Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice

Detalhes bibliográficos
Autor(a) principal: Bocco, B. M.
Data de Publicação: 2016
Outros Autores: Fernandes, G. W., Lorena, F. B., Cysneiros, R. M., Christoffolete, M. A., Grecco, S. S., Lancellotti, C. L., Romoff, P., Lago, J. H. G. [UNIFESP], Bianco, A. C., Ribeiro, M. O.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://repositorio.unifesp.br/handle/11600/57929
http://dx.doi.org/10.1590/1414-431X20155003
Resumo: Fractionation of the EtOH extract from aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to isolation of caffeic and ferulic acids, which were identified from spectroscopic and spectrometric evidence. These compounds exhibit antioxidant and anti-inflammatory properties and have been shown to be effective in the prevention/treatment of metabolic syndrome. This study investigated whether the combined treatment of caffeic and ferulic acids exhibits a more significant beneficial effect in a mouse model with metabolic syndrome. The combination treatment with caffeic and ferulic acids was tested for 60 days in C57 mice kept on a high-fat (40%) diet. The data obtained indicated that treatment with caffeic and ferulic acids prevented gain in body weight induced by the high-fat diet and improved hyperglycemia, hypercholesterolemia and hypertriglyceridemia. The expression of a number of metabolically relevant genes was affected in the liver of these animals, showing that caffeic and ferulic acid treatment results in increased cholesterol uptake and reduced hepatic triglyceride synthesis in the liver, which is a likely explanation for the prevention of hepatic steatosis. In conclusion, the combined treatment of caffeic and ferulic acids displayed major positive effects towards prevention of multiple aspects of the metabolic syndrome and liver steatosis in an obese mouse model.
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spelling Bocco, B. M.Fernandes, G. W.Lorena, F. B.Cysneiros, R. M.Christoffolete, M. A.Grecco, S. S.Lancellotti, C. L.Romoff, P.Lago, J. H. G. [UNIFESP]Bianco, A. C.Ribeiro, M. O.2020-08-21T17:00:18Z2020-08-21T17:00:18Z2016Brazilian Journal Of Medical And Biological Research. Sao Paulo, v. 49, n. 3, p. -, 2016.0100-879Xhttps://repositorio.unifesp.br/handle/11600/57929http://dx.doi.org/10.1590/1414-431X20155003S0100-879X2016000300604-en.pdfS0100-879X201600030060410.1590/1414-431X20155003WOS:000370521400006Fractionation of the EtOH extract from aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to isolation of caffeic and ferulic acids, which were identified from spectroscopic and spectrometric evidence. These compounds exhibit antioxidant and anti-inflammatory properties and have been shown to be effective in the prevention/treatment of metabolic syndrome. This study investigated whether the combined treatment of caffeic and ferulic acids exhibits a more significant beneficial effect in a mouse model with metabolic syndrome. The combination treatment with caffeic and ferulic acids was tested for 60 days in C57 mice kept on a high-fat (40%) diet. The data obtained indicated that treatment with caffeic and ferulic acids prevented gain in body weight induced by the high-fat diet and improved hyperglycemia, hypercholesterolemia and hypertriglyceridemia. The expression of a number of metabolically relevant genes was affected in the liver of these animals, showing that caffeic and ferulic acid treatment results in increased cholesterol uptake and reduced hepatic triglyceride synthesis in the liver, which is a likely explanation for the prevention of hepatic steatosis. In conclusion, the combined treatment of caffeic and ferulic acids displayed major positive effects towards prevention of multiple aspects of the metabolic syndrome and liver steatosis in an obese mouse model.CAPESFAPESPMackPesquisaUniv Presbiteriana Mackenzie, Programa Posgrad Disturbios Desenvolvimento, Ctr Ciencias Biol & Saude, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Med Translac, Escola Paulista Med, Sao Paulo, SP, BrazilUniv Fed ABC, Ctr Ciencias Nat & Humanas, Sao Paulo, SP, BrazilEscola Ciencias Med, Dept Ciencias Patol, Sao Paulo, SP, BrazilUniv Presbiteriana Mackenzie, Escola Engn, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Sao Paulo, SP, BrazilRush Univ & Med Ctr, Dept Internal Med, Div Endocrinol & Metab, Chicago, IL 60612 USAUniv Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Sao Paulo, SP, BrazilFAPESP: 2011/21847-6Web of Science-engAssoc Bras Divulg CientificaBrazilian Journal Of Medical And Biological ResearchObesityCaffeic acidFerulic acidMetabolic syndromeCombined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSao Paulo493info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2016000300604-en.pdfapplication/pdf883174${dspace.ui.url}/bitstream/11600/57929/1/S0100-879X2016000300604-en.pdfe639aa53277abf8b762bfec7c53c3d9fMD51open accessTEXTS0100-879X2016000300604-en.pdf.txtS0100-879X2016000300604-en.pdf.txtExtracted texttext/plain27786${dspace.ui.url}/bitstream/11600/57929/8/S0100-879X2016000300604-en.pdf.txt8d1c85479a00b33d42524bf5e3b2bf26MD58open accessTHUMBNAILS0100-879X2016000300604-en.pdf.jpgS0100-879X2016000300604-en.pdf.jpgIM Thumbnailimage/jpeg7022${dspace.ui.url}/bitstream/11600/57929/10/S0100-879X2016000300604-en.pdf.jpgcb623ca895a17a7ede1dd13a75423e9eMD510open access11600/579292023-06-05 19:27:31.039open accessoai:repositorio.unifesp.br:11600/57929Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:27:31Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice
title Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice
spellingShingle Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice
Bocco, B. M.
Obesity
Caffeic acid
Ferulic acid
Metabolic syndrome
title_short Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice
title_full Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice
title_fullStr Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice
title_full_unstemmed Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice
title_sort Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice
author Bocco, B. M.
author_facet Bocco, B. M.
Fernandes, G. W.
Lorena, F. B.
Cysneiros, R. M.
Christoffolete, M. A.
Grecco, S. S.
Lancellotti, C. L.
Romoff, P.
Lago, J. H. G. [UNIFESP]
Bianco, A. C.
Ribeiro, M. O.
author_role author
author2 Fernandes, G. W.
Lorena, F. B.
Cysneiros, R. M.
Christoffolete, M. A.
Grecco, S. S.
Lancellotti, C. L.
Romoff, P.
Lago, J. H. G. [UNIFESP]
Bianco, A. C.
Ribeiro, M. O.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bocco, B. M.
Fernandes, G. W.
Lorena, F. B.
Cysneiros, R. M.
Christoffolete, M. A.
Grecco, S. S.
Lancellotti, C. L.
Romoff, P.
Lago, J. H. G. [UNIFESP]
Bianco, A. C.
Ribeiro, M. O.
dc.subject.eng.fl_str_mv Obesity
Caffeic acid
Ferulic acid
Metabolic syndrome
topic Obesity
Caffeic acid
Ferulic acid
Metabolic syndrome
description Fractionation of the EtOH extract from aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to isolation of caffeic and ferulic acids, which were identified from spectroscopic and spectrometric evidence. These compounds exhibit antioxidant and anti-inflammatory properties and have been shown to be effective in the prevention/treatment of metabolic syndrome. This study investigated whether the combined treatment of caffeic and ferulic acids exhibits a more significant beneficial effect in a mouse model with metabolic syndrome. The combination treatment with caffeic and ferulic acids was tested for 60 days in C57 mice kept on a high-fat (40%) diet. The data obtained indicated that treatment with caffeic and ferulic acids prevented gain in body weight induced by the high-fat diet and improved hyperglycemia, hypercholesterolemia and hypertriglyceridemia. The expression of a number of metabolically relevant genes was affected in the liver of these animals, showing that caffeic and ferulic acid treatment results in increased cholesterol uptake and reduced hepatic triglyceride synthesis in the liver, which is a likely explanation for the prevention of hepatic steatosis. In conclusion, the combined treatment of caffeic and ferulic acids displayed major positive effects towards prevention of multiple aspects of the metabolic syndrome and liver steatosis in an obese mouse model.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2020-08-21T17:00:18Z
dc.date.available.fl_str_mv 2020-08-21T17:00:18Z
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status_str publishedVersion
dc.identifier.citation.fl_str_mv Brazilian Journal Of Medical And Biological Research. Sao Paulo, v. 49, n. 3, p. -, 2016.
dc.identifier.uri.fl_str_mv https://repositorio.unifesp.br/handle/11600/57929
http://dx.doi.org/10.1590/1414-431X20155003
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dc.identifier.file.none.fl_str_mv S0100-879X2016000300604-en.pdf
dc.identifier.scielo.none.fl_str_mv S0100-879X2016000300604
dc.identifier.doi.none.fl_str_mv 10.1590/1414-431X20155003
dc.identifier.wos.none.fl_str_mv WOS:000370521400006
identifier_str_mv Brazilian Journal Of Medical And Biological Research. Sao Paulo, v. 49, n. 3, p. -, 2016.
0100-879X
S0100-879X2016000300604-en.pdf
S0100-879X2016000300604
10.1590/1414-431X20155003
WOS:000370521400006
url https://repositorio.unifesp.br/handle/11600/57929
http://dx.doi.org/10.1590/1414-431X20155003
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dc.publisher.none.fl_str_mv Assoc Bras Divulg Cientifica
publisher.none.fl_str_mv Assoc Bras Divulg Cientifica
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