Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/57929 http://dx.doi.org/10.1590/1414-431X20155003 |
Resumo: | Fractionation of the EtOH extract from aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to isolation of caffeic and ferulic acids, which were identified from spectroscopic and spectrometric evidence. These compounds exhibit antioxidant and anti-inflammatory properties and have been shown to be effective in the prevention/treatment of metabolic syndrome. This study investigated whether the combined treatment of caffeic and ferulic acids exhibits a more significant beneficial effect in a mouse model with metabolic syndrome. The combination treatment with caffeic and ferulic acids was tested for 60 days in C57 mice kept on a high-fat (40%) diet. The data obtained indicated that treatment with caffeic and ferulic acids prevented gain in body weight induced by the high-fat diet and improved hyperglycemia, hypercholesterolemia and hypertriglyceridemia. The expression of a number of metabolically relevant genes was affected in the liver of these animals, showing that caffeic and ferulic acid treatment results in increased cholesterol uptake and reduced hepatic triglyceride synthesis in the liver, which is a likely explanation for the prevention of hepatic steatosis. In conclusion, the combined treatment of caffeic and ferulic acids displayed major positive effects towards prevention of multiple aspects of the metabolic syndrome and liver steatosis in an obese mouse model. |
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Bocco, B. M.Fernandes, G. W.Lorena, F. B.Cysneiros, R. M.Christoffolete, M. A.Grecco, S. S.Lancellotti, C. L.Romoff, P.Lago, J. H. G. [UNIFESP]Bianco, A. C.Ribeiro, M. O.2020-08-21T17:00:18Z2020-08-21T17:00:18Z2016Brazilian Journal Of Medical And Biological Research. Sao Paulo, v. 49, n. 3, p. -, 2016.0100-879Xhttps://repositorio.unifesp.br/handle/11600/57929http://dx.doi.org/10.1590/1414-431X20155003S0100-879X2016000300604-en.pdfS0100-879X201600030060410.1590/1414-431X20155003WOS:000370521400006Fractionation of the EtOH extract from aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to isolation of caffeic and ferulic acids, which were identified from spectroscopic and spectrometric evidence. These compounds exhibit antioxidant and anti-inflammatory properties and have been shown to be effective in the prevention/treatment of metabolic syndrome. This study investigated whether the combined treatment of caffeic and ferulic acids exhibits a more significant beneficial effect in a mouse model with metabolic syndrome. The combination treatment with caffeic and ferulic acids was tested for 60 days in C57 mice kept on a high-fat (40%) diet. The data obtained indicated that treatment with caffeic and ferulic acids prevented gain in body weight induced by the high-fat diet and improved hyperglycemia, hypercholesterolemia and hypertriglyceridemia. The expression of a number of metabolically relevant genes was affected in the liver of these animals, showing that caffeic and ferulic acid treatment results in increased cholesterol uptake and reduced hepatic triglyceride synthesis in the liver, which is a likely explanation for the prevention of hepatic steatosis. In conclusion, the combined treatment of caffeic and ferulic acids displayed major positive effects towards prevention of multiple aspects of the metabolic syndrome and liver steatosis in an obese mouse model.CAPESFAPESPMackPesquisaUniv Presbiteriana Mackenzie, Programa Posgrad Disturbios Desenvolvimento, Ctr Ciencias Biol & Saude, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Med Translac, Escola Paulista Med, Sao Paulo, SP, BrazilUniv Fed ABC, Ctr Ciencias Nat & Humanas, Sao Paulo, SP, BrazilEscola Ciencias Med, Dept Ciencias Patol, Sao Paulo, SP, BrazilUniv Presbiteriana Mackenzie, Escola Engn, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Sao Paulo, SP, BrazilRush Univ & Med Ctr, Dept Internal Med, Div Endocrinol & Metab, Chicago, IL 60612 USAUniv Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Sao Paulo, SP, BrazilFAPESP: 2011/21847-6Web of Science-engAssoc Bras Divulg CientificaBrazilian Journal Of Medical And Biological ResearchObesityCaffeic acidFerulic acidMetabolic syndromeCombined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSao Paulo493info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2016000300604-en.pdfapplication/pdf883174${dspace.ui.url}/bitstream/11600/57929/1/S0100-879X2016000300604-en.pdfe639aa53277abf8b762bfec7c53c3d9fMD51open accessTEXTS0100-879X2016000300604-en.pdf.txtS0100-879X2016000300604-en.pdf.txtExtracted texttext/plain27786${dspace.ui.url}/bitstream/11600/57929/8/S0100-879X2016000300604-en.pdf.txt8d1c85479a00b33d42524bf5e3b2bf26MD58open accessTHUMBNAILS0100-879X2016000300604-en.pdf.jpgS0100-879X2016000300604-en.pdf.jpgIM Thumbnailimage/jpeg7022${dspace.ui.url}/bitstream/11600/57929/10/S0100-879X2016000300604-en.pdf.jpgcb623ca895a17a7ede1dd13a75423e9eMD510open access11600/579292023-06-05 19:27:31.039open accessoai:repositorio.unifesp.br:11600/57929Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:27:31Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice |
title |
Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice |
spellingShingle |
Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice Bocco, B. M. Obesity Caffeic acid Ferulic acid Metabolic syndrome |
title_short |
Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice |
title_full |
Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice |
title_fullStr |
Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice |
title_full_unstemmed |
Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice |
title_sort |
Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice |
author |
Bocco, B. M. |
author_facet |
Bocco, B. M. Fernandes, G. W. Lorena, F. B. Cysneiros, R. M. Christoffolete, M. A. Grecco, S. S. Lancellotti, C. L. Romoff, P. Lago, J. H. G. [UNIFESP] Bianco, A. C. Ribeiro, M. O. |
author_role |
author |
author2 |
Fernandes, G. W. Lorena, F. B. Cysneiros, R. M. Christoffolete, M. A. Grecco, S. S. Lancellotti, C. L. Romoff, P. Lago, J. H. G. [UNIFESP] Bianco, A. C. Ribeiro, M. O. |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Bocco, B. M. Fernandes, G. W. Lorena, F. B. Cysneiros, R. M. Christoffolete, M. A. Grecco, S. S. Lancellotti, C. L. Romoff, P. Lago, J. H. G. [UNIFESP] Bianco, A. C. Ribeiro, M. O. |
dc.subject.eng.fl_str_mv |
Obesity Caffeic acid Ferulic acid Metabolic syndrome |
topic |
Obesity Caffeic acid Ferulic acid Metabolic syndrome |
description |
Fractionation of the EtOH extract from aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to isolation of caffeic and ferulic acids, which were identified from spectroscopic and spectrometric evidence. These compounds exhibit antioxidant and anti-inflammatory properties and have been shown to be effective in the prevention/treatment of metabolic syndrome. This study investigated whether the combined treatment of caffeic and ferulic acids exhibits a more significant beneficial effect in a mouse model with metabolic syndrome. The combination treatment with caffeic and ferulic acids was tested for 60 days in C57 mice kept on a high-fat (40%) diet. The data obtained indicated that treatment with caffeic and ferulic acids prevented gain in body weight induced by the high-fat diet and improved hyperglycemia, hypercholesterolemia and hypertriglyceridemia. The expression of a number of metabolically relevant genes was affected in the liver of these animals, showing that caffeic and ferulic acid treatment results in increased cholesterol uptake and reduced hepatic triglyceride synthesis in the liver, which is a likely explanation for the prevention of hepatic steatosis. In conclusion, the combined treatment of caffeic and ferulic acids displayed major positive effects towards prevention of multiple aspects of the metabolic syndrome and liver steatosis in an obese mouse model. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2020-08-21T17:00:18Z |
dc.date.available.fl_str_mv |
2020-08-21T17:00:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal Of Medical And Biological Research. Sao Paulo, v. 49, n. 3, p. -, 2016. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/57929 http://dx.doi.org/10.1590/1414-431X20155003 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
dc.identifier.file.none.fl_str_mv |
S0100-879X2016000300604-en.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X2016000300604 |
dc.identifier.doi.none.fl_str_mv |
10.1590/1414-431X20155003 |
dc.identifier.wos.none.fl_str_mv |
WOS:000370521400006 |
identifier_str_mv |
Brazilian Journal Of Medical And Biological Research. Sao Paulo, v. 49, n. 3, p. -, 2016. 0100-879X S0100-879X2016000300604-en.pdf S0100-879X2016000300604 10.1590/1414-431X20155003 WOS:000370521400006 |
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https://repositorio.unifesp.br/handle/11600/57929 http://dx.doi.org/10.1590/1414-431X20155003 |
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Brazilian Journal Of Medical And Biological Research |
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Sao Paulo |
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Assoc Bras Divulg Cientifica |
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Assoc Bras Divulg Cientifica |
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