2332, 20120100-4042http://repositorio.unifesp.br/handle/11600/6908http://dx.doi.org/10.1590/S0100-40422012001100025S0100-40422012001100025.pdfS0100-4042201200110002510.1590/S0100-40422012001100025WOS:000312034600025MeOH extract from the leaves of Plectranthus barbatus Andrews (Lamiaceae), showed in vitro anti-trypanosomal activity. The bioassay-guided fractionation resulted in the isolation of a gallic acid derivative, identified as 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG), after thorough NMR and MS spectral analysis. Finally, this compound was tested against trypomastigote forms of T. cruzi and displayed an EC50 value of 67 µM, at least 6.6-fold more effective than the standard drug benznidazole. This is the first occurrence of PGG in the Plectranthus genus and the first anti-parasitic activity described for PGG in the literature.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Federal de São Paulo (UNIFESP) Instituto de Ciências Ambientais, Químicas e FarmacêuticasInstituto Adolfo Lutz Departamento de ParasitologiaUniversidade de São Paulo Instituto de Medicina Tropical de São PauloInstituto Plantarum de Estudos da FloraUNIFESP, Instituto de Ciências Ambientais, Químicas e FarmacêuticasSciELO2229-2332engSociedade Brasileira de QuímicaQuímica NovaPlectranthus barbatus1,2,3,4,6-penta-O-galloyl-β-D-glucoseanti-trypanosomal activityAnti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-40422012001100025.pdfapplication/pdf234697${dspace.ui.url}/bitstream/11600/6908/1/S0100-40422012001100025.pdf9d4ff9f14ff1330734aadb03daf256a4MD51open accessTEXTS0100-40422012001100025.pdf.txtS0100-40422012001100025.pdf.txtExtracted texttext/plain19250${dspace.ui.url}/bitstream/11600/6908/9/S0100-40422012001100025.pdf.txt8b7a4fd861635d92bf0c28bbd88e6c6dMD59open accessTHUMBNAILS0100-40422012001100025.pdf.jpgS0100-40422012001100025.pdf.jpgIM Thumbnailimage/jpeg6532${dspace.ui.url}/bitstream/11600/6908/11/S0100-40422012001100025.pdf.jpgd31df06605c6417699797f322756c8fcMD511open access11600/69082023-06-05 19:35:41.985open accessoai:repositorio.unifesp.br:11600/6908Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:35:41Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae) |
title |
Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae) |
spellingShingle |
Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae) Santos, Roberta Tancredi dos [UNIFESP] Plectranthus barbatus 1,2,3,4,6-penta-O-galloyl-β-D-glucose anti-trypanosomal activity |
title_short |
Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae) |
title_full |
Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae) |
title_fullStr |
Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae) |
title_full_unstemmed |
Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae) |
title_sort |
Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae) |
author |
Santos, Roberta Tancredi dos [UNIFESP] |
author_facet |
Santos, Roberta Tancredi dos [UNIFESP] Hiramoto, Liliane Lumi [UNIFESP] Lago, Joao Henrique Ghilardi [UNIFESP] Sartorelli, Patricia [UNIFESP] Tempone, André Gustavo [UNIFESP] Pinto, Erika Gracielle |
author_role |
author |
author2 |
Hiramoto, Liliane Lumi [UNIFESP] Lago, Joao Henrique Ghilardi [UNIFESP] Sartorelli, Patricia [UNIFESP] Tempone, André Gustavo [UNIFESP] Pinto, Erika Gracielle |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Instituto Adolfo Lutz Departamento de Parasitologia Universidade de São Paulo (USP) Instituto Plantarum de Estudos da Flora |
dc.contributor.author.fl_str_mv |
Santos, Roberta Tancredi dos [UNIFESP] Hiramoto, Liliane Lumi [UNIFESP] Lago, Joao Henrique Ghilardi [UNIFESP] Sartorelli, Patricia [UNIFESP] Tempone, André Gustavo [UNIFESP] Pinto, Erika Gracielle |
dc.subject.eng.fl_str_mv |
Plectranthus barbatus 1,2,3,4,6-penta-O-galloyl-β-D-glucose anti-trypanosomal activity |
topic |
Plectranthus barbatus 1,2,3,4,6-penta-O-galloyl-β-D-glucose anti-trypanosomal activity |
description |
MeOH extract from the leaves of Plectranthus barbatus Andrews (Lamiaceae), showed in vitro anti-trypanosomal activity. The bioassay-guided fractionation resulted in the isolation of a gallic acid derivative, identified as 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG), after thorough NMR and MS spectral analysis. Finally, this compound was tested against trypomastigote forms of T. cruzi and displayed an EC50 value of 67 µM, at least 6.6-fold more effective than the standard drug benznidazole. This is the first occurrence of PGG in the Plectranthus genus and the first anti-parasitic activity described for PGG in the literature. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-01-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:43:32Z |
dc.date.available.fl_str_mv |
2015-06-14T13:43:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SANTOS, Roberta Tancredi dos et al . Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae). Quím. Nova, São Paulo , v. 35, n. 11, p. 2229-2332, 2012 |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/6908 http://dx.doi.org/10.1590/S0100-40422012001100025 |
dc.identifier.issn.none.fl_str_mv |
0100-4042 |
dc.identifier.file.none.fl_str_mv |
S0100-40422012001100025.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-40422012001100025 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-40422012001100025 |
dc.identifier.wos.none.fl_str_mv |
WOS:000312034600025 |
identifier_str_mv |
SANTOS, Roberta Tancredi dos et al . Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae). Quím. Nova, São Paulo , v. 35, n. 11, p. 2229-2332, 2012 0100-4042 S0100-40422012001100025.pdf S0100-40422012001100025 10.1590/S0100-40422012001100025 WOS:000312034600025 |
url |
http://repositorio.unifesp.br/handle/11600/6908 http://dx.doi.org/10.1590/S0100-40422012001100025 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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Química Nova |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
2229-2332 |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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Repositório Institucional da UNIFESP |
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