Parasite and egg burden, hepatic collagen and histologic pattern of liver granulomas in selection III high and low antibody responder mice infected with Schistosoma mansoni
Autor(a) principal: | |
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Data de Publicação: | 1994 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/332 http://dx.doi.org/10.1590/S0074-02761994000100012 |
Resumo: | Selection III mice have particular immunological characteristics: they are high (H III) or low (L III) antibody producer animals, yet both lines display similar T cell responses and macrophage activities. We submittedthese mice to infection with Schistosoma mansoni to assess in vivo parasite and egg burden, hepatic collagen and cellular composition of granulomas in both lines. Titration of anti-Schistosoma IgG by ELISA showed remarkably higher values inH III line, at both studied periods (8th and 12th weeks post-infection). Nevertheless, the number of adult worms recovered from the portal system was similar inboth lines, being not associated with anti-Schistosoma antibody levels. There isan increase in hepatic collagen from the 8th to the 12th weeks post-infection, which is paralleled by an increase in the number of eggs in the liver. This association apparently occurs at the same radio in H III and L III animals. The most important difference found between the two lines was the outstanding contrast interms of volume and eosinophil counts in the granulomas, with lesions from H IIImice clearly being larger and containing more of these cells than LIII lesions. |
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Catapani, Wilson RobertoParise, Edison Roberto [UNIFESP]Leite-Mór, Marilisa Moraes Barros [UNIFESP]Sadigursky, M.Andrade, Z. A.Sant'Anna, O. A.Miszputen, Sender Jankiel [UNIFESP]Siqueira, M.Universidade Federal de São Paulo (UNIFESP)FIOCRUZ Centro de Pesquisas Gonçalo MunizInstituto Butantan Laboratório de Imunogenética2015-06-14T13:24:25Z2015-06-14T13:24:25Z1994-03-01Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 89, n. 1, p. 63-67, 1994.0074-0276http://repositorio.unifesp.br/handle/11600/332http://dx.doi.org/10.1590/S0074-02761994000100012S0074-02761994000100012.pdfS0074-0276199400010001210.1590/S0074-02761994000100012WOS:A1994NW66100012Selection III mice have particular immunological characteristics: they are high (H III) or low (L III) antibody producer animals, yet both lines display similar T cell responses and macrophage activities. We submittedthese mice to infection with Schistosoma mansoni to assess in vivo parasite and egg burden, hepatic collagen and cellular composition of granulomas in both lines. Titration of anti-Schistosoma IgG by ELISA showed remarkably higher values inH III line, at both studied periods (8th and 12th weeks post-infection). Nevertheless, the number of adult worms recovered from the portal system was similar inboth lines, being not associated with anti-Schistosoma antibody levels. There isan increase in hepatic collagen from the 8th to the 12th weeks post-infection, which is paralleled by an increase in the number of eggs in the liver. This association apparently occurs at the same radio in H III and L III animals. The most important difference found between the two lines was the outstanding contrast interms of volume and eosinophil counts in the granulomas, with lesions from H IIImice clearly being larger and containing more of these cells than LIII lesions.Escola Paulista de Medicina Disciplina de GastroenterologiaFIOCRUZ Centro de Pesquisas Gonçalo MunizInstituto Butantan Laboratório de ImunogenéticaUNIFESP, EPM, Disciplina de GastroenterologiaSciELO63-67engInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo CruzSchistosoma mansonicollagengranulomasschistosomiasishight and low antibody miceParasite and egg burden, hepatic collagen and histologic pattern of liver granulomas in selection III high and low antibody responder mice infected with Schistosoma mansoniinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0074-02761994000100012.pdfapplication/pdf285542${dspace.ui.url}/bitstream/11600/332/1/S0074-02761994000100012.pdf1d65ef3ccbb2671e91ebda02b5e52e7dMD51open accessTEXTS0074-02761994000100012.pdf.txtS0074-02761994000100012.pdf.txtExtracted texttext/plain5${dspace.ui.url}/bitstream/11600/332/2/S0074-02761994000100012.pdf.txtcc9067c2ee470dc248b14b194209a34eMD52open access11600/3322021-10-04 21:27:09.696open accessoai:repositorio.unifesp.br:11600/332Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-10-05T00:27:09Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Parasite and egg burden, hepatic collagen and histologic pattern of liver granulomas in selection III high and low antibody responder mice infected with Schistosoma mansoni |
title |
Parasite and egg burden, hepatic collagen and histologic pattern of liver granulomas in selection III high and low antibody responder mice infected with Schistosoma mansoni |
spellingShingle |
Parasite and egg burden, hepatic collagen and histologic pattern of liver granulomas in selection III high and low antibody responder mice infected with Schistosoma mansoni Catapani, Wilson Roberto Schistosoma mansoni collagen granulomas schistosomiasis hight and low antibody mice |
title_short |
Parasite and egg burden, hepatic collagen and histologic pattern of liver granulomas in selection III high and low antibody responder mice infected with Schistosoma mansoni |
title_full |
Parasite and egg burden, hepatic collagen and histologic pattern of liver granulomas in selection III high and low antibody responder mice infected with Schistosoma mansoni |
title_fullStr |
Parasite and egg burden, hepatic collagen and histologic pattern of liver granulomas in selection III high and low antibody responder mice infected with Schistosoma mansoni |
title_full_unstemmed |
Parasite and egg burden, hepatic collagen and histologic pattern of liver granulomas in selection III high and low antibody responder mice infected with Schistosoma mansoni |
title_sort |
Parasite and egg burden, hepatic collagen and histologic pattern of liver granulomas in selection III high and low antibody responder mice infected with Schistosoma mansoni |
author |
Catapani, Wilson Roberto |
author_facet |
Catapani, Wilson Roberto Parise, Edison Roberto [UNIFESP] Leite-Mór, Marilisa Moraes Barros [UNIFESP] Sadigursky, M. Andrade, Z. A. Sant'Anna, O. A. Miszputen, Sender Jankiel [UNIFESP] Siqueira, M. |
author_role |
author |
author2 |
Parise, Edison Roberto [UNIFESP] Leite-Mór, Marilisa Moraes Barros [UNIFESP] Sadigursky, M. Andrade, Z. A. Sant'Anna, O. A. Miszputen, Sender Jankiel [UNIFESP] Siqueira, M. |
author2_role |
author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) FIOCRUZ Centro de Pesquisas Gonçalo Muniz Instituto Butantan Laboratório de Imunogenética |
dc.contributor.author.fl_str_mv |
Catapani, Wilson Roberto Parise, Edison Roberto [UNIFESP] Leite-Mór, Marilisa Moraes Barros [UNIFESP] Sadigursky, M. Andrade, Z. A. Sant'Anna, O. A. Miszputen, Sender Jankiel [UNIFESP] Siqueira, M. |
dc.subject.eng.fl_str_mv |
Schistosoma mansoni collagen granulomas schistosomiasis hight and low antibody mice |
topic |
Schistosoma mansoni collagen granulomas schistosomiasis hight and low antibody mice |
description |
Selection III mice have particular immunological characteristics: they are high (H III) or low (L III) antibody producer animals, yet both lines display similar T cell responses and macrophage activities. We submittedthese mice to infection with Schistosoma mansoni to assess in vivo parasite and egg burden, hepatic collagen and cellular composition of granulomas in both lines. Titration of anti-Schistosoma IgG by ELISA showed remarkably higher values inH III line, at both studied periods (8th and 12th weeks post-infection). Nevertheless, the number of adult worms recovered from the portal system was similar inboth lines, being not associated with anti-Schistosoma antibody levels. There isan increase in hepatic collagen from the 8th to the 12th weeks post-infection, which is paralleled by an increase in the number of eggs in the liver. This association apparently occurs at the same radio in H III and L III animals. The most important difference found between the two lines was the outstanding contrast interms of volume and eosinophil counts in the granulomas, with lesions from H IIImice clearly being larger and containing more of these cells than LIII lesions. |
publishDate |
1994 |
dc.date.issued.fl_str_mv |
1994-03-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:24:25Z |
dc.date.available.fl_str_mv |
2015-06-14T13:24:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 89, n. 1, p. 63-67, 1994. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/332 http://dx.doi.org/10.1590/S0074-02761994000100012 |
dc.identifier.issn.none.fl_str_mv |
0074-0276 |
dc.identifier.file.none.fl_str_mv |
S0074-02761994000100012.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0074-02761994000100012 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0074-02761994000100012 |
dc.identifier.wos.none.fl_str_mv |
WOS:A1994NW66100012 |
identifier_str_mv |
Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 89, n. 1, p. 63-67, 1994. 0074-0276 S0074-02761994000100012.pdf S0074-02761994000100012 10.1590/S0074-02761994000100012 WOS:A1994NW66100012 |
url |
http://repositorio.unifesp.br/handle/11600/332 http://dx.doi.org/10.1590/S0074-02761994000100012 |
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eng |
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eng |
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Memórias do Instituto Oswaldo Cruz |
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info:eu-repo/semantics/openAccess |
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openAccess |
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63-67 |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
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Instituto Oswaldo Cruz, Ministério da Saúde |
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